Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans
Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans(393 views) Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
Department of Biochemistry and Medical Biotechnology, Federico II University Medical School, Naples, Italy.
SDN, Istituto di Ricerca Diagnostica-Nucleare, Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University Medical School, Naples, Italy
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Ferme, C., Sebban, C., Hennequin, C., Divine, M., Lederlin, P., Gabane, J., Comparison of chemotherapy to radiotherapy as consolidation of complete or good partial response after six cycles of chemotherapy for patients with advanced Hodgkin's disease: Results of the groupe d'etudes des lymphomas de l'Adulte H89 trial (2000) Blood, 95, pp. 2246-2252
Laskar, S., Gupta, T., Vimal, S., Muckaden, M.A., Saikia, T.K., Pai, K.S., Consolidation radiation after complete remission in Hodgkin's disease following six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy: Is there a need? (2004) J Clin Oncol, 22, pp. 62-68
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Juweid, M.E., Stroobants, S., Hoekstra, O.S., Mottaghy, F.M., Dietlein, M., Guermazi, A., Use of positron emission tomography for response assessment of lymphoma: Consensus of the Imaging Subcommittee of International Harmonization Project in lymphoma (2007) J Clin Oncol, 25, pp. 571-578
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Horning, S. J., Hoppe, R. T., Breslin, S., Bartlett, N. L., Brown, B. W., Rosenberg, S. A., Stanford V and radiotherapy for locally extensive and advanced Hodgkin's disease: Mature results of a prospective clinical trial (2002) J Clin Oncol, 20, pp. 630-637
Juweid, M. E., Utility of positron emission tomography (PET) scanning in managing patients with Hodgkin lymphoma (2006) American Society of Hematology Education Program Book, pp. 259-265. , American Society of Hematology, Washington, DC
Canellos, G. P., Residual mass in lymphoma may not be residual disease (1988) J Clin Oncol, 6, pp. 931-933
Juweid, E. M., Wiseman, G. A., Vose, J. M., Ritchie, J. M., Meuda, Y., Wooldridge, J. E., Response assessment of aggressive non-Hodgkin's lymphoma by integrated International Workshop Criteria and fluorine-18-fluorodeoxyglucose positron emission tomography (2005) J Clin Oncol, 23, pp. 4652-4661
Cheson, B. D., Horning, S. J., Coiffier, B., Shipp, M. A., Fisher, R. I., Connors, J. M., Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas (1999) J Clin Oncol, 17, pp. 1244-1253
Aleman, B. M., Raemaekers, J. M., Tirelli, U., Bartolous, R., Veer, M. B., van't Lybeert, M. L., European Organization for Research and Treatment of Cancer Lymphoma Group: Involved-field radiotherapy for advanced Hodgkin's lymphoma (2003) N Engl J Med, 348, pp. 2396-2406
Aleman, B. M., Belt-Dusebout, A. W., van den Klokman, W. J., Veer, M. B., van't Bartelink, H., van Leeuwen, F. E., Long-term cause-specific mortality of patients treated for Hodgkin's disease (2003) J Clin Oncol, 21, pp. 3431-3439
Isasi, C. R., Blaufox, M. D., A metaanalysis of 18 F-2-deoxy-2-fluoro-glucose positron emission tomography in the staging and restaging of patients with lymphoma (2005) Cancer, 104, pp. 1066-1074
Juweid, M. E., Stroobants, S., Hoekstra, O. S., Mottaghy, F. M., Dietlein, M., Guermazi, A., Use of positron emission tomography for response assessment of lymphoma: Consensus of the Imaging Subcommittee of International Harmonization Project in lymphoma (2007) J Clin Oncol, 25, pp. 571-578
Lavely, W. C., Delbeke, D., Greer, J. P., Morgan, D. S., Byrne, D. W., Price, R. R., FDG PET in the follow-up management of patients with newly diagnosed Hodgkin's and non-Hodgkin's lymphoma after first-line chemotherapy (2003) Int J Radiot Oncol Biol Phyo, 57, pp. 307-315
Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans
This study aimed at evaluating the role of consolidation radiation in a setting of Hodgkin's lymphoma (HL) patients, using event-free survival (EFS) as end point. Among 260 patients treated with induction chemotherapy for bulky HL, 160 patients achieved negative residual masses at 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scans. They were randomly divided into two well-matched groups to receive either 32 Gy radiotherapy to bulky area or no further therapy. At a median follow-up of 40 months, histology showed a malignancy in 14% of patients in the chemotherapy-only group (HL, 11 patients) and in 4% of patients in the chemotherapy + radiotherapy group (HL, 2 patients; carcinoma in previously irradiated area, 1 patient) (P = 0.03). All the relapses in the chemotherapy-only group involved the bulky site and the contiguous nodal regions. Thus, the overall diagnostic accuracy of FDG-PET to exclude future relapses in the patients nonprotected by radiotherapy was 86% with a false-negative rate of 14%. Our study suggests that the addition of irradiation helps improve EFS in HL patients with post-chemotherapy FDG-PET-negative residual masses.
Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans
Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(284 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote