Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
CNR Ibb | back to homepage
CNR Ibb | back to homepage

Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (517 views)

Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C

Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.

Export to BibTeX    Export to EndNote

Paper type: Journal Article,

Impact factor: 4.532, 5-year impact factor: 4.625

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e

Keywords: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,

Affiliations:
*** IBB - CNR ***

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium


References:
Not available.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

No results.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

Filter those results▼
Query:  [X]
Options:
   Extended  
   IBB affiliation
 
Authors:  [X]
Paper type:  [X]
Start date:  [X]
End date:  [X]
Site:
[Clear form]
Select the year: 
Other filter: ([btitle,keywords] "S)-[18f]fmener-D2" O ...

Sort by:   date ▼▲   title ▲ ▼   journal ▲ ▼   authors ▲ ▼   I.F. ▲ ▼
Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (340 views)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
View    Export to BibTeX    Export to EndNote

Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (376 views) (PDF 221 views)
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
View    Export to BibTeX    Export to EndNote

Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (704 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
View    Export to BibTeX    Export to EndNote

Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (652 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View    Export to BibTeX    Export to EndNote

Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (553 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View    Export to BibTeX    Export to EndNote

Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (431 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
View    Export to BibTeX    Export to EndNote

Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (466 views) (PDF 218 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
View    Export to BibTeX    Export to EndNote

Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (467 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
View    Export to BibTeX    Export to EndNote

Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (650 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
View    Export to BibTeX    Export to EndNote

Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (602 views)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
View    Export to BibTeX    Export to EndNote

10 Records (10 excluding Abstracts).
Total impact factor: 48.584 (48.584 excluding Abstracts).
Total 5 year impact factor: 52.794 (52.794 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:04
517 views. Last view on Sunday 08 September 2024, 19:08:06