A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.472, 5-year impact factor: 4.733
Url: Not available.
Keywords: Bioinformatics, Chaperone, Donor-Strand Exchange, Protein-Protein Interaction, Escherichia Coli Protein, Pilin, Protein Papd, Protein Subunit, Unclassified Drug, Amino Terminal Sequence, Article, Bacterium Pilus, Carboxy Terminal Sequence, Hydrogen Bond, Molecular Dynamics, Nonhuman, Priority Journal, Protein Analysis, Protein Conformation, Protein Domain, Protein Folding, Protein Polymerization, Protein Protein Interaction, Protein Stability, Protein Structure, Structure Activity Relation, Bacterial Proteins, Fimbriae Proteins, Membrane Proteins, Models, Molecular Chaperones, Morphogenesis, Periplasmic Proteins, Protein Binding, Tertiary, Proton-Translocating Atpases, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134 Napoli, Italy
Dipartimento delle Scienze Biologiche - Sezione di Biostrutture, Università degli Studi di Napoli Federico II, I-80134 Napoli, Italy
References:
Chen, C.P., Posy, S., Ben-Shaul, A., Shapiro, L., Honig, B.H., Specificity of cell-cell adhesion by classical cadherins: critical role for low-affinity dimerization through beta-strand swapping (2005) Proc. Natl Acad. Sci. USA, 102, pp. 8531-853
Guo, Z., Eisenberg, D., Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I (2006) Proc. Natl Acad. Sci. USA, 103, pp. 8042-8047
Bennett, M.J., Sawaya, M.R., Eisenberg, D., Deposition diseases and 3D domain swapping (2006) Structure, 14, pp. 811-824
Krasan, G.P., Sauer, F.G., Cutter, D., Farley, M.M., Gilsdorf, J.R., Hultgren, S.J., St Geme III, J.W., Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili (2000) Mol. Microbiol., 35, pp. 1335-1347
Remaut, H., Waksman, G., Protein-protein interaction through beta-strand addition (2006) Trends Biochem. Sci., 31, pp. 436-444
Sauer, F.G., Mulvey, M.A., Schilling, J.D., Martinez, J.J., Hultgren, S.J., Bacterial pili: molecular mechanisms of pathogenesis (2000) Curr. Opin. Microbiol., 3, pp. 65-72
Ng, T.W., Akman, L., Osisami, M., Thanassi, D.G., The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events (2004) J. Bacteriol., 186, pp. 5321-5331
Henderson, N.S., So, S.S., Martin, C., Kulkarni, R., Thanassi, D.G., Topology of the outer membrane usher PapC determined by site-directed fluorescence labeling (2004) J. Biol. Chem., 279, pp. 53747-53754
Li, H., Qian, L., Chen, Z., Thibault, D., Liu, G., Liu, T., Thanassi, D.G., The outer membrane usher forms a twin-pore secretion complex (2004) J. Mol. Biol., 344, pp. 1397-1407
Dodson, K.W., Jacob-Dubuisson, F., Striker, R.T., Hultgren, S.J., Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3670-3674
Bullitt, E., Makowski, L., Structural polymorphism of bacterial adhesion pili (1995) Nature, 373, pp. 164-167
Sauer, F.G., Futterer, K., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Waksman, G., Structural basis of chaperone function and pilus biogenesis (1999) Science, 285, pp. 1058-1061
Sauer, F.G., Pinkner, J.S., Waksman, G., Hultgren, S.J., Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation (2002) Cell, 111, pp. 543-551
Kuehn, M.J., Ogg, D.J., Kihlberg, J., Slonim, L.N., Flemmer, K., Bergfors, T., Hultgren, S.J., Structural basis of pilus subunit recognition by the PapD chaperone (1993) Science, 262, pp. 1234-1241
Holmgren, A., Branden, C.I., Crystal structure of chaperone protein PapD reveals an immunoglobulin fold (1989) Nature, 342, pp. 248-251
Nishiyama, M., Horst, R., Eidam, O., Herrmann, T., Ignatov, O., Vetsch, M., et al Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD (2005) EMBO J., 24, pp. 2075-2086
Nishiyama, M., Vetsch, M., Puorger, C., Jelesarov, I., Glockshuber, R., Identification and characterization of the chaperone-subunit complex-binding domain from the type 1 pilus assembly platform FimD (2003) J. Mol. Biol., 330, pp. 513-525
Choudhury, D., Thompson, A., Stojanoff, V., Langermann, S., Pinkner, J., Hultgren, S.J., Knight, S.D., X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli (1999) Science, 285, pp. 1061-1066
Hermanns, U., Sebbel, P., Eggli, V., Glockshuber, R., Characterization of FimC, a periplasmic assembly factor for biogenesis of type 1 pili in Escherichia coli (2000) Biochemistry, 39, pp. 11564-11570
Zavialov, A.V., Berglund, J., Pudney, A.F., Fooks, L.J., Ibrahim, T.M., MacIntyre, S., Knight, S.D., Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation (2003) Cell, 113, pp. 587-596
Bann, J.G., Pinkner, J.S., Frieden, C., Hultgren, S.J., Catalysis of protein folding by chaperones in pathogenic bacteria (2004) Proc. Natl Acad. Sci. USA, 101, pp. 17389-17393
Vetsch, M., Sebbel, P., Glockshuber, R., Chaperone-independent folding of type 1 pilus domains (2002) J. Mol. Biol., 322, pp. 827-840
Aberg, V., Hedenstrom, M., Pinkner, J.S., Hultgren, S.J., Almqvist, F., C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli (2005) Org. Biomol. Chem., 3, pp. 3886-3892
Hedenstrom, M., Emtenas, H., Pemberton, N., Aberg, V., Hultgren, S.J., Pinkner, J.S., NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly (2005) Org. Biomol. Chem., 3, pp. 4193-4200
Pinkner, J.S., Remaut, H., Buelens, F., Miller, E., Aberg, V., Pemberton, N., Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria (2006) Proc. Natl Acad. Sci. USA, 103, pp. 17897-17902
Vetsch, M., Erilov, D., Moliere, N., Nishiyama, M., Ignatov, O., Glockshuber, R., Mechanism of fibre assembly through the chaperone-usher pathway (2006) EMBO Rep., 7, pp. 734-738
Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G., Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism (2006) Mol. Cell, 22, pp. 831-842
Verger, D., Miller, E., Remaut, H., Waksman, G., Hultgren, S., Molecular mechanism of P pilus termination in uropathogenic Escherichia coli (2006) EMBO Rep., 7, pp. 1228-1232
Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A.E., Berendsen, H.J., GROMACS: fast, flexible, and free (2005) J. Comput. Chem., 26, pp. 1701-1718
Esposito, L., Pedone, C., Vitagliano, L., Molecular dynamics analyses of cross β-spine steric zipper models: β-sheet twisting and aggregation (2006) Proc. Natl Acad. Sci. USA, 103, pp. 11533-11538
Merlino, A., Esposito, L., Vitagliano, L., Polyglutamine repeats and beta-helix structure: molecular dynamics study (2006) Proteins: Struct. Funct. Genet., 63, pp. 918-927
Kawata, M., Nagashima, U., Particle mesh Ewald method for three-dimensional systems with two-dimensional periodicity (2001) Chem. Phys. Letters, 340, pp. 165-172
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-33847716307&partnerID=40&md5=c72620134c7aabb8b8ac13c23cf8c8cf
Chen, C. P., Posy, S., Ben-Shaul, A., Shapiro, L., Honig, B. H., Specificity of cell-cell adhesion by classical cadherins: critical role for low-affinity dimerization through beta-strand swapping (2005) Proc. Natl Acad. Sci. USA, 102, pp. 8531-853
Bennett, M. J., Sawaya, M. R., Eisenberg, D., Deposition diseases and 3D domain swapping (2006) Structure, 14, pp. 811-824
Krasan, G. P., Sauer, F. G., Cutter, D., Farley, M. M., Gilsdorf, J. R., Hultgren, S. J., St Geme III, J. W., Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili (2000) Mol. Microbiol., 35, pp. 1335-1347
Sauer, F. G., Mulvey, M. A., Schilling, J. D., Martinez, J. J., Hultgren, S. J., Bacterial pili: molecular mechanisms of pathogenesis (2000) Curr. Opin. Microbiol., 3, pp. 65-72
Ng, T. W., Akman, L., Osisami, M., Thanassi, D. G., The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events (2004) J. Bacteriol., 186, pp. 5321-5331
Henderson, N. S., So, S. S., Martin, C., Kulkarni, R., Thanassi, D. G., Topology of the outer membrane usher PapC determined by site-directed fluorescence labeling (2004) J. Biol. Chem., 279, pp. 53747-53754
Dodson, K. W., Jacob-Dubuisson, F., Striker, R. T., Hultgren, S. J., Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3670-3674
Sauer, F. G., Futterer, K., Pinkner, J. S., Dodson, K. W., Hultgren, S. J., Waksman, G., Structural basis of chaperone function and pilus biogenesis (1999) Science, 285, pp. 1058-1061
Sauer, F. G., Pinkner, J. S., Waksman, G., Hultgren, S. J., Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation (2002) Cell, 111, pp. 543-551
Kuehn, M. J., Ogg, D. J., Kihlberg, J., Slonim, L. N., Flemmer, K., Bergfors, T., Hultgren, S. J., Structural basis of pilus subunit recognition by the PapD chaperone (1993) Science, 262, pp. 1234-1241
Zavialov, A. V., Berglund, J., Pudney, A. F., Fooks, L. J., Ibrahim, T. M., MacIntyre, S., Knight, S. D., Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation (2003) Cell, 113, pp. 587-596
Bann, J. G., Pinkner, J. S., Frieden, C., Hultgren, S. J., Catalysis of protein folding by chaperones in pathogenic bacteria (2004) Proc. Natl Acad. Sci. USA, 101, pp. 17389-17393
Pinkner, J. S., Remaut, H., Buelens, F., Miller, E., Aberg, V., Pemberton, N., Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria (2006) Proc. Natl Acad. Sci. USA, 103, pp. 17897-17902
UR - http: //www. scopus. com/inward/record. url? eid=2-s2. 0-33847716307&partnerID=40&md5=c72620134c7aabb8b8ac13c23cf8c8cf
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.472, 5-year impact factor: 4.733
Url: Not available.
Keywords: Bioinformatics, Chaperone, Donor-Strand Exchange, Protein-Protein Interaction, Escherichia Coli Protein, Pilin, Protein Papd, Protein Subunit, Unclassified Drug, Amino Terminal Sequence, Article, Bacterium Pilus, Carboxy Terminal Sequence, Hydrogen Bond, Molecular Dynamics, Nonhuman, Priority Journal, Protein Analysis, Protein Conformation, Protein Domain, Protein Folding, Protein Polymerization, Protein Protein Interaction, Protein Stability, Protein Structure, Structure Activity Relation, Bacterial Proteins, Fimbriae Proteins, Membrane Proteins, Models, Molecular Chaperones, Morphogenesis, Periplasmic Proteins, Protein Binding, Tertiary, Proton-Translocating Atpases, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134 Napoli, Italy
Dipartimento delle Scienze Biologiche - Sezione di Biostrutture, Università degli Studi di Napoli Federico II, I-80134 Napoli, Italy
References:
Chen, C.P., Posy, S., Ben-Shaul, A., Shapiro, L., Honig, B.H., Specificity of cell-cell adhesion by classical cadherins: critical role for low-affinity dimerization through beta-strand swapping (2005) Proc. Natl Acad. Sci. USA, 102, pp. 8531-853
Guo, Z., Eisenberg, D., Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I (2006) Proc. Natl Acad. Sci. USA, 103, pp. 8042-8047
Bennett, M.J., Sawaya, M.R., Eisenberg, D., Deposition diseases and 3D domain swapping (2006) Structure, 14, pp. 811-824
Krasan, G.P., Sauer, F.G., Cutter, D., Farley, M.M., Gilsdorf, J.R., Hultgren, S.J., St Geme III, J.W., Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili (2000) Mol. Microbiol., 35, pp. 1335-1347
Remaut, H., Waksman, G., Protein-protein interaction through beta-strand addition (2006) Trends Biochem. Sci., 31, pp. 436-444
Sauer, F.G., Mulvey, M.A., Schilling, J.D., Martinez, J.J., Hultgren, S.J., Bacterial pili: molecular mechanisms of pathogenesis (2000) Curr. Opin. Microbiol., 3, pp. 65-72
Ng, T.W., Akman, L., Osisami, M., Thanassi, D.G., The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events (2004) J. Bacteriol., 186, pp. 5321-5331
Henderson, N.S., So, S.S., Martin, C., Kulkarni, R., Thanassi, D.G., Topology of the outer membrane usher PapC determined by site-directed fluorescence labeling (2004) J. Biol. Chem., 279, pp. 53747-53754
Li, H., Qian, L., Chen, Z., Thibault, D., Liu, G., Liu, T., Thanassi, D.G., The outer membrane usher forms a twin-pore secretion complex (2004) J. Mol. Biol., 344, pp. 1397-1407
Dodson, K.W., Jacob-Dubuisson, F., Striker, R.T., Hultgren, S.J., Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3670-3674
Bullitt, E., Makowski, L., Structural polymorphism of bacterial adhesion pili (1995) Nature, 373, pp. 164-167
Sauer, F.G., Futterer, K., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Waksman, G., Structural basis of chaperone function and pilus biogenesis (1999) Science, 285, pp. 1058-1061
Sauer, F.G., Pinkner, J.S., Waksman, G., Hultgren, S.J., Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation (2002) Cell, 111, pp. 543-551
Kuehn, M.J., Ogg, D.J., Kihlberg, J., Slonim, L.N., Flemmer, K., Bergfors, T., Hultgren, S.J., Structural basis of pilus subunit recognition by the PapD chaperone (1993) Science, 262, pp. 1234-1241
Holmgren, A., Branden, C.I., Crystal structure of chaperone protein PapD reveals an immunoglobulin fold (1989) Nature, 342, pp. 248-251
Nishiyama, M., Horst, R., Eidam, O., Herrmann, T., Ignatov, O., Vetsch, M., et al Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD (2005) EMBO J., 24, pp. 2075-2086
Nishiyama, M., Vetsch, M., Puorger, C., Jelesarov, I., Glockshuber, R., Identification and characterization of the chaperone-subunit complex-binding domain from the type 1 pilus assembly platform FimD (2003) J. Mol. Biol., 330, pp. 513-525
Choudhury, D., Thompson, A., Stojanoff, V., Langermann, S., Pinkner, J., Hultgren, S.J., Knight, S.D., X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli (1999) Science, 285, pp. 1061-1066
Hermanns, U., Sebbel, P., Eggli, V., Glockshuber, R., Characterization of FimC, a periplasmic assembly factor for biogenesis of type 1 pili in Escherichia coli (2000) Biochemistry, 39, pp. 11564-11570
Zavialov, A.V., Berglund, J., Pudney, A.F., Fooks, L.J., Ibrahim, T.M., MacIntyre, S., Knight, S.D., Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation (2003) Cell, 113, pp. 587-596
Bann, J.G., Pinkner, J.S., Frieden, C., Hultgren, S.J., Catalysis of protein folding by chaperones in pathogenic bacteria (2004) Proc. Natl Acad. Sci. USA, 101, pp. 17389-17393
Vetsch, M., Sebbel, P., Glockshuber, R., Chaperone-independent folding of type 1 pilus domains (2002) J. Mol. Biol., 322, pp. 827-840
Aberg, V., Hedenstrom, M., Pinkner, J.S., Hultgren, S.J., Almqvist, F., C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli (2005) Org. Biomol. Chem., 3, pp. 3886-3892
Hedenstrom, M., Emtenas, H., Pemberton, N., Aberg, V., Hultgren, S.J., Pinkner, J.S., NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly (2005) Org. Biomol. Chem., 3, pp. 4193-4200
Pinkner, J.S., Remaut, H., Buelens, F., Miller, E., Aberg, V., Pemberton, N., Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria (2006) Proc. Natl Acad. Sci. USA, 103, pp. 17897-17902
Vetsch, M., Erilov, D., Moliere, N., Nishiyama, M., Ignatov, O., Glockshuber, R., Mechanism of fibre assembly through the chaperone-usher pathway (2006) EMBO Rep., 7, pp. 734-738
Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G., Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism (2006) Mol. Cell, 22, pp. 831-842
Verger, D., Miller, E., Remaut, H., Waksman, G., Hultgren, S., Molecular mechanism of P pilus termination in uropathogenic Escherichia coli (2006) EMBO Rep., 7, pp. 1228-1232
Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A.E., Berendsen, H.J., GROMACS: fast, flexible, and free (2005) J. Comput. Chem., 26, pp. 1701-1718
Esposito, L., Pedone, C., Vitagliano, L., Molecular dynamics analyses of cross β-spine steric zipper models: β-sheet twisting and aggregation (2006) Proc. Natl Acad. Sci. USA, 103, pp. 11533-11538
Merlino, A., Esposito, L., Vitagliano, L., Polyglutamine repeats and beta-helix structure: molecular dynamics study (2006) Proteins: Struct. Funct. Genet., 63, pp. 918-927
Kawata, M., Nagashima, U., Particle mesh Ewald method for three-dimensional systems with two-dimensional periodicity (2001) Chem. Phys. Letters, 340, pp. 165-172
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-33847716307&partnerID=40&md5=c72620134c7aabb8b8ac13c23cf8c8cf
Chen, C. P., Posy, S., Ben-Shaul, A., Shapiro, L., Honig, B. H., Specificity of cell-cell adhesion by classical cadherins: critical role for low-affinity dimerization through beta-strand swapping (2005) Proc. Natl Acad. Sci. USA, 102, pp. 8531-853
Bennett, M. J., Sawaya, M. R., Eisenberg, D., Deposition diseases and 3D domain swapping (2006) Structure, 14, pp. 811-824
Krasan, G. P., Sauer, F. G., Cutter, D., Farley, M. M., Gilsdorf, J. R., Hultgren, S. J., St Geme III, J. W., Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili (2000) Mol. Microbiol., 35, pp. 1335-1347
Sauer, F. G., Mulvey, M. A., Schilling, J. D., Martinez, J. J., Hultgren, S. J., Bacterial pili: molecular mechanisms of pathogenesis (2000) Curr. Opin. Microbiol., 3, pp. 65-72
Ng, T. W., Akman, L., Osisami, M., Thanassi, D. G., The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events (2004) J. Bacteriol., 186, pp. 5321-5331
Henderson, N. S., So, S. S., Martin, C., Kulkarni, R., Thanassi, D. G., Topology of the outer membrane usher PapC determined by site-directed fluorescence labeling (2004) J. Biol. Chem., 279, pp. 53747-53754
Dodson, K. W., Jacob-Dubuisson, F., Striker, R. T., Hultgren, S. J., Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3670-3674
Sauer, F. G., Futterer, K., Pinkner, J. S., Dodson, K. W., Hultgren, S. J., Waksman, G., Structural basis of chaperone function and pilus biogenesis (1999) Science, 285, pp. 1058-1061
Sauer, F. G., Pinkner, J. S., Waksman, G., Hultgren, S. J., Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation (2002) Cell, 111, pp. 543-551
Kuehn, M. J., Ogg, D. J., Kihlberg, J., Slonim, L. N., Flemmer, K., Bergfors, T., Hultgren, S. J., Structural basis of pilus subunit recognition by the PapD chaperone (1993) Science, 262, pp. 1234-1241
Zavialov, A. V., Berglund, J., Pudney, A. F., Fooks, L. J., Ibrahim, T. M., MacIntyre, S., Knight, S. D., Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation (2003) Cell, 113, pp. 587-596
Bann, J. G., Pinkner, J. S., Frieden, C., Hultgren, S. J., Catalysis of protein folding by chaperones in pathogenic bacteria (2004) Proc. Natl Acad. Sci. USA, 101, pp. 17389-17393
Pinkner, J. S., Remaut, H., Buelens, F., Miller, E., Aberg, V., Pemberton, N., Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria (2006) Proc. Natl Acad. Sci. USA, 103, pp. 17897-17902
UR - http: //www. scopus. com/inward/record. url? eid=2-s2. 0-33847716307&partnerID=40&md5=c72620134c7aabb8b8ac13c23cf8c8cf
A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis
Biogenesis of pili in the uropathogenic Echerichia coli, essential to the bacterial pathogenicity, is a complex molecular process, which involves several protein components of the Pap gene cluster. A crucial role in the process is played by the chaperone PapD and by the PapE pilus subunit. Interestingly, PapE exhibits an Ig-like fold with a missing strand. The missing G strand is donated by the chaperone during pilin folding and by adjacent pilus subunits in the final fibre. In order to obtain a detailed picture at atomic level of the molecular events related to this process, we undertook molecular dynamics studies of the non-canonical imuno-globulin-like PapE in its unliganded state. These analyses were extended to the complexes of PapE with the complementary G1 strand of PapD and with the N-terminal extension of PapK. All three systems investigated were stable in the time interval considered (20 ns). However, significant differences in their local and overall flexibilities were detected. Notably, the equilibrated structure of unliganded PapE, which is difficult to characterise experimentally, displays unexpected features. Indeed, a significant rearrangement of the local structure of the groove, which hosts the complementary strands, is observed. This reorganisation, characterised by the formation of several new hydrogen bonds, leads to a closure of the groove that likely makes pilin polymerisation more difficult. These data suggest that chaperone release and pilin-pilin association must be concerted processes and that chaperone plays an important role in preventing pilin transitions towards states that are not prone to polymerise. © 2007 Elsevier Ltd. All rights reserved.
Biogenesis of pili in the uropathogenic Echerichia coli, essential to the bacterial pathogenicity, is a complex molecular process, which involves several protein components of the Pap gene cluster. A crucial role in the process is played by the chaperone PapD and by the PapE pilus subunit. Interestingly, PapE exhibits an Ig-like fold with a missing strand. The missing G strand is donated by the chaperone during pilin folding and by adjacent pilus subunits in the final fibre. In order to obtain a detailed picture at atomic level of the molecular events related to this process, we undertook molecular dynamics studies of the non-canonical imuno-globulin-like PapE in its unliganded state. These analyses were extended to the complexes of PapE with the complementary G1 strand of PapD and with the N-terminal extension of PapK. All three systems investigated were stable in the time interval considered (20 ns). However, significant differences in their local and overall flexibilities were detected. Notably, the equilibrated structure of unliganded PapE, which is difficult to characterise experimentally, displays unexpected features. Indeed, a significant rearrangement of the local structure of the groove, which hosts the complementary strands, is observed. This reorganisation, characterised by the formation of several new hydrogen bonds, leads to a closure of the groove that likely makes pilin polymerisation more difficult. These data suggest that chaperone release and pilin-pilin association must be concerted processes and that chaperone plays an important role in preventing pilin transitions towards states that are not prone to polymerise. © 2007 Elsevier Ltd. All rights reserved.
A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis
A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis
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Impact Factor: 4.411
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
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Impact Factor: 6.126
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Vincenzi M, Mercurio FA, Leone M
* Protein Interaction Domains: structural features and drug discovery applications (part 2) (79 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(5): 854-892.
Impact Factor: 4.184
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Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G
* The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway (8 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2366: 343-356.
Impact Factor: 1.17
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Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
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Impact Factor: 2.74
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
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Impact Factor: 2.641
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
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Impact Factor: 2.598
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Vincenzi M, Mercurio FA, Leone M
* Sam Domains in Multiple Diseases (237 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020; 27(3): 450-476.
Impact Factor: 3.469
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Rega C, Russo R, Foca A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A
* Probing the interaction interface of the GADD45beta/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry (276 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 15; 114: 114-123.
Impact Factor: 1.427
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Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D
* Biochemical characterization of a novel thermostable beta-glucosidase from Dictyoglomus turgidum (927 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 1; 113: 783-791.
Impact Factor: 4.784
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Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (367 views) (PDF 190 views)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
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Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
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Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (279 views) (PDF 172 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Dec 05; 22(49): 17767-17775.
Impact Factor: 5.317
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
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Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (261 views) (PDF 207 views)
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
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Ruvo M, Doti N, Lorenzo V, Vitagliano L, Mascanzoni F
* The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability (280 views)
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Impact Factor: 1.634
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Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (679 views) (PDF 233 views)
Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
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Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
* High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (422 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
Impact Factor: 2.98
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
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Impact Factor: 3.234
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (366 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (389 views)
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Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (467 views)
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Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (697 views)
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Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (414 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (357 views)
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Impact Factor: 2.92
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
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Impact Factor: 4.779
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Ruggiero A, Smaldone G, Squeglia F, Berisio R
* Enhanced crystallizability by protein engineering approaches: A general overview (2078 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
Impact Factor: 1.994
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (390 views)
Gene Expression Omnibus, 2011 Dec 2; 59(2): 302-308.
Impact Factor: 2.082
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (523 views)
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Impact Factor: 4.859
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (435 views)
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Impact Factor: 3.022
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (674 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (558 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (485 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (362 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Conformational states and association mechanism of Yersinia pestis Caf1 subunits (322 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2008 Sep 8; 372(4): 804-810.
Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
* Peptide antagonists of protein-protein interactions identified by screening protein fragments derived by enzyme degradation (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (456 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (445 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (366 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (303 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (589 views)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (241 views)
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Impact Factor: 3.73
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Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
* Polyproline helices in protein structures: A statistical survey (333 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
Impact Factor: 1.13
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Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C
* Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli (334 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Oct; 59(10): 1846-1848.
Impact Factor: 2.208
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* Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA-mimic protein and may be involved in the adaptation of Burkholderia cenocepacia (5 views)
Microbiologyopen (ISSN: 2045-8827linking), 2022 Feb; 11(1): e1264-N/D.
Impact Factor: 3.48
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La Gatta S, Leone L, Maglio O, De Fenza M, Nastri F, Pavone V, Chino M, Lombardi A
* Unravelling the Structure of the Tetrahedral Metal-Binding Site in METP3 through an Experimental and Computational Approach (7 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Aug 28; 26(17): N/D-N/D.
Impact Factor: 4.411
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 13; 13(16): N/D-N/D.
Impact Factor: 6.126
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Vincenzi M, Mercurio FA, Leone M
* Protein Interaction Domains: structural features and drug discovery applications (part 2) (79 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(5): 854-892.
Impact Factor: 4.184
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Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G
* The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway (8 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2366: 343-356.
Impact Factor: 1.17
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Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
Plosone (ISSN: 1932-6203linking, 1932-6203electronic), 2020 Nov 23; 15(11): e0242593-N/D.
Impact Factor: 2.74
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Vincenzi M, Mercurio FA, Leone M
* Sam Domains in Multiple Diseases (237 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020; 27(3): 450-476.
Impact Factor: 3.469
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Rega C, Russo R, Foca A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A
* Probing the interaction interface of the GADD45beta/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry (276 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 15; 114: 114-123.
Impact Factor: 1.427
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Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D
* Biochemical characterization of a novel thermostable beta-glucosidase from Dictyoglomus turgidum (927 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 1; 113: 783-791.
Impact Factor: 4.784
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Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (367 views) (PDF 190 views)
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
View Export to BibTeX Export to EndNote
Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
View Export to BibTeX Export to EndNote
Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (279 views) (PDF 172 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Dec 05; 22(49): 17767-17775.
Impact Factor: 5.317
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
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Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (261 views) (PDF 207 views)
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
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Ruvo M, Doti N, Lorenzo V, Vitagliano L, Mascanzoni F
* The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability (280 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2016 May; 58(5): 328-339.
Impact Factor: 1.634
View Export to BibTeX Export to EndNote
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (679 views) (PDF 233 views)
Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
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Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
* High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (422 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
Impact Factor: 2.98
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (366 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (389 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (467 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (697 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (414 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (357 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Ruggiero A, Smaldone G, Squeglia F, Berisio R
* Enhanced crystallizability by protein engineering approaches: A general overview (2078 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
Impact Factor: 1.994
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (390 views)
Gene Expression Omnibus, 2011 Dec 2; 59(2): 302-308.
Impact Factor: 2.082
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (523 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (435 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (674 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (558 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (485 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (362 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Conformational states and association mechanism of Yersinia pestis Caf1 subunits (322 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2008 Sep 8; 372(4): 804-810.
Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
* Peptide antagonists of protein-protein interactions identified by screening protein fragments derived by enzyme degradation (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (456 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (445 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (366 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (303 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (589 views)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (241 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
Impact Factor: 3.73
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Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
* Polyproline helices in protein structures: A statistical survey (333 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
Impact Factor: 1.13
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Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C
* Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli (334 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Oct; 59(10): 1846-1848.
Impact Factor: 2.208
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48 Records (44 excluding Abstracts).
Total impact factor: 163.473 (149.182 excluding Abstracts).
Total 5 year impact factor: 174.827 (161.646 excluding Abstracts).
Total impact factor: 163.473 (149.182 excluding Abstracts).
Total 5 year impact factor: 174.827 (161.646 excluding Abstracts).
447 views. Last view on Tuesday 21 March 2023, 23:39:03
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