Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.421, 5-year impact factor: 3.865
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-31444432039&partnerID=40&md5=b53ca7d127bce69efcaddf31da82634a
Keywords: Apoptosis, Cancer, Cell Cycle, Facs, Hadrontherapy, Proton Beam, Rt-Pcr, Double Stranded Dna, Hydroxyl Group, Reactive Oxygen Metabolite, Transcriptome, Article, Cancer Therapy, Cell Count, Cell Cycle Arrest, Cell Cycle G2 Phase, Cell Cycle M Phase, Cell Line, Cell Membrane, Cell Population, Cell Strain Mcf 7, Cell Structure, Controlled Study, Dna Strand Breakage, Dose Response, Electron Spin Resonance, Fluorescence Activated Cell Sorting, Human, Human Cell, Irradiation, Necrosis, Nucleotide Sequence, Priority Journal, Proton Radiation, Radiation Dose, Reverse Transcription Polymerase Chain Reaction, Statistical Significance, Base Sequence, Tumor, Dna Damage, Dna Primers, Electron Spin Resonance Spectroscopy, Female, Flow Cytometry, Neoplasms, Photons, Reactive Oxygen Species, Reverse Transcriptase Polymerase Chain Reaction, Messenger, Mink Cell Focus-Forming Virus, Apoptosis Genetics Radiation Effects, Cell Cycle Radiation Effects, Dna Primers Genetics, Neoplasms Genetics Metabolism Pathology Radiotherapy, Photons Therapeutic Use, Protons Therapeutic Use, Messenger Genetics, Neoplasm Genetics, Reactive Oxygen Species Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Biomediche, Sezione di Biologia, Genetica e Bioinformatica, Università di Catania, 95123 Catania, Italy
Dipartimento di Medicina Interna e Medicina Specialistica, Sezione di Endocrinologia, Ospedale Garibaldi, 95124 Catania, Italy
Istituto di Biostrutture e Bioimmagini, CNR, 95125 Catania, Italy
Istituto Nazionale di Fisica Nucleare, Laboratorio Nazionale del Sud, 95125 Catania, Italy
Dipartimento di Diagnostica Per Immagini e Radioterapia, Università di Catania, 95125 Catania, Italy
Dipartimento di Matematica ed Informatica, Università di Catania, 95125 Catania, Italy
Dipartimento di Fisica e di Astronomia, Università di Catania, 95125 Catania, Italy
References:
Okada, H., Mak, T.W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J.F.R., Harman, B.V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M.O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Meier, P., Finch, A., Evan, G., Apoptosis in development (2000) Nature, 407, pp. 796-801
Savill, J., Fadok, V., Corpse cleaning defines the meaning of cell death (2000) Nature, 407, pp. 784-788
Aravind, L., Dixit, V.M., Koonin, E.V., Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons (2001) Science, 291, pp. 1279-1284
Adams, J.M., Cory, S., The Bcl-2 protein family: Arbiters of cell survival (1998) Science, 281, pp. 1322-1326
Korsmeyer, S.J., Bcl-2 gene family and the regulation of programmed cell death (1999) Cancer Res, 59, pp. 1693s-1700s
Cory, S., Adams, J.M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nature Rev Cancer, 2, pp. 647-656
Murray, A.W., Marks, D., Can sequencing shed light on cell cycling? (2001) Nature, 409, pp. 844-846
Evan, G., Littlewood, T.A., A matter of life and death (1998) Science, 281, pp. 1317-1321
Evan, G.I., Vousden, K.H., Proliferation, cell cycle and apoptosis in cancer (2001) Nature, 411, pp. 342-348
Hoeijmakers, J.H., Genome maintenance mechanisms for preventing cancer (2000) Nature, 411, pp. 366-374
Wood, R.D., Mitchell, M., Sgouros, J., Lindahl, T., Human DNA repair genes (2001) Science, 291, pp. 1284-1289
Saraste, M., Oxidative phosphorylation at the fin de siecle (1999) Science, 283, pp. 1488-1492
Martinou, J.C., Green, D.R., Breaking the mitochondrial barrier (2001) Nature Rev, 283, pp. 63-67
Zamzani, N., Kroemer, G., The mitochondrion in apoptosis (2001) Nature Rev, 2, pp. 67-71
Michaelson, J., The significance of cell death (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 31-46. , Tomei LD and Cope FO, eds. Cold Spring Harbor Laboratory Press
Lockshin, R.A., Zakeri, Z., Programmed cell death and apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 47-60. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Koonin, E.V., Aravind, L., Origin and evolution of eukaryotic apoptosis: The bacterial connection (2002) Cell Death Diff, 9, pp. 394-404
(2003) Proceedings of the Meeting Apoptosis: From Signaling Pathways to Therapeutic Tools, , http://www.transduction-meeting.lu
Onori, S., De Angelis, C., Fattibene, P., Dosimetric characterization of silicon and diamond detectors in low energy proton beams (2000) Phys Med Biol, 45, pp. 3045-3058
Raffaele, L., Cuttone, G., Barone Tonghi, L., Use of 70 MeV proton beam for medical application at INFN - LNS (1997) Proceedings of the International Conference on Nuclear Data, pp. 1668-1673. , ISFN, Trieste
(1997) Technical Reports Series, p. 381. , IAEA, Vienna
Cuttone, G., Raffaele, L., Barone Tonghi, L., First dosimetry intercomparison results for the CATANA Project (1999) Phys Med, 15, pp. 121-130
Purrello, M., Scalia, M., Corsaro, C., Di Pietro, C., Piro, S., Sichel, G., Melanosynthesis, differentiation and apoptosis in Kupffer cells from Rana esculenta (2001) Pigment Cell Res, 14, pp. 126-131
Purrello, M., Di Pietro, C., Rapisarda, A., Genes for human general transcription initiation factors TFIIIB, TFIIIB-Associated Proteins, TFIIIC2, and PTF/SNAPC: Functional and positional candidates for tumour predisposition or inherited genetic diseases? (2001) Oncogene, 20, pp. 4877-4883
Piro, S., Patanè, G., Di Pietro, C., Exposure to FFA or to high levels of glucose increases apoptosis in rat pancreatic islets cells (2002) Metabolism, 51, pp. 1340-1347
Tabbì, G., Fry, S.C., Bonomo, R.P., ESR study of non-enzymic scission of xyloglucan by an ascorbate - H 2O2- copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (2001) J Inorg Biochem, 84, pp. 179-187
Duling, D.R., Simulation of multiple isotropic spin trap EPR spectra (1994) J Magn Res, 104, pp. 105-110
Cramer, H., (1946) Mathematical Methods of Statistics, , Princeton University Press, Princeton, USA
Dudewicz, E.J., Mishra, S.N., (1988) Modern Mathematical Statistics, , Wiley New York, USA
Hamid, T., Kakar, S.S., PTTG/securin activates expression of p53 and modulates its function (2004) Mol Cancer, 3, p. 18
Neu-Yilik, G., Gehring, N.H., Hentze, M.W., Kulozik, A.E., Nonsense-mediated mRNA decay: From vacuum cleaner to Swiss army knife (2004) Genome Biol, 5, p. 218
Peto, J., Cancer epidemiology in the last century and the next decade (2001) Nature, 411, pp. 390-395
(2002) Cancer Facts and Figures, , http://www.cancer.org
Lewanski, C.R., Gullick, W.J., Radiotherapy and cellular signalling (2001) The Lancet Oncol, 2, pp. 366-370
Johnstone, R.W., Ruefli, A.A., Lowe, S.W., Apoptosis: A link between cancer genetics and chemotherapy (2002) Cell, 108, pp. 153-164
Rosenberg, S.A., Progress in human tumour immunology and immunotherapy (2000) Nature, 411, pp. 380-384
Appelbaum, F.R., Haematopoietic cell transplantation as immunotherapy (2000) Nature, 411, pp. 385-389
Nicholson, D.W., From bench to clinic with apoptosis based therapeutic agents (2000) Nature, 407, pp. 810-816
Tamm, I., Schriever, F., Dorken, B., Apoptosis: Implications of basic research for clinical oncology (2001) The Lancet Oncol, 2, pp. 33-42
Hug, F.B., Nevinny-Stickel, M., Fuss, M., Miller, D.W., Shaefer, R.A., Slater, J.D., Conformal proton radiation treatment for retroperitoneal neuroblastoma: Introduction of a novel technique (2001) Med Ped Oncol, 37, pp. 36-41
Noel, G., Habrand, J.L., Helfre, S., Proton beam therapy in the management of central nervous system tumors in childhood: The preliminary experience of the Centre de Protontherapie d'Orsay (2003) Med Ped Oncol, 40, pp. 309-315
Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., Vogelstein, B., A model for p53 induced apoptosis (1997) Nature, 389, pp. 300-306
Carr, A.M., Piecing together the p53 puzzle (2000) Science, 287, pp. 1765-1766
Flores, E.R., Tsai, K.Y., Crowley, D., p63 and p73 are required for p53 - Dependent apoptosis in response to DNA damage (2000) Nature, 416, pp. 560-564
Vogelstein, B., Lane, D., Levine, A.J., Surfing the p53 network (2000) Nature, 408, pp. 307-310
Khan, A.U.K., Wilson, T., Reactive oxygen species as cellular messengers (1995) Curr Biol, 2, pp. 437-445
Motoori, S., Majima, H.J., Ebara, M., Overexpression of mitochondrial Manganese Superoxide Dismutase protects against radiation induced cell death in the human hepatocellular carcinoma cell line HLE (2001) Cancer Res, 61, pp. 5382-5388
Epperly, M.W., Sikora, C.A., De Filippi, S.J., Manganese superoxide dismutase (SOD2) inhibits radiation induced apoptosis by stabilization of the mitochondrial membrane (2002) Rad Res, 157, pp. 568-577
Kroemer, G., Zamzami, N., Susin, S.A., Mitochondrial control of apoptosis (1997) Immun Today, 18, pp. 44-51
Rich, T., Allen, R.L., Wyllie, A.H., Defying death after DNA damage (2000) Nature, 407, pp. 777-781
Li, L., Story, M., Legerski, R.J., Cellular responses to ionizing radiation damage (2001) Int J Rad Oncol Biol Phys, 49, pp. 1157-1162
Belli, M., Bettega, D., Calzolari, P., Inactivation of human normal and tumour cells irradiated with low energy protons (2000) Int J Radiat Biol, 76, pp. 831-839
Green, L.M., Murray, D.K., Tran, D.T., Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (2001) Radiat Res, 155, pp. 32-42
Strasser-Wozak, E.M.C., Hartmann, B.L., Geley, S., Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukaemia cells without affecting Bcl-2 and Bax expression (1998) Cell Death Diff, 5, pp. 687-693
Ponder, B.A., Cancer Genet (2001) Nature, 411, pp. 336-341
Tate, S.K., Goldstein, D.B., Will tomorrow's medicines work for everyone? (2004) Nature Genet, 36, pp. 34-42
Amaldi, U., Future trends in cancer therapy with particle accelerators (2004) Z Med Phys, 14, pp. 7-16
Okada, H., Mak, T. W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J. F. R., Harman, B. V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Adams, J. M., Cory, S., The Bcl-2 protein family: Arbiters of cell survival (1998) Science, 281, pp. 1322-1326
Korsmeyer, S. J., Bcl-2 gene family and the regulation of programmed cell death (1999) Cancer Res, 59, pp. 1693s-1700s
Murray, A. W., Marks, D., Can sequencing shed light on cell cycling? (2001) Nature, 409, pp. 844-846
Evan, G. I., Vousden, K. H., Proliferation, cell cycle and apoptosis in cancer (2001) Nature, 411, pp. 342-348
Hoeijmakers, J. H., Genome maintenance mechanisms for preventing cancer (2000) Nature, 411, pp. 366-374
Wood, R. D., Mitchell, M., Sgouros, J., Lindahl, T., Human DNA repair genes (2001) Science, 291, pp. 1284-1289
Martinou, J. C., Green, D. R., Breaking the mitochondrial barrier (2001) Nature Rev, 283, pp. 63-67
Lockshin, R. A., Zakeri, Z., Programmed cell death and apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 47-60. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Koonin, E. V., Aravind, L., Origin and evolution of eukaryotic apoptosis: The bacterial connection (2002) Cell Death Diff, 9, pp. 394-404
(2003) Proceedings of the Meeting Apoptosis: From Signaling Pathways to Therapeutic Tools, , http: //www. transduction-meeting. lu
(1997) Technical Reports Series, p. 381. , IAEA, Vienna
Piro, S., Patan, G., Di Pietro, C., Exposure to FFA or to high levels of glucose increases apoptosis in rat pancreatic islets cells (2002) Metabolism, 51, pp. 1340-1347
Tabb, G., Fry, S. C., Bonomo, R. P., ESR study of non-enzymic scission of xyloglucan by an ascorbate - H 2O2- copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (2001) J Inorg Biochem, 84, pp. 179-187
Duling, D. R., Simulation of multiple isotropic spin trap EPR spectra (1994) J Magn Res, 104, pp. 105-110
Dudewicz, E. J., Mishra, S. N., (1988) Modern Mathematical Statistics, , Wiley New York, USA
(2002) Cancer Facts and Figures, , http: //www. cancer. org
Lewanski, C. R., Gullick, W. J., Radiotherapy and cellular signalling (2001) The Lancet Oncol, 2, pp. 366-370
Johnstone, R. W., Ruefli, A. A., Lowe, S. W., Apoptosis: A link between cancer genetics and chemotherapy (2002) Cell, 108, pp. 153-164
Rosenberg, S. A., Progress in human tumour immunology and immunotherapy (2000) Nature, 411, pp. 380-384
Appelbaum, F. R., Haematopoietic cell transplantation as immunotherapy (2000) Nature, 411, pp. 385-389
Nicholson, D. W., From bench to clinic with apoptosis based therapeutic agents (2000) Nature, 407, pp. 810-816
Hug, F. B., Nevinny-Stickel, M., Fuss, M., Miller, D. W., Shaefer, R. A., Slater, J. D., Conformal proton radiation treatment for retroperitoneal neuroblastoma: Introduction of a novel technique (2001) Med Ped Oncol, 37, pp. 36-41
Carr, A. M., Piecing together the p53 puzzle (2000) Science, 287, pp. 1765-1766
Flores, E. R., Tsai, K. Y., Crowley, D., p63 and p73 are required for p53 - Dependent apoptosis in response to DNA damage (2000) Nature, 416, pp. 560-564
Khan, A. U. K., Wilson, T., Reactive oxygen species as cellular messengers (1995) Curr Biol, 2, pp. 437-445
Epperly, M. W., Sikora, C. A., De Filippi, S. J., Manganese superoxide dismutase (SOD2) inhibits radiation induced apoptosis by stabilization of the mitochondrial membrane (2002) Rad Res, 157, pp. 568-577
Green, L. M., Murray, D. K., Tran, D. T., Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (2001) Radiat Res, 155, pp. 32-42
Strasser-Wozak, E. M. C., Hartmann, B. L., Geley, S., Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukaemia cells without affecting Bcl-2 and Bax expression (1998) Cell Death Diff, 5, pp. 687-693
Ponder, B. A., Cancer Genet (2001) Nature, 411, pp. 336-341
Tate, S. K., Goldstein, D. B., Will tomorrow's medicines work for everyone? (2004) Nature Genet, 36, pp. 34-42
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.421, 5-year impact factor: 3.865
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-31444432039&partnerID=40&md5=b53ca7d127bce69efcaddf31da82634a
Keywords: Apoptosis, Cancer, Cell Cycle, Facs, Hadrontherapy, Proton Beam, Rt-Pcr, Double Stranded Dna, Hydroxyl Group, Reactive Oxygen Metabolite, Transcriptome, Article, Cancer Therapy, Cell Count, Cell Cycle Arrest, Cell Cycle G2 Phase, Cell Cycle M Phase, Cell Line, Cell Membrane, Cell Population, Cell Strain Mcf 7, Cell Structure, Controlled Study, Dna Strand Breakage, Dose Response, Electron Spin Resonance, Fluorescence Activated Cell Sorting, Human, Human Cell, Irradiation, Necrosis, Nucleotide Sequence, Priority Journal, Proton Radiation, Radiation Dose, Reverse Transcription Polymerase Chain Reaction, Statistical Significance, Base Sequence, Tumor, Dna Damage, Dna Primers, Electron Spin Resonance Spectroscopy, Female, Flow Cytometry, Neoplasms, Photons, Reactive Oxygen Species, Reverse Transcriptase Polymerase Chain Reaction, Messenger, Mink Cell Focus-Forming Virus, Apoptosis Genetics Radiation Effects, Cell Cycle Radiation Effects, Dna Primers Genetics, Neoplasms Genetics Metabolism Pathology Radiotherapy, Photons Therapeutic Use, Protons Therapeutic Use, Messenger Genetics, Neoplasm Genetics, Reactive Oxygen Species Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Biomediche, Sezione di Biologia, Genetica e Bioinformatica, Università di Catania, 95123 Catania, Italy
Dipartimento di Medicina Interna e Medicina Specialistica, Sezione di Endocrinologia, Ospedale Garibaldi, 95124 Catania, Italy
Istituto di Biostrutture e Bioimmagini, CNR, 95125 Catania, Italy
Istituto Nazionale di Fisica Nucleare, Laboratorio Nazionale del Sud, 95125 Catania, Italy
Dipartimento di Diagnostica Per Immagini e Radioterapia, Università di Catania, 95125 Catania, Italy
Dipartimento di Matematica ed Informatica, Università di Catania, 95125 Catania, Italy
Dipartimento di Fisica e di Astronomia, Università di Catania, 95125 Catania, Italy
References:
Okada, H., Mak, T.W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J.F.R., Harman, B.V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M.O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Meier, P., Finch, A., Evan, G., Apoptosis in development (2000) Nature, 407, pp. 796-801
Savill, J., Fadok, V., Corpse cleaning defines the meaning of cell death (2000) Nature, 407, pp. 784-788
Aravind, L., Dixit, V.M., Koonin, E.V., Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons (2001) Science, 291, pp. 1279-1284
Adams, J.M., Cory, S., The Bcl-2 protein family: Arbiters of cell survival (1998) Science, 281, pp. 1322-1326
Korsmeyer, S.J., Bcl-2 gene family and the regulation of programmed cell death (1999) Cancer Res, 59, pp. 1693s-1700s
Cory, S., Adams, J.M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nature Rev Cancer, 2, pp. 647-656
Murray, A.W., Marks, D., Can sequencing shed light on cell cycling? (2001) Nature, 409, pp. 844-846
Evan, G., Littlewood, T.A., A matter of life and death (1998) Science, 281, pp. 1317-1321
Evan, G.I., Vousden, K.H., Proliferation, cell cycle and apoptosis in cancer (2001) Nature, 411, pp. 342-348
Hoeijmakers, J.H., Genome maintenance mechanisms for preventing cancer (2000) Nature, 411, pp. 366-374
Wood, R.D., Mitchell, M., Sgouros, J., Lindahl, T., Human DNA repair genes (2001) Science, 291, pp. 1284-1289
Saraste, M., Oxidative phosphorylation at the fin de siecle (1999) Science, 283, pp. 1488-1492
Martinou, J.C., Green, D.R., Breaking the mitochondrial barrier (2001) Nature Rev, 283, pp. 63-67
Zamzani, N., Kroemer, G., The mitochondrion in apoptosis (2001) Nature Rev, 2, pp. 67-71
Michaelson, J., The significance of cell death (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 31-46. , Tomei LD and Cope FO, eds. Cold Spring Harbor Laboratory Press
Lockshin, R.A., Zakeri, Z., Programmed cell death and apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 47-60. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Koonin, E.V., Aravind, L., Origin and evolution of eukaryotic apoptosis: The bacterial connection (2002) Cell Death Diff, 9, pp. 394-404
(2003) Proceedings of the Meeting Apoptosis: From Signaling Pathways to Therapeutic Tools, , http://www.transduction-meeting.lu
Onori, S., De Angelis, C., Fattibene, P., Dosimetric characterization of silicon and diamond detectors in low energy proton beams (2000) Phys Med Biol, 45, pp. 3045-3058
Raffaele, L., Cuttone, G., Barone Tonghi, L., Use of 70 MeV proton beam for medical application at INFN - LNS (1997) Proceedings of the International Conference on Nuclear Data, pp. 1668-1673. , ISFN, Trieste
(1997) Technical Reports Series, p. 381. , IAEA, Vienna
Cuttone, G., Raffaele, L., Barone Tonghi, L., First dosimetry intercomparison results for the CATANA Project (1999) Phys Med, 15, pp. 121-130
Purrello, M., Scalia, M., Corsaro, C., Di Pietro, C., Piro, S., Sichel, G., Melanosynthesis, differentiation and apoptosis in Kupffer cells from Rana esculenta (2001) Pigment Cell Res, 14, pp. 126-131
Purrello, M., Di Pietro, C., Rapisarda, A., Genes for human general transcription initiation factors TFIIIB, TFIIIB-Associated Proteins, TFIIIC2, and PTF/SNAPC: Functional and positional candidates for tumour predisposition or inherited genetic diseases? (2001) Oncogene, 20, pp. 4877-4883
Piro, S., Patanè, G., Di Pietro, C., Exposure to FFA or to high levels of glucose increases apoptosis in rat pancreatic islets cells (2002) Metabolism, 51, pp. 1340-1347
Tabbì, G., Fry, S.C., Bonomo, R.P., ESR study of non-enzymic scission of xyloglucan by an ascorbate - H 2O2- copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (2001) J Inorg Biochem, 84, pp. 179-187
Duling, D.R., Simulation of multiple isotropic spin trap EPR spectra (1994) J Magn Res, 104, pp. 105-110
Cramer, H., (1946) Mathematical Methods of Statistics, , Princeton University Press, Princeton, USA
Dudewicz, E.J., Mishra, S.N., (1988) Modern Mathematical Statistics, , Wiley New York, USA
Hamid, T., Kakar, S.S., PTTG/securin activates expression of p53 and modulates its function (2004) Mol Cancer, 3, p. 18
Neu-Yilik, G., Gehring, N.H., Hentze, M.W., Kulozik, A.E., Nonsense-mediated mRNA decay: From vacuum cleaner to Swiss army knife (2004) Genome Biol, 5, p. 218
Peto, J., Cancer epidemiology in the last century and the next decade (2001) Nature, 411, pp. 390-395
(2002) Cancer Facts and Figures, , http://www.cancer.org
Lewanski, C.R., Gullick, W.J., Radiotherapy and cellular signalling (2001) The Lancet Oncol, 2, pp. 366-370
Johnstone, R.W., Ruefli, A.A., Lowe, S.W., Apoptosis: A link between cancer genetics and chemotherapy (2002) Cell, 108, pp. 153-164
Rosenberg, S.A., Progress in human tumour immunology and immunotherapy (2000) Nature, 411, pp. 380-384
Appelbaum, F.R., Haematopoietic cell transplantation as immunotherapy (2000) Nature, 411, pp. 385-389
Nicholson, D.W., From bench to clinic with apoptosis based therapeutic agents (2000) Nature, 407, pp. 810-816
Tamm, I., Schriever, F., Dorken, B., Apoptosis: Implications of basic research for clinical oncology (2001) The Lancet Oncol, 2, pp. 33-42
Hug, F.B., Nevinny-Stickel, M., Fuss, M., Miller, D.W., Shaefer, R.A., Slater, J.D., Conformal proton radiation treatment for retroperitoneal neuroblastoma: Introduction of a novel technique (2001) Med Ped Oncol, 37, pp. 36-41
Noel, G., Habrand, J.L., Helfre, S., Proton beam therapy in the management of central nervous system tumors in childhood: The preliminary experience of the Centre de Protontherapie d'Orsay (2003) Med Ped Oncol, 40, pp. 309-315
Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., Vogelstein, B., A model for p53 induced apoptosis (1997) Nature, 389, pp. 300-306
Carr, A.M., Piecing together the p53 puzzle (2000) Science, 287, pp. 1765-1766
Flores, E.R., Tsai, K.Y., Crowley, D., p63 and p73 are required for p53 - Dependent apoptosis in response to DNA damage (2000) Nature, 416, pp. 560-564
Vogelstein, B., Lane, D., Levine, A.J., Surfing the p53 network (2000) Nature, 408, pp. 307-310
Khan, A.U.K., Wilson, T., Reactive oxygen species as cellular messengers (1995) Curr Biol, 2, pp. 437-445
Motoori, S., Majima, H.J., Ebara, M., Overexpression of mitochondrial Manganese Superoxide Dismutase protects against radiation induced cell death in the human hepatocellular carcinoma cell line HLE (2001) Cancer Res, 61, pp. 5382-5388
Epperly, M.W., Sikora, C.A., De Filippi, S.J., Manganese superoxide dismutase (SOD2) inhibits radiation induced apoptosis by stabilization of the mitochondrial membrane (2002) Rad Res, 157, pp. 568-577
Kroemer, G., Zamzami, N., Susin, S.A., Mitochondrial control of apoptosis (1997) Immun Today, 18, pp. 44-51
Rich, T., Allen, R.L., Wyllie, A.H., Defying death after DNA damage (2000) Nature, 407, pp. 777-781
Li, L., Story, M., Legerski, R.J., Cellular responses to ionizing radiation damage (2001) Int J Rad Oncol Biol Phys, 49, pp. 1157-1162
Belli, M., Bettega, D., Calzolari, P., Inactivation of human normal and tumour cells irradiated with low energy protons (2000) Int J Radiat Biol, 76, pp. 831-839
Green, L.M., Murray, D.K., Tran, D.T., Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (2001) Radiat Res, 155, pp. 32-42
Strasser-Wozak, E.M.C., Hartmann, B.L., Geley, S., Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukaemia cells without affecting Bcl-2 and Bax expression (1998) Cell Death Diff, 5, pp. 687-693
Ponder, B.A., Cancer Genet (2001) Nature, 411, pp. 336-341
Tate, S.K., Goldstein, D.B., Will tomorrow's medicines work for everyone? (2004) Nature Genet, 36, pp. 34-42
Amaldi, U., Future trends in cancer therapy with particle accelerators (2004) Z Med Phys, 14, pp. 7-16
Okada, H., Mak, T. W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J. F. R., Harman, B. V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
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Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy
Due to their ballistic precision, apoptosis induction by protons could be a strategy to specifically eliminate neoplastic cells. To characterize the cellular and molecular effects of these hadrons, we performed dose-response and time-course experiments by exposing different cell lines (PC3, Ca301D, MCF7) to increasing doses of protons and examining them with FACS, RT-PCR, and electron spin resonance (ESR). Irradiation with a dose of 10 Gy of a 26,7 Mev proton beam altered cell structures such as membranes, caused DNA double strand breaks, and significantly increased intracellular levels of hydroxyl ions, are active oxygen species (ROS). This modified the transcriptome of irradiated cells, activated the mitochondrial (intrinsic) pathway of apoptosis, and resulted in cycle arrest at the G2/M boundary. The number of necrotic cells within the irradiated cell population did not significantly increase with respect to the controls. The effects of irradiation with 20 Gy were qualitatively as well as quantitatively similar, but exposure to 40 Gy caused massive necrosis. Similar experiments with photons demonstrated that they induce apoptosis in a significantly lower number of cells and in a temporally delayed manner. These data advance our knowledge on the cellular and molecular effects of proton irradiation and could be useful for improving current hadrontherapy protocols. © 2006 Springer Science + Business Media, Inc.
Due to their ballistic precision, apoptosis induction by protons could be a strategy to specifically eliminate neoplastic cells. To characterize the cellular and molecular effects of these hadrons, we performed dose-response and time-course experiments by exposing different cell lines (PC3, Ca301D, MCF7) to increasing doses of protons and examining them with FACS, RT-PCR, and electron spin resonance (ESR). Irradiation with a dose of 10 Gy of a 26,7 Mev proton beam altered cell structures such as membranes, caused DNA double strand breaks, and significantly increased intracellular levels of hydroxyl ions, are active oxygen species (ROS). This modified the transcriptome of irradiated cells, activated the mitochondrial (intrinsic) pathway of apoptosis, and resulted in cycle arrest at the G2/M boundary. The number of necrotic cells within the irradiated cell population did not significantly increase with respect to the controls. The effects of irradiation with 20 Gy were qualitatively as well as quantitatively similar, but exposure to 40 Gy caused massive necrosis. Similar experiments with photons demonstrated that they induce apoptosis in a significantly lower number of cells and in a temporally delayed manner. These data advance our knowledge on the cellular and molecular effects of proton irradiation and could be useful for improving current hadrontherapy protocols. © 2006 Springer Science + Business Media, Inc.
Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy
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Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy
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Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Miralbell R, Lomax A, Cella L, Schneider U
* Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (262 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2002 Nov 1; 54(3): 824-829.
Impact Factor: 3.756
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (274 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
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Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (323 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Miralbell R, Cella L, Weber D, Lomax A
Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams (329 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2000; 47(4): 1111-1119.
Impact Factor: 3.058
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (485 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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* Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams (108 views)
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Impact Factor: 5.252
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
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Impact Factor: 2.598
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
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Impact Factor: 3.345
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Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (397 views)
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Impact Factor: 4.784
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Pisciotta P, Cammarata FP, Stefano A, Romano F, Marchese V, Torrisi F, Forte GI, Cella L, Cirrone GAP, Petringa G, Gilardi MC, Cuttone G, Russo G
* Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility (314 views)
Phys Med (ISSN: 1120-1797linking), 2018 Jul 20; 54: 173-178.
Impact Factor: 2.24
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
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Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Musumeci D, Roviello V, Roviello GN
* DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications (1541 views)
Int J Nanomed (ISSN: 1176-9114linking, 1178-2013electronic), 2018 May 1; 2018:13: 2613-2629.
Impact Factor: 4.3
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (408 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
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Impact Factor: 4.48
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Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A
* The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies (342 views)
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Impact Factor: 5.476
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Zhang Y, de La Harpe K, Beckstead AA, Improta R, Kohler B
* UV-Induced Proton Transfer between DNA Strands (358 views) (PDF 242 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015 Jun 10; 137(22): 7059-7062.
Impact Factor: 13.038
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Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (629 views)
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Impact Factor: 3.345
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
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Impact Factor: 3.73
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (596 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (957 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (422 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (529 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (856 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (415 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (411 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Impact Factor: 2.605
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (241 views)
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Impact Factor: 8.58
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (424 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (363 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Ruggiero A, Chambery A, Di Maro A, Parente A, Berisio R
* Atomic Resolution (1. 1 Angstrom) Structure Of The Ribosome-Inactivating Protein Pd-L4 From Phytolacca Dioica L. Leaves (388 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Apr; 71(1): 8-15.
Impact Factor: 3.419
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (372 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (508 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (361 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Musumeci D, Roviello GN, Sica D
* The oxidation of Δ2, Δ2, 4 and Δ4, 6 steroids with RuO4 (386 views)
Steroids (ISSN: 0039-128x), 2004 Mar; 69(3): 173-179.
Impact Factor: 2.337
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (490 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Miralbell R, Lomax A, Cella L, Schneider U
* Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (262 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2002 Nov 1; 54(3): 824-829.
Impact Factor: 3.756
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (274 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
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Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (323 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Miralbell R, Cella L, Weber D, Lomax A
Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams (329 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2000; 47(4): 1111-1119.
Impact Factor: 3.058
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (485 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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58 Records (56 excluding Abstracts).
Total impact factor: 258.563 (251.599 excluding Abstracts).
Total 5 year impact factor: 277.45 (269.504 excluding Abstracts).
Total impact factor: 258.563 (251.599 excluding Abstracts).
Total 5 year impact factor: 277.45 (269.504 excluding Abstracts).
520 views. Last view on Saturday 11 March 2023, 17:46:32
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