Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (350 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
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Paper type: Journal Article,
Impact factor: 0.723, 5-year impact factor: 0.657
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36949017074&partnerID=40&md5=df739d56cd28b0b6a2b8ee5ddc9c4079
Keywords: Bent Duplexes, Hmgb1 Inhibition, Adenine, Curved Dna, Double Stranded Dna, High Mobility Group B1 Protein, High Mobility Group B1 Protein Inhibitor, Oligonucleotide, Polynucleotide, Unclassified Drug, Article, Chimera, Circular Dichroism, Comparative Study, Dna Helix, Drug Activity, Ic 50, Inflammation, Inhibition Kinetics, Molecule, Spectroscopy, Thermodynamics, Titrimetry, Hmgb1 Protein, Humans,
Affiliations:
*** IBB - CNR ***
Istituto di Biostutture e Bioimmagini-CNR, Naples, Italy
Bionucleon Srl, Colleretto Giacosa (TO), Italy
Creabilis Therapeutics SpA, Colleretto Giacosa (TO), Italy
Instituto di Biostuture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
References:
Bucci, E.M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Yang, H., Wang, H., Tracey, K.J., HMG-1 rediscovered as a cytokine (2001) Shock, 15, pp. 247-253
Barone, D.G., Bianchi, M.E., Bucci, E.M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Bucci, E. M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Barone, D. G., Bianchi, M. E., Bucci, E. M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V. A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.723, 5-year impact factor: 0.657
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36949017074&partnerID=40&md5=df739d56cd28b0b6a2b8ee5ddc9c4079
Keywords: Bent Duplexes, Hmgb1 Inhibition, Adenine, Curved Dna, Double Stranded Dna, High Mobility Group B1 Protein, High Mobility Group B1 Protein Inhibitor, Oligonucleotide, Polynucleotide, Unclassified Drug, Article, Chimera, Circular Dichroism, Comparative Study, Dna Helix, Drug Activity, Ic 50, Inflammation, Inhibition Kinetics, Molecule, Spectroscopy, Thermodynamics, Titrimetry, Hmgb1 Protein, Humans,
Affiliations:
*** IBB - CNR ***
Istituto di Biostutture e Bioimmagini-CNR, Naples, Italy
Bionucleon Srl, Colleretto Giacosa (TO), Italy
Creabilis Therapeutics SpA, Colleretto Giacosa (TO), Italy
Instituto di Biostuture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
References:
Bucci, E.M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Yang, H., Wang, H., Tracey, K.J., HMG-1 rediscovered as a cytokine (2001) Shock, 15, pp. 247-253
Barone, D.G., Bianchi, M.E., Bucci, E.M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V.A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Bucci, E. M., Musumeci, D., Valente, M., More than antisense. Targeting extracellular proteins by oligonucleotide analogues (2006) Screening Trends in Drug Discovery, 2, pp. 32-3
Barone, D. G., Bianchi, M. E., Bucci, E. M., Fumero, S., Valente, M., Sapio, R., Musumeci, D., Therapeutic agents comprising synthetic double-stranded nucleic acid with a bent shape structure for the treatment of HMGB1-related pathologies (2006), PCT Int. Appl, WO 2006002971Kurreck, J., Wyszko, E., Gillen, C., Erdmann, V. A., Design of antisense oligonucleotides stabilized by locked nucleic acids (2002) Nucleic Acids Res, 30 (9), pp. 1911-1918
Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view. Copyright © Taylor & Francis Group, LLC.
In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view. Copyright © Taylor & Francis Group, LLC.
Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
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Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study
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Impact Factor: 4.3
View Export to BibTeX Export to EndNote
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Impact Factor: 8.709
View Export to BibTeX Export to EndNote
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J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015 Jun 10; 137(22): 7059-7062.
Impact Factor: 13.038
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Montesarchio D
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Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
View Export to BibTeX Export to EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (481 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
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Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
View Export to BibTeX Export to EndNote
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Impact Factor: 2.572
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
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Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (362 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
View Export to BibTeX Export to EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (600 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
View Export to BibTeX Export to EndNote
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (431 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
View Export to BibTeX Export to EndNote
Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
View Export to BibTeX Export to EndNote
14 Records (14 excluding Abstracts).
Total impact factor: 72.04 (72.04 excluding Abstracts).
Total 5 year impact factor: 71.845 (71.845 excluding Abstracts).
Total impact factor: 72.04 (72.04 excluding Abstracts).
Total 5 year impact factor: 71.845 (71.845 excluding Abstracts).
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