Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (676 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
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Paper type: Journal Article,
Impact factor: 0.723, 5-year impact factor: 0.657
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36949017074&partnerID=40&md5=df739d56cd28b0b6a2b8ee5ddc9c4079
Keywords: Bent Duplexes, Hmgb1 Inhibition, Adenine, Curved Dna, Double Stranded Dna, High Mobility Group B1 Protein, High Mobility Group B1 Protein Inhibitor, Oligonucleotide, Polynucleotide, Unclassified Drug, Article, Chimera, Circular Dichroism, Comparative Study, Dna Helix, Drug Activity, Ic 50, Inflammation, Inhibition Kinetics, Molecule, Spectroscopy, Thermodynamics, Titrimetry, Hmgb1 Protein, Humans,
Affiliations:
*** IBB - CNR ***
Istituto di Biostutture e Bioimmagini-CNR, Naples, Italy
Bionucleon Srl, Colleretto Giacosa (TO), Italy
Creabilis Therapeutics SpA, Colleretto Giacosa (TO), Italy
Instituto di Biostuture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
References:
Not available.
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.723, 5-year impact factor: 0.657
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36949017074&partnerID=40&md5=df739d56cd28b0b6a2b8ee5ddc9c4079
Keywords: Bent Duplexes, Hmgb1 Inhibition, Adenine, Curved Dna, Double Stranded Dna, High Mobility Group B1 Protein, High Mobility Group B1 Protein Inhibitor, Oligonucleotide, Polynucleotide, Unclassified Drug, Article, Chimera, Circular Dichroism, Comparative Study, Dna Helix, Drug Activity, Ic 50, Inflammation, Inhibition Kinetics, Molecule, Spectroscopy, Thermodynamics, Titrimetry, Hmgb1 Protein, Humans,
Affiliations:
*** IBB - CNR ***
Istituto di Biostutture e Bioimmagini-CNR, Naples, Italy
Bionucleon Srl, Colleretto Giacosa (TO), Italy
Creabilis Therapeutics SpA, Colleretto Giacosa (TO), Italy
Instituto di Biostuture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
References:
Not available.
Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view. Copyright © Taylor & Francis Group, LLC.
In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view. Copyright © Taylor & Francis Group, LLC.
Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
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Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.421
View Export to BibTeX Export to EndNote
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Impact Factor: 1.567
View Export to BibTeX Export to EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
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Impact Factor: 6.482
View Export to BibTeX Export to EndNote
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
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Impact Factor: 3.542
View Export to BibTeX Export to EndNote
Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
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Impact Factor: 1.826
View Export to BibTeX Export to EndNote
14 Records (14 excluding Abstracts).
Total impact factor: 72.04 (72.04 excluding Abstracts).
Total 5 year impact factor: 71.845 (71.845 excluding Abstracts).
Total impact factor: 72.04 (72.04 excluding Abstracts).
Total 5 year impact factor: 71.845 (71.845 excluding Abstracts).
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