Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (343 views visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.301, 5-year impact factor Impact factor a 5 anni: 2.548
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250160541&partnerID=40&md5=a65d0b29e2713290019cc8a607581f9a
Keywords Parole chiave: β-Cylodextrin, Carnosine, Homocarnosine, Low Density Lipoprotein, Pulse Radiolysis, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 6a Deoxy Beta Cyclodextrin, Cupric Ion, Reactive Oxygen Metabolite, Scavenger, Unclassified Drug, Antioxidant Activity, Article, Controlled Study, Drug Activity, Drug Structure, Drug Synthesis, Human, In Vitro Study, In Vivo Study, Nuclear Magnetic Resonance, Oxidation, Beta-Cyclodextrins, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 6a Deoxy Beta Cyclodextrin,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy
Istituto di Biochimica, Biochimica Clinica, Università Cattolica Sacro Cuore, Largo F. Vito 1, 00164 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Catania, V.le A. Doria 6, 95125 Catania, Italy
References Riferimenti:
Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-175
Pralhad, T., Rajendrakumar, K., (2004) J. Pharm. Biomed. Anal., 34, pp. 333-339
Uekama, K., (2004) Chem. Pharm. Bull., 52, pp. 900-915
Di Blasio, B., Pavone, V., Nastri, F., Isernia, C., Saviano, M., Pedone, C., Cucinotta, V., Vecchio, G., (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 7218-7221
Djedaini-Pilard, F., Desalos, J., Perly, B., (1993) Tetrahedron Lett., 34, pp. 2457-2460
Fernandez, M., Fragoso, A., Cao, R., Banos, M., Ansorge-Schumacher, M., Hartmeier, W., Villalonga, R., (2004) J. Mol. Catal. B Enzym., 31, pp. 47-52
Hristova-Kazmierski, M.K., Horan, P., Davis, P., Yamamura, H.I., Kramer, T., Horvath, R., Kazmierski, W.M., Hruby, V.J., (1993) Bioorg. Med. Chem. Lett., 3, pp. 831-834
Parrot-Lopez, H., Djedaini, F., Perly, B., Coleman, A.W., Galons, H., Miocque, M., (1990) Tetrahedron Lett., 31, pp. 1999-2002
Pean, C., Creminon, C., Wijkhuisen, A., Grassi, J., Guenot, P., Jehan, P., Dalbiez, J.-P., Djedaini-Pilard, F., (2000) J. Chem. Soc. Perkin Trans., 2, pp. 853-863
Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Mueller, G., Moroder, L., (1998) J. Am. Chem. Soc., 120, pp. 7030-7038
Boldyrev, A.A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A.A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V.P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Tabakman, R., Lazarovici, P., Kohen, R., (2002) J. Neurosci. Res., 68, pp. 463-469
Mzhelskaya, T.I., Boldyrev, A.A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O.A., Hyder, F., Mattson, R.H., Rothman, D.L., (1999) Neurology, 52, pp. 473-478
Guiotto, A., Calderan, A., Ruzza, P., Borin, G., (2005) Curr. Med. Chem., 12, pp. 2293-2315
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., (2002) Helv. Chim. Acta, 85, pp. 1633-1643
Bonomo, R.P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, T., (1998) J. Carbohydr. Chem., 17, pp. 489-494
Mulazzani, Q.G., D'Angelantonio, M., Venturi, M., Hoffman, M.Z., Rodgers, M.A.J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Lazzarino, G., Di Pierro, D., Tavazzi, B., Cerroni, L., Giardina, B., (1991) Anal. Biochem., 197, pp. 191-196
Donze, C., Rizzarelli, E., Vecchio, G., (1998) Supramol. Chem., 10, pp. 33-42
Vecchio, G., La Mendola, D., Rizzarelli, E., (2001) J. Supramol. Chem., 1, pp. 87-95
Di Blasio, B., Galdiero, S., Saviano, M., Pedone, C., Benedetti, E., Rizzarelli, E., Pedotti, S., Gibbons, W.A., (1996) Carbohydr. Res., 282, pp. 41-52
Bonomo, R.P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., Vecchio, G., (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 800, pp. 127-133
Nogami, Y., Nasu, K., Koga, T., Ohta, K., Fujita, K., Immel, S., Lindner, H.J., Lichtenthaler, F.W., (1997) Angew. Chem. Int. Ed. Engl., 36, pp. 1899-1902
Chen, W.-H., Yuan, D.-Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Fujita, K., Chen, W.-H., Yuan, D.-Q., Nogami, Y., Koga, T., Fujioka, T., Mihashi, K., Lichtenthaler, F.W., (1999) Tetrahedron: Asymmetry, 10, pp. 1689-1696
Fujita, K., Ohta, K., Ikegami, Y., Shimada, H., Tahara, T., Nogami, Y., Koga, T., Nakajima, T., (1994) Tetrahedron Lett., 35, pp. 9577-9580
Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Tamba, M., Torreggiani, A., (1998) Int. J. Radiat. Biol., 74, pp. 333-340
Bansal, K.M., Sellers, R.M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Tsimikas, S., (2006) Curr. Atheroscler. Rep., 8, pp. 55-61
Patel, R.P., Darley-Usmar, V.M., (1999) Free Radic. Res., 30, pp. 1-9
Kuzuya, M., Yamada, K., Hayashi, T., Funaki, C., Naito, M., Asai, K., Kuzuya, F., (1992) Biochim. Biophys. Acta, 1123, pp. 334-341
Decker, E.A., Ivanov, V., Zhu, B.Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Kritharides, L., Kus, M., Brown, A.J., Jessup, W., Dean, R.T., (1996) J. Biol. Chem., 271, pp. 27450-27455
Giessauf, A., Steiner, E., Esterbauer, H., (1995) Biochim. Biophys. Acta, 1256, pp. 221-232
Aachmann, F.L., Otzen, D.E., Larsen, K.L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L.X., Teng, C.F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M.A., Qasim, S., Warrington, T.L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., (2004) Comp. Biochem. Physiol. Biochem. Mol. Biol., 137, pp. 81-88
Boldyrev, A. A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A. A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V. P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Mzhelskaya, T. I., Boldyrev, A. A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O. A., Hyder, F., Mattson, R. H., Rothman, D. L., (1999) Neurology, 52, pp. 473-478
Bonomo, R. P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
Bonomo, R. P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Mulazzani, Q. G., D'Angelantonio, M., Venturi, M., Hoffman, M. Z., Rodgers, M. A. J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Bonomo, R. P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Chen, W. -H., Yuan, D. -Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Buxton, G. V., Greenstock, C. L., Helman, W. P., Ross, A. B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Bansal, K. M., Sellers, R. M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Patel, R. P., Darley-Usmar, V. M., (1999) Free Radic. Res., 30, pp. 1-9
Decker, E. A., Ivanov, V., Zhu, B. Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Aachmann, F. L., Otzen, D. E., Larsen, K. L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L. X., Teng, C. F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M. A., Qasim, S., Warrington, T. L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.301, 5-year impact factor Impact factor a 5 anni: 2.548
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250160541&partnerID=40&md5=a65d0b29e2713290019cc8a607581f9a
Keywords Parole chiave: β-Cylodextrin, Carnosine, Homocarnosine, Low Density Lipoprotein, Pulse Radiolysis, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl)ethyl]amino] 4 Oxobutyl]amino] 6a Deoxy Beta Cyclodextrin, Cupric Ion, Reactive Oxygen Metabolite, Scavenger, Unclassified Drug, Antioxidant Activity, Article, Controlled Study, Drug Activity, Drug Structure, Drug Synthesis, Human, In Vitro Study, In Vivo Study, Nuclear Magnetic Resonance, Oxidation, Beta-Cyclodextrins, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, 3a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 3a Deoxy Beta Cyclodextrin, 6a [[4 [[1 Carboxy 2 (1h Imidazol 4 Yl) Ethyl] Amino] 4 Oxobutyl] Amino] 6a Deoxy Beta Cyclodextrin,
Affiliations Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy
Istituto di Biochimica, Biochimica Clinica, Università Cattolica Sacro Cuore, Largo F. Vito 1, 00164 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Catania, V.le A. Doria 6, 95125 Catania, Italy
References Riferimenti:
Szejtli, J., (1998) Chem. Rev., 98, pp. 1743-175
Pralhad, T., Rajendrakumar, K., (2004) J. Pharm. Biomed. Anal., 34, pp. 333-339
Uekama, K., (2004) Chem. Pharm. Bull., 52, pp. 900-915
Di Blasio, B., Pavone, V., Nastri, F., Isernia, C., Saviano, M., Pedone, C., Cucinotta, V., Vecchio, G., (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 7218-7221
Djedaini-Pilard, F., Desalos, J., Perly, B., (1993) Tetrahedron Lett., 34, pp. 2457-2460
Fernandez, M., Fragoso, A., Cao, R., Banos, M., Ansorge-Schumacher, M., Hartmeier, W., Villalonga, R., (2004) J. Mol. Catal. B Enzym., 31, pp. 47-52
Hristova-Kazmierski, M.K., Horan, P., Davis, P., Yamamura, H.I., Kramer, T., Horvath, R., Kazmierski, W.M., Hruby, V.J., (1993) Bioorg. Med. Chem. Lett., 3, pp. 831-834
Parrot-Lopez, H., Djedaini, F., Perly, B., Coleman, A.W., Galons, H., Miocque, M., (1990) Tetrahedron Lett., 31, pp. 1999-2002
Pean, C., Creminon, C., Wijkhuisen, A., Grassi, J., Guenot, P., Jehan, P., Dalbiez, J.-P., Djedaini-Pilard, F., (2000) J. Chem. Soc. Perkin Trans., 2, pp. 853-863
Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Mueller, G., Moroder, L., (1998) J. Am. Chem. Soc., 120, pp. 7030-7038
Boldyrev, A.A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A.A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V.P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Tabakman, R., Lazarovici, P., Kohen, R., (2002) J. Neurosci. Res., 68, pp. 463-469
Mzhelskaya, T.I., Boldyrev, A.A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O.A., Hyder, F., Mattson, R.H., Rothman, D.L., (1999) Neurology, 52, pp. 473-478
Guiotto, A., Calderan, A., Ruzza, P., Borin, G., (2005) Curr. Med. Chem., 12, pp. 2293-2315
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., (2002) Helv. Chim. Acta, 85, pp. 1633-1643
Bonomo, R.P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, T., (1998) J. Carbohydr. Chem., 17, pp. 489-494
Mulazzani, Q.G., D'Angelantonio, M., Venturi, M., Hoffman, M.Z., Rodgers, M.A.J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Lazzarino, G., Di Pierro, D., Tavazzi, B., Cerroni, L., Giardina, B., (1991) Anal. Biochem., 197, pp. 191-196
Donze, C., Rizzarelli, E., Vecchio, G., (1998) Supramol. Chem., 10, pp. 33-42
Vecchio, G., La Mendola, D., Rizzarelli, E., (2001) J. Supramol. Chem., 1, pp. 87-95
Di Blasio, B., Galdiero, S., Saviano, M., Pedone, C., Benedetti, E., Rizzarelli, E., Pedotti, S., Gibbons, W.A., (1996) Carbohydr. Res., 282, pp. 41-52
Bonomo, R.P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., Vecchio, G., (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 800, pp. 127-133
Nogami, Y., Nasu, K., Koga, T., Ohta, K., Fujita, K., Immel, S., Lindner, H.J., Lichtenthaler, F.W., (1997) Angew. Chem. Int. Ed. Engl., 36, pp. 1899-1902
Chen, W.-H., Yuan, D.-Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Fujita, K., Chen, W.-H., Yuan, D.-Q., Nogami, Y., Koga, T., Fujioka, T., Mihashi, K., Lichtenthaler, F.W., (1999) Tetrahedron: Asymmetry, 10, pp. 1689-1696
Fujita, K., Ohta, K., Ikegami, Y., Shimada, H., Tahara, T., Nogami, Y., Koga, T., Nakajima, T., (1994) Tetrahedron Lett., 35, pp. 9577-9580
Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Tamba, M., Torreggiani, A., (1998) Int. J. Radiat. Biol., 74, pp. 333-340
Bansal, K.M., Sellers, R.M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Tsimikas, S., (2006) Curr. Atheroscler. Rep., 8, pp. 55-61
Patel, R.P., Darley-Usmar, V.M., (1999) Free Radic. Res., 30, pp. 1-9
Kuzuya, M., Yamada, K., Hayashi, T., Funaki, C., Naito, M., Asai, K., Kuzuya, F., (1992) Biochim. Biophys. Acta, 1123, pp. 334-341
Decker, E.A., Ivanov, V., Zhu, B.Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Kritharides, L., Kus, M., Brown, A.J., Jessup, W., Dean, R.T., (1996) J. Biol. Chem., 271, pp. 27450-27455
Giessauf, A., Steiner, E., Esterbauer, H., (1995) Biochim. Biophys. Acta, 1256, pp. 221-232
Aachmann, F.L., Otzen, D.E., Larsen, K.L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L.X., Teng, C.F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M.A., Qasim, S., Warrington, T.L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., (2004) Comp. Biochem. Physiol. Biochem. Mol. Biol., 137, pp. 81-88
Boldyrev, A. A., Johnson, P., (2002) Oxidative Stress at Molecular, Cellular and Organ Levels, pp. 101-113. , Boldyrev A. A., and Johnson P. (Eds), Research Signpost, India
Skulachev, V. P., (2000) Biochemistry (Mosc), 65, pp. 749-750
Mzhelskaya, T. I., Boldyrev, A. A., (1999) Neirokhimiya, 16, pp. 133-144
Petroff, O. A., Hyder, F., Mattson, R. H., Rothman, D. L., (1999) Neurology, 52, pp. 473-478
Bonomo, R. P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) J. Chem. Soc. Dalton Trans., pp. 4406-4415
Bonomo, R. P., Cucinotta, V., D'Alessandro, F., Impellizzeri, G., Maccarrone, G., Vecchio, G., Rizzarelli, E., (1991) Inorg. Chem., 30, pp. 2708-2713
Mulazzani, Q. G., D'Angelantonio, M., Venturi, M., Hoffman, M. Z., Rodgers, M. A. J., (1986) J. Phys. Chem., 90, pp. 5347-5352
Bonomo, R. P., Maccarrone, G., Rizzarelli, E., Vecchio, G., (2002) Inorg. Chim. Acta, 339, pp. 455-460
Chen, W. -H., Yuan, D. -Q., Fujita, K., (1996) Tetrahedron Lett., 37, pp. 7561-7564
Buxton, G. V., Greenstock, C. L., Helman, W. P., Ross, A. B., (1988) J. Phys. Chem. Ref. Data, 17, pp. 513-886
Bansal, K. M., Sellers, R. M., (1975) J. Phys. Chem., 79, pp. 1775-1780
Patel, R. P., Darley-Usmar, V. M., (1999) Free Radic. Res., 30, pp. 1-9
Decker, E. A., Ivanov, V., Zhu, B. Z., Frei, B., (2001) J. Agric. Food Chem., 49, pp. 511-516
Aachmann, F. L., Otzen, D. E., Larsen, K. L., Wimmer, R., (2003) Protein Eng., 16, pp. 905-912
Song, L. X., Teng, C. F., Yang, Y., (2006) J. Incl. Phenom. Macr. Chem., 54, pp. 221-232
Yi, Z., Qasim, M. A., Qasim, S., Warrington, T. L., Laskowski Jr., M., (2006) Biochim. Biophys. Acta, 1760, pp. 372-379
Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates
Several in vitro and in vivo studies have suggested that carnosine (β-alanil-l-histidine) and homocarnosine (β-aminobutyril-l-histidine) can act as scavengers of reactive oxygen species. β-Cyclodextrin was functionalized with homocarnosine, obtaining the following new bioconjugate isomers: 6A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-6A-deoxy-β-cyclodextrin and (2AS,3AR)-3A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-3A-deoxy-β-cyclodextrin. Pulse radiolysis investigations show that the β-cyclodextrin homocarnosine bioconjugates are scavengers of {radical dot}OH radicals because of the formation of stable imidazole-centered radicals and the scavenger ability of glucose molecules of the macrocycle. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. © 2007 Elsevier Masson SAS. All rights reserved.
Several in vitro and in vivo studies have suggested that carnosine (β-alanil-l-histidine) and homocarnosine (β-aminobutyril-l-histidine) can act as scavengers of reactive oxygen species. β-Cyclodextrin was functionalized with homocarnosine, obtaining the following new bioconjugate isomers: 6A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-6A-deoxy-β-cyclodextrin and (2AS,3AR)-3A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-3A-deoxy-β-cyclodextrin. Pulse radiolysis investigations show that the β-cyclodextrin homocarnosine bioconjugates are scavengers of {radical dot}OH radicals because of the formation of stable imidazole-centered radicals and the scavenger ability of glucose molecules of the macrocycle. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. © 2007 Elsevier Masson SAS. All rights reserved.
Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates
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Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates
Bellia F, Vecchio G, Rizzarelli E
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* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (372 visite)
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Tabbì G, Nauser T, Koppenol WH, Reedijk J
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Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 57.11 (57.11 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 59.708 (59.708 escludendo Abstract e Conferenze).
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (381 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (390 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli Esporta in BibTeX Esporta in EndNote
Perrone-Filardi P, Musella F, Savarese G, Cecere M, Marciano C, Scala O, Rengo G, Dellegrottaglie S, Cuocolo A, Leosco D
* Coronary computed tomography: current role and future perspectives for cardiovascular risk stratification (333 visite)
Eur Heart J-Card Img (ISSN: 2047-2412, 2047-2404, 2047-2412electronic), 2012 Jun; 13(6): 453-458.
Impact Factor: 3.669
Dettagli Esporta in BibTeX Esporta in EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (307 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (643 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (557 visite)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
Dettagli Esporta in BibTeX Esporta in EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (384 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
Dettagli Esporta in BibTeX Esporta in EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (358 visite)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Bonomo RP, Caminati S, Di Natale G, Emmi SS, Hansson O, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E
* Copper(II) complexes with an avian prion N-terminal region and their potential SOD-like activity (357 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2009 Feb; 103(2): 195-204.
Impact Factor: 3.252
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (430 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (587 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (228 visite)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
Dettagli Esporta in BibTeX Esporta in EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (372 visite)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
Dettagli Esporta in BibTeX Esporta in EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (428 visite)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (369 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (334 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
Dettagli Esporta in BibTeX Esporta in EndNote
Tabbì G, Nauser T, Koppenol WH, Reedijk J
A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (239 visite)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 57.11 (57.11 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 59.708 (59.708 escludendo Abstract e Conferenze).
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