Carnosine interaction with nitric oxide and astroglial cell protection (698 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547437365&partnerID=40&md5=8dc6e49f2eb8f24a3e75771ab9185248
Keywords: β-Alanyl-L-Histidine, Astrocytes, Esi-Mass Spectrometry, Carcinine, Carnosine, Gamma Interferon, Homocarnosine, Lipopolysaccharide, Nitric Oxide, Scavenger, Unclassified Drug, Animal Cell, Apoptosis, Article, Cell Culture, Cell Death, Cell Protection, Controlled Study, Electrospray Mass Spectrometry, Neuroprotection, Newborn, Nonhuman, Priority Journal, Spectrophotometry, Cytoprotection, Dose-Response Relationship, Drug Combinations, Drug Interactions, Free Radical Scavengers, Interferon Type Ii, Neurotoxins, Wistar,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy. nicovigi@unict.it
Istituto Biostrutture e Bioimmagini, CNR Catania, Catania, Italy
References:
Not available.
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547437365&partnerID=40&md5=8dc6e49f2eb8f24a3e75771ab9185248
Keywords: β-Alanyl-L-Histidine, Astrocytes, Esi-Mass Spectrometry, Carcinine, Carnosine, Gamma Interferon, Homocarnosine, Lipopolysaccharide, Nitric Oxide, Scavenger, Unclassified Drug, Animal Cell, Apoptosis, Article, Cell Culture, Cell Death, Cell Protection, Controlled Study, Electrospray Mass Spectrometry, Neuroprotection, Newborn, Nonhuman, Priority Journal, Spectrophotometry, Cytoprotection, Dose-Response Relationship, Drug Combinations, Drug Interactions, Free Radical Scavengers, Interferon Type Ii, Neurotoxins, Wistar,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy. nicovigi@unict.it
Istituto Biostrutture e Bioimmagini, CNR Catania, Catania, Italy
References:
Not available.
Carnosine interaction with nitric oxide and astroglial cell protection
The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (c) 2007 Wiley-Liss, Inc.
The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (c) 2007 Wiley-Liss, Inc.
Carnosine interaction with nitric oxide and astroglial cell protection
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Carnosine interaction with nitric oxide and astroglial cell protection
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.187
View Export to BibTeX Export to EndNote
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Impact Factor: 6.696
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
20 Records (19 excluding Abstracts).
Total impact factor: 76.052 (76.052 excluding Abstracts).
Total 5 year impact factor: 76.375 (76.375 excluding Abstracts).
Total impact factor: 76.052 (76.052 excluding Abstracts).
Total 5 year impact factor: 76.375 (76.375 excluding Abstracts).
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