Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Dipartimento delle Scienze Biologiche-Sezione Biostrutture, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Polo Scientifico, Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
Laboratoire de Chimie Biomoléculaire, Ecole Nationale Supérieure de Chimie de Montpellier, Université Montpellier II, 8 Rue de l'Ecole Normale, 34296 Montpellier Cedex, France
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Potter, C. P. S., Harris, A. L., Diagnostics, prognostics and therapeutic implications of carbonic anhydrases in cancer (2003) Br. J. Cancer, 89, pp. 2-7
Jain, R. K., Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy (2005) Science, 307, pp. 58-62
Opavsk, R., Pastorekova, S., Zelnik, V., Gibadulinova, A., Stanbridge, E. J., Zavada, J., Kettmann, R., Pastorek, J., Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationship (1996) Genomics, 33, pp. 480-487
Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Ratcliffe, P. J., The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999) Nature, 399, pp. 271-275
Epstein, A. C. R., Gleadle, J. M., McNeil, L. A., C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation (2001) Cell, 107, pp. 43-54
Ratcliffe, P. J., Pugh, C. W., Maxwell, P. H., Targeting tumors through the HIF system (2000) Nat. Med., 6, pp. 1315-1316
Semenza, G. L., Targeting HIF-1 for cancer therapy (2003) Nat. Rev. Cancer, 3, pp. 721-732
Casey, J. R., Morgan, P. E., Vullo, D., Scozzafava, A., Mastrolorenzo, A., Supuran, C. T., Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX (2004) J. Med. Chem., 47, pp. 2337-2347
Winum, J. Y., Scozzafava, A., Montero, J. L., Supuran, C. T., Sulfamates and their therapeutic potential (2005) Med. Res. Rev., 25, pp. 186-228
Supuran, C. T., Briganti, F., Tilli, S., Chegwidden, W. R., Scozzafava, A., Carbonic anhydrase inhibitors: Sulfonamides as antitumor agents? (2001) Bioorg. Med. Chem., 9, pp. 703-714
Denny, W. A., Tumor-activated prodrugs. A new approach to cancer therapy (2004) Cancer Invest., 22, pp. 604-619
Stratford, I. J., Williams, K. J., Cowen, R. L., Jaffar, M., Combining bioreductive drugs and radiation for the treatment of solid tumors (2003) Semin. Radiat. Oncol., 13, pp. 42-52
Hay, M. P., Pruijn, F. B., Gamage, S. A., Liyanage, H. D., Kovacs, M. S., Patterson, A. V., Wilson, W. R., Denny, W. A., DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: Potent analogues of the hypoxia-selective cytotoxin tirapazamine (2004) J. Med. Chem., 47, pp. 475-488
Seow, H. A., Penketh, P. G., Shyam, K., Rockwell, S., Sartorelli, A. C., 1, 2-Bis (methylsulfonyl) -1- (2-chloroethyl) -2- [[1- (4-nitrophenyl) -ethoxy] carbonyl] hydrazine: An anticancer agent targeting hypoxic cells (2005) Proc. Natl. Acad. Sci. U. S. A., 102, pp. 9282-9287
Phillips, R. M., Jaffar, M., Maitland, D. J., Loadman, P. M., Shnyder, S. D., Steans, G., Cooper, P. A., Stratford, I. J., Pharmacological and biological evaluation of a series of substituted 1, 4-naphthoquinone bioreductive drugs (2004) Biochem. Pharmacol., 68, pp. 2107-2116
Welsh, S. J., Williams, R. R., Birmingham, A., Newman, D. J., Kirkpatrick, D. L., Powis, G., The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1-alpha and vascular endothelial growth factor formation (2003) Mol. Cancer Ther., 2, pp. 235-243
Winum, J. Y., Dogne, J. M., Casini, A., De Leval, X., Montero, J. L., Scozzafava, A., Vullo, D., Supuran, C. T., Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties (2005) J. Med. Chem., 48, pp. 2121-2125
Turpin, J. A., Song, Y., Inman, J. K., Huang, M., Wallqvist, A., Maynard, A., Covell, D. G., Appella, E., Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers (1999) J. Med. Chem., 42, pp. 67-86
Khalifah, R. G., The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C (1971) J. Biol. Chem., 246, pp. 2561-2573
Eriksson, A. E., Jones, T. A., Liljas, A., Refined structure of human carbonic anhydrase II at 2. 0 resolution (1988) Proteins: Struct., Funct., Genet., 4, pp. 274-282
Br nger, A. T., Adams, P. D., Clore, G. M., De Lano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Warren, G. L., Crystallography & NMR system: A new software suite for macromolecular structure determination (1998) Acta Crystallogr., Sect. D: Biol. Crystallogr., 54, pp. 905-921
Jones, T. A., Zou, J. Y., Cowan, S. W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr., Sect. A, 47, pp. 110-119
Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham III, T. E., DeBolt, S., Ferguson, D., Kollman, P., "AMBER", a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to stimulate the structural and energetic properties of molecules (1995) Comput. Phys. Commun., 91, pp. 1-42
Bayly, C. I., Cieplak, P., Cornell, W., Kollman, P. A., A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model (1993) J. Phys. Chem., 97, pp. 10269-10280
Schmidt, M. W., Baldridge, K. K., Boatz, J. A., Elbert, S. T., Gordon, M. S., Jensen, J. H., Koseki, S., Nguyen, K. A., General atomic and molecular electronic structure system (1993) J. Comput. Chem., 14, pp. 1347-1363
Hoops, S. C., Anderson, K. W., Merz Jr., K. M., Force field design for metalloproteins (1991) J. Am. Chem. Soc., 113, pp. 8262-8270
Ryckaert, J. P., Ciccotti, G., Berendsen, H. J., Numerical integration of the Cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes (1977) C. J. Comput. Phys., 23, pp. 327-341
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX