Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (440 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
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Paper type: Journal Article,
Impact factor: 5.115, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33646076226&partnerID=40&md5=88e47eb1a452d41d261243c3a72c427d
Keywords: 3 Phenyl [2 (cinnamoylamino)benzoylamino]propionic Acid, [2 [(1h Indole 2 Carbonyl)amino]benzoylamino] 3 Phenylpropionic Acid, [2 [(1h Indole 2 Carbonyl)amino]benzoylamino]propionic Acid, [2 [(2 Acetylaminocinnamoyl)amino]benzoylamino] 3 Phenylpropionic Acid, Anthranilic Acid Derivative, Cholecystokinin A Receptor, Cholecystokinin A Receptor Antagonist, Cholecystokinin Octapeptide, Cholecystokinin Receptor Blocking Agent, Loxiglumide, Unclassified Drug, Vl 0395, Amino Terminal Sequence, Article, Drug Structure, Fluorescence Spectroscopy, Molecular Interaction, Nuclear Magnetic Resonance, Protein Conformation, Receptor Binding, Animals, Competitive, Biological Assay, Humans, Ligands, Magnetic Resonance Spectroscopy, Models, Molecular Structure, Pancreas, Proglumide, Sincalide, Spectrometry, Structure-Activity Relationship, 3 Phenyl [2 (cinnamoylamino) Benzoylamino] Propionic Acid, [2 [(1h Indole 2 Carbonyl) Amino] Benzoylamino] 3 Phenylpropionic Acid, [2 [(1h Indole 2 Carbonyl) Amino] Benzoylamino] Propionic Acid, [2 [(2 Acetylaminocinnamoyl) Amino] Benzoylamino] 3 Phenylpropionic Acid,
Affiliations:
*** IBB - CNR ***
Interuniversity Research Center on Bioactive Peptides (CIRPeB), University of Naples Federico II, Institute of Biostructures and Bioimaging of CNR, Via Mezzocannone, 16, I-80134 Naples, Italy
Department of Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127 Trieste, Italy
Institute of Physical Chemistry, NCSR Demokritos Ag. Paraskevi, 15310 Athens, Greece
References:
Not available.
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.115, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33646076226&partnerID=40&md5=88e47eb1a452d41d261243c3a72c427d
Keywords: 3 Phenyl [2 (cinnamoylamino)benzoylamino]propionic Acid, [2 [(1h Indole 2 Carbonyl)amino]benzoylamino] 3 Phenylpropionic Acid, [2 [(1h Indole 2 Carbonyl)amino]benzoylamino]propionic Acid, [2 [(2 Acetylaminocinnamoyl)amino]benzoylamino] 3 Phenylpropionic Acid, Anthranilic Acid Derivative, Cholecystokinin A Receptor, Cholecystokinin A Receptor Antagonist, Cholecystokinin Octapeptide, Cholecystokinin Receptor Blocking Agent, Loxiglumide, Unclassified Drug, Vl 0395, Amino Terminal Sequence, Article, Drug Structure, Fluorescence Spectroscopy, Molecular Interaction, Nuclear Magnetic Resonance, Protein Conformation, Receptor Binding, Animals, Competitive, Biological Assay, Humans, Ligands, Magnetic Resonance Spectroscopy, Models, Molecular Structure, Pancreas, Proglumide, Sincalide, Spectrometry, Structure-Activity Relationship, 3 Phenyl [2 (cinnamoylamino) Benzoylamino] Propionic Acid, [2 [(1h Indole 2 Carbonyl) Amino] Benzoylamino] 3 Phenylpropionic Acid, [2 [(1h Indole 2 Carbonyl) Amino] Benzoylamino] Propionic Acid, [2 [(2 Acetylaminocinnamoyl) Amino] Benzoylamino] 3 Phenylpropionic Acid,
Affiliations:
*** IBB - CNR ***
Interuniversity Research Center on Bioactive Peptides (CIRPeB), University of Naples Federico II, Institute of Biostructures and Bioimaging of CNR, Via Mezzocannone, 16, I-80134 Naples, Italy
Department of Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127 Trieste, Italy
Institute of Physical Chemistry, NCSR Demokritos Ag. Paraskevi, 15310 Athens, Greece
References:
Not available.
Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes"
The interaction between the 1-47 N-terminus of the CCK1-R and the anthranilic acid based antagonists has been investigated by fluorescence spectroscopy. These antagonists interact with W39 of the N-terminal domain of the CCK1-R like that of the endogenous ligand CCK-8. This specific interaction was not found in other nonpeptide ligands of the CCK1-R. Conformational studies, using NMR and energy minimization procedures, have allowed formulation of a new hypothesis on the CCK1-R binding mode of the anthranilic antagonists. © 2006 American Chemical Society.
The interaction between the 1-47 N-terminus of the CCK1-R and the anthranilic acid based antagonists has been investigated by fluorescence spectroscopy. These antagonists interact with W39 of the N-terminal domain of the CCK1-R like that of the endogenous ligand CCK-8. This specific interaction was not found in other nonpeptide ligands of the CCK1-R. Conformational studies, using NMR and energy minimization procedures, have allowed formulation of a new hypothesis on the CCK1-R binding mode of the anthranilic antagonists. © 2006 American Chemical Society.
Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes"
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