Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.046, 5-year impact factor: 3.105
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33749022768&partnerID=40&md5=6f9b4b73b3f375fbefa1b73dc09c5405
Keywords: Cholecystokinin, Cyclic Constraints, Nmr Structures, Peptides, Receptors, Cholecystokinin Receptor, Drug Derivative, Ligand, Peptide Library, Article, Chemical Structure, Chemistry, Conformation, Drug Antagonism, Drug Design, Nuclear Magnetic Resonance Spectroscopy, Synthesis, Models, Molecular, Molecular Conformation,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, Centro Interuniversitario per la Ricerca Sui Peptidi Bioattivi (CIRPeB), Via Mezzocannone 16, 80134 Napoli, Italy
Bioindustry Park del Canadese, Via Ribes 5, 10010 Colleretto Giocosa, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
References:
Fourmy, D., Escrieut, C., Archer, E., Gales, C., Gigoux, V., Maigret, B., Moroder, L., Pradayrol, L., (2002) Pharmacol. Toxicol., 91, pp. 313-32
De Tullio, P., Delarge, J., Piroette, B., (1999) Curr. Med. Chem., 6, pp. 433-455
Anders, J., Blüggel, M., Meyer, H.E., Kühne, R., Ter Laak, A.M., Kojro, E., Fahrenholz, F., (1999) Biochemistry, 38, pp. 6043-6055
Low, C.M.R., Black, J.W., Broughton, H.B., Buck, I.M., Davies, J.M.R., Dunstone, D.J., Hull, R.A.D., Steel, K.I.M., (2000) J. Med. Chem., 43, pp. 3505-3517
Bellier, B., Million, M.E., Danascimento, S., Meudal, H., Kellou, S., Maigret, B., Garbay, C., (2000) J. Med. Chem., 43, pp. 3614-3623
Martin-Martinez, M., De La Figuera, N., Latorre, M., Garcia-Lopez, M.T., Cenarruzabeitia, E., Del Rio, J., Gonzales-Muñiz, R., (2005) J. Med. Chem., 48, pp. 7667-7674
Silvente-Poirot, S., Wank, S.A., (1996) J. Biol. Chem., 271, pp. 1468-14706
Schmitz, F., Pratt, D.S., Wu, M.J., Kolakowski, L.F., Beinborn, M., Kopin, A., (1996) Mol. Pharmacol., 50, pp. 3804-3809
Archer-Lahlou, E., Tikhonova, I., Escrieut, C., Dufresne, M., Seva, C., Pradayrol, L., Moroder, L., Fourmy, D., (2005) J. Med. Chem., 48, pp. 180-191
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., (2001) Biochemistry, 40, pp. 3804-3809
Harikumar, K.G., Clain, J., Pinon, D.I., Dong, M., Miller, L.J., (2005) J. Biol. Chem., 280, p. 10441050
De Luca, S., Ragone, R., Bracco, C., Digilio, G., Aloj, L., Tesauro, D., Saviano, M., Morelli, G., (2003) ChemBioChem, 4, pp. 1176-1187
Aloj, L., Caracò, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2003) J. Nucl. Med., 44, pp. 485-494
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Moroder, L., Romano, R., Guba, W., Mierke, D.F., Kessler, H., Delporte, C., Winand, J., Christophe, J., (1993) Biochemistry, 32, pp. 13551-13559
Lifson, S., Hagler, A.T., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5111-5121
Hagler, A.T., Lifson, S., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Hagler, A.T., Hagler, A.T., Lifson, S., (1979) J. Am. Chem. Soc., 101, pp. 5131-5140
Kaiser, E., Colescott, R.L., Bossinger, C.D., Cook, P.I., (1970) Anal. Biochem., 34, pp. 595-598
Sheppard, R.C., Williams, B.J., (1982) Int. J. Pept. Protein Res., 20, pp. 451-454
Piotto, M., Saudek, V., Sklenar, V., (1992) J. Biomol. NMR, 2, pp. 661-666
Sklenar, V., Piotto, M., Leppik, R., Saudek, V., (1993) J. Magn. Keson. Ser. A, 102, pp. 241-245
Braunschweiler, L., Ernst, R.R., (1983) J. Magn. Reson., 53, pp. 521-528
Bax, A., Davis, D.G., (1985) J. Magn. Reson., 65, pp. 355-360
Jeener, J., Meier, B.H., Bachmann, P., Ernst, R.R., (1979) J. Chem. Phys., 71, pp. 4546-4553
Piantini, U., Sørensen, O.W., Ernst, R.R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C.H., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
Güntert, P., Mumenthaler, C., Wüthrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., (1996) J. Mol. Graphics, 14, pp. 51-55
Nèmethy, G., Pottle, M.S., Scheraga, H.A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Mohamadi, F., Richards, N.G.J., Guida, W.C., Liskamp, R., Lipton, M., Caufield, C., Chang, G., Still, W.C., (1990) J. Comput. Chem., 11, pp. 440-467
Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D.Q., Still, W.C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Anders, J., Bl ggel, M., Meyer, H. E., K hne, R., Ter Laak, A. M., Kojro, E., Fahrenholz, F., (1999) Biochemistry, 38, pp. 6043-6055
Low, C. M. R., Black, J. W., Broughton, H. B., Buck, I. M., Davies, J. M. R., Dunstone, D. J., Hull, R. A. D., Steel, K. I. M., (2000) J. Med. Chem., 43, pp. 3505-3517
Harikumar, K. G., Clain, J., Pinon, D. I., Dong, M., Miller, L. J., (2005) J. Biol. Chem., 280, p. 10441050
Aloj, L., Carac, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2003) J. Nucl. Med., 44, pp. 485-494
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Hagler, A. T., Lifson, S., Dauber, P. J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Hagler, A. T., Hagler, A. T., Lifson, S., (1979) J. Am. Chem. Soc., 101, pp. 5131-5140
Sheppard, R. C., Williams, B. J., (1982) Int. J. Pept. Protein Res., 20, pp. 451-454
Bax, A., Davis, D. G., (1985) J. Magn. Reson., 65, pp. 355-360
Piantini, U., S rensen, O. W., Ernst, R. R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C. H., Xia, T. -H., Billeter, M., G ntert, P., W thrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
G ntert, P., Mumenthaler, C., W thrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
N methy, G., Pottle, M. S., Scheraga, H. A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D. Q., Still, W. C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.046, 5-year impact factor: 3.105
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33749022768&partnerID=40&md5=6f9b4b73b3f375fbefa1b73dc09c5405
Keywords: Cholecystokinin, Cyclic Constraints, Nmr Structures, Peptides, Receptors, Cholecystokinin Receptor, Drug Derivative, Ligand, Peptide Library, Article, Chemical Structure, Chemistry, Conformation, Drug Antagonism, Drug Design, Nuclear Magnetic Resonance Spectroscopy, Synthesis, Models, Molecular, Molecular Conformation,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, Centro Interuniversitario per la Ricerca Sui Peptidi Bioattivi (CIRPeB), Via Mezzocannone 16, 80134 Napoli, Italy
Bioindustry Park del Canadese, Via Ribes 5, 10010 Colleretto Giocosa, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Napoli, Italy
References:
Fourmy, D., Escrieut, C., Archer, E., Gales, C., Gigoux, V., Maigret, B., Moroder, L., Pradayrol, L., (2002) Pharmacol. Toxicol., 91, pp. 313-32
De Tullio, P., Delarge, J., Piroette, B., (1999) Curr. Med. Chem., 6, pp. 433-455
Anders, J., Blüggel, M., Meyer, H.E., Kühne, R., Ter Laak, A.M., Kojro, E., Fahrenholz, F., (1999) Biochemistry, 38, pp. 6043-6055
Low, C.M.R., Black, J.W., Broughton, H.B., Buck, I.M., Davies, J.M.R., Dunstone, D.J., Hull, R.A.D., Steel, K.I.M., (2000) J. Med. Chem., 43, pp. 3505-3517
Bellier, B., Million, M.E., Danascimento, S., Meudal, H., Kellou, S., Maigret, B., Garbay, C., (2000) J. Med. Chem., 43, pp. 3614-3623
Martin-Martinez, M., De La Figuera, N., Latorre, M., Garcia-Lopez, M.T., Cenarruzabeitia, E., Del Rio, J., Gonzales-Muñiz, R., (2005) J. Med. Chem., 48, pp. 7667-7674
Silvente-Poirot, S., Wank, S.A., (1996) J. Biol. Chem., 271, pp. 1468-14706
Schmitz, F., Pratt, D.S., Wu, M.J., Kolakowski, L.F., Beinborn, M., Kopin, A., (1996) Mol. Pharmacol., 50, pp. 3804-3809
Archer-Lahlou, E., Tikhonova, I., Escrieut, C., Dufresne, M., Seva, C., Pradayrol, L., Moroder, L., Fourmy, D., (2005) J. Med. Chem., 48, pp. 180-191
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., (2001) Biochemistry, 40, pp. 3804-3809
Harikumar, K.G., Clain, J., Pinon, D.I., Dong, M., Miller, L.J., (2005) J. Biol. Chem., 280, p. 10441050
De Luca, S., Ragone, R., Bracco, C., Digilio, G., Aloj, L., Tesauro, D., Saviano, M., Morelli, G., (2003) ChemBioChem, 4, pp. 1176-1187
Aloj, L., Caracò, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2003) J. Nucl. Med., 44, pp. 485-494
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Moroder, L., Romano, R., Guba, W., Mierke, D.F., Kessler, H., Delporte, C., Winand, J., Christophe, J., (1993) Biochemistry, 32, pp. 13551-13559
Lifson, S., Hagler, A.T., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5111-5121
Hagler, A.T., Lifson, S., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Hagler, A.T., Hagler, A.T., Lifson, S., (1979) J. Am. Chem. Soc., 101, pp. 5131-5140
Kaiser, E., Colescott, R.L., Bossinger, C.D., Cook, P.I., (1970) Anal. Biochem., 34, pp. 595-598
