Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (506 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 5.581, 5-year impact factor: 5.676
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847714347&partnerID=40&md5=26c9a69b8b736cedca59c0c597a71b49
Keywords: Amyloid Precursor Protein (app), Dna Damage, Genotoxic Stress, Proteolytic Processing, Brain, Fibroblasts, Ionizing Radiation, Phosphorylation, Etoposide, Gamma Secretase, Hydrogen Peroxide, Protein Fe65, Protein P53, Antineoplastic Agent, Apbb1 Protein, Mouse, Gamma H2ax Protein, Gamma-H2ax Protein, Histone, Nerve Protein, Nuclear Protein, Oxidizing Agent, Unclassified Drug, Animal Cell, Article, Cell Nucleus, Comparative Study, Controlled Study, Embryo, Genotoxicity, Nonhuman, Phenotype, Priority Journal, Protein Degradation, Protein Function, Sensitivity Analysis, Wild Type, X Ray, Cell Culture, Cytology, Drug Effect, Genetics, Metabolism, Mouse Mutant, Oxidative Stress, Physiology, Radiation Exposure, Amyloid Beta-Protein Precursor, Phytogenic, Mice, Knockout, Nerve Tissue Proteins, Oxidants, Tumor Suppressor Protein P53, Airway Obstruction, Brain Damage, Chronic Obstructive Lung Disease, Cognition, Cognitive Defect, Disease Severity, Drawing, Exercise, Hypoxemia, Letter, Major Clinical Study, Prognosis, Risk Assessment, Survival, Task Performance, Contrast Medium, Abdominal Aorta Aneurysm, Artificial Embolism, Calcification, Computed Tomographic Angiography, Contrast Enhancement, Diagnostic Accuracy, Diagnostic Imaging, Diagnostic Value, Endovascular Surgery, Follow Up, Multidetector Computed Tomography,
Affiliations:
*** IBB - CNR ***
CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Napoli, Italy
BioGeM Scarl-CEINGE, 80145 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, 80131 Napoli, Italy
SEMM, European School of Molecular Medicine, Italy
University Campus Bio-Medico, Rome, Italy
Italian National Research Center on Aging, Cosenza, Italy
Federico II University School of Medicine, Naples, Italy
Viale della Resistenza Pal. Alfa Scala H, I-87036 Rende (CS), Italy
Department of Clinical Science and Bioimaging, Section of Radiology, University of Chieti, via dei Vestini, Chieti 66013, Italy
Department of Bioimaging and Radiological Sciences, Catholic University of Rome, Italy
References:
Russo, T., Faraonio, R., Minopoli, G., De Candia, P., De Renzis, S., Zambrano, N., (1998) FEBS Lett, 434, pp. 1-
Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., Russo, T., (1995) J. Biol. Chem, 270, pp. 30853-30856
Guenette, S.Y., Chen, J., Jondro, P.D., Tanzi, R.E., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 10832-10837
Duilio, A., Faraonio, R., Minopoli, G., Zambrano, N., Russo, T., (1998) Biochem. J, 330, pp. 513-519
Kinoshita, A., Whelan, C.M., Smith, C.J., Mikhailenko, I., Rebeck, G.W., Strickland, D.K., Hyman, B.T., (2001) J. Neurosci, 21, pp. 8354-8361
Hoe, H.S., Magill, L.A., Guenette, S., Fu, Z., Vicini, S., Rebeck, G.W., (2006) J. Biol. Chem, 281, pp. 24521-24530
Pietrzik, C.U., Yoon, I.S., Jaeger, S., Busse, T., Weggen, S., Koo, E.H., (2004) J. Neurosci, 24, pp. 4259-4265
Cao, X., Sudhof, T.C., (2001) Science, 293, pp. 115-120
Ermekova, K.S., Zambrano, N., Linn, H., Minopoli, G., Gertler, F., Russo, T., Sudol, M., (1997) J. Biol. Chem, 272, pp. 32869-32877
Zambrano, N., Bruni, P., Minopoli, G., Mosca, R., Molino, D., Russo, C., Schettini, G., Russo, T., (2001) J. Biol. Chem, 276, pp. 19787-19792
Telese, F., Bruni, P., Donizetti, A., Gianni, D., D'Ambrosio, C., Scaloni, A., Zambrano, N., Russo, T., (2005) EMBO Rep, 6, pp. 77-82
Sabo, S.L., Ikin, A.F., Buxbaum, J.D., Greengard, P., (2001) J. Cell Biol, 153, pp. 1403-1414
