Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy(520 views) Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
Dipartimento di Scienze Biomediche, Sezione di Biologia, Genetica e Bioinformatica, Università di Catania, 95123 Catania, Italy
Dipartimento di Medicina Interna e Medicina Specialistica, Sezione di Endocrinologia, Ospedale Garibaldi, 95124 Catania, Italy
Istituto di Biostrutture e Bioimmagini, CNR, 95125 Catania, Italy
Istituto Nazionale di Fisica Nucleare, Laboratorio Nazionale del Sud, 95125 Catania, Italy
Dipartimento di Diagnostica Per Immagini e Radioterapia, Università di Catania, 95125 Catania, Italy
Dipartimento di Matematica ed Informatica, Università di Catania, 95125 Catania, Italy
Dipartimento di Fisica e di Astronomia, Università di Catania, 95125 Catania, Italy
References: Okada, H., Mak, T.W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J.F.R., Harman, B.V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M.O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Meier, P., Finch, A., Evan, G., Apoptosis in development (2000) Nature, 407, pp. 796-801
Savill, J., Fadok, V., Corpse cleaning defines the meaning of cell death (2000) Nature, 407, pp. 784-788
Aravind, L., Dixit, V.M., Koonin, E.V., Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons (2001) Science, 291, pp. 1279-1284
Adams, J.M., Cory, S., The Bcl-2 protein family: Arbiters of cell survival (1998) Science, 281, pp. 1322-1326
Korsmeyer, S.J., Bcl-2 gene family and the regulation of programmed cell death (1999) Cancer Res, 59, pp. 1693s-1700s
Cory, S., Adams, J.M., The Bcl-2 family: Regulators of the cellular life-or-death switch (2002) Nature Rev Cancer, 2, pp. 647-656
Murray, A.W., Marks, D., Can sequencing shed light on cell cycling? (2001) Nature, 409, pp. 844-846
Evan, G., Littlewood, T.A., A matter of life and death (1998) Science, 281, pp. 1317-1321
Evan, G.I., Vousden, K.H., Proliferation, cell cycle and apoptosis in cancer (2001) Nature, 411, pp. 342-348
Hoeijmakers, J.H., Genome maintenance mechanisms for preventing cancer (2000) Nature, 411, pp. 366-374
Wood, R.D., Mitchell, M., Sgouros, J., Lindahl, T., Human DNA repair genes (2001) Science, 291, pp. 1284-1289
Saraste, M., Oxidative phosphorylation at the fin de siecle (1999) Science, 283, pp. 1488-1492
Martinou, J.C., Green, D.R., Breaking the mitochondrial barrier (2001) Nature Rev, 283, pp. 63-67
Zamzani, N., Kroemer, G., The mitochondrion in apoptosis (2001) Nature Rev, 2, pp. 67-71
Michaelson, J., The significance of cell death (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 31-46. , Tomei LD and Cope FO, eds. Cold Spring Harbor Laboratory Press
Lockshin, R.A., Zakeri, Z., Programmed cell death and apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 47-60. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Koonin, E.V., Aravind, L., Origin and evolution of eukaryotic apoptosis: The bacterial connection (2002) Cell Death Diff, 9, pp. 394-404
(2003) Proceedings of the Meeting Apoptosis: From Signaling Pathways to Therapeutic Tools, , http://www.transduction-meeting.lu
Onori, S., De Angelis, C., Fattibene, P., Dosimetric characterization of silicon and diamond detectors in low energy proton beams (2000) Phys Med Biol, 45, pp. 3045-3058
Raffaele, L., Cuttone, G., Barone Tonghi, L., Use of 70 MeV proton beam for medical application at INFN - LNS (1997) Proceedings of the International Conference on Nuclear Data, pp. 1668-1673. , ISFN, Trieste
(1997) Technical Reports Series, p. 381. , IAEA, Vienna
Cuttone, G., Raffaele, L., Barone Tonghi, L., First dosimetry intercomparison results for the CATANA Project (1999) Phys Med, 15, pp. 121-130
Purrello, M., Scalia, M., Corsaro, C., Di Pietro, C., Piro, S., Sichel, G., Melanosynthesis, differentiation and apoptosis in Kupffer cells from Rana esculenta (2001) Pigment Cell Res, 14, pp. 126-131
Purrello, M., Di Pietro, C., Rapisarda, A., Genes for human general transcription initiation factors TFIIIB, TFIIIB-Associated Proteins, TFIIIC2, and PTF/SNAPC: Functional and positional candidates for tumour predisposition or inherited genetic diseases? (2001) Oncogene, 20, pp. 4877-4883
