Acetyl-l-carnitine in neuropathic pain (385 views)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
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Paper type: Abstract, Conference,
Impact factor: 4.514, 5-year impact factor: 4.31
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-35348878570&partnerID=40&md5=e2275125b864d4039674e705bc3b1872
Keywords: Acetylcarnitine, Metabotropic Receptor, Muscarinic Receptor, Nootropic Agent, Phospholipase C, Analgesia, Animal, Drug Effect, Genetics, Human, Metabolism, Pathophysiology, Peripheral Neuropathy, Review, Peripheral Nervous System Diseases, Metabotropic Glutamate,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy.
References:
Not available.
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference,
Impact factor: 4.514, 5-year impact factor: 4.31
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-35348878570&partnerID=40&md5=e2275125b864d4039674e705bc3b1872
Keywords: Acetylcarnitine, Metabotropic Receptor, Muscarinic Receptor, Nootropic Agent, Phospholipase C, Analgesia, Animal, Drug Effect, Genetics, Human, Metabolism, Pathophysiology, Peripheral Neuropathy, Review, Peripheral Nervous System Diseases, Metabotropic Glutamate,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy.
References:
Not available.
Acetyl-l-carnitine in neuropathic pain
Acetyl-L-carnitine (ALC) has gained clinical interest for its analgesic effect in different forms of neuropathies associated with chronic pain, such as diabetic and HIV-related peripheral neuropathies. The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy-induced neuropathy, and the sciatic nerve chronic constriction injury model. In these models, prophylactic administration of ALC has proven to be effective in preventing the development of neuropathic pain. In addition, ALC is known to produce a strong antinociceptive effect when given after neuropathic pain has been established. ALC can also improve the function of peripheral nerves by increasing nerve conduction velocity, reducing sensory neuronal loss, and promoting nerve regeneration. Analgesia requires repeated administrations of ALC, suggesting that the drug regulates neuroplasticity across the pain neuraxis. Recent evidence indicates that ALC regulates processes that go beyond its classical role in energy metabolism. These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons. Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-kappa B family.
Acetyl-L-carnitine (ALC) has gained clinical interest for its analgesic effect in different forms of neuropathies associated with chronic pain, such as diabetic and HIV-related peripheral neuropathies. The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy-induced neuropathy, and the sciatic nerve chronic constriction injury model. In these models, prophylactic administration of ALC has proven to be effective in preventing the development of neuropathic pain. In addition, ALC is known to produce a strong antinociceptive effect when given after neuropathic pain has been established. ALC can also improve the function of peripheral nerves by increasing nerve conduction velocity, reducing sensory neuronal loss, and promoting nerve regeneration. Analgesia requires repeated administrations of ALC, suggesting that the drug regulates neuroplasticity across the pain neuraxis. Recent evidence indicates that ALC regulates processes that go beyond its classical role in energy metabolism. These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons. Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-kappa B family.
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View Export to BibTeX Export to EndNote
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9 Records (9 excluding Abstracts).
Total impact factor: 53.819 (53.819 excluding Abstracts).
Total 5 year impact factor: 56.937 (56.937 excluding Abstracts).
Total impact factor: 53.819 (53.819 excluding Abstracts).
Total 5 year impact factor: 56.937 (56.937 excluding Abstracts).
385 views. Last view on Sunday 01 December 2024, 3:33:19
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