Kimberly, W.T., Zheng, J.B., Guenette, S.Y., Selkoe, D.J., (2001) J. Biol. Chem, 276, pp. 40288-40292
Gao, Y., Pimplikar, S.W., (2001) Proc. Natl. Acad. Sci. U. S. A, 98, pp. 14979-14984
Scheinfeld, M.H., Ghersi, E., Laky, K., Fowlkes, B.J., D'Adamio, L., (2002) J. Biol. Chem, 277, pp. 44195-44201
Baek, S.H., Ohgi, K.A., Rose, D.W., Koo, E.H., Glass, C.K., Rosenfeld, M.G., (2002) Cell, 110, pp. 55-67
Pardossi-Piquard, R., Petit, A., Kawarai, T., Sunyach, C., Alves da Costa, C., Vincent, B., Ring, S., Checler, F., (2005) Neuron, 46, pp. 541-554
Zambrano, N., Bimonte, M., Arbucci, S., Gianni, D., Russo, T., and Bazzicalupo, P. (2002)) J. Cell Sci. 115, 1411-1422Guenette, S., Chang, Y., Hiesberger, T., Richardson, J.A., Eckman, C.B., Eckman, E.A., Hammer, R.E., Herz, J., (2006) EMBO J, 25, pp. 420-431
Herms, J., Anliker, B., Heber, S., Ring, S., Fuhrmann, M., Kretzschmar, H., Sisodia, S., Muller, U., (2004) EMBO J, 23, pp. 4106-4115
Walsh, D.M., Selkoe, D.J., (2004) Neuron, 44, pp. 181-193
Nakaya, T., Suzuki, T., (2006) Genes Cells, 11, pp. 633-645
King, G.D., Scott Turner, R., (2004) Exp. Neurol, 185, pp. 208-219
Wang, B., Hu, Q., Hearn, M.G., Shimizu, K., Ware, C.B., Liggitt, D.H., Jin, L.W., Martin, G.M., (2004) J. Neurosci. Res, 75, pp. 12-24
Holway, A.H., Kim, S.H., La Volpe, A., Michael, W.M., (2006) J. Cell Biol, 172, pp. 999-1008
Rolig, R.L., McKinnon, P.J., (2000) Trends Neurosci, 23, pp. 417-424
Adamec, E., Vonsattel, J.P., Nixon, R.A., (1999) Brain Res, 849, pp. 67-77
Parshad, R.P., Sanford, K.K., Price, F.M., Melnick, L.K., Nee, L.E., Schapiro, M.B., Tarone, R.E., Robbins, J.H., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 5146-5150
Reddy, P.H., (2006) J. Neurochem, 96, pp. 1-13
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci, 24, pp. 9232-9239
Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae, R., Mattson, M.P., (2004) Neuron, 41, pp. 540-561
Guenette, S. Y., Chen, J., Jondro, P. D., Tanzi, R. E., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 10832-10837
Hoe, H. S., Magill, L. A., Guenette, S., Fu, Z., Vicini, S., Rebeck, G. W., (2006) J. Biol. Chem, 281, pp. 24521-24530
Pietrzik, C. U., Yoon, I. S., Jaeger, S., Busse, T., Weggen, S., Koo, E. H., (2004) J. Neurosci, 24, pp. 4259-4265
Ermekova, K. S., Zambrano, N., Linn, H., Minopoli, G., Gertler, F., Russo, T., Sudol, M., (1997) J. Biol. Chem, 272, pp. 32869-32877
Sabo, S. L., Ikin, A. F., Buxbaum, J. D., Greengard, P., (2001) J. Cell Biol, 153, pp. 1403-1414
Kimberly, W. T., Zheng, J. B., Guenette, S. Y., Selkoe, D. J., (2001) J. Biol. Chem, 276, pp. 40288-40292
Scheinfeld, M. H., Ghersi, E., Laky, K., Fowlkes, B. J., D'Adamio, L., (2002) J. Biol. Chem, 277, pp. 44195-44201
Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K., Rosenfeld, M. G., (2002) Cell, 110, pp. 55-67
Walsh, D. M., Selkoe, D. J., (2004) Neuron, 44, pp. 181-193
King, G. D., Scott Turner, R., (2004) Exp. Neurol, 185, pp. 208-219
Holway, A. H., Kim, S. H., La Volpe, A., Michael, W. M., (2006) J. Cell Biol, 172, pp. 999-1008
Rolig, R. L., McKinnon, P. J., (2000) Trends Neurosci, 23, pp. 417-424
Parshad, R. P., Sanford, K. K., Price, F. M., Melnick, L. K., Nee, L. E., Schapiro, M. B., Tarone, R. E., Robbins, J. H., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 5146-5150
Reddy, P. H., (2006) J. Neurochem, 96, pp. 1-13
Kruman, I. I., Wersto, R. P., Cardozo-Pelaez, F., Smilenov, L., Chan, S. L., Chrest, F. J., Emokpae, R., Mattson, M. P., (2004) Neuron, 41, pp. 540-561
Iezzi, R., Cotroneo, A.R., Filippone, A., Multidetector CT in abdominal aortic aneurysm treated with endovascular repair: Are unenhanced and delayed phase enhanced images effective for endoleak detection? (2006) Radiology, 241 (3), pp. 915-92