Piro, S., Patanè, G., Di Pietro, C., Exposure to FFA or to high levels of glucose increases apoptosis in rat pancreatic islets cells (2002) Metabolism, 51, pp. 1340-1347
Tabbì, G., Fry, S.C., Bonomo, R.P., ESR study of non-enzymic scission of xyloglucan by an ascorbate - H 2O2- copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (2001) J Inorg Biochem, 84, pp. 179-187
Duling, D.R., Simulation of multiple isotropic spin trap EPR spectra (1994) J Magn Res, 104, pp. 105-110
Cramer, H., (1946) Mathematical Methods of Statistics, , Princeton University Press, Princeton, USA
Dudewicz, E.J., Mishra, S.N., (1988) Modern Mathematical Statistics, , Wiley New York, USA
Hamid, T., Kakar, S.S., PTTG/securin activates expression of p53 and modulates its function (2004) Mol Cancer, 3, p. 18
Neu-Yilik, G., Gehring, N.H., Hentze, M.W., Kulozik, A.E., Nonsense-mediated mRNA decay: From vacuum cleaner to Swiss army knife (2004) Genome Biol, 5, p. 218
Peto, J., Cancer epidemiology in the last century and the next decade (2001) Nature, 411, pp. 390-395
(2002) Cancer Facts and Figures, , http://www.cancer.org
Lewanski, C.R., Gullick, W.J., Radiotherapy and cellular signalling (2001) The Lancet Oncol, 2, pp. 366-370
Johnstone, R.W., Ruefli, A.A., Lowe, S.W., Apoptosis: A link between cancer genetics and chemotherapy (2002) Cell, 108, pp. 153-164
Rosenberg, S.A., Progress in human tumour immunology and immunotherapy (2000) Nature, 411, pp. 380-384
Appelbaum, F.R., Haematopoietic cell transplantation as immunotherapy (2000) Nature, 411, pp. 385-389
Nicholson, D.W., From bench to clinic with apoptosis based therapeutic agents (2000) Nature, 407, pp. 810-816
Tamm, I., Schriever, F., Dorken, B., Apoptosis: Implications of basic research for clinical oncology (2001) The Lancet Oncol, 2, pp. 33-42
Hug, F.B., Nevinny-Stickel, M., Fuss, M., Miller, D.W., Shaefer, R.A., Slater, J.D., Conformal proton radiation treatment for retroperitoneal neuroblastoma: Introduction of a novel technique (2001) Med Ped Oncol, 37, pp. 36-41
Noel, G., Habrand, J.L., Helfre, S., Proton beam therapy in the management of central nervous system tumors in childhood: The preliminary experience of the Centre de Protontherapie d'Orsay (2003) Med Ped Oncol, 40, pp. 309-315
Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., Vogelstein, B., A model for p53 induced apoptosis (1997) Nature, 389, pp. 300-306
Carr, A.M., Piecing together the p53 puzzle (2000) Science, 287, pp. 1765-1766
Flores, E.R., Tsai, K.Y., Crowley, D., p63 and p73 are required for p53 - Dependent apoptosis in response to DNA damage (2000) Nature, 416, pp. 560-564
Vogelstein, B., Lane, D., Levine, A.J., Surfing the p53 network (2000) Nature, 408, pp. 307-310
Khan, A.U.K., Wilson, T., Reactive oxygen species as cellular messengers (1995) Curr Biol, 2, pp. 437-445
Motoori, S., Majima, H.J., Ebara, M., Overexpression of mitochondrial Manganese Superoxide Dismutase protects against radiation induced cell death in the human hepatocellular carcinoma cell line HLE (2001) Cancer Res, 61, pp. 5382-5388
Epperly, M.W., Sikora, C.A., De Filippi, S.J., Manganese superoxide dismutase (SOD2) inhibits radiation induced apoptosis by stabilization of the mitochondrial membrane (2002) Rad Res, 157, pp. 568-577
Kroemer, G., Zamzami, N., Susin, S.A., Mitochondrial control of apoptosis (1997) Immun Today, 18, pp. 44-51
Rich, T., Allen, R.L., Wyllie, A.H., Defying death after DNA damage (2000) Nature, 407, pp. 777-781
Li, L., Story, M., Legerski, R.J., Cellular responses to ionizing radiation damage (2001) Int J Rad Oncol Biol Phys, 49, pp. 1157-1162
Belli, M., Bettega, D., Calzolari, P., Inactivation of human normal and tumour cells irradiated with low energy protons (2000) Int J Radiat Biol, 76, pp. 831-839
Green, L.M., Murray, D.K., Tran, D.T., Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (2001) Radiat Res, 155, pp. 32-42
Strasser-Wozak, E.M.C., Hartmann, B.L., Geley, S., Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukaemia cells without affecting Bcl-2 and Bax expression (1998) Cell Death Diff, 5, pp. 687-693
Ponder, B.A., Cancer Genet (2001) Nature, 411, pp. 336-341
Tate, S.K., Goldstein, D.B., Will tomorrow's medicines work for everyone? (2004) Nature Genet, 36, pp. 34-42
Amaldi, U., Future trends in cancer therapy with particle accelerators (2004) Z Med Phys, 14, pp. 7-16
Okada, H., Mak, T. W., Pathways of apoptotic and non-apoptotic death in tumour cells (2004) Nature Rev Cancer, 4, pp. 592-60
Kerr, J. F. R., Harman, B. V., Definition and incidence of apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 5-29. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Adams, J. M., Cory, S., The Bcl-2 protein family: Arbiters of cell survival (1998) Science, 281, pp. 1322-1326
Korsmeyer, S. J., Bcl-2 gene family and the regulation of programmed cell death (1999) Cancer Res, 59, pp. 1693s-1700s
Murray, A. W., Marks, D., Can sequencing shed light on cell cycling? (2001) Nature, 409, pp. 844-846
Evan, G. I., Vousden, K. H., Proliferation, cell cycle and apoptosis in cancer (2001) Nature, 411, pp. 342-348
Hoeijmakers, J. H., Genome maintenance mechanisms for preventing cancer (2000) Nature, 411, pp. 366-374
Wood, R. D., Mitchell, M., Sgouros, J., Lindahl, T., Human DNA repair genes (2001) Science, 291, pp. 1284-1289
Martinou, J. C., Green, D. R., Breaking the mitochondrial barrier (2001) Nature Rev, 283, pp. 63-67
Lockshin, R. A., Zakeri, Z., Programmed cell death and apoptosis (1991) Apoptosis, the Molecular Bases of Cell Death, pp. 47-60. , Tomei LD, Cope FO, eds. Cold Spring Harbor Laboratory Press
Koonin, E. V., Aravind, L., Origin and evolution of eukaryotic apoptosis: The bacterial connection (2002) Cell Death Diff, 9, pp. 394-404
(2003) Proceedings of the Meeting Apoptosis: From Signaling Pathways to Therapeutic Tools, , http: //www. transduction-meeting. lu
(1997) Technical Reports Series, p. 381. , IAEA, Vienna
Piro, S., Patan, G., Di Pietro, C., Exposure to FFA or to high levels of glucose increases apoptosis in rat pancreatic islets cells (2002) Metabolism, 51, pp. 1340-1347
Tabb, G., Fry, S. C., Bonomo, R. P., ESR study of non-enzymic scission of xyloglucan by an ascorbate - H 2O2- copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (2001) J Inorg Biochem, 84, pp. 179-187
Duling, D. R., Simulation of multiple isotropic spin trap EPR spectra (1994) J Magn Res, 104, pp. 105-110
Dudewicz, E. J., Mishra, S. N., (1988) Modern Mathematical Statistics, , Wiley New York, USA
(2002) Cancer Facts and Figures, , http: //www. cancer. org
Lewanski, C. R., Gullick, W. J., Radiotherapy and cellular signalling (2001) The Lancet Oncol, 2, pp. 366-370
Johnstone, R. W., Ruefli, A. A., Lowe, S. W., Apoptosis: A link between cancer genetics and chemotherapy (2002) Cell, 108, pp. 153-164
Rosenberg, S. A., Progress in human tumour immunology and immunotherapy (2000) Nature, 411, pp. 380-384
Appelbaum, F. R., Haematopoietic cell transplantation as immunotherapy (2000) Nature, 411, pp. 385-389
Nicholson, D. W., From bench to clinic with apoptosis based therapeutic agents (2000) Nature, 407, pp. 810-816
Hug, F. B., Nevinny-Stickel, M., Fuss, M., Miller, D. W., Shaefer, R. A., Slater, J. D., Conformal proton radiation treatment for retroperitoneal neuroblastoma: Introduction of a novel technique (2001) Med Ped Oncol, 37, pp. 36-41
Carr, A. M., Piecing together the p53 puzzle (2000) Science, 287, pp. 1765-1766
Flores, E. R., Tsai, K. Y., Crowley, D., p63 and p73 are required for p53 - Dependent apoptosis in response to DNA damage (2000) Nature, 416, pp. 560-564
Khan, A. U. K., Wilson, T., Reactive oxygen species as cellular messengers (1995) Curr Biol, 2, pp. 437-445
Epperly, M. W., Sikora, C. A., De Filippi, S. J., Manganese superoxide dismutase (SOD2) inhibits radiation induced apoptosis by stabilization of the mitochondrial membrane (2002) Rad Res, 157, pp. 568-577
Green, L. M., Murray, D. K., Tran, D. T., Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (2001) Radiat Res, 155, pp. 32-42
Strasser-Wozak, E. M. C., Hartmann, B. L., Geley, S., Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukaemia cells without affecting Bcl-2 and Bax expression (1998) Cell Death Diff, 5, pp. 687-693
Ponder, B. A., Cancer Genet (2001) Nature, 411, pp. 336-341
Tate, S. K., Goldstein, D. B., Will tomorrow's medicines work for everyone? (2004) Nature Genet, 36, pp. 34-42
Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(284 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote