Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
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Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (1785 views)

Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C

Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.

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Paper type: Journal Article,

Impact factor: 4.532, 5-year impact factor: 4.625

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e

Keywords: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,

Affiliations:
*** IBB - CNR ***

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium


References:
Not available.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

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Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2

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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
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Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (1500 views)
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Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (1151 views) (PDF 282 views)
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
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10 Records (10 excluding Abstracts).
Total impact factor: 48.584 (48.584 excluding Abstracts).
Total 5 year impact factor: 52.794 (52.794 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:04
1785 views. Last view on Sunday 22 June 2025, 0:14:21