Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy. nicovigi@unict.it
Istituto Biostrutture e Bioimmagini, CNR Catania, Catania, Italy
References: Abe, H., Histidine-related dipeptides: Distribution, metabolism and physiological function (1995) Biochemistry and molecular biology of fishes, 4, pp. 310-333. , Hochachka PW, Mommsen TP, editors, Amsterdam: Elsevier Science.
Bharadwaj LA, Davies GF, Xavier IJ, Ovsenek N. 2002. L-Carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1a) H9c2 cardiomyoblasts. Pharmacol Res 45:177-181Bian, K., Murad, F., Nitric oxide (NO) bio-generation, regulation, and relevance to human diseases (2003) Front Biosci, 8, pp. 264-278
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., Protection of neuronal cells against reactive oxygen species by carnosine and related compounds (2004) Comp Biochem Physiol Part B Biochem Mol Biol, 137, pp. 81-88
Boldyrev, A., Johnson, P., Carnosine and related compounds: Antioxidant dipeptides (2002) Oxidative stress at molecular, cellular and organ levels, pp. 101-114. , Johnson P, Boldyrev A, editors, Research Signpost. p
Boldyrev, A.A., Leinsoo, T.A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671 .7), pp. 33rd. , Abstract, Washington, DC
Brown, G.C., Bal, P.A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
De Marchis, S., Modena, C., Peretto, P., Migheli, A., Margolis, F.L., Fasolo, A., Carnosine-related dipeptides in neurons and glia (2000) Biochemistry (Mosc), 65, pp. 824-833
Dell'Albani, P., Santangelo, R., Torrisi, L., Nicoletti, V.G., Giuffrida Stella, A.M., Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS (2003) Neurochem Res, 28, pp. 53-64
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Guiotto, A., Calderan, A., Ruzza, P., Boring, G., Carnosine and carnosine-related antioxidants: A review (2005) Curr Med Chem, 12, pp. 2293-2315
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A.R., Brownson, C., Bertani, M.F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L.J., Seibel, I., Yeargans, G.S., Seidler, N.W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Holliday, R., McFarland, G.A., Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine (1996) Br J Cancer, 73, pp. 966-971
Marletta, M.A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M.A., Hurshman, A.R., Rusche, K.M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A.F., Jakeman, P.M., Dunnett, M., Harris, R.C., Willan, P.L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V.G., Caruso, A., Tendi, E.A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A.M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V.G., Marino, V.M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A.M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R.W., Cook, J.C., Krishna, M.C., Christodoulou, D., Poore, C.M.B., Miles, A.M., Grisham, M.B., Wink, D.A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Pegova, A., Abe, H., Boldyrev, A., Hydrolysis of carnosine and related compounds by mammalian carnosinases (2000) Comp Biochem Physiol B, 127, pp. 443-446
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbot, J.N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P.R., Boldyrev, A.A., Formazuyk, V.E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E.V., Bastrikova, N.A., Stvolinsky, S.L., Fedorova, T.N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Sultana, R., Poon, F.H., Cai, J., Pierce, W.M., Merchant, M., Klein, J.B., Markesbery, W.R., Butterfield, D.A., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurob Dis, 22, pp. 76-87
Vistoli, G., Pedretti, A., Cattaneo, M., Aldini, G., Testa, B., Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate (2006) J Med Chem, 49, pp. 3269-3277
Wishnok, J.S., Glogowski, J.A., Tannenbaum, S.R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Boldyrev, A. A., Leinsoo, T. A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671. 7), pp. 33rd. , Abstract, Washington, DC
Brown, G. C., Bal, P. A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Hipkiss, A. R., Preston, J. E., Himsworth, D. T., Worthington, V. C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N. J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A. R., Brownson, C., Bertani, M. F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L. J., Seibel, I., Yeargans, G. S., Seidler, N. W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Marletta, M. A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M. A., Hurshman, A. R., Rusche, K. M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A. F., Jakeman, P. M., Dunnett, M., Harris, R. C., Willan, P. L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V. G., Caruso, A., Tendi, E. A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A. M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V. G., Marino, V. M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A. M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R. W., Cook, J. C., Krishna, M. C., Christodoulou, D., Poore, C. M. B., Miles, A. M., Grisham, M. B., Wink, D. A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Preston, J. E., Hipkiss, A. R., Himsworth, D. T., Romero, I. A., Abbot, J. N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P. R., Boldyrev, A. A., Formazuyk, V. E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I. S., Bussygina, O. G., Pyatakova, N. V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S. H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E. V., Bastrikova, N. A., Stvolinsky, S. L., Fedorova, T. N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Wishnok, J. S., Glogowski, J. A., Tannenbaum, S. R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Carnosine interaction with nitric oxide and astroglial cell protection
The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (c) 2007 Wiley-Liss, Inc.
Carnosine interaction with nitric oxide and astroglial cell protection
No results.
Carnosine interaction with nitric oxide and astroglial cell protection