Golzarian, J., Dussaussois, L., Abada, H.T., Helical CT of aorta after endoluminal stent-graft therapy: Value of biphasic acquisition (1998) AJR Am J Roentgenol, 171 (2), pp. 329-331
Golzarian, J., Valenti, D., Endoleakage after endovascular treatment of abdominal aortic aneurysms: Diagnosis, significance and treatment (2006) Eur Radiol, 16 (12), pp. 2849-2857
Wintersperger, B., Jakobs, T., Herzog, P., Aorto-iliac multidetector-row CT angiography with low kV settings: Improved vessel enhancement and simultaneous reduction of radiation dose (2005) Eur Radiol, 15 (2), pp. 334-341
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 5.581, 5-year impact factor: 5.676
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847714347&partnerID=40&md5=26c9a69b8b736cedca59c0c597a71b49
Keywords: Amyloid Precursor Protein (app), Dna Damage, Genotoxic Stress, Proteolytic Processing, Brain, Fibroblasts, Ionizing Radiation, Phosphorylation, Etoposide, Gamma Secretase, Hydrogen Peroxide, Protein Fe65, Protein P53, Antineoplastic Agent, Apbb1 Protein, Mouse, Gamma H2ax Protein, Gamma-H2ax Protein, Histone, Nerve Protein, Nuclear Protein, Oxidizing Agent, Unclassified Drug, Animal Cell, Article, Cell Nucleus, Comparative Study, Controlled Study, Embryo, Genotoxicity, Nonhuman, Phenotype, Priority Journal, Protein Degradation, Protein Function, Sensitivity Analysis, Wild Type, X Ray, Cell Culture, Cytology, Drug Effect, Genetics, Metabolism, Mouse Mutant, Oxidative Stress, Physiology, Radiation Exposure, Amyloid Beta-Protein Precursor, Phytogenic, Mice, Knockout, Nerve Tissue Proteins, Oxidants, Tumor Suppressor Protein P53, Airway Obstruction, Brain Damage, Chronic Obstructive Lung Disease, Cognition, Cognitive Defect, Disease Severity, Drawing, Exercise, Hypoxemia, Letter, Major Clinical Study, Prognosis, Risk Assessment, Survival, Task Performance, Contrast Medium, Abdominal Aorta Aneurysm, Artificial Embolism, Calcification, Computed Tomographic Angiography, Contrast Enhancement, Diagnostic Accuracy, Diagnostic Imaging, Diagnostic Value, Endovascular Surgery, Follow Up, Multidetector Computed Tomography,
Affiliations:
*** IBB - CNR ***
CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Napoli, Italy
BioGeM Scarl-CEINGE, 80145 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, 80131 Napoli, Italy
SEMM, European School of Molecular Medicine, Italy
University Campus Bio-Medico, Rome, Italy
Italian National Research Center on Aging, Cosenza, Italy
Federico II University School of Medicine, Naples, Italy
Viale della Resistenza Pal. Alfa Scala H, I-87036 Rende (CS), Italy
Department of Clinical Science and Bioimaging, Section of Radiology, University of Chieti, via dei Vestini, Chieti 66013, Italy
Department of Bioimaging and Radiological Sciences, Catholic University of Rome, Italy
References:
Russo, T., Faraonio, R., Minopoli, G., De Candia, P., De Renzis, S., Zambrano, N., (1998) FEBS Lett, 434, pp. 1-
Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., Russo, T., (1995) J. Biol. Chem, 270, pp. 30853-30856
Guenette, S.Y., Chen, J., Jondro, P.D., Tanzi, R.E., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 10832-10837
Duilio, A., Faraonio, R., Minopoli, G., Zambrano, N., Russo, T., (1998) Biochem. J, 330, pp. 513-519
Kinoshita, A., Whelan, C.M., Smith, C.J., Mikhailenko, I., Rebeck, G.W., Strickland, D.K., Hyman, B.T., (2001) J. Neurosci, 21, pp. 8354-8361
Hoe, H.S., Magill, L.A., Guenette, S., Fu, Z., Vicini, S., Rebeck, G.W., (2006) J. Biol. Chem, 281, pp. 24521-24530
Pietrzik, C.U., Yoon, I.S., Jaeger, S., Busse, T., Weggen, S., Koo, E.H., (2004) J. Neurosci, 24, pp. 4259-4265
Cao, X., Sudhof, T.C., (2001) Science, 293, pp. 115-120
