Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (545 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
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Paper type: Journal Article,
Impact factor: 3.396, 5-year impact factor: 3.405
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547760795&partnerID=40&md5=ed6de646c31d2fcc2ea552d1db8b15c0
Keywords: Cyay, Friedreich, S Ataxia, Iron Binding, X-Ray, Aspartic Acid, Cation, Cyay Protein, Cysteine, Frataxin, Glutamic Acid, Histidine, Iron Binding Protein, Metal, Unclassified Drug, Binding Affinity, Binding Site, Electricity, Iron Chelation, Metal Binding, Nuclear Magnetic Resonance, Orthology, Priority Journal, Protein Binding, Protein Function, X Ray Crystallography, Amino Acid Sequence, Bacterial Proteins, Competitive, Cobalt, Gadolinium, Iron-Binding Proteins, Iron-Sulfur Proteins, Lanthanoid Series Elements, Lutetium, Magnesium, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Mutation, Protein Conformation, Protein Structure, Tertiary, Sequence Homology, Zinc, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
NIMR, The Ridgeway, London, NW71AA, United Kingdom
National Institute for Medical Research, London, United Kingdom
Dipartimento di Chimica, University of Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
References:
Campuzano, V., Montermini, L., Molto, M.D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Monticelli, A., Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion (1996) Science, 271, pp. 1423-142
Cossee, M., Puccio, H., Gansmuller, A., Koutnikova, H., Dierich, A., Lemeur, M., Fischbeck, K., Koenig, M., Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation (2000) Hum Mol Genet, 9, pp. 1219-1226
Yoon, T., Cowan, J.A., Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins (2003) J Am Chem Soc, 125, pp. 6078-6084
Bulteau, A.L., O'Neill, H.A., Kennedy, M.C., Ikeda-Saito, M., Isaya, G., Szweda, L.I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Gerber, J., Muhlenhoff, U., Lill, R., An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1 (2003) EMBO Reports, 4, pp. 906-911
Park, S., Gakh, O., O'Neill, H.A., Mangravita, A., Nichol, H., Ferreira, G.C., Isaya, G., Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation (2003) J Biol Chem, 278, pp. 31340-31351
Cavadini, P., O'Neill, H.A., Benada, O., Isaya, G., Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich's ataxia (2002) Hum Mol Genet, 11, pp. 217-227
Delatycki, M.B., Williamson, R., Forrest, S.M., Freidreich's ataxia: An overview (2000) J Med Genet, 37, pp. 1-8
Huynen, M.A., Snel, B., Bork, P., Gibson, T.J., The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly (2001) Hum Mol Genet, 10, pp. 2463-2468
Muhlenhoff, U., Richhardt, N., Ristow, M., Kispal, G., Lill, R., The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins (2002) Hum Mol Genet, 11, pp. 2025-2036
Stehling, O., Elsasser, H.-P., Bruckel, B., Muhlenhoff, U., Lill, R., Iron-sulfur protein maturation in human cells: Evidence for a function of frataxin (2004) Hum Mol Genet, 13, pp. 3007-3015
Wong, A., Yang, J., Cavadini, P., Gellera, C., Lonnerdal, B., Taroni, F., Cortopassi, G., The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis (1999) Hum Mol Genet, 8, pp. 425-430
Ristow, M., Pfister, M.F., Yee, A.J., Schubert, M., Michael, L., Zhang, C.-Y., Ueki, K., Kahn, C.R., Frataxin activates mitochondrial energy conversion and oxidative phosphorylation (2000) Proc Natl Acad Sci USA, 97, pp. 12239-12243
Tan, G., Napoli, E., Taroni, F., Cortopassi, G., Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells (2003) Hum Mol Genet, 12, pp. 1699-1711
Lesuisse, E., Santos, R., Matzanke, B.F., Knight, S.A.B., Camadro, J.-M., Dancis, A., Iron use for heme synthesis is under control of the yeast frataxin homologue (Yfh1) (2003) Hum Mol Genet, 12, pp. 879-889
Radisky, D.C., Babcock, M.C., Kaplan, J., The yeast frataxin homologue mediates mitochondrial iron efflux: Evidence for a mitochondrial iron cycle (1999) J Biol Chem, 274, pp. 4497-4499
Foury, F., Talibi, D., Mitochondrial control of iron homeostasis. a genome wide analysis of gene expression in a yeast frataxin-deficient strain (2001) J Biol Chem, 276, pp. 7762-7768
Que Jr., L., Ho, R.Y., Dioxygen activation by enzymes with mononuclear non-heme iron active sites (1996) Chem Rev, 96, pp. 2607-2624
Musco, G., Stier, G., Kolmerer, B., Adinolfi, S., Martin, S., Frenkiel, T., Gibson, T., Pastore, A., Towards a structural understanding of Friedreich's ataxia: The olution structure of frataxin (2000) Structure, 8, pp. 695-707
Dhe-Paganon, S., Shigeta, R., Chi, Y.-I., Ristow, M., Shoelson, S.E., Crystal structure of human frataxin (2000) J Biol Chem, 275, pp. 30753-30756
Cho, S.J., Lee, M.G., Yang, J.Y., Song, H.K., Suh, S.W., Crystal structure of Escherichia coli CyaY reveals a previously unidentified fold for the evolutionary conserved frataxin family (2000) Proc Natl Acad Sci USA, 97, pp. 8932-8937
Nair, M., Adinolfi, S., Pastore, C., Kelly, G., Temussi, P., Pastore, A., Solution structure of the bacterial frataxin ortholog, CyaY: Mapping the iron binding sites (2004) Structure (Camb), 12, pp. 2037-2048
He, Y., Alam, S.L., Proteasa, S.V., Zhang, Y., Lesuisse, E., Dancis, A., Stemmler, T.L., Yeast frataxin solution structure, iron binding and ferrochelatase interaction (2004) Biochemistry, 43, pp. 16254-16262
Bou-Abdallah, F., Adinolfi, S., Pastore, A., Laue, T.M., Chasteen, D.N., Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli (2004) J Mol Biol, 341, pp. 605-615
Adinolfi, S., Trifuoggi, M., Politou, A.S., Martin, S., Pastore, A., A structural approach to understanding the iron-binding properties of phylogenetically different frataxins (2002) Hum Mol Genet, 11, pp. 1865-1877
Adinolfi, S., Nair, M., Politou, A., Bayer, E., Martin, S., Temussi, P., Pastore, A., The factors governing the thermal stability of frataxin orthologues: How to increase a protein's stability (2004) Biochemistry, 43, pp. 6511-6518
Butchard, C.G., Dwek, R.A., Ferguson, S.J., Kent, P.W., Williams, R.J.P., Xavier, A.V., (1972) FEBS Lett, 25, pp. 91-93. , Mapping of the binding site of N-fluoroacetyl-d-glucosamine and analogues in hen egg lysozyme by 1H and 19F-NMR techniques with Gd(III) and Mn(II) as paramagnetic probes
Bertini, I., Luchinat, C., NMR of paramagnetic substances (1996) Coord Chem Rev, 150, p. 1
Saito, T., Wormald, M.R., Williams, R.J., Some structural features of the iron-uptake regulation protein (1991) Eur J Biochem, 197, pp. 29-38
Evans, C.H., (1990) Biochemistry of the Lanthanides., , Plenum Press, New York, NY
Carter Jr., C.W., Sweet, R.M., Macromolecular crystallography. Part a (1997) Methods Enzymol, 276, pp. 530-538
Karlberg, T., Schagerlof, U., Gakh, O., Park, S., Ryde, U., Lindahl, M., Leath, K., Al-Karadaghi, S., The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron (2006) Structure, 14, pp. 1535-1546
Foury, F., Pastore, A., Trincal, M., Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly (2007) EMBO Report, 8, pp. 194-199
Delaglio, F., Grzesiek, S., Vuister, G., Zhu, G., Pfeifer, J., Bax, A., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J Biomol NMR, 6, pp. 277-293
Bartels, C., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J Biomol NMR, 5, pp. 1-10
Otwinowski, Z., Minor, W., Processing of X-ray diffraction data collected in oscillation mode (1997) Methods Enzymol, 276, pp. 307-326
Brünger, A.T., Adams, P.D., Clore, G.M., Delano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.-S., Pannu, N.S., Crystallography and NMR system: A new software suite for macromolecular structure determination (1998) Acta Crystallogr, 54, pp. 905-921
Schneider, T.R., Sheldrick, G.M., Substructure solution with SHELXD (2002) Acta Crystallogr D Biol Crystallogr, 58, pp. 1772-1779
The CCP4 suite: Programs for protein crystallography (1994) Acta Crystallogr D Biol Crystallogr, 50, pp. 760-763. , Collaborative Computational Project Number 4 (
Jones, T.A., Zou, J.Y., Cowan, S.W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr, 47, pp. 110-119
Laskowski, R.A., MacArthur, M.W., Moss, D.S., Thornton, J.M., PROCHECK: A program to check the stereochemical quality of protein structure (1993) J Appl Crystallogr, 26, pp. 283-291
Hooft, R.W., Vriend, G.S., Abola, E.E., Errors in protein structures (1996) Nature, 381, p. 272
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structure (1996) J Mol Graph, 14, pp. 51-55
Esnouf, R.M., Further additions to Molscript, Version 1.4, including reading and contouring of electron-density maps (1999) Acta Crystallogr, 55, pp. 938-940
Bulteau, A. L., O'Neill, H. A., Kennedy, M. C., Ikeda-Saito, M., Isaya, G., Szweda, L. I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Delatycki, M. B., Williamson, R., Forrest, S. M., Freidreich's ataxia: An overview (2000) J Med Genet, 37, pp. 1-8
Huynen, M. A., Snel, B., Bork, P., Gibson, T. J., The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly (2001) Hum Mol Genet, 10, pp. 2463-2468
Radisky, D. C., Babcock, M. C., Kaplan, J., The yeast frataxin homologue mediates mitochondrial iron efflux: Evidence for a mitochondrial iron cycle (1999) J Biol Chem, 274, pp. 4497-4499
Cho, S. J., Lee, M. G., Yang, J. Y., Song, H. K., Suh, S. W., Crystal structure of Escherichia coli CyaY reveals a previously unidentified fold for the evolutionary conserved frataxin family (2000) Proc Natl Acad Sci USA, 97, pp. 8932-8937
He, Y., Alam, S. L., Proteasa, S. V., Zhang, Y., Lesuisse, E., Dancis, A., Stemmler, T. L., Yeast frataxin solution structure, iron binding and ferrochelatase interaction (2004) Biochemistry, 43, pp. 16254-16262
Butchard, C. G., Dwek, R. A., Ferguson, S. J., Kent, P. W., Williams, R. J. P., Xavier, A. V., (1972) FEBS Lett, 25, pp. 91-93. , Mapping of the binding site of N-fluoroacetyl-d-glucosamine and analogues in hen egg lysozyme by 1H and 19F-NMR techniques with Gd (III) and Mn (II) as paramagnetic probes
Evans, C. H., (1990) Biochemistry of the Lanthanides., , Plenum Press, New York, NY
Carter Jr., C. W., Sweet, R. M., Macromolecular crystallography. Part a (1997) Methods Enzymol, 276, pp. 530-538
Br nger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. -S., Pannu, N. S., Crystallography and NMR system: A new software suite for macromolecular structure determination (1998) Acta Crystallogr, 54, pp. 905-921
Schneider, T. R., Sheldrick, G. M., Substructure solution with SHELXD (2002) Acta Crystallogr D Biol Crystallogr, 58, pp. 1772-1779
Jones, T. A., Zou, J. Y., Cowan, S. W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr, 47, pp. 110-119
Laskowski, R. A., MacArthur, M. W., Moss, D. S., Thornton, J. M., PROCHECK: A program to check the stereochemical quality of protein structure (1993) J Appl Crystallogr, 26, pp. 283-291
Hooft, R. W., Vriend, G. S., Abola, E. E., Errors in protein structures (1996) Nature, 381, p. 272
Esnouf, R. M., Further additions to Molscript, Version 1. 4, including reading and contouring of electron-density maps (1999) Acta Crystallogr, 55, pp. 938-940
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.396, 5-year impact factor: 3.405
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547760795&partnerID=40&md5=ed6de646c31d2fcc2ea552d1db8b15c0
Keywords: Cyay, Friedreich, S Ataxia, Iron Binding, X-Ray, Aspartic Acid, Cation, Cyay Protein, Cysteine, Frataxin, Glutamic Acid, Histidine, Iron Binding Protein, Metal, Unclassified Drug, Binding Affinity, Binding Site, Electricity, Iron Chelation, Metal Binding, Nuclear Magnetic Resonance, Orthology, Priority Journal, Protein Binding, Protein Function, X Ray Crystallography, Amino Acid Sequence, Bacterial Proteins, Competitive, Cobalt, Gadolinium, Iron-Binding Proteins, Iron-Sulfur Proteins, Lanthanoid Series Elements, Lutetium, Magnesium, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Mutation, Protein Conformation, Protein Structure, Tertiary, Sequence Homology, Zinc, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
NIMR, The Ridgeway, London, NW71AA, United Kingdom
National Institute for Medical Research, London, United Kingdom
Dipartimento di Chimica, University of Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
References:
Campuzano, V., Montermini, L., Molto, M.D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Monticelli, A., Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion (1996) Science, 271, pp. 1423-142
Cossee, M., Puccio, H., Gansmuller, A., Koutnikova, H., Dierich, A., Lemeur, M., Fischbeck, K., Koenig, M., Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation (2000) Hum Mol Genet, 9, pp. 1219-1226
Yoon, T., Cowan, J.A., Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins (2003) J Am Chem Soc, 125, pp. 6078-6084
Bulteau, A.L., O'Neill, H.A., Kennedy, M.C., Ikeda-Saito, M., Isaya, G., Szweda, L.I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Gerber, J., Muhlenhoff, U., Lill, R., An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1 (2003) EMBO Reports, 4, pp. 906-911
Park, S., Gakh, O., O'Neill, H.A., Mangravita, A., Nichol, H., Ferreira, G.C., Isaya, G., Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation (2003) J Biol Chem, 278, pp. 31340-31351
Cavadini, P., O'Neill, H.A., Benada, O., Isaya, G., Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich's ataxia (2002) Hum Mol Genet, 11, pp. 217-227
Delatycki, M.B., Williamson, R., Forrest, S.M., Freidreich's ataxia: An overview (2000) J Med Genet, 37, pp. 1-8
Huynen, M.A., Snel, B., Bork, P., Gibson, T.J., The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly (2001) Hum Mol Genet, 10, pp. 2463-2468
Muhlenhoff, U., Richhardt, N., Ristow, M., Kispal, G., Lill, R., The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins (2002) Hum Mol Genet, 11, pp. 2025-2036
Stehling, O., Elsasser, H.-P., Bruckel, B., Muhlenhoff, U., Lill, R., Iron-sulfur protein maturation in human cells: Evidence for a function of frataxin (2004) Hum Mol Genet, 13, pp. 3007-3015
Wong, A., Yang, J., Cavadini, P., Gellera, C., Lonnerdal, B., Taroni, F., Cortopassi, G., The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis (1999) Hum Mol Genet, 8, pp. 425-430
Ristow, M., Pfister, M.F., Yee, A.J., Schubert, M., Michael, L., Zhang, C.-Y., Ueki, K., Kahn, C.R., Frataxin activates mitochondrial energy conversion and oxidative phosphorylation (2000) Proc Natl Acad Sci USA, 97, pp. 12239-12243
Tan, G., Napoli, E., Taroni, F., Cortopassi, G., Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells (2003) Hum Mol Genet, 12, pp. 1699-1711
Lesuisse, E., Santos, R., Matzanke, B.F., Knight, S.A.B., Camadro, J.-M., Dancis, A., Iron use for heme synthesis is under control of the yeast frataxin homologue (Yfh1) (2003) Hum Mol Genet, 12, pp. 879-889
Radisky, D.C., Babcock, M.C., Kaplan, J., The yeast frataxin homologue mediates mitochondrial iron efflux: Evidence for a mitochondrial iron cycle (1999) J Biol Chem, 274, pp. 4497-4499
Foury, F., Talibi, D., Mitochondrial control of iron homeostasis. a genome wide analysis of gene expression in a yeast frataxin-deficient strain (2001) J Biol Chem, 276, pp. 7762-7768
Que Jr., L., Ho, R.Y., Dioxygen activation by enzymes with mononuclear non-heme iron active sites (1996) Chem Rev, 96, pp. 2607-2624
Musco, G., Stier, G., Kolmerer, B., Adinolfi, S., Martin, S., Frenkiel, T., Gibson, T., Pastore, A., Towards a structural understanding of Friedreich's ataxia: The olution structure of frataxin (2000) Structure, 8, pp. 695-707
Dhe-Paganon, S., Shigeta, R., Chi, Y.-I., Ristow, M., Shoelson, S.E., Crystal structure of human frataxin (2000) J Biol Chem, 275, pp. 30753-30756
Cho, S.J., Lee, M.G., Yang, J.Y., Song, H.K., Suh, S.W., Crystal structure of Escherichia coli CyaY reveals a previously unidentified fold for the evolutionary conserved frataxin family (2000) Proc Natl Acad Sci USA, 97, pp. 8932-8937
Nair, M., Adinolfi, S., Pastore, C., Kelly, G., Temussi, P., Pastore, A., Solution structure of the bacterial frataxin ortholog, CyaY: Mapping the iron binding sites (2004) Structure (Camb), 12, pp. 2037-2048
He, Y., Alam, S.L., Proteasa, S.V., Zhang, Y., Lesuisse, E., Dancis, A., Stemmler, T.L., Yeast frataxin solution structure, iron binding and ferrochelatase interaction (2004) Biochemistry, 43, pp. 16254-16262
Bou-Abdallah, F., Adinolfi, S., Pastore, A., Laue, T.M., Chasteen, D.N., Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli (2004) J Mol Biol, 341, pp. 605-615
Adinolfi, S., Trifuoggi, M., Politou, A.S., Martin, S., Pastore, A., A structural approach to understanding the iron-binding properties of phylogenetically different frataxins (2002) Hum Mol Genet, 11, pp. 1865-1877
Adinolfi, S., Nair, M., Politou, A., Bayer, E., Martin, S., Temussi, P., Pastore, A., The factors governing the thermal stability of frataxin orthologues: How to increase a protein's stability (2004) Biochemistry, 43, pp. 6511-6518
Butchard, C.G., Dwek, R.A., Ferguson, S.J., Kent, P.W., Williams, R.J.P., Xavier, A.V., (1972) FEBS Lett, 25, pp. 91-93. , Mapping of the binding site of N-fluoroacetyl-d-glucosamine and analogues in hen egg lysozyme by 1H and 19F-NMR techniques with Gd(III) and Mn(II) as paramagnetic probes
Bertini, I., Luchinat, C., NMR of paramagnetic substances (1996) Coord Chem Rev, 150, p. 1
Saito, T., Wormald, M.R., Williams, R.J., Some structural features of the iron-uptake regulation protein (1991) Eur J Biochem, 197, pp. 29-38
Evans, C.H., (1990) Biochemistry of the Lanthanides., , Plenum Press, New York, NY
Carter Jr., C.W., Sweet, R.M., Macromolecular crystallography. Part a (1997) Methods Enzymol, 276, pp. 530-538
Karlberg, T., Schagerlof, U., Gakh, O., Park, S., Ryde, U., Lindahl, M., Leath, K., Al-Karadaghi, S., The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron (2006) Structure, 14, pp. 1535-1546
Foury, F., Pastore, A., Trincal, M., Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly (2007) EMBO Report, 8, pp. 194-199
Delaglio, F., Grzesiek, S., Vuister, G., Zhu, G., Pfeifer, J., Bax, A., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J Biomol NMR, 6, pp. 277-293
Bartels, C., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J Biomol NMR, 5, pp. 1-10
Otwinowski, Z., Minor, W., Processing of X-ray diffraction data collected in oscillation mode (1997) Methods Enzymol, 276, pp. 307-326
Brünger, A.T., Adams, P.D., Clore, G.M., Delano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.-S., Pannu, N.S., Crystallography and NMR system: A new software suite for macromolecular structure determination (1998) Acta Crystallogr, 54, pp. 905-921
Schneider, T.R., Sheldrick, G.M., Substructure solution with SHELXD (2002) Acta Crystallogr D Biol Crystallogr, 58, pp. 1772-1779
The CCP4 suite: Programs for protein crystallography (1994) Acta Crystallogr D Biol Crystallogr, 50, pp. 760-763. , Collaborative Computational Project Number 4 (
Jones, T.A., Zou, J.Y., Cowan, S.W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr, 47, pp. 110-119
Laskowski, R.A., MacArthur, M.W., Moss, D.S., Thornton, J.M., PROCHECK: A program to check the stereochemical quality of protein structure (1993) J Appl Crystallogr, 26, pp. 283-291
Hooft, R.W., Vriend, G.S., Abola, E.E., Errors in protein structures (1996) Nature, 381, p. 272
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structure (1996) J Mol Graph, 14, pp. 51-55
Esnouf, R.M., Further additions to Molscript, Version 1.4, including reading and contouring of electron-density maps (1999) Acta Crystallogr, 55, pp. 938-940
Bulteau, A. L., O'Neill, H. A., Kennedy, M. C., Ikeda-Saito, M., Isaya, G., Szweda, L. I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Delatycki, M. B., Williamson, R., Forrest, S. M., Freidreich's ataxia: An overview (2000) J Med Genet, 37, pp. 1-8
Huynen, M. A., Snel, B., Bork, P., Gibson, T. J., The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly (2001) Hum Mol Genet, 10, pp. 2463-2468
Radisky, D. C., Babcock, M. C., Kaplan, J., The yeast frataxin homologue mediates mitochondrial iron efflux: Evidence for a mitochondrial iron cycle (1999) J Biol Chem, 274, pp. 4497-4499
Cho, S. J., Lee, M. G., Yang, J. Y., Song, H. K., Suh, S. W., Crystal structure of Escherichia coli CyaY reveals a previously unidentified fold for the evolutionary conserved frataxin family (2000) Proc Natl Acad Sci USA, 97, pp. 8932-8937
He, Y., Alam, S. L., Proteasa, S. V., Zhang, Y., Lesuisse, E., Dancis, A., Stemmler, T. L., Yeast frataxin solution structure, iron binding and ferrochelatase interaction (2004) Biochemistry, 43, pp. 16254-16262
Butchard, C. G., Dwek, R. A., Ferguson, S. J., Kent, P. W., Williams, R. J. P., Xavier, A. V., (1972) FEBS Lett, 25, pp. 91-93. , Mapping of the binding site of N-fluoroacetyl-d-glucosamine and analogues in hen egg lysozyme by 1H and 19F-NMR techniques with Gd (III) and Mn (II) as paramagnetic probes
Evans, C. H., (1990) Biochemistry of the Lanthanides., , Plenum Press, New York, NY
Carter Jr., C. W., Sweet, R. M., Macromolecular crystallography. Part a (1997) Methods Enzymol, 276, pp. 530-538
Br nger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. -S., Pannu, N. S., Crystallography and NMR system: A new software suite for macromolecular structure determination (1998) Acta Crystallogr, 54, pp. 905-921
Schneider, T. R., Sheldrick, G. M., Substructure solution with SHELXD (2002) Acta Crystallogr D Biol Crystallogr, 58, pp. 1772-1779
Jones, T. A., Zou, J. Y., Cowan, S. W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr, 47, pp. 110-119
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Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin
Deficiency of the small mitochondrial protein frataxin causes Friedreich's ataxia, a severe neurodegenerative pathology. Frataxin, which has been highly conserved throughout evolution, is thought to be involved in, among other processes, Fe-S cluster formation. Independent evidence shows that it binds iron directly, although with very distinct features and low affinity. Here, we have carried out an extensive study of the binding properties of CyaY, the bacterial ortholog of frataxin, to different divalent and trivalent cations, using NMR and X-ray crystallography. We demonstrate that the protein has low cation specificity and contains multiple binding sites able to chelate divalent and trivalent metals with low affinity. Binding does not involve cavities or pockets, but exposed glutamates and aspartates, which are residues that are unusual for iron chelation when not assisted by histidines and/or cysteines. We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function.
Deficiency of the small mitochondrial protein frataxin causes Friedreich's ataxia, a severe neurodegenerative pathology. Frataxin, which has been highly conserved throughout evolution, is thought to be involved in, among other processes, Fe-S cluster formation. Independent evidence shows that it binds iron directly, although with very distinct features and low affinity. Here, we have carried out an extensive study of the binding properties of CyaY, the bacterial ortholog of frataxin, to different divalent and trivalent cations, using NMR and X-ray crystallography. We demonstrate that the protein has low cation specificity and contains multiple binding sites able to chelate divalent and trivalent metals with low affinity. Binding does not involve cavities or pockets, but exposed glutamates and aspartates, which are residues that are unusual for iron chelation when not assisted by histidines and/or cysteines. We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function.
Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin
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Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin
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Russo L, Mascanzoni F, Farina B, Dolga AM, Monti A, Caporale A, Culmsee C, Fattorusso R, Ruvo M, Doti N
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
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Ferraro G, Messori L, Merlino A
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
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GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
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Lin L-L, Chen Y-Y, Chi M-C, Merlino A
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
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Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (564 views)
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
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Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2193 views)
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Impact Factor: 2.282
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
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Impact Factor: 5.328
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1356 views)
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (659 views)
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Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A
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Monfregola L, Saviano M, De Luca S
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (399 views)
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Impact Factor: 2.26
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
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Impact Factor: 4.627
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
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Impact Factor: 3.325
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (310 views)
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Impact Factor: 2.538
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (402 views)
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (507 views)
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Impact Factor: 7.696
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
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Impact Factor: 3.73
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
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Impact Factor: 2.507
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Herga S, Brutus A, Vitale RM, Miche H, Perrier J, Puigserver A, Scaloni A, Giardina T
* Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family (338 views)
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Impact Factor: 3
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
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Impact Factor: 2.478
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (379 views)
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Impact Factor: 3.3
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (483 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (545 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (411 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (693 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, Rossi M, Pedone C
* The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2001 Nov 30; 314(3): 507-518.
Impact Factor: 5.826
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Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (454 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
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Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
* Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (531 views)
Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
Impact Factor: 1.021
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (681 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (724 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Martínez JC, Viguera AR, Berisio R, Wilmanns M, Mateo PL, Filimonov VV, Serrano L
Thermodynamic analysis of α-spectrin SH3 and two of its circular permutants with different loop lengths: Discerning the reasons for rapid folding in proteins (382 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1999 Jan 12; 38(2): 549-559.
Impact Factor: 4.493
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De Michele G, Mainenti PP, Soricelli A, Di Salle F, Salvatore E, Longobardi MR, Postiglione A, Salvatore M, Filla A
Cerebral blood flow in spinocerebellar degenerations: a single photon emission tomography study in 28 patients (292 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1998 Sep; 245(9): 603-608.
Impact Factor: 2.3
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (488 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (350 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
J Med Chem (ISSN: 0022-2623linking), 2021 Aug 12; 64 (15 ): 11445-11459.
Impact Factor:
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Cocozza S, Costabile T, Tedeschi E, Abate F, Russo C, Liguori A, Del Vecchio W, Paciello F, Quarantelli M, Filla A, Brunetti A, Saccà F
* Cognitive and functional connectivity alterations in Friedreich's ataxia (1391 views)
Ann Clin Transl Neurol (ISSN: 2328-9503linking, 2328-9503electronic), 2018 Apr 14; 5(6): 677-686.
Impact Factor: 4.649
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (399 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (420 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
* Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications (411 views) (PDF 160 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Dec 8; 180: 89-100.
Impact Factor: 3.063
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (334 views)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
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D'Abrosca G, Russo L, Palmieri M, Baglivo I, Netti F, De Paola I, Zaccaro L, Farina B, Iacovino R, Pedone PV, Isernia C, Fattorusso R, Malgieri G
* The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domain (259 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016 Aug; 161: 91-98.
Impact Factor: 3.348
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (407 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (505 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (1360 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
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Cervo A, Cocozza S, Saccà F, Giorgio SM, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M
* The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis (424 views)
Eur J Radiol (ISSN: 0720-048x), 2015 Jan; 84(1): 151-157.
Impact Factor: 2.593
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Ferraro G, Messori L, Merlino A
* The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome (323 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015; 51(13): 2559-2561.
Impact Factor: 6.567
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (528 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Jan; 130(1): 92-102.
Impact Factor: 3.444
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Lin L-L, Chen Y-Y, Chi M-C, Merlino A
* Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (696 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(9): 1523-1529.
Impact Factor: 4.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (503 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
Impact Factor: 1.994
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (564 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (793 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (461 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (460 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2193 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1356 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (659 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A
* Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry (487 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Apr; 38(4): 1031-1041.
Impact Factor: 4.106
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Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (542 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (433 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (539 views)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (324 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (364 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1133 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (399 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (310 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (402 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Nov 1; 65(2): 490-498.
Impact Factor: 3.73
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (507 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Herga S, Brutus A, Vitale RM, Miche H, Perrier J, Puigserver A, Scaloni A, Giardina T
* Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family (338 views)
Biochem Biophys Res Commun (ISSN: 0006-291xprint, 0006-291xlinking), 2005 May 6; 330(2): 540-546.
Impact Factor: 3
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (379 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (483 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (545 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (411 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (693 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, Rossi M, Pedone C
* The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2001 Nov 30; 314(3): 507-518.
Impact Factor: 5.826
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Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (454 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
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Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
* Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (531 views)
Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
Impact Factor: 1.021
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (681 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (724 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Martínez JC, Viguera AR, Berisio R, Wilmanns M, Mateo PL, Filimonov VV, Serrano L
Thermodynamic analysis of α-spectrin SH3 and two of its circular permutants with different loop lengths: Discerning the reasons for rapid folding in proteins (382 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1999 Jan 12; 38(2): 549-559.
Impact Factor: 4.493
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De Michele G, Mainenti PP, Soricelli A, Di Salle F, Salvatore E, Longobardi MR, Postiglione A, Salvatore M, Filla A
Cerebral blood flow in spinocerebellar degenerations: a single photon emission tomography study in 28 patients (292 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1998 Sep; 245(9): 603-608.
Impact Factor: 2.3
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (488 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (350 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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74 Records (73 excluding Abstracts).
Total impact factor: 316.294 (311.28 excluding Abstracts).
Total 5 year impact factor: 317.666 (312.375 excluding Abstracts).
Total impact factor: 316.294 (311.28 excluding Abstracts).
Total 5 year impact factor: 317.666 (312.375 excluding Abstracts).
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