Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (285 views visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 4.532, 5-year impact factor Impact factor a 5 anni: 4.625
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e
Keywords Parole chiave: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,
Affiliations Affiliazioni:
*** IBB - CNR ***
Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium
References Riferimenti:
Roy, A., Pickar, D., De Jong, J., Karoum, F., Linnoila, M., Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression (1988) Arch Gen Psychiatry, 45, pp. 849-85
Biederman, J., Spencer, T., Attention-deficit/hyperactivity disorder (ADHD) as a norepinephrine disorder (1999) Biol Psychiatry, 46, pp. 1234-1242
Schou, M., Halldin, C., Sovago, J., Pike, V.W., Gulyas, B., Mozley, P.D., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl Med Biol, 30, pp. 707-714
Wilson, A.A., Johnson, D.P., Mozley, D., Hussey, D., Ginovart, N., Nobrega, J., Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter (2003) Nucl Med Biol, 30, pp. 85-92
Ding, Y.S., Lin, K.S., Garza, V., Carter, P., Alexoff, D., Logan, J., Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs (2003) Synapse, 50, pp. 345-352
Seneca, N., Gulyas, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F] FMeNERD2 (2006) Psychopharmacology (Berl), 188, pp. 119-127
Ghose, S., Fujita, M., Morrison, P., Uhl, G., Murphy, D.L., Mozley, P.D., Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters (2005) Synapse, 56, pp. 100-104
Seneca, N., Andree, B., Sjoholm, N., Schou, M., Pauli, S., Mozley, P.D., Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates (2005) Nucl Med Commun, 26, pp. 695-700
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 4.532, 5-year impact factor Impact factor a 5 anni: 4.625
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849042554&partnerID=40&md5=febd912bfecd388771d9bb12aa67e72e
Keywords Parole chiave: S)-[18f]fmener-D2, Human Brain, Norepinephrine Transporter, Thalamus, 2 [alpha (2 Fluoro[2 H2]methoxyphenoxy)benzyl]morpholine F 18, Morpholine Derivative, Noradrenalin, Noradrenalin Transporter, Radioligand, Unclassified Drug, Adult, Article, Brain Region, Catecholamine Metabolism, Caudate Nucleus, Clinical Trial, Controlled Clinical Trial, Controlled Study, Drug Distribution, Drug Penetration, Human Experiment, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Protein Analysis, Quantitative Analysis, Radioactivity, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Stereoisomerism, Tissue Distribution, Young Adult,
Affiliations Affiliazioni:
*** IBB - CNR ***
Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 76, Sweden
Lilly Research Laboratories, Mont-Saint-Guibert, Belgium
References Riferimenti:
Roy, A., Pickar, D., De Jong, J., Karoum, F., Linnoila, M., Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression (1988) Arch Gen Psychiatry, 45, pp. 849-85
Biederman, J., Spencer, T., Attention-deficit/hyperactivity disorder (ADHD) as a norepinephrine disorder (1999) Biol Psychiatry, 46, pp. 1234-1242
Schou, M., Halldin, C., Sovago, J., Pike, V.W., Gulyas, B., Mozley, P.D., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl Med Biol, 30, pp. 707-714
Wilson, A.A., Johnson, D.P., Mozley, D., Hussey, D., Ginovart, N., Nobrega, J., Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter (2003) Nucl Med Biol, 30, pp. 85-92
Ding, Y.S., Lin, K.S., Garza, V., Carter, P., Alexoff, D., Logan, J., Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs (2003) Synapse, 50, pp. 345-352
Seneca, N., Gulyas, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F] FMeNERD2 (2006) Psychopharmacology (Berl), 188, pp. 119-127
Ghose, S., Fujita, M., Morrison, P., Uhl, G., Murphy, D.L., Mozley, P.D., Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters (2005) Synapse, 56, pp. 100-104
Seneca, N., Andree, B., Sjoholm, N., Schou, M., Pauli, S., Mozley, P.D., Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates (2005) Nucl Med Commun, 26, pp. 695-700
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Introduction: (S,S)-[18F]FMeNER-D2 is a recently developed positron emission tomography (PET) ligand for in vivo quantification of norepinephrine transporter. A monkey occupancy study with the radioligand indicated that (S,S)-[18F]FMeNER-D2 can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated. Materials and methods: Brain PET measurements were performed for a total of 255 min after the injection of 188.3 ± 5.7 MBq of (S,S)-[18F]FMeNER-D2 in four healthy male subjects. Regions of interests were drawn on the thalamus and the caudate in the coregistered MRI/PET images. Results: (S,S)-[18F]FMeNER-D 2 displayed good brain penetration and selective retention in regions rich in norepinephrine reuptake sites. The transient peak equilibrium was reached during the PET measurements. The ratios of radioactivity uptake in the thalamus to that in the caudate were 1.50 ± 0.06 for the time period of 90-255 min. Conclusion: The present preliminary investigation indicates that (S,S)-[18F]FMeNER-D2 has suitable characteristics for probing the norepinephrine reuptake system with PET in the human brain. © 2007 Springer-Verlag.
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
| ▼ Relaxometry based MRI brain segmentation Segmentazione RM cerebrale basata sulla rilassometria |
Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2
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J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (523 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Pellecchia MT, Barone P, Vicidomini C, Mollica C, Salvatore E, Ianniciello M, Liuzzi R, Longo K, Picillo M, De Michele G, Filla A, Brunetti A, Salvatore M, Pappata S
* Progression of striatal and extrastriatal degeneration in multiple system atrophy: a longitudinal diffusion-weighted MR study (334 visite)
Mov Disord (ISSN: 1531-8257, 0885-3185), 2011 Jun; 26(7): 1303-1309.
Impact Factor: 4.505
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Esmaeilzadeh M, Kullingsjo J, Ullman H, Varrone A, Tedroff J
* Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with huntington disease (321 visite)
Clin Neuropharmacol (ISSN: 0362-5664), 2011 May; 34(3): 95-100.
Impact Factor: 2.166
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (373 visite)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (492 visite)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
Impact Factor: 2.925
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Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A
* Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry (388 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Apr; 38(4): 1031-1041.
Impact Factor: 4.106
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Bilo L, Meo R, de Leva MF, Vicidomini C, Salvatore M, Pappata S
* Thalamic activation and cortical deactivation during typical absence status monitored using [18F]FDG-PET: a case report (455 visite)
Seizure (ISSN: 1532-2688, 1059-1311), 2010 Apr; 19(3): 198-201.
Impact Factor: 1.649
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (405 visite)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (341 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
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Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (249 visite) (PDF 199 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (233 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (411 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
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Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (377 visite)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
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Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (343 visite) (PDF 215 visite)
J Neuroimaging (ISSN: 1051-2284), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
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Hervé D, Molko N, Pappata S, Buffon F, LeBihan D, Bousser MG, Chabriat H
* Longitudinal thalamic diffusion changes after middle cerebral artery infarcts (275 visite)
J Neurol Neurosurg Psychiatry (ISSN: 0022-3050), 2005 Feb; 76(2): 200-205.
Impact Factor: 3.122
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Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (306 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
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Soricelli A, Postiglione A, Cuocolo A, De Chiara S, Ruocco A, Brunetti A, Salvatore M, Ell PJ
EFFECT OF ADENOSINE ON CEREBRAL BLOOD-FLOW AS EVALUATED BY SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN NORMAL SUBJECTS AND IN PATIENTS WITH OCCLUSIVE CAROTID DISEASE - A COMPARISON WITH ACETAZOLAMIDE (240 visite)
Stroke (ISSN: 0039-2499), 1995 Sep; 26(9): 1572-1576.
Impact Factor: 4.323
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (300 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Ferrara LA, Pisanti N, Fasano ML, Mancini M
Effects of sodium intake on blood pressure and adrenergic vascular reactivity (784 visite)
J Clin Hypertens (ISSN: 0748-450x), 1986; 2(4): 315-321.
Impact Factor: 0
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29 Records (29 escludendo Abstract e Conferenze).
Impact factor totale: 115.723 (115.723 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 127.011 (127.011 escludendo Abstract e Conferenze).
Impact factor totale: 115.723 (115.723 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 127.011 (127.011 escludendo Abstract e Conferenze).
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