Sheppard, R.C., Williams, B.J., (1982) Int. J. Pept. Protein Res., 20, pp. 451-454
Piotto, M., Saudek, V., Sklenar, V., (1992) J. Biomol. NMR, 2, pp. 661-666
Sklenar, V., Piotto, M., Leppik, R., Saudek, V., (1993) J. Magn. Keson. Ser. A, 102, pp. 241-245
Braunschweiler, L., Ernst, R.R., (1983) J. Magn. Reson., 53, pp. 521-528
Bax, A., Davis, D.G., (1985) J. Magn. Reson., 65, pp. 355-360
Jeener, J., Meier, B.H., Bachmann, P., Ernst, R.R., (1979) J. Chem. Phys., 71, pp. 4546-4553
Piantini, U., Sørensen, O.W., Ernst, R.R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C.H., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
Güntert, P., Mumenthaler, C., Wüthrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., (1996) J. Mol. Graphics, 14, pp. 51-55
Nèmethy, G., Pottle, M.S., Scheraga, H.A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Mohamadi, F., Richards, N.G.J., Guida, W.C., Liskamp, R., Lipton, M., Caufield, C., Chang, G., Still, W.C., (1990) J. Comput. Chem., 11, pp. 440-467
Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D.Q., Still, W.C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Anders, J., Bl ggel, M., Meyer, H. E., K hne, R., Ter Laak, A. M., Kojro, E., Fahrenholz, F., (1999) Biochemistry, 38, pp. 6043-6055
Low, C. M. R., Black, J. W., Broughton, H. B., Buck, I. M., Davies, J. M. R., Dunstone, D. J., Hull, R. A. D., Steel, K. I. M., (2000) J. Med. Chem., 43, pp. 3505-3517
Harikumar, K. G., Clain, J., Pinon, D. I., Dong, M., Miller, L. J., (2005) J. Biol. Chem., 280, p. 10441050
Aloj, L., Carac, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., (2003) J. Nucl. Med., 44, pp. 485-494
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Hagler, A. T., Lifson, S., Dauber, P. J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Hagler, A. T., Hagler, A. T., Lifson, S., (1979) J. Am. Chem. Soc., 101, pp. 5131-5140
Sheppard, R. C., Williams, B. J., (1982) Int. J. Pept. Protein Res., 20, pp. 451-454
Bax, A., Davis, D. G., (1985) J. Magn. Reson., 65, pp. 355-360
Piantini, U., S rensen, O. W., Ernst, R. R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C. H., Xia, T. -H., Billeter, M., G ntert, P., W thrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
G ntert, P., Mumenthaler, C., W thrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
N methy, G., Pottle, M. S., Scheraga, H. A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D. Q., Still, W. C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor
A library of 14 cyclic peptide analogues derived from the octapeptide C-terminal sequence of the human cholecystokinin hormone (CCK (26-33), or CCK8) was designed, synthesized, and characterized. The 14 peptide analogues were rationally designed to specifically interact with the CCK type B receptor (CCK8-R) on the basis of the structure of the bimolecular complex between CCK8 and the third extracellular loop of CCK8-R, namely CCK8-R- (352-379). The rational design of new ligands for CCK 8-R has relied on stabilization by cyclic constraints of the structural motifs that bring the key residues of the ligand (especially Trp 30, Met31, and Phe33) in the proper spatial orientation for optimal interaction with the receptor. The binding affinity of the new ligands for CCK8-R was assessed by displacement experiments of 111In-radiolabeled CCK8 in cells that overexpress the CCK8 receptor. The new ligands generally showed binding affinities lower than that of parent CCK8, with the best compounds having IC50 values around 10 M. Structure-activity relationship data show that preservation of the Trp30-Met31 motif is essential and that the Phe33 side chain must be present. NMR conformational studies of the compound with maximal binding affinity (cyclo-B11, IC50 = 11 M) in DPC micelles shows that this compound presents a turn-like conformation centered at the Trp 30-Met31 segment, as planned by rational design. Such a conformation is stabilized by its interaction with the micelle rather than by the cyclic constraint. 2006 Wiley-VCH Verlag GmbH & Co. KGaA
A library of 14 cyclic peptide analogues derived from the octapeptide C-terminal sequence of the human cholecystokinin hormone (CCK (26-33), or CCK8) was designed, synthesized, and characterized. The 14 peptide analogues were rationally designed to specifically interact with the CCK type B receptor (CCK8-R) on the basis of the structure of the bimolecular complex between CCK8 and the third extracellular loop of CCK8-R, namely CCK8-R- (352-379). The rational design of new ligands for CCK 8-R has relied on stabilization by cyclic constraints of the structural motifs that bring the key residues of the ligand (especially Trp 30, Met31, and Phe33) in the proper spatial orientation for optimal interaction with the receptor. The binding affinity of the new ligands for CCK8-R was assessed by displacement experiments of 111In-radiolabeled CCK8 in cells that overexpress the CCK8 receptor. The new ligands generally showed binding affinities lower than that of parent CCK8, with the best compounds having IC50 values around 10 M. Structure-activity relationship data show that preservation of the Trp30-Met31 motif is essential and that the Phe33 side chain must be present. NMR conformational studies of the compound with maximal binding affinity (cyclo-B11, IC50 = 11 M) in DPC micelles shows that this compound presents a turn-like conformation centered at the Trp 30-Met31 segment, as planned by rational design. Such a conformation is stabilized by its interaction with the micelle rather than by the cyclic constraint. 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor
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Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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Impact Factor: 5.036
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
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Impact Factor: 3.415
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
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Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
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Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
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Impact Factor: 1.736
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
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Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
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Impact Factor: 3.15
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
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Impact Factor: 1.888
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Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
* Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours (432 views)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2008 Feb 12; N/D: N/D-N/D.
Impact Factor: 0
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
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Impact Factor: 2.823
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
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Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
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Impact Factor: 2.662
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
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Impact Factor: 4.627
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
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Impact Factor: 4.101
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
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Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
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Impact Factor: 3.325
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
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Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
* Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (338 views)
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Impact Factor: 4.1
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Nuernberger P, Vogt G, Gerber G, Improta R, Santoro F
* Femtosecond study on the isomerization dynamics of NK88. I. Ground-state dynamics after photoexcitation (351 views)
J Chem Phys (ISSN: 0021-9606, 0021-9606print, 0897-690online), 2006 Jul 28; 125(4): 44512-44544.
Impact Factor: 3.247
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Vogt G, Nuernberger P, Gerber G, Improta R, Santoro F, Nuernberger P, Vogt G, Gerber G, Improta R, Santoro F
* Femtosecond study on the isomerization dynamics of NK88. II. Excited-state dynamics (339 views)
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Impact Factor: 3.166
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (438 views)
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Impact Factor: 5.115
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (361 views)
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Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
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Impact Factor: 1.652
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (386 views)
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Impact Factor: 3.474
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (519 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
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Impact Factor: 3.992
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (278 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
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De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
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Impact Factor: 1.377
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
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Impact Factor: 1.621
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
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Impact Factor: 1.691
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Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (489 views)
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Impact Factor: 4.238
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
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Impact Factor: 1.451
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (469 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
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Impact Factor: 2.405
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Vinale F, Monti SM, Panunzi B, Fogliano V
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems (380 views)
J Agric Food Chem (ISSN: 0021-8561), 1999 Nov; 47(11): 4700-4706.
Impact Factor: 1.453
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
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Impact Factor: 0.957
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (373 views)
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Impact Factor: 1.623
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Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
Impact Factor: 1.311
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (292 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
Impact Factor: 2.361
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Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (350 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (409 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (660 views)
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Impact Factor: 2.416
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
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Impact Factor: 3.18
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Pennacchio A, Sannino V, Sorrentino G, Rossi M, Raia CA, Esposito L
* Biochemical and structural characterization of recombinant short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius highly enantioselective on diaryl diketone benzil (393 views)
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Impact Factor: 3.811
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Vergara A, D’Errico G, Montesarchio D, Mangiapia G, Paduano L, Merlino A
* Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu (352 views)
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Impact Factor: 4.794
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Gustavsson T, Sarkar S, Vaya I, Jimenez MC, Markovitsi D, Improta R
* A joint experimental/theoretical study of the ultrafast excited state deactivation of deoxyadenosine and 9-methyladenine in water and acetonitrile (337 views)
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Impact Factor: 2.939
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Improta R
* Photophysics and photochemistry of thymine deoxy-dinucleotide in water: A PCM/TD-DFT quantum mechanical study (305 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Dec 13; 116(49): 14261-14274.
Impact Factor: 3.607
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Monfregola L, Leone M, Calce E, de Luca S
* Postsynthetic modification of peptides via chemoselective N-alkylation of their side chains (468 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2012 Apr 6; 14(7): 1664-1667.
Impact Factor: 6.142
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
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Impact Factor: 3.463
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (380 views)
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Impact Factor: 1.799
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
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Impact Factor: 3.534
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
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Impact Factor: 2.87
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (446 views)
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Impact Factor: 3.451
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (479 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (831 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (359 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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Saviano M, De Luca S, Morelli G, Tesauro D, Pedone C
* Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours (432 views)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2008 Feb 12; N/D: N/D-N/D.
Impact Factor: 0
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (426 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (476 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
* Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (338 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
Impact Factor: 4.1
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Nuernberger P, Vogt G, Gerber G, Improta R, Santoro F
* Femtosecond study on the isomerization dynamics of NK88. I. Ground-state dynamics after photoexcitation (351 views)
J Chem Phys (ISSN: 0021-9606, 0021-9606print, 0897-690online), 2006 Jul 28; 125(4): 44512-44544.
Impact Factor: 3.247
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Vogt G, Nuernberger P, Gerber G, Improta R, Santoro F, Nuernberger P, Vogt G, Gerber G, Improta R, Santoro F
* Femtosecond study on the isomerization dynamics of NK88. II. Excited-state dynamics (339 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online), 2006 Jul 28; 125(4): 44512-44512.
Impact Factor: 3.166
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (438 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (361 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (386 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (519 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (278 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
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De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
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Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (469 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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Vinale F, Monti SM, Panunzi B, Fogliano V
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems (380 views)
J Agric Food Chem (ISSN: 0021-8561), 1999 Nov; 47(11): 4700-4706.
Impact Factor: 1.453
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (373 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
Impact Factor: 1.311
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (292 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
Impact Factor: 2.361
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Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R
1H MR spectroscopy in patients with metastatic brain tumors: A multicenter study (350 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1995 Jun; 33(6): 818-826.
Impact Factor: 3.012
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64 Records (62 excluding Abstracts).
Total impact factor: 185.673 (179.26 excluding Abstracts).
Total 5 year impact factor: 205.069 (198.884 excluding Abstracts).
Total impact factor: 185.673 (179.26 excluding Abstracts).
Total 5 year impact factor: 205.069 (198.884 excluding Abstracts).
421 views. Last view on Tuesday 28 February 2023, 8:32:24
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