Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective(454 views) Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
Keywords: Amyloid, Anions, Cations, Counterions, Hofmeister Series, Prion Helix 2 Derived Peptides, Prion Structure, Transmissible Spongiform Encephalopathies, Prion Protein, Prion Protein Helix 2 Derivative, Sodium Chloride, Alpha Helix, Article, Beta Sheet, Human, Ionic Strength, Peptide Synthesis, Priority Journal, Protein Binding, Protein Conformation, Protein Folding, Protein Function, Protein Modification, Amino Acid Sequence, Circular Dichroism, Electrostatics, Hydrogen-Ion Concentration, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Salts, Sulfates,
Affiliations: *** IBB - CNR ***
Dipartimento delle Scienze Biologiche, C.I.R.Pe.B, Università Federico II di Napoli, Via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Biochimica e Biofisica, CRISCEB, Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy
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Morrissey, M. P., Shakhnovich, E. I., Evidence for the role of PrPc helix 1 in the hydrophilic seeding of prion aggregates (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 11293-11298
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Nandi, P. K., Leclerc, E., Marc, D., Unusual property of prion protein unfolding in neutral salt solution (2002) Biochemistry, 41, pp. 11017-11024
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Brown, D. R., Guantieri, V., Grasso, G., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., Copper (II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper (II) and the binding motif in C-terminal protein region (2004) J. Inorg. Biochem., 98, pp. 133-143
Brown, D. R., Qin, K., Herms, J. W., Madlung, A., Manson, J., Strome, R., Fraser, P. E., Kretzschmar, H., The cellular prion protein binds copper in vivo (1997) Nature, 390, pp. 684-687
Millhauser, G. L., Copper binding in the prion protein (2004) Acc. Chem. Res., 37, pp. 79-85
Cereghetti, G. M., Schweiger, A., Glockshuber, R., van Doorslaer, S., Stability and Cu (II) binding of prion protein variants related to inherited human prion diseases (2003) Biophys. J., 84, pp. 1985-1997
Collins, K. D., Charge density-dependent strength of hydration and biological structure (1997) Biophys. J., 72, pp. 65-76
Collins, K. D., Ions from the hofmeister series and osmolytes: Effects on proteins in solution and in the crystallization process (2004) Methods, 34, pp. 300-311
Niedz, R. P., Evens, T. J., A solution to the problem of ion confounding in experimental biology (2006) Nat. Methods, 3, p. 417
Chen, Y. R., Huang, H. B., Chyan, C. L., Shiao, M. S., Lin, T. H., Chen, Y. C., The effect of A conformation on the metal affinity and aggregation mechanism studied by circular dichroism spectroscopy (2006) J. Biochem. (Tokyo), 139, pp. 733-740
Roberts, M. F., Organic compatible solutes of halotolerant and halophilic microorganisms (2005) Saline Syst., 1, pp. 1-30
Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective