Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study(350 views) Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
Keywords: Bent Duplexes, Hmgb1 Inhibition, Adenine, Curved Dna, Double Stranded Dna, High Mobility Group B1 Protein, High Mobility Group B1 Protein Inhibitor, Oligonucleotide, Polynucleotide, Unclassified Drug, Article, Chimera, Circular Dichroism, Comparative Study, Dna Helix, Drug Activity, Ic 50, Inflammation, Inhibition Kinetics, Molecule, Spectroscopy, Thermodynamics, Titrimetry, Hmgb1 Protein, Humans,
Affiliations: *** IBB - CNR ***
Istituto di Biostutture e Bioimmagini-CNR, Naples, Italy
Bionucleon Srl, Colleretto Giacosa (TO), Italy
Creabilis Therapeutics SpA, Colleretto Giacosa (TO), Italy
Instituto di Biostuture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
References: Bucci, E.M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Yang, H., Wang, H., Tracey, K.J., HMG-1 rediscovered as a cytokine (2001) Shock, 15, pp. 247-253
Barone, D.G., Bianchi, M.E., Bucci, E.M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Bucci, E. M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Barone, D. G., Bianchi, M. E., Bucci, E. M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V. A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study