Ermekova, K.S., Zambrano, N., Linn, H., Minopoli, G., Gertler, F., Russo, T., Sudol, M., (1997) J. Biol. Chem, 272, pp. 32869-32877
Zambrano, N., Bruni, P., Minopoli, G., Mosca, R., Molino, D., Russo, C., Schettini, G., Russo, T., (2001) J. Biol. Chem, 276, pp. 19787-19792
Telese, F., Bruni, P., Donizetti, A., Gianni, D., D'Ambrosio, C., Scaloni, A., Zambrano, N., Russo, T., (2005) EMBO Rep, 6, pp. 77-82
Sabo, S.L., Ikin, A.F., Buxbaum, J.D., Greengard, P., (2001) J. Cell Biol, 153, pp. 1403-1414
Kimberly, W.T., Zheng, J.B., Guenette, S.Y., Selkoe, D.J., (2001) J. Biol. Chem, 276, pp. 40288-40292
Gao, Y., Pimplikar, S.W., (2001) Proc. Natl. Acad. Sci. U. S. A, 98, pp. 14979-14984
Scheinfeld, M.H., Ghersi, E., Laky, K., Fowlkes, B.J., D'Adamio, L., (2002) J. Biol. Chem, 277, pp. 44195-44201
Baek, S.H., Ohgi, K.A., Rose, D.W., Koo, E.H., Glass, C.K., Rosenfeld, M.G., (2002) Cell, 110, pp. 55-67
Pardossi-Piquard, R., Petit, A., Kawarai, T., Sunyach, C., Alves da Costa, C., Vincent, B., Ring, S., Checler, F., (2005) Neuron, 46, pp. 541-554
Zambrano, N., Bimonte, M., Arbucci, S., Gianni, D., Russo, T., and Bazzicalupo, P. (2002)) J. Cell Sci. 115, 1411-1422Guenette, S., Chang, Y., Hiesberger, T., Richardson, J.A., Eckman, C.B., Eckman, E.A., Hammer, R.E., Herz, J., (2006) EMBO J, 25, pp. 420-431
Herms, J., Anliker, B., Heber, S., Ring, S., Fuhrmann, M., Kretzschmar, H., Sisodia, S., Muller, U., (2004) EMBO J, 23, pp. 4106-4115
Walsh, D.M., Selkoe, D.J., (2004) Neuron, 44, pp. 181-193
Nakaya, T., Suzuki, T., (2006) Genes Cells, 11, pp. 633-645
King, G.D., Scott Turner, R., (2004) Exp. Neurol, 185, pp. 208-219
Wang, B., Hu, Q., Hearn, M.G., Shimizu, K., Ware, C.B., Liggitt, D.H., Jin, L.W., Martin, G.M., (2004) J. Neurosci. Res, 75, pp. 12-24
Holway, A.H., Kim, S.H., La Volpe, A., Michael, W.M., (2006) J. Cell Biol, 172, pp. 999-1008
Rolig, R.L., McKinnon, P.J., (2000) Trends Neurosci, 23, pp. 417-424
Adamec, E., Vonsattel, J.P., Nixon, R.A., (1999) Brain Res, 849, pp. 67-77
Parshad, R.P., Sanford, K.K., Price, F.M., Melnick, L.K., Nee, L.E., Schapiro, M.B., Tarone, R.E., Robbins, J.H., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 5146-5150
Reddy, P.H., (2006) J. Neurochem, 96, pp. 1-13
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci, 24, pp. 9232-9239
Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae, R., Mattson, M.P., (2004) Neuron, 41, pp. 540-561
Guenette, S. Y., Chen, J., Jondro, P. D., Tanzi, R. E., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 10832-10837
Hoe, H. S., Magill, L. A., Guenette, S., Fu, Z., Vicini, S., Rebeck, G. W., (2006) J. Biol. Chem, 281, pp. 24521-24530
Pietrzik, C. U., Yoon, I. S., Jaeger, S., Busse, T., Weggen, S., Koo, E. H., (2004) J. Neurosci, 24, pp. 4259-4265
Ermekova, K. S., Zambrano, N., Linn, H., Minopoli, G., Gertler, F., Russo, T., Sudol, M., (1997) J. Biol. Chem, 272, pp. 32869-32877
Sabo, S. L., Ikin, A. F., Buxbaum, J. D., Greengard, P., (2001) J. Cell Biol, 153, pp. 1403-1414
Kimberly, W. T., Zheng, J. B., Guenette, S. Y., Selkoe, D. J., (2001) J. Biol. Chem, 276, pp. 40288-40292
Scheinfeld, M. H., Ghersi, E., Laky, K., Fowlkes, B. J., D'Adamio, L., (2002) J. Biol. Chem, 277, pp. 44195-44201
Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K., Rosenfeld, M. G., (2002) Cell, 110, pp. 55-67
Walsh, D. M., Selkoe, D. J., (2004) Neuron, 44, pp. 181-193
King, G. D., Scott Turner, R., (2004) Exp. Neurol, 185, pp. 208-219
Holway, A. H., Kim, S. H., La Volpe, A., Michael, W. M., (2006) J. Cell Biol, 172, pp. 999-1008
Rolig, R. L., McKinnon, P. J., (2000) Trends Neurosci, 23, pp. 417-424
Parshad, R. P., Sanford, K. K., Price, F. M., Melnick, L. K., Nee, L. E., Schapiro, M. B., Tarone, R. E., Robbins, J. H., (1996) Proc. Natl. Acad. Sci. U. S. A, 93, pp. 5146-5150
Reddy, P. H., (2006) J. Neurochem, 96, pp. 1-13
Kruman, I. I., Wersto, R. P., Cardozo-Pelaez, F., Smilenov, L., Chan, S. L., Chrest, F. J., Emokpae, R., Mattson, M. P., (2004) Neuron, 41, pp. 540-561
Iezzi, R., Cotroneo, A.R., Filippone, A., Multidetector CT in abdominal aortic aneurysm treated with endovascular repair: Are unenhanced and delayed phase enhanced images effective for endoleak detection? (2006) Radiology, 241 (3), pp. 915-92
Golzarian, J., Dussaussois, L., Abada, H.T., Helical CT of aorta after endoluminal stent-graft therapy: Value of biphasic acquisition (1998) AJR Am J Roentgenol, 171 (2), pp. 329-331
Golzarian, J., Valenti, D., Endoleakage after endovascular treatment of abdominal aortic aneurysms: Diagnosis, significance and treatment (2006) Eur Radiol, 16 (12), pp. 2849-2857
Wintersperger, B., Jakobs, T., Herzog, P., Aorto-iliac multidetector-row CT angiography with low kV settings: Improved vessel enhancement and simultaneous reduction of radiation dose (2005) Eur Radiol, 15 (2), pp. 334-341
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
Fe65 interacts with the cytosolic domain of the Alzheimer amyloid precursor protein (APP). The functions of the Fe65 are still unknown. To address this point we generated Fe65 knockout (KO) mice. These mice do not show any obvious phenotype; however, when fibroblasts (mouse embryonic fibroblasts), isolated from Fe65 KO embryos, were exposed to low doses of DNA damaging agents, such as etoposide or H2O2, an increased sensitivity to genotoxic stress, compared with wild type animals, clearly emerged. Accordingly, brain extracts from Fe65 KO mice, exposed to non-lethal doses of ionizing radiations, showed high levels of gamma-H2AX and p53, thus demonstrating a higher sensitivity to X-rays than wild type mice. Nuclear Fe65 is necessary to rescue the observed phenotype, and few minutes after the exposure of MEFs to DNA damaging agents, Fe65 undergoes phosphorylation in the nucleus. With a similar timing, the proteolytic processing of APP is rapidly affected by the genotoxic stress: in fact, the cleavage of the APP COOH-terminal fragments by gamma-secretase is induced soon after the exposure of cells to etoposide, in a Fe65-dependent manner. These results demonstrate that Fe65 plays an essential role in the response of the cells to DNA damage.
Fe65 interacts with the cytosolic domain of the Alzheimer amyloid precursor protein (APP). The functions of the Fe65 are still unknown. To address this point we generated Fe65 knockout (KO) mice. These mice do not show any obvious phenotype; however, when fibroblasts (mouse embryonic fibroblasts), isolated from Fe65 KO embryos, were exposed to low doses of DNA damaging agents, such as etoposide or H2O2, an increased sensitivity to genotoxic stress, compared with wild type animals, clearly emerged. Accordingly, brain extracts from Fe65 KO mice, exposed to non-lethal doses of ionizing radiations, showed high levels of gamma-H2AX and p53, thus demonstrating a higher sensitivity to X-rays than wild type mice. Nuclear Fe65 is necessary to rescue the observed phenotype, and few minutes after the exposure of MEFs to DNA damaging agents, Fe65 undergoes phosphorylation in the nucleus. With a similar timing, the proteolytic processing of APP is rapidly affected by the genotoxic stress: in fact, the cleavage of the APP COOH-terminal fragments by gamma-secretase is induced soon after the exposure of cells to etoposide, in a Fe65-dependent manner. These results demonstrate that Fe65 plays an essential role in the response of the cells to DNA damage.
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
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Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
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Grasso G, Giuffrida ML, Rizzarelli E
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
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Rachidi W, De Rosa V
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
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Hill BS, Sarnella A, D'Avino G, Zannetti A
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Esposito MV, Minopoli G, Esposito L, D'Argenio V, Di Maggio F, Sasso E, D'Aiuto M, Zambrano N, Salvatore F
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Impact Factor: 3.454
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Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-baruffi M, Carvalho I, Campo VL
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
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Impact Factor: 5.16
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
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Impact Factor: 3.257
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
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Impact Factor: 4.839
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
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Impact Factor: 5.531
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
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Impact Factor: 2.76
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
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Impact Factor: 23.523
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Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (363 views)
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Impact Factor: 12.113
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
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Impact Factor: 4.466
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
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Impact Factor: 5.177
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
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Impact Factor: 4.907
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
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Impact Factor: 4.906
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Bera S, De Rosa V, Rachidi W, Diamond AM
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Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
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Impact Factor: 4.779
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
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Impact Factor: 4.803
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
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Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3468 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (505 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (407 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (856 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (509 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (558 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (410 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (661 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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44 Records (41 excluding Abstracts).
Total impact factor: 224.447 (209.867 excluding Abstracts).
Total 5 year impact factor: 193.004 (178.667 excluding Abstracts).
Total impact factor: 224.447 (209.867 excluding Abstracts).
Total 5 year impact factor: 193.004 (178.667 excluding Abstracts).
506 views. Last view on Tuesday 21 March 2023, 18:52:12
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