Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547437365&partnerID=40&md5=8dc6e49f2eb8f24a3e75771ab9185248
Keywords: β-Alanyl-L-Histidine, Astrocytes, Esi-Mass Spectrometry, Carcinine, Carnosine, Gamma Interferon, Homocarnosine, Lipopolysaccharide, Nitric Oxide, Scavenger, Unclassified Drug, Animal Cell, Apoptosis, Article, Cell Culture, Cell Death, Cell Protection, Controlled Study, Electrospray Mass Spectrometry, Neuroprotection, Newborn, Nonhuman, Priority Journal, Spectrophotometry, Cytoprotection, Dose-Response Relationship, Drug Combinations, Drug Interactions, Free Radical Scavengers, Interferon Type Ii, Neurotoxins, Wistar,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy. nicovigi@unict.it
Istituto Biostrutture e Bioimmagini, CNR Catania, Catania, Italy
References:
Abe, H., Histidine-related dipeptides: Distribution, metabolism and physiological function (1995) Biochemistry and molecular biology of fishes, 4, pp. 310-333. , Hochachka PW, Mommsen TP, editors, Amsterdam: Elsevier Science.
Bharadwaj LA, Davies GF, Xavier IJ, Ovsenek N. 2002. L-Carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1a) H9c2 cardiomyoblasts. Pharmacol Res 45:177-181Bian, K., Murad, F., Nitric oxide (NO) bio-generation, regulation, and relevance to human diseases (2003) Front Biosci, 8, pp. 264-278
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., Protection of neuronal cells against reactive oxygen species by carnosine and related compounds (2004) Comp Biochem Physiol Part B Biochem Mol Biol, 137, pp. 81-88
Boldyrev, A., Johnson, P., Carnosine and related compounds: Antioxidant dipeptides (2002) Oxidative stress at molecular, cellular and organ levels, pp. 101-114. , Johnson P, Boldyrev A, editors, Research Signpost. p
Boldyrev, A.A., Leinsoo, T.A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671 .7), pp. 33rd. , Abstract, Washington, DC
Brown, G.C., Bal, P.A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
De Marchis, S., Modena, C., Peretto, P., Migheli, A., Margolis, F.L., Fasolo, A., Carnosine-related dipeptides in neurons and glia (2000) Biochemistry (Mosc), 65, pp. 824-833
Dell'Albani, P., Santangelo, R., Torrisi, L., Nicoletti, V.G., Giuffrida Stella, A.M., Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS (2003) Neurochem Res, 28, pp. 53-64
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Guiotto, A., Calderan, A., Ruzza, P., Boring, G., Carnosine and carnosine-related antioxidants: A review (2005) Curr Med Chem, 12, pp. 2293-2315
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A.R., Brownson, C., Bertani, M.F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L.J., Seibel, I., Yeargans, G.S., Seidler, N.W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Holliday, R., McFarland, G.A., Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine (1996) Br J Cancer, 73, pp. 966-971
Marletta, M.A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M.A., Hurshman, A.R., Rusche, K.M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A.F., Jakeman, P.M., Dunnett, M., Harris, R.C., Willan, P.L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V.G., Caruso, A., Tendi, E.A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A.M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V.G., Marino, V.M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A.M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R.W., Cook, J.C., Krishna, M.C., Christodoulou, D., Poore, C.M.B., Miles, A.M., Grisham, M.B., Wink, D.A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Pegova, A., Abe, H., Boldyrev, A., Hydrolysis of carnosine and related compounds by mammalian carnosinases (2000) Comp Biochem Physiol B, 127, pp. 443-446
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbot, J.N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P.R., Boldyrev, A.A., Formazuyk, V.E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E.V., Bastrikova, N.A., Stvolinsky, S.L., Fedorova, T.N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Sultana, R., Poon, F.H., Cai, J., Pierce, W.M., Merchant, M., Klein, J.B., Markesbery, W.R., Butterfield, D.A., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurob Dis, 22, pp. 76-87
Vistoli, G., Pedretti, A., Cattaneo, M., Aldini, G., Testa, B., Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate (2006) J Med Chem, 49, pp. 3269-3277
Wishnok, J.S., Glogowski, J.A., Tannenbaum, S.R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Boldyrev, A. A., Leinsoo, T. A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671. 7), pp. 33rd. , Abstract, Washington, DC
Brown, G. C., Bal, P. A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Hipkiss, A. R., Preston, J. E., Himsworth, D. T., Worthington, V. C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N. J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A. R., Brownson, C., Bertani, M. F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L. J., Seibel, I., Yeargans, G. S., Seidler, N. W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Marletta, M. A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M. A., Hurshman, A. R., Rusche, K. M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A. F., Jakeman, P. M., Dunnett, M., Harris, R. C., Willan, P. L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V. G., Caruso, A., Tendi, E. A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A. M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V. G., Marino, V. M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A. M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R. W., Cook, J. C., Krishna, M. C., Christodoulou, D., Poore, C. M. B., Miles, A. M., Grisham, M. B., Wink, D. A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Preston, J. E., Hipkiss, A. R., Himsworth, D. T., Romero, I. A., Abbot, J. N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P. R., Boldyrev, A. A., Formazuyk, V. E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I. S., Bussygina, O. G., Pyatakova, N. V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S. H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E. V., Bastrikova, N. A., Stvolinsky, S. L., Fedorova, T. N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Wishnok, J. S., Glogowski, J. A., Tannenbaum, S. R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547437365&partnerID=40&md5=8dc6e49f2eb8f24a3e75771ab9185248
Keywords: β-Alanyl-L-Histidine, Astrocytes, Esi-Mass Spectrometry, Carcinine, Carnosine, Gamma Interferon, Homocarnosine, Lipopolysaccharide, Nitric Oxide, Scavenger, Unclassified Drug, Animal Cell, Apoptosis, Article, Cell Culture, Cell Death, Cell Protection, Controlled Study, Electrospray Mass Spectrometry, Neuroprotection, Newborn, Nonhuman, Priority Journal, Spectrophotometry, Cytoprotection, Dose-Response Relationship, Drug Combinations, Drug Interactions, Free Radical Scavengers, Interferon Type Ii, Neurotoxins, Wistar,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy. nicovigi@unict.it
Istituto Biostrutture e Bioimmagini, CNR Catania, Catania, Italy
References:
Abe, H., Histidine-related dipeptides: Distribution, metabolism and physiological function (1995) Biochemistry and molecular biology of fishes, 4, pp. 310-333. , Hochachka PW, Mommsen TP, editors, Amsterdam: Elsevier Science.
Bharadwaj LA, Davies GF, Xavier IJ, Ovsenek N. 2002. L-Carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1a) H9c2 cardiomyoblasts. Pharmacol Res 45:177-181Bian, K., Murad, F., Nitric oxide (NO) bio-generation, regulation, and relevance to human diseases (2003) Front Biosci, 8, pp. 264-278
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., Protection of neuronal cells against reactive oxygen species by carnosine and related compounds (2004) Comp Biochem Physiol Part B Biochem Mol Biol, 137, pp. 81-88
Boldyrev, A., Johnson, P., Carnosine and related compounds: Antioxidant dipeptides (2002) Oxidative stress at molecular, cellular and organ levels, pp. 101-114. , Johnson P, Boldyrev A, editors, Research Signpost. p
Boldyrev, A.A., Leinsoo, T.A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671 .7), pp. 33rd. , Abstract, Washington, DC
Brown, G.C., Bal, P.A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
De Marchis, S., Modena, C., Peretto, P., Migheli, A., Margolis, F.L., Fasolo, A., Carnosine-related dipeptides in neurons and glia (2000) Biochemistry (Mosc), 65, pp. 824-833
Dell'Albani, P., Santangelo, R., Torrisi, L., Nicoletti, V.G., Giuffrida Stella, A.M., Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS (2003) Neurochem Res, 28, pp. 53-64
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Guiotto, A., Calderan, A., Ruzza, P., Boring, G., Carnosine and carnosine-related antioxidants: A review (2005) Curr Med Chem, 12, pp. 2293-2315
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A.R., Brownson, C., Bertani, M.F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L.J., Seibel, I., Yeargans, G.S., Seidler, N.W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Holliday, R., McFarland, G.A., Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine (1996) Br J Cancer, 73, pp. 966-971
Marletta, M.A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M.A., Hurshman, A.R., Rusche, K.M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A.F., Jakeman, P.M., Dunnett, M., Harris, R.C., Willan, P.L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V.G., Caruso, A., Tendi, E.A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A.M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V.G., Marino, V.M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A.M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R.W., Cook, J.C., Krishna, M.C., Christodoulou, D., Poore, C.M.B., Miles, A.M., Grisham, M.B., Wink, D.A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Pegova, A., Abe, H., Boldyrev, A., Hydrolysis of carnosine and related compounds by mammalian carnosinases (2000) Comp Biochem Physiol B, 127, pp. 443-446
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbot, J.N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P.R., Boldyrev, A.A., Formazuyk, V.E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E.V., Bastrikova, N.A., Stvolinsky, S.L., Fedorova, T.N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Sultana, R., Poon, F.H., Cai, J., Pierce, W.M., Merchant, M., Klein, J.B., Markesbery, W.R., Butterfield, D.A., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurob Dis, 22, pp. 76-87
Vistoli, G., Pedretti, A., Cattaneo, M., Aldini, G., Testa, B., Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate (2006) J Med Chem, 49, pp. 3269-3277
Wishnok, J.S., Glogowski, J.A., Tannenbaum, S.R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Boldyrev, A. A., Leinsoo, T. A., Abe, H., Methylation of neuropeptide carnosine modifies its protecting but not antioxidant properties (2002) Annual Meeting of Society for Neuroscience, (671. 7), pp. 33rd. , Abstract, Washington, DC
Brown, G. C., Bal, P. A., Inflammatory neurodegeneration mediated by nitric oxide, glutamate and mitochondria (2003) Mol Neurobiol, 27, pp. 325-355
Hipkiss, A. R., Preston, J. E., Himsworth, D. T., Worthington, V. C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N. J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N Y Acad Sci, 854, pp. 37-53
Hipkiss, A. R., Brownson, C., Bertani, M. F., Ruiz, E., Ferro, A., Reaction of carnosine with aged proteins: Another protective process? (2002) Ann NY Acad Sci, 959, pp. 285-294
Hobart, L. J., Seibel, I., Yeargans, G. S., Seidler, N. W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sci, 75, pp. 1379-1389
Marletta, M. A., Nitric oxide: Biosynthesis and biological significance (1989) Trends Biochem Sci, 14, pp. 488-492
Marletta, M. A., Hurshman, A. R., Rusche, K. M., Catalysis by nitric oxide synthase (1998) Curr Opin Chem Biol, 2, pp. 656-663
Mannion, A. F., Jakeman, P. M., Dunnett, M., Harris, R. C., Willan, P. L., Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans (1992) Eur J Appl Physiol Occup Physiol, 64, pp. 47-50
Nicoletti, V. G., Caruso, A., Tendi, E. A., Privitera, A., Console, A., Calabrese, V., Spadaro, F., Giuffrida Stella, A. M., Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits (1998) Biochimie, 80, pp. 871-881
Nicoletti, V. G., Marino, V. M., Cuppari, C., Licciardello, D., Patti, D., Spina Purrello, V., Giuffrida Stella, A. M., Effect of antioxidant diets on mitochondrial gene expression in rat brain during aging (2005) Neurochem Res, 30, pp. 737-752
Nims, R. W., Cook, J. C., Krishna, M. C., Christodoulou, D., Poore, C. M. B., Miles, A. M., Grisham, M. B., Wink, D. A., Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds (1996) Methods in enzymology, 268 A, pp. 93-120. , Cook JC, Krishna MC, Packer L, editors, San Diego, CA: Academic Press. p
Preston, J. E., Hipkiss, A. R., Himsworth, D. T., Romero, I. A., Abbot, J. N., Toxic effects of beta-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Quinn, P. R., Boldyrev, A. A., Formazuyk, V. E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Severina, I. S., Bussygina, O. G., Pyatakova, N. V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 921-927
Snyder, S. H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Sorokina, E. V., Bastrikova, N. A., Stvolinsky, S. L., Fedorova, T. N., Effects of carnosine and selegiline under MPTP induced parkinsonism in senescence accelerated mice (2003) Neurochem Moscow, 20, pp. 133-138
Wishnok, J. S., Glogowski, J. A., Tannenbaum, S. R., Quantitation of nitrate, nitrite, and nitrosating agents (1996) Methods in enzymology, 268 A, pp. 130-142. , Packer L, editor, San Diego, CA: Academic Press. p
Carnosine interaction with nitric oxide and astroglial cell protection
The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (c) 2007 Wiley-Liss, Inc.
The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (c) 2007 Wiley-Liss, Inc.
Carnosine interaction with nitric oxide and astroglial cell protection
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Carnosine interaction with nitric oxide and astroglial cell protection
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* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (995 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (534 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (880 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (674 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (370 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
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Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (254 views)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (372 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (660 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (995 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (534 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (880 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (674 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
View Export to BibTeX Export to EndNote
Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (370 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
View Export to BibTeX Export to EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (254 views)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (372 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
20 Records (19 excluding Abstracts).
Total impact factor: 76.052 (76.052 excluding Abstracts).
Total 5 year impact factor: 76.375 (76.375 excluding Abstracts).
Total impact factor: 76.052 (76.052 excluding Abstracts).
Total 5 year impact factor: 76.375 (76.375 excluding Abstracts).
648 views. Last view on Thursday 23 March 2023, 20:19:19
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