The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily(372 views) Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Keywords: Alzheimer, S Disease, Apoe, Cdc2, Cell Cycle, Genetic Polymorphism, Risk Factor, Apolipoprotein E, Apolipoprotein E Epsilon 4, Cell Cycle Protein, Unclassified Drug, Adult, Aged, Alzheimer Disease, Article, Controlled Study, Female, Gene Frequency, Genetic Risk, Genotype, Haplotype, Heterozygote, Human, Italy, Major Clinical Study, Population Genetics, Priority Journal, Genetic Predisposition To Disease, Polymerase Chain Reaction, Sicily,
Affiliations: *** IBB - CNR ***
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Enna, Italy
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Department of Clinical and Experimental Pharmacology, University of Catania, Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
INM Neuromed, Pozzilli, Italy
IBB-CNR, Catania, Italy
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Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell Jr., P. C., Rimmler, J. B., Schmader, K. E., Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease (1994) Nat. Genet., 7, pp. 180-184
de la Torre, J. C., Alzheimer disease as a vascular disorder: nosological evidence (2002) Stroke, 33, pp. 1152-1162
Gibb, G. M., Pearce, J., Betts, J. C., Lovestone, S., Hoffmann, M. M., Maerz, W., Blackstock, W. P., Anderton, B. H., Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry (2000) FEBS Lett., 485, pp. 99-103
Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., Huang, Y., Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc (2004) J. Biol. Chem., 279, pp. 44795-44801
Hixon, J. E., Vernier, D. T., Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI (1990) J. Lipid Res., 31, pp. 545-548
Ledesma, M. D., Correas, I., Avila, J., Diaz-Nido, J., Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease (1992) FEBS Lett., 308, pp. 218-224
Lee, K. Y., Clark, A. W., Rosales, J. L., Chapman, K., Fung, T., Johnston, R. N., Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain (1999) Neurosci. Res., 34, pp. 21-29
Milton, N. G., Phosphorylated amyloid-beta: the toxic intermediate in Alzheimer's disease neurodegeneration (2005) Subcell. Biochem., 38, pp. 381-402
Murray, A. W., Recycling the cell cycle: cyclins revisited (2004) Cell, 116, pp. 221-234
Niu, T., Qin, Z. S., Xu, X., Liu, J. S., Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms (2002) Am. J. Hum. Genet., 70, pp. 157-169
Pei, J. J., Braak, H., Gong, C. X., Grundke-Iqbal, I., Iqbal, K., Winblad, B., Cowburn, R. F., Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration (2002) Acta Neuropathol., 104, pp. 369-376
Roses, A. D., Einstein, G., Gilbert, J., Goedert, M., Han, S. H., Huang, D., Hulette, C., Xi, P. T., Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism (1996) Ann. N. Y. Acad. Sci., 777, pp. 146-157
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Roses, A. D., Association of apolipoprotein E allele 4 with late-onset familial and sporadic Alzheimer's disease (1993) Neurology, 43, pp. 1467-1472
West, H. L., Rebeck, G. W., Hyman, B. T., Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease (1994) Neurosci. Lett., 175, pp. 46-48
The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily
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126 Records (119 excluding Abstracts). Total impact factor: 544.975 (526.234 excluding Abstracts). Total 5 year impact factor: 533.058 (515.591 excluding Abstracts).