Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
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Paper type: Journal Article,
Impact factor: 4.532, 5-year impact factor: 4.625
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e
Keywords: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,
Affiliations:
*** IBB - CNR ***
Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium
References:
Roy, A., Pickar, D., De Jong, J., Karoum, F., Linnoila, M., Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression (1988) Arch Gen Psychiatry, 45, pp. 849-85
Biederman, J., Spencer, T., Attention-deficit/hyperactivity disorder (ADHD) as a norepinephrine disorder (1999) Biol Psychiatry, 46, pp. 1234-1242
Schou, M., Halldin, C., Sovago, J., Pike, V.W., Gulyas, B., Mozley, P.D., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl Med Biol, 30, pp. 707-714
Wilson, A.A., Johnson, D.P., Mozley, D., Hussey, D., Ginovart, N., Nobrega, J., Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter (2003) Nucl Med Biol, 30, pp. 85-92
Ding, Y.S., Lin, K.S., Garza, V., Carter, P., Alexoff, D., Logan, J., Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs (2003) Synapse, 50, pp. 345-352
Seneca, N., Gulyas, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F] FMeNERD2 (2006) Psychopharmacology (Berl), 188, pp. 119-127
Ghose, S., Fujita, M., Morrison, P., Uhl, G., Murphy, D.L., Mozley, P.D., Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters (2005) Synapse, 56, pp. 100-104
Seneca, N., Andree, B., Sjoholm, N., Schou, M., Pauli, S., Mozley, P.D., Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates (2005) Nucl Med Commun, 26, pp. 695-700
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.532, 5-year impact factor: 4.625
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e
Keywords: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,
Affiliations:
*** IBB - CNR ***
Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium
References:
Roy, A., Pickar, D., De Jong, J., Karoum, F., Linnoila, M., Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression (1988) Arch Gen Psychiatry, 45, pp. 849-85
Biederman, J., Spencer, T., Attention-deficit/hyperactivity disorder (ADHD) as a norepinephrine disorder (1999) Biol Psychiatry, 46, pp. 1234-1242
Schou, M., Halldin, C., Sovago, J., Pike, V.W., Gulyas, B., Mozley, P.D., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl Med Biol, 30, pp. 707-714
Wilson, A.A., Johnson, D.P., Mozley, D., Hussey, D., Ginovart, N., Nobrega, J., Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter (2003) Nucl Med Biol, 30, pp. 85-92
Ding, Y.S., Lin, K.S., Garza, V., Carter, P., Alexoff, D., Logan, J., Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs (2003) Synapse, 50, pp. 345-352
Seneca, N., Gulyas, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F] FMeNERD2 (2006) Psychopharmacology (Berl), 188, pp. 119-127
Ghose, S., Fujita, M., Morrison, P., Uhl, G., Murphy, D.L., Mozley, P.D., Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters (2005) Synapse, 56, pp. 100-104
Seneca, N., Andree, B., Sjoholm, N., Schou, M., Pauli, S., Mozley, P.D., Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates (2005) Nucl Med Commun, 26, pp. 695-700
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
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Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (292 views) (PDF 204 views)
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View Export to BibTeX Export to EndNote
Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (264 views)
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Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
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View Export to BibTeX Export to EndNote
Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (423 views)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
View Export to BibTeX Export to EndNote
10 Records (10 excluding Abstracts).
Total impact factor: 48.584 (48.584 excluding Abstracts).
Total 5 year impact factor: 52.794 (52.794 excluding Abstracts).
Total impact factor: 48.584 (48.584 excluding Abstracts).
Total 5 year impact factor: 52.794 (52.794 excluding Abstracts).
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