Development and characterization of an integrated silicon micro flow cytometer
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Development and characterization of an integrated silicon micro flow cytometer (415 views)

Bernini E De Nuccio R, Brescia F, Minardo A, Zeni L, Sarro PM, Palumbo R, Scarf MR

Anal Bioanal Chem (ISSN: 1618-2642), 2006; 386(5): 1267-1272.

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Paper type: Journal Article,

Impact factor: 2.591, 5-year impact factor: 3.744

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33750438125&partnerID=40&md5=0139c03a8cbc84e0556442067facf57a

Keywords: Biochips, High-Throughput Screening, Microfabrication, Microfluidics, Optical Sensors, Channel Flow, Fluorescence, Hydrodynamics, Optical Design, Optical Waveguides, Signal To Noise Ratio, High Throughput Screening, Flow Measurement, Silicon, Article, Chemistry, Comparative Study, Electrode, Equipment, Equipment Design, Fiber Optics, Flow Cytometry, Instrumentation, Sensitivity And Specificity, Temperature, Equipment Failure Analysis,

Affiliations:
*** IBB - CNR ***

IREA-CNR, Via Diocleziano 328, 80124 Napoli, Italy
DII, Seconda Università di Napoli, Via Roma 29, 81031 Aversa, Italy
ECTM-DIMES, TUDelft, Feldmannweg 17, 2600 Delft, Netherlands
IBB-CNR, Via Mezzocannone 16, 80134 Napoli, Italy


References:
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Development and characterization of an integrated silicon micro flow cytometer

This paper describes an innovative integrated micro flow cytometer that presents a new arrangement for the excitation/detection system. The sample liquid, containing the fluorescent marked particles/cells under analysis, is hydrodynamically squeezed into a narrow stream by two sheath flows so that the particles/cells flow individually through a detection region. The detection of the particles/cells emitted fluorescence is carried out by using a collection fiber placed orthogonally to the flow. The device is based on silicon hollow core antiresonant reflecting optical waveguides (ARROWs). ARROW geometry allows one to use the same channel to guide both the sample stream and the fluorescence excitation light, leading to a simplification of the optical configuration and to an increase of the signal-to-noise ratio. The integrated micro flow cytometer has been characterized by using biological samples marked with standard fluorochromes. The experimental investigation confirms the success of the proposed microdevice in the detection of cells. © Springer-Verlag 2006.
Development and characterization of an integrated silicon micro flow cytometer

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Development and characterization of an integrated silicon micro flow cytometer

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9 Records (8 excluding Abstracts).
Total impact factor: 18.695 (18.695 excluding Abstracts).
Total 5 year impact factor: 18.723 (18.723 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:07
415 views. Last view on Wednesday 02 October 2024, 8:20:57