Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues
CNR Ibb | back to homepage
CNR Ibb | back to homepage

Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)

Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I

Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.

Export to BibTeX    Export to EndNote

Paper type: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 4.907, 5-year impact factor: 5.608

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-29544452166&partnerID=40&md5=15ed58326ff17a1c8d13175016c22117

Keywords: Copper, Helical Structures, Membranes, Peptides, Prions, Conformations, Diseases, Mathematical Models, Pathology, Proteins, Toxicity, Artificial Membranes, Metal Interaction, Copper Compounds, Peptide Fragment, Prion Protein, Prion Protein (180 193), Prion Protein (180-193), Amino Acid Sequence, Animal, Article, Binding Site, Cell Membrane, Chemistry, Human, Molecular Genetics, Protein Secondary Structure, Protein Tertiary Structure, Spectroscopy, Molecular Sequence Data, Protein Structure, Prpc Proteins, Spectrum Analysis,

Affiliations:
*** IBB - CNR ***

Università di Catania, Dipartimento di Scienze Chimiche, Viale Andrea Doria 6, 95125 Catania, Italy
Istituto CNR di Biostrutture e Bioimmagini, Sezione di Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Univcrsità di Padova, Dipartimento di Chimica Inorganica, Metallorganica Ed. Analitica, Via F. Marzolo 1, 35131 Padova, Italy
Università di Sassari, Dipartimento di Chimica, via Vienna 2, 07100 Sassari, Italy
University of Debreccn, Department of Inorganic and Analytical Chemistry, 4010 Debrecen, Hungary
Istituto CNR di Chimica Biomolecolare, Sezione di Sassari, Traversa La Crucca 3, 07040 Li Punti (SS), Italy
Universit di Catania, Dipartimento di Scienze Chimiche, Viale Andrea Doria 6, 95125 Catania, Italy
Univcrsit di Padova, Dipartimento di Chimica Inorganica, Metallorganica Ed. Analitica, Via F. Marzolo 1, 35131 Padova, Italy
Universit di Sassari, Dipartimento di Chimica, via Vienna 2, 07100 Sassari, Italy
Universita di Catania, Dipartimento di Scienze Chimiche, Viale Andrea Doria 6, 95125 Catania, Italy.,


References:
Prusiner, S.B., (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 13363-1338

Harrison, P.M., Chan, H.S., Prusiner, S.B., Cohen, F.E., (2001) Protein Sci., 10, pp. 819-835

Zahn, R., Liu, A., Luhrs, T., Riek, R., Von Schroetter, C., Lopez-Garcia, F., Billeter, M., Wuthrich, K., (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 145-150

Calzolai, L., Lysek, D.A., Guntert, P.G., Von Schroetter, C., Riek, R., Zahn, R., Wuthrich, K., (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 8340-8345

Bonomo, R.P., Grasso, D., Grasso, G., Guantieri, V., Impellizzeri, G., La Rosa, C., Milardi, D., Rizzarelli, E., (2003) Metal Ligand Interactions in Nano-, Micro-, and Macro-Systems in Complex Environments, pp. 19-36. , (Eds.: N. Russo, D. R. Salahub, M. Witko), Kluwer Academic Publishers, Dordrecht

Burns, C.S., Aronoff-Spencer, E., Dunham, C.M., Lario, P., Avdievich, N.I., Antholine, E.E., Olmstead, M.M., Millhauser, G.L., (2002) Biochemistry, 41, pp. 3991-4001

Mentler, M., Weiss, A., Grantner, K., Del Pino, P., Deluca, D., Fiori, S., Renner, C., Parak, F.G., (2005) Eur. Biophys. J., 34, pp. 97-112

Bonomo, R.P., Cucinotta, V., Giuffrida, A., Impellizzeri, G., Magrí, A., Pappalardo, G., Rizzarelli, E., Vagliasindi, L.I., (2005) Dalton Trans., pp. 150-158

Brown, D.R., Guantieri, V., Grasso, G., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., (2004) J. Inorg. Biochem., 98, pp. 133-143

Jobling, M.F., Huang, X., Stewart, L.R., Barnham, K.J., Curtain, C., Volitakis, I., Perugini, M., Cappai, R., (2001) Biochemistry, 40, pp. 8073-8084

Cereghetti, G.M., Schweiger, A., Glockshuber, R., Van Doorslaer, S., (2001) Biophys. J., 81, pp. 516-525

Van Doorslaer, S., Cereghetti, G.M., Glockshuber, R., Schweiger, A., (2001) J. Phys. Chem. B, 105, pp. 1631-1639

Thompson, A., White, A.R., McLean, C., Masters, C.L., Cappai, R., Barrow, C.J., (2000) J. Neurosci. Res., 62, pp. 293-301

Morillas, M., Swietnicki, W., Gambetti, P., Surewicz, W.K., (1999) J. Biol. Chem., 274, pp. 36859-36865

Harper, J.D., Lansbury Jr., P.T., (1997) Annu. Rev. Biochem., 66, pp. 385-407

Walsh, D.M., Lomakin, A., Benedek, G.B., Condron, M.M., Teplow, D.B., (1997) J. Biol. Chem., 272, pp. 22364-22372

Lashuel, H.A., Zhihong, L., Kelly, J.W., (1998) Biochemistry, 37, pp. 17851-17864

Anguiano, M., Nowak, R.J., Lansbury Jr., P.T., (2002) Biochemistry, 41, pp. 11338-11343

Kourie, J.I., Henry, C.L., (2001) Croat. Med. J., 42, pp. 359-374

Salmona, M., Forloni, G., Diomede, L., Algeri, M., De Gioia, L., Angeretti, N., Giaccone, G., Bugiani, O., (1997) Neurobiol, Dis., 4, pp. 47-57

Grasso, D., Miliardi, D., La Rosa, C., Rizzarelli, E., (2001) New J. Chem., 25, pp. 1543-1548

Grasso, O., Miliardi, D., Guantieri, V., La Rosa, C., Rizzarelli, E., (2003) New J. Chem., 27, pp. 359-364

Zékány, L., Nagypál, I., (1985) Computational Methods for the Determination of Stability Constants, p. 291. , (Ed.: D. J. Leggett), Plenum Press, New York

Chen, G.C., Yang, J.T., (1977) Anal. Lett., 10, pp. 1195-1207

La Mendola, D., Mineo, P., Rizzarelli, E., Scamporrino, E., Vecchio, G., Vitalini, D., (2001) J. Supramol. Chem., 1, pp. 147-151

Mineo, P., Vitalini, D., La Mendola, D., Rizzarelli, E., Scamporrino, E., Vecchio, G., (2002) Mass Spectrom. Rapid Commun., 16, pp. 722-729

Heimburg, T., (1998) Biochim. Biophys. Acta, 1415, pp. 147-162

Sovago, I., Bertalan, C., Gobi, L., Sovago, I., Nyeki, O., (1994) J. Inorg. Biochem., 55, pp. 67-75

Bonomo, R.P., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., Tabbí, G., (2000) Chem. Eur. J., 6, pp. 4195-4202

Bonomo, R.P., Conte, E., Impellizzeri, G., Pappalardo, G., Purrello, R., Rizzarelli, E., (1996) J. Chem. Soc. Dalton Trans., pp. 3093-3099

Viles, J.H., Cohen, F.E., Prusiner, S.B., Goodin, D.B., Wright, P.E., Dyson, H.J., (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 2042-2047

Garnett, A.P., Viles, J.H., (2003) J. Biol. Chem., 278, pp. 6795-6802

Brooks, G., Pettit, L.D., (1975) J. Chem. Soc. Dalton Trans., pp. 2112-2117

Perczel, A., Hollosi, M., (1996) Circular Dichroism and the Conformational Analysis of Biomolecules, pp. 285-380. , (Ed.: G. D. Fasman), Plenum Press, New York

Luczkowski, M., Kozlowski, H., Stawikowski, M., Rolka, K., Gaggelli, E., Valensin, D., Valensin, G., (2002) J. Chem. Soc. Dalton Trans., pp. 2269-2274

Valensin, D., Luczkowski, M., Mancini, F.M., Legowska, A., Gaggelli, E., Valensin, G., Rolka, K., Kozlowski, H., (2004) Dalton Trans., pp. 1284-1293

G. Di Natale, G. Grasso, G. Impellizzeri, D. La Mendola, G. Micera, N. Mihala, Z. Nagy, K. Õsz, G. Pappalardo, V. Rigó, E. Rizzarelli, D. Sanna, I. Sóvágó, unpublished resultsNagle, J.F., (1980) Annu. Rev. Phys. Chem., 31, p. 175

Basler, K., Oesch, B., Walchli, M., Groth, D.F., Mckinley, M.P., White, S.H., Wimley, W.C., (1999) Annu. Rev. Biophys. Biomol. Struct., 28, p. 319

Bush, A.I., (2003) Trends Neurosci., 26, pp. 207-214

Belosi, B., Gaggelli, E., Guerrini, R., Kozlowski, H., Luczkowski, M., Mancini, F.M., Remelli, M., Valensin, G., (2004) ChemBioChem, 5, pp. 349-359

Jones, C.E., Abdelraheim, S.R., Brown, D.R., Viles, J.H., (2004) J. Biol. Chem., 279, pp. 32018-32027

Jackson, G.S., Murray, I., Hosszu, L.L.P., Gibbs, N., Waltho, J.P., Clarke, A.R., Collinge, J., (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 8531-8535

Hathaway, B.J., Billing, D.E., (1970) Coord. Chem. Rev., 5, pp. 143-207

Shmerling, D., Hegy, I., Fischer, M., Blattler, T., Brandner, S., Gotz, J., Rulicke, T., Weissmann, C., (1998) Cell, 93, pp. 203-214

Prusiner, S. B., (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 13363-1338

Harrison, P. M., Chan, H. S., Prusiner, S. B., Cohen, F. E., (2001) Protein Sci., 10, pp. 819-835

Bonomo, R. P., Grasso, D., Grasso, G., Guantieri, V., Impellizzeri, G., La Rosa, C., Milardi, D., Rizzarelli, E., (2003) Metal Ligand Interactions in Nano-, Micro-, and Macro-Systems in Complex Environments, pp. 19-36. , (Eds.: N. Russo, D. R. Salahub, M. Witko), Kluwer Academic Publishers, Dordrecht

Burns, C. S., Aronoff-Spencer, E., Dunham, C. M., Lario, P., Avdievich, N. I., Antholine, E. E., Olmstead, M. M., Millhauser, G. L., (2002) Biochemistry, 41, pp. 3991-4001

Bonomo, R. P., Cucinotta, V., Giuffrida, A., Impellizzeri, G., Magr, A., Pappalardo, G., Rizzarelli, E., Vagliasindi, L. I., (2005) Dalton Trans., pp. 150-158

Brown, D. R., Guantieri, V., Grasso, G., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., (2004) J. Inorg. Biochem., 98, pp. 133-143

Jobling, M. F., Huang, X., Stewart, L. R., Barnham, K. J., Curtain, C., Volitakis, I., Perugini, M., Cappai, R., (2001) Biochemistry, 40, pp. 8073-8084

Cereghetti, G. M., Schweiger, A., Glockshuber, R., Van Doorslaer, S., (2001) Biophys. J., 81, pp. 516-525

Harper, J. D., Lansbury Jr., P. T., (1997) Annu. Rev. Biochem., 66, pp. 385-407

Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M., Teplow, D. B., (1997) J. Biol. Chem., 272, pp. 22364-22372

Lashuel, H. A., Zhihong, L., Kelly, J. W., (1998) Biochemistry, 37, pp. 17851-17864

Kourie, J. I., Henry, C. L., (2001) Croat. Med. J., 42, pp. 359-374

Z k ny, L., Nagyp l, I., (1985) Computational Methods for the Determination of Stability Constants, p. 291. , (Ed.: D. J. Leggett), Plenum Press, New York

Chen, G. C., Yang, J. T., (1977) Anal. Lett., 10, pp. 1195-1207

Bonomo, R. P., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., Tabb, G., (2000) Chem. Eur. J., 6, pp. 4195-4202

Bonomo, R. P., Conte, E., Impellizzeri, G., Pappalardo, G., Purrello, R., Rizzarelli, E., (1996) J. Chem. Soc. Dalton Trans., pp. 3093-3099

Viles, J. H., Cohen, F. E., Prusiner, S. B., Goodin, D. B., Wright, P. E., Dyson, H. J., (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 2042-2047

Garnett, A. P., Viles, J. H., (2003) J. Biol. Chem., 278, pp. 6795-6802

Bush, A. I., (2003) Trends Neurosci., 26, pp. 207-214

Jones, C. E., Abdelraheim, S. R., Brown, D. R., Viles, J. H., (2004) J. Biol. Chem., 279, pp. 32018-32027

Jackson, G. S., Murray, I., Hosszu, L. L. P., Gibbs, N., Waltho, J. P., Clarke, A. R., Collinge, J., (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 8531-8535

Hathaway, B. J., Billing, D. E., (1970) Coord. Chem. Rev., 5, pp. 143-207

Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues

An abnormal interaction between copper and the prion protein is believed to play a pivotal role in the pathogenesis of prion diseases. Copper binding has been mainly attributed to the N-terminal domain of the prion protein, but this hypothesis has recently been challenged in some papers which suggest that the C-terminal domain might also compete for metal anchoring. In particular, the segment corresponding to the helix II region of the prion protein, namely PrP180-193, has been shown both to bind copper and to exhibit a copper-enhanced cytotoxicity, as well as to interact with artificial membranes. The present work is aimed at extending these results by choosing the most representative model of this domain and by determining its copper affinity. With this aim, the different role played by the electrostatic properties of the C- and N-termini of PrP180-193 (VNITIKQHTVTTTT) in determining its conformational behaviour, copper coordination and ability to perturb model membranes was investigated. Owing to the low solubility of PrP180-193, its copper affinity was evaluated by using the shorter PrPAc184-188NH2 (IKQHT) analogue as a model. ESI-MS, ESR, UV/Vis, and CD measurements were carried out on the copper(II)/PrPAc184-188NH2 and copper(II)/PrP180-193NH2 systems, and showed that PrPAc184-188NH2 is a reliable model for the metal interaction with the helix II domain. The affinity of copper(II) for the helix II fragment is higher than that for the octarepeat and PrP106-126 peptides. Finally, the different ability of PrP180-193 analogues to perturb the DPPC model membrane was assessed by DSC measurements. The possible biological consequences of these findings are also discussed briefly.
Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues

▼    Molecular dynamics simulation approach to study UV-induced DNA damage
Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues

Filter those results▼
Query:  [X]
Options:
   Extended  
   IBB affiliation
 
Authors:  [X]
Paper type:  [X]
Start date:  [X]
End date:  [X]
Site:
[Clear form]
Select the year: 
Other filter: ([btitle,keywords] "Helical Structures" ...

Sort by:   date ▼▲   title ▲ ▼   journal ▲ ▼   authors ▲ ▼   I.F. ▲ ▼
Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
View    Export to BibTeX    Export to EndNote

Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (364 views)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
View    Export to BibTeX    Export to EndNote

Picone D, Donnarumma F, Ferraro G, Gotte G, Fagagnini A, Butera G, Donadelli M, Merlino A
* A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin (343 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Aug; 173: 105-112.
Impact Factor: 3.063
View    Export to BibTeX    Export to EndNote

Chino M, Maglio O, Nastri F, Pavone V, Degrado WF, Lombardi A
* Artificial Diiron Enzymes with a de Novo Designed Four-Helix Bundle Structure (563 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2015; 2015(21): 3371-3390.
Impact Factor: 2.686
View    Export to BibTeX    Export to EndNote

Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A
* Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 146: 37-43.
Impact Factor: 3.205
View    Export to BibTeX    Export to EndNote

Pannuzzo M, Raudino A, Milardi D, La Rosa C, Karttunen M
* α-Helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes (740 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013; 3: N/D-N/D.
Impact Factor: 5.078
View    Export to BibTeX    Export to EndNote

La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
View    Export to BibTeX    Export to EndNote

Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
View    Export to BibTeX    Export to EndNote

Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (290 views)
Chem Phys Lett (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
Impact Factor: 2.207
View    Export to BibTeX    Export to EndNote

Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
View    Export to BibTeX    Export to EndNote

Santoro F, Improta R, Lami A, Bloino J, Barone V
* Effective method to compute Franck-Condon integrals for optical spectra of large molecules in solution (268 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online), 2007 Feb 28; 126(8): 084509-084509.
Impact Factor: 3.044
View    Export to BibTeX    Export to EndNote

Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (385 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
View    Export to BibTeX    Export to EndNote

Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (484 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
View    Export to BibTeX    Export to EndNote

Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
View    Export to BibTeX    Export to EndNote

Improta R, Antonello S, Formaggio F, Maran F, Rega N, Barone V
* Understanding Electron Transfer across Negatively-Charged Aib Oligopeptides (575 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2005 Jan 20; 109(2): 1023-1033.
Impact Factor: 4.033
View    Export to BibTeX    Export to EndNote

Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, Degrado WF
* Artificial diiron proteins: From structure to function (480 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 264-278.
Impact Factor: 2.545
View    Export to BibTeX    Export to EndNote

Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M
* A New Class of Foldamers Based on cis-γ-Amino-L-proline (491 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 May 19; 126(19): 6048-6057.
Impact Factor: 6.903
View    Export to BibTeX    Export to EndNote

Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
View    Export to BibTeX    Export to EndNote

Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (383 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
View    Export to BibTeX    Export to EndNote

Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (385 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View    Export to BibTeX    Export to EndNote

Improta R, Barone V
* Interplay of electronic, environmental, and vibrational effects in determining the hyperfine coupling constants of organic free radicals (294 views)
Chem Rev (ISSN: 0009-2665), 2004 Mar; 104(3): 1231-1253.
Impact Factor: 20.233
View    Export to BibTeX    Export to EndNote

De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
View    Export to BibTeX    Export to EndNote

Improta R, Barone V
* Assesing the reliability of density functional methods in the conformational study of polypeptides: The treatment of intraresidue nonbonding interactions (405 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2004; 25(11): 1333-1341.
Impact Factor: 3.168
View    Export to BibTeX    Export to EndNote

Barone V, Formaggio F, Improta R, Polo F, Maran F
* Electron transfer to and conformational preferences of Aib oligo-peptides (385 views)
Proc Electrochem Soc, 2004; 10: 29-32.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (499 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
View    Export to BibTeX    Export to EndNote

Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (533 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
View    Export to BibTeX    Export to EndNote

Formaggio F, Crisma M, Toniolo C, Broxterman QB, Kaptein B, Corbier C, Saviano M, Palladino P, Benedetti E
* Cα-Methyl, Cα-n-Propylglycine Homo-oligomers (306 views)
Macromolecules (ISSN: 0024-9297), 2003; 36(21): 8164-8170.
Impact Factor: 3.621
View    Export to BibTeX    Export to EndNote

D'Amore M, Improta R, Barone V
* Conformational behavior and magnetic properties of a nitroxide amino acid derivative in vacuo and in aqueous solution (238 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2003; 107(32): 6264-6269.
Impact Factor: 2.792
View    Export to BibTeX    Export to EndNote

Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (385 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
View    Export to BibTeX    Export to EndNote

Improta R, Kudin KN, Scuseria GE, Barone V
* Structure and magnetic properties of nitroxide molecular crystals by density functional calculations employing periodic boundary conditions (240 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Jan 9; 124(1): 113-120.
Impact Factor: 6.201
View    Export to BibTeX    Export to EndNote

Grasso D, Milardi D, La Rosa C, Rizzarelli E
* DSC study of the interaction of the prion peptide PrP106-126 with artificial membranes (377 views)
New J Chem (ISSN: 1144-0546), 2001; 25(12): 1543-1548.
Impact Factor: 2.44
View    Export to BibTeX    Export to EndNote

Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (463 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001; 7(7): 1479-1485.
Impact Factor: 4.614
View    Export to BibTeX    Export to EndNote

Carotenuto L, Berisio R, Piccolo C, Vitagliano L, Zagari A
* Video observation of protein crystal growth in the advanced protein crystallization facility aboard the space shuttle mission STS-95 (384 views)
J Cryst Growth (ISSN: 0022-0248), 2001; 232(1-4): 481-488.
Impact Factor: 1.283
View    Export to BibTeX    Export to EndNote

Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Miniaturized hemoproteins (423 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
Impact Factor: 2.086
View    Export to BibTeX    Export to EndNote

Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (483 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
View    Export to BibTeX    Export to EndNote

Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Nastri F, Lombardi A, Morelli G, Maglio O, D'Auria G, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 1. Design, synthesis, and characterization (536 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 340-349.
Impact Factor: 4.828
View    Export to BibTeX    Export to EndNote

D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (483 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
Impact Factor: 4.828
View    Export to BibTeX    Export to EndNote

Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (396 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (560 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

Capasso S, Mazzarella L, Sica F, Zagari A
Solid-state conformations of aminosuccinyl peptides: crystal structure of tert-butyloxycarbonyl-L-leucyl-L-aminosuccinyl-L-phenylalaninami de (688 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989; 28(1): 139-147.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

44 Records (42 excluding Abstracts).
Total impact factor: 176.189 (168.067 excluding Abstracts).
Total 5 year impact factor: 231.297 (223.176 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:07
432 views. Last view on Saturday 18 February 2023, 19:44:14