A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study,
Impact factor: 1.801, 5-year impact factor: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33644801965&partnerID=40&md5=32660e12ee16bbcab8d097667a27c17d
Keywords: 3c Protease, Coxsackievirus B3, Rhinovirus, Viral Rna, Genomic Rna, Oligonucleotide, Peptide Nucleic Acid, Untranslated Region, Article, Base Pairing, Cell Transport, Chemosensitivity, Complex Formation, Controlled Study, Coxsackie Virus B3, Cytolysis, Drug Design, Drug Purification, Drug Synthesis, Enzyme Degradation, Gene Targeting, Human, Human Cell, Kinetics, Molecular Recognition, Nonhuman, Peptide Analysis, Priority Journal, Protein Stability, Protein Synthesis, Protein Targeting, Regulatory Rna Sequence, Rna Binding, Rna Structure, Thermodynamics, Virus Inhibition, Antiviral Agents, Cell Proliferation, Cultured, Coxsackievirus Infections, Cytopathogenic Effect, Dose-Response Relationship, Enterovirus B, Hela Cells, Microbial Sensitivity Tests, Structure-Activity Relationship, Chemical Synthesis, Chemistry, Pharmacology, Drug Effects, Virology, Genetics,
Affiliations:
*** IBB - CNR ***
Instituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Naples, Italy
Abteilung Molekulare Biophysik and NMR-Spektrikopie, Institut für Molekulare Biotechnologie, D-07741 Jena, Germany
Institut für Virologie und Antivirale Therapie, Friedrich-Schiller-Universität, D-07445 Jena, Germany
Institut f r Virologie und Antivirale Therapie, Friedrich-Schiller-Universit t, D-07445 Jena, Germany
Istituto di Biostrutture e Bioimmagini, CNR, I-80134 Naples, Italy.,
References:
Dean, N.M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W.Y., Han, F.S., Storm, C., Egan, W., Cheng, Y.C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B.A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P.E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A.G., Nawrocki, A.R., Nielsen, P.E., Bernasconi, A.G., Bernal-Mendez, E., Frey, B.M., Frey, F.J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M.R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S.Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Eriksson, M., Nielsen, P.E., Good, L., Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli (2002) J. Biol. Chem., 277, pp. 7144-7147
Svanvik, N., Nygren, J., Westman, G., Kubista, M., Free-probe fluorescence of light-up probes (2001) J. Am. Chem. Soc., 123, pp. 803-809
Friebe, P., Lohmann, V., Krieger, N., Bartenschlager, R., Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication (2001) J. Virol., 75, pp. 12047-12057
Becher, P., Orlich, M., Thiel, H.J., Mutations in the 5′ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics (2000) J. Virol., 74, pp. 7884-7894
Kusov, Y.Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5′ terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K.H., Hemenway, C., The 5′ nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Basso, J., Dallaire, P., Charest, P.J., Devantier, Y., Laliberte, J.F., Evidence for an internal ribosome entry site within the 5′ non-translated region of turnip mosaic potyvirus RNA (1994) J. Gen. Virol., 75 (PART 11), pp. 3157-3165
Lyons, T., Murray, K.E., Roberts, A.W., Barton, D.J., Poliovirus 5′-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis (2001) J. Virol., 75, pp. 10696-10708
Richards, O.C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wimmer, E., Kuhn, R.J., Pincus, S., Yang, C.F., Toyoda, H., Nicklin, M.D., Takeda, N., Molecular events leading to picornavirus genome replication (1987) J. Cell Sci. Suppl., 7, pp. 251-276
Santti, J., Vainionpaa, R., Hyypia, T., Molecular detection and typing of human picornaviruses (1999) Virus Res., 62, pp. 177-183
Wang, Q.M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J.S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T.A., Wang, Q.M., Aube, J., Hanzlik, R.P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Andino, R., Rieckhof, G.E., Baltimore, D., A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA (1990) Cell, 63, pp. 369-380
Zell, R., Sidigi, K., Bucci, E., Stelzner, A., Gorlach, M., Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (2002) RNA, 8, pp. 188-201
Ohlenschlager, O., Wohnert, J., Bucci, E., Seitz, S., Hafner, S., Ramachandran, R., Zell, R., Gorlach, M., The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C (2004) Structure, 12, pp. 237-248
Hingamp, P., van den Brock, A.E., Stoesser, G., Baker, W., The EMBL nucleotide sequence database. Contributing and accessing data (1999) Mol. Biotechnol., 12, pp. 255-267
Skripkin, E.A., Jacobson, A.B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q β RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Schmidtke, M., Schnittler, U., Jahn, B., Dahse, H., Stelzner, A., A rapid assay for evaluation of antiviral activity against coxsackievirus B3, influenza virus A, and herpes simplex virus type 1 (2001) J. Virol. Methods, 95, pp. 133-143
Isernia, C., Bucci, E., Leone, M., Zaccaro, L., Di Lello, P., Digilio, G., Esposito, S., Fattorusso, R., NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (2003) Chem Biochem, 4, pp. 171-180
Sosnick, T.R., Fang, X., Shelton, V.M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Koppelhus, U., Nielsen, P.E., Cellular delivery of peptide nucleic acid (PNA) (2003) Adv. Drug Deliv. Rev., 55, pp. 267-280
Wang, G., Xu, X.S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
Filipovska, A., Eccles, M.R., Smith, R.A., Murphy, M.P., Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation (2004) FEBS Lett., 556, pp. 180-186
Sazani, P., Kang, S.H., Mauer, M.A., Wie, C., Dillman, J., Summerton, J., Manoharan, M., Kole, R., Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs (2001) Nucleic Acids Res., 29, pp. 3965-3974
Kole, R., Williams, T., Cohen, L., RNA modulation, repair and remodeling by splice switching oligonucleotides (2004) Acta Biochim Pol., 51, pp. 373-378
Moulton, H., Moulton, J.D., Peptide-assisted delivery of steric-blocking antisense oligomers (2003) Curr. Opin. Mol. Ther., 5, pp. 123-132
Koppelhus, U., Zachar, V., Nielsen, P.E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA (1997) Nucleic Acids Res., 25, pp. 2167-2173
Terreux, R., Pairot, S., Cabrol-Bass, D., Patino, N., Condom, R., Interaction of new PNA-based molecules with TAR RNA of HIV-1: Molecular modelling and biological evaluation (2001) J. Mol. Graph., 19, pp. 579-585
Lee, R., Kaushik, N., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription (1998) Biochemistry, 37, pp. 900-910
Rozhon, E., Cox, S., Buontempo, P., O'Connell, J., Slater, W., De Martino, J., Schwartz, J., Zhang, A., SCH 38057: A picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating (1993) Antiviral Res., 21, pp. 15-35
Dean, N. M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W. Y., Han, F. S., Storm, C., Egan, W., Cheng, Y. C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B. A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P. E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A. G., Nawrocki, A. R., Nielsen, P. E., Bernasconi, A. G., Bernal-Mendez, E., Frey, B. M., Frey, F. J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M. R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S. Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Kusov, Y. Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5 terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K. H., Hemenway, C., The 5 nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Richards, O. C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wang, Q. M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J. S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T. A., Wang, Q. M., Aube, J., Hanzlik, R. P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Skripkin, E. A., Jacobson, A. B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Sosnick, T. R., Fang, X., Shelton, V. M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Wang, G., Xu, X. S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study,
Impact factor: 1.801, 5-year impact factor: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33644801965&partnerID=40&md5=32660e12ee16bbcab8d097667a27c17d
Keywords: 3c Protease, Coxsackievirus B3, Rhinovirus, Viral Rna, Genomic Rna, Oligonucleotide, Peptide Nucleic Acid, Untranslated Region, Article, Base Pairing, Cell Transport, Chemosensitivity, Complex Formation, Controlled Study, Coxsackie Virus B3, Cytolysis, Drug Design, Drug Purification, Drug Synthesis, Enzyme Degradation, Gene Targeting, Human, Human Cell, Kinetics, Molecular Recognition, Nonhuman, Peptide Analysis, Priority Journal, Protein Stability, Protein Synthesis, Protein Targeting, Regulatory Rna Sequence, Rna Binding, Rna Structure, Thermodynamics, Virus Inhibition, Antiviral Agents, Cell Proliferation, Cultured, Coxsackievirus Infections, Cytopathogenic Effect, Dose-Response Relationship, Enterovirus B, Hela Cells, Microbial Sensitivity Tests, Structure-Activity Relationship, Chemical Synthesis, Chemistry, Pharmacology, Drug Effects, Virology, Genetics,
Affiliations:
*** IBB - CNR ***
Instituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Naples, Italy
Abteilung Molekulare Biophysik and NMR-Spektrikopie, Institut für Molekulare Biotechnologie, D-07741 Jena, Germany
Institut für Virologie und Antivirale Therapie, Friedrich-Schiller-Universität, D-07445 Jena, Germany
Institut f r Virologie und Antivirale Therapie, Friedrich-Schiller-Universit t, D-07445 Jena, Germany
Istituto di Biostrutture e Bioimmagini, CNR, I-80134 Naples, Italy.,
References:
Dean, N.M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W.Y., Han, F.S., Storm, C., Egan, W., Cheng, Y.C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B.A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P.E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A.G., Nawrocki, A.R., Nielsen, P.E., Bernasconi, A.G., Bernal-Mendez, E., Frey, B.M., Frey, F.J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M.R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S.Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Eriksson, M., Nielsen, P.E., Good, L., Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli (2002) J. Biol. Chem., 277, pp. 7144-7147
Svanvik, N., Nygren, J., Westman, G., Kubista, M., Free-probe fluorescence of light-up probes (2001) J. Am. Chem. Soc., 123, pp. 803-809
Friebe, P., Lohmann, V., Krieger, N., Bartenschlager, R., Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication (2001) J. Virol., 75, pp. 12047-12057
Becher, P., Orlich, M., Thiel, H.J., Mutations in the 5′ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics (2000) J. Virol., 74, pp. 7884-7894
Kusov, Y.Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5′ terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K.H., Hemenway, C., The 5′ nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Basso, J., Dallaire, P., Charest, P.J., Devantier, Y., Laliberte, J.F., Evidence for an internal ribosome entry site within the 5′ non-translated region of turnip mosaic potyvirus RNA (1994) J. Gen. Virol., 75 (PART 11), pp. 3157-3165
Lyons, T., Murray, K.E., Roberts, A.W., Barton, D.J., Poliovirus 5′-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis (2001) J. Virol., 75, pp. 10696-10708
Richards, O.C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wimmer, E., Kuhn, R.J., Pincus, S., Yang, C.F., Toyoda, H., Nicklin, M.D., Takeda, N., Molecular events leading to picornavirus genome replication (1987) J. Cell Sci. Suppl., 7, pp. 251-276
Santti, J., Vainionpaa, R., Hyypia, T., Molecular detection and typing of human picornaviruses (1999) Virus Res., 62, pp. 177-183
Wang, Q.M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J.S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T.A., Wang, Q.M., Aube, J., Hanzlik, R.P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Andino, R., Rieckhof, G.E., Baltimore, D., A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA (1990) Cell, 63, pp. 369-380
Zell, R., Sidigi, K., Bucci, E., Stelzner, A., Gorlach, M., Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (2002) RNA, 8, pp. 188-201
Ohlenschlager, O., Wohnert, J., Bucci, E., Seitz, S., Hafner, S., Ramachandran, R., Zell, R., Gorlach, M., The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C (2004) Structure, 12, pp. 237-248
Hingamp, P., van den Brock, A.E., Stoesser, G., Baker, W., The EMBL nucleotide sequence database. Contributing and accessing data (1999) Mol. Biotechnol., 12, pp. 255-267
Skripkin, E.A., Jacobson, A.B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q β RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Schmidtke, M., Schnittler, U., Jahn, B., Dahse, H., Stelzner, A., A rapid assay for evaluation of antiviral activity against coxsackievirus B3, influenza virus A, and herpes simplex virus type 1 (2001) J. Virol. Methods, 95, pp. 133-143
Isernia, C., Bucci, E., Leone, M., Zaccaro, L., Di Lello, P., Digilio, G., Esposito, S., Fattorusso, R., NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (2003) Chem Biochem, 4, pp. 171-180
Sosnick, T.R., Fang, X., Shelton, V.M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Koppelhus, U., Nielsen, P.E., Cellular delivery of peptide nucleic acid (PNA) (2003) Adv. Drug Deliv. Rev., 55, pp. 267-280
Wang, G., Xu, X.S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
Filipovska, A., Eccles, M.R., Smith, R.A., Murphy, M.P., Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation (2004) FEBS Lett., 556, pp. 180-186
Sazani, P., Kang, S.H., Mauer, M.A., Wie, C., Dillman, J., Summerton, J., Manoharan, M., Kole, R., Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs (2001) Nucleic Acids Res., 29, pp. 3965-3974
Kole, R., Williams, T., Cohen, L., RNA modulation, repair and remodeling by splice switching oligonucleotides (2004) Acta Biochim Pol., 51, pp. 373-378
Moulton, H., Moulton, J.D., Peptide-assisted delivery of steric-blocking antisense oligomers (2003) Curr. Opin. Mol. Ther., 5, pp. 123-132
Koppelhus, U., Zachar, V., Nielsen, P.E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA (1997) Nucleic Acids Res., 25, pp. 2167-2173
Terreux, R., Pairot, S., Cabrol-Bass, D., Patino, N., Condom, R., Interaction of new PNA-based molecules with TAR RNA of HIV-1: Molecular modelling and biological evaluation (2001) J. Mol. Graph., 19, pp. 579-585
Lee, R., Kaushik, N., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription (1998) Biochemistry, 37, pp. 900-910
Rozhon, E., Cox, S., Buontempo, P., O'Connell, J., Slater, W., De Martino, J., Schwartz, J., Zhang, A., SCH 38057: A picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating (1993) Antiviral Res., 21, pp. 15-35
Dean, N. M., Functional genomics and target validation approaches using antisense oligonucleotide, technology (2001) Curr. Opin. Biotechnol., 12, pp. 622-62
Gao, W. Y., Han, F. S., Storm, C., Egan, W., Cheng, Y. C., Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology (1992) Mol. Pharmacol., 41, pp. 223-229
Armitage, B. A., The impact of nucleic acid secondary structure on PNA hybridization (2003) Drug Discov. Today, 8, pp. 222-228
Nielsen, P. E., Peptide nucleic acids as therapeutic agents (1999) Curr. Opin. Struct. Biol., 9, pp. 353-357
Rebuffat, A. G., Nawrocki, A. R., Nielsen, P. E., Bernasconi, A. G., Bernal-Mendez, E., Frey, B. M., Frey, F. J., Gene delivery by a steroid-peptide nucleic acid conjugate (2002) FASEB J., 16, pp. 1426-1428
Lewis, M. R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S. Z., Hannink, M., Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding (2002) Bioconjug. Chem., 13, pp. 1176-1180
Kusov, Y. Y., Gauss-Muller, V., In vitro RNA binding of the hepatitis A virus protienase 3C (HAV 3Cpro) to secondary structure elements within the 5 terminus of the HAV genome (1997) RNA, 3, pp. 291-302
Kim, K. H., Hemenway, C., The 5 nontranslated region of potato virus X RNA affects both genomic and subgenomic RNA synthesis (1996) J. Virol., 70, pp. 5533-5540
Richards, O. C., Ehrenfeld, E., Poliovirus RNA replication (1990) Curr. Top. Microbiol. Immunol., 161, pp. 89-119
Wang, Q. M., Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections (2001) Prog. Drug Res., 52 (SPEC. ISSUE), pp. 229-253
Kong, J. S., Venkatraman, S., Furness, K., Nimkar, S., Shepherd, T. A., Wang, Q. M., Aube, J., Hanzlik, R. P., Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication (1998) J. Med. Chem., 41, pp. 2579-2587
Skripkin, E. A., Jacobson, A. B., A two-dimensional model at the nucleotide level for the central hairpin of coliphage Q RNA (1993) J. Mol. Biol., 233, pp. 245-260
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Sosnick, T. R., Fang, X., Shelton, V. M., Application of circular dichroism to study RNA folding transitions (2000) Meth. Enzymol., 317, pp. 393-409
Wang, G., Xu, X. S., Peptide nucleic acid (PNA) binding-mediated gene regulation (2004) Cell Res., 14, pp. 111-116
A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis
Targeting regulatory RNA regions to interfere with the biosynthesis of a protein is an intriguing alternative to targeting a protein itself. Regulatory regions are often unique in sequence and/or structure and, thus, ideally suited for specific recognition with a low risk of undesired side effects. Targeting regulatory RNA elements, however, is complicated by their complex three-dimensional structure, which poses kinetic and thermodynamic constraints to the recognition by a complementary oligonucleotide. Oligonucleotide mimics, which shift the thermodynamic equilibrium towards complex formation and yield stable complexes with a target RNA, can overcome this problem. Peptide nucleic acids (PNA) represent such a promising class of molecules. PNA are very stable, non-ionic compounds and they are not sensitive to enzymatic degradation. Yet, PNA form specific base pairs with a target sequence. We have designed, synthesised and characterised PNA able to enter infected cells and to bind specifically to a control region of the genomic RNA of coxsackievirus B3 (CV133), which is an important human pathogen. The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
Targeting regulatory RNA regions to interfere with the biosynthesis of a protein is an intriguing alternative to targeting a protein itself. Regulatory regions are often unique in sequence and/or structure and, thus, ideally suited for specific recognition with a low risk of undesired side effects. Targeting regulatory RNA elements, however, is complicated by their complex three-dimensional structure, which poses kinetic and thermodynamic constraints to the recognition by a complementary oligonucleotide. Oligonucleotide mimics, which shift the thermodynamic equilibrium towards complex formation and yield stable complexes with a target RNA, can overcome this problem. Peptide nucleic acids (PNA) represent such a promising class of molecules. PNA are very stable, non-ionic compounds and they are not sensitive to enzymatic degradation. Yet, PNA form specific base pairs with a target sequence. We have designed, synthesised and characterised PNA able to enter infected cells and to bind specifically to a control region of the genomic RNA of coxsackievirus B3 (CV133), which is an important human pathogen. The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis
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A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis
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Greco F, Marzano M, Falanga AP, Terracciano M, Piccialli G, Roviello GN, D , #xerrico S, Borbone N, Oliviero G
* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (8 views)
Int J Biol Macromol (ISSN: 0141-8130linking), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
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Borbone N, Piccialli I, Falanga AP, Piccialli V, Roviello GN, Oliviero G
* Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era (33 views)
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
Impact Factor: 5.924
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Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (61 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
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Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (249 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
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Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (339 views) (PDF 121 views)
Pharmaceuticals (ISSN: 1424-8247print, 1424-8247linking), 2018 Nov 13; 11(4): N/D-N/D.
Impact Factor: 4.286
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Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R
* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (195 views) (PDF 106 views)
Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.
Impact Factor: 1.545
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (279 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
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Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (867 views)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Avitabile C, D'Andrea LD, Romanelli A
* Exploring the dark matter of the human genome using oligonucleotide-based molecules (281 views)
Future Med Chem (ISSN: 1756-8919, 1756-8919linking, 1756-8927electronic), 2015; 7(13): 1627-1630.
Impact Factor: 3.345
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Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (517 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
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Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (351 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (557 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (365 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (590 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
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Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (458 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (754 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (364 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (362 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (302 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (398 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (399 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (583 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (511 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (545 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (623 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (519 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (538 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (461 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (399 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Fully automated synthesis of peptide-oligonucleotide conjugates (355 views)
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
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* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (8 views)
Int J Biol Macromol (ISSN: 0141-8130linking), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
View Export to BibTeX Export to EndNote
Borbone N, Piccialli I, Falanga AP, Piccialli V, Roviello GN, Oliviero G
* Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era (33 views)
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
Impact Factor: 5.924
View Export to BibTeX Export to EndNote
Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (61 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Marzano M, Falanga AP, D'Errico S, Pinto B, Roviello GN, Piccialli G, Oliviero G, Borbone N
* New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (249 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (339 views) (PDF 121 views)
Pharmaceuticals (ISSN: 1424-8247print, 1424-8247linking), 2018 Nov 13; 11(4): N/D-N/D.
Impact Factor: 4.286
View Export to BibTeX Export to EndNote
Martinez Fernandez L, Muñoz-losa A, Esposito L, Improta R
* The optical properties of adenine cation in different oligonucleotides: a PCM/TD‑DFT study (195 views) (PDF 106 views)
Theor Chem Acc (ISSN: 1432-881x), 2018; 137(3): N/D-N/D.
Impact Factor: 1.545
View Export to BibTeX Export to EndNote
Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (279 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
View Export to BibTeX Export to EndNote
Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (867 views)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
View Export to BibTeX Export to EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Exploring the dark matter of the human genome using oligonucleotide-based molecules (281 views)
Future Med Chem (ISSN: 1756-8919, 1756-8919linking, 1756-8927electronic), 2015; 7(13): 1627-1630.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (517 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
View Export to BibTeX Export to EndNote
Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (351 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (557 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
View Export to BibTeX Export to EndNote
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (365 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
View Export to BibTeX Export to EndNote
Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (590 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (458 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (754 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (364 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
View Export to BibTeX Export to EndNote
D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
View Export to BibTeX Export to EndNote
Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (362 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (302 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (398 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (399 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (583 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (511 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (545 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (623 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (519 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (538 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (461 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (399 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Fully automated synthesis of peptide-oligonucleotide conjugates (355 views)
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
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43 Records (40 excluding Abstracts).
Total impact factor: 218.102 (214.925 excluding Abstracts).
Total 5 year impact factor: 216.599 (213.568 excluding Abstracts).
Total impact factor: 218.102 (214.925 excluding Abstracts).
Total 5 year impact factor: 216.599 (213.568 excluding Abstracts).
395 views. Last view on Saturday 14 January 2023, 19:29:27
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