2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity(1074 views) Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Keywords: Animals, Antineoplastic Agents, Chemical Synthesis, Chemistry, Pharmacology, Binding Sites, Breast Neoplasms, Drug Therapy, Carbonic Anhydrase Ii, Metabolism, Carcinoma, Lewis Lung, Blood Supply, Cell Proliferation, Drug Effects, Crystallography, X-Ray, Estradiol, Analogs, Derivatives, Female, Humans, Nude, Models, Molecular, Neovascularization, Pathologic, Steryl-Sulfatase, Antagonists, Inhibitors, Structure-Activity Relationship, Sulfonic Acids, Survival Rate, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Zinc, 2 Ethylestradiol 3, 17 O, O Bisulfamate, 2 Methoxyestradiol 3, Carbonate Dehydratase Ii, Estradiol 17 O Sulfamate, Estradiol Derivative, Steryl Sulfatase, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Breast Carcinoma, Cancer Inhibition, Controlled Study, Drug Binding, Drug Structure, Drug Synthesis, Human Cell, Lewis Carcinoma, Mouse, Nonhuman, Structure Activity Relation, Tumor Xenograft, X Ray Crystallography,
Affiliations: *** IBB - CNR ***
Medicinal Chemistry, Department of Pharmacy and Pharmacology & Sterix Ltd., University of Bath, Bath BA2 7AY, United Kingdom.,
Faculty of Medicine, Imperial College, St. Mary's Hospital, London W2 1NY, United Kingdom
Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy
Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Florence, Italy
References: Not available.
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(666 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote