Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2(304 views) Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
Keywords: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,
Affiliations: *** IBB - CNR ***
Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium
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Seneca, N., Gulyas, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F] FMeNERD2 (2006) Psychopharmacology (Berl), 188, pp. 119-127
Ghose, S., Fujita, M., Morrison, P., Uhl, G., Murphy, D.L., Mozley, P.D., Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters (2005) Synapse, 56, pp. 100-104
Seneca, N., Andree, B., Sjoholm, N., Schou, M., Pauli, S., Mozley, P.D., Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates (2005) Nucl Med Commun, 26, pp. 695-700
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2