Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis (370 views)
Viral Immunol (ISSN: 0882-8245), 2006 Jun; 19(3): 363-372.
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Paper type: Journal Article,
Impact factor: 2.133, 5-year impact factor: 1.892
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33750941974&partnerID=40&md5=d869a957875a5f604577f6b4ee32ef7a
Keywords: Antiretrovirus Agent, Cd40 Ligand, Spiramycin, Zidovudine, Antigen Expression, Cd4+ T Lymphocyte, Cd8+ T Lymphocyte, Clinical Article, Conference Paper, Controlled Study, Highly Active Antiretroviral Therapy, Human, Human Immunodeficiency Virus Infection, Immune Response, Immunostimulation, Infant, Peripheral Blood Mononuclear Cell, Postnatal Care, Prenatal Care, T Lymphocyte Activation, Toxoplasmosis, Treatment Outcome, Vertical Transmission, Virus Transmission, Cd4-Positive T-Lymphocytes, Cd8-Positive T-Lymphocytes, Child, Preschool, Disease Transmission, Female, Hiv Infections, Hiv Seropositivity, Newborn, Pregnancy, Pregnancy Complications, Viral Load,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Medical Biotechnologies, Federico II Medical School, Naples University, Naples, Italy
Department of Pediatrics, Federico II Medical School, Naples University, Naples, Italy
Institute of Biostructure and Bioimaging-National Research Council (CNR), Naples, Italy
Institute of Child Health, University College London, London, United Kingdom
References:
Not available.
Viral Immunol (ISSN: 0882-8245), 2006 Jun; 19(3): 363-372.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.133, 5-year impact factor: 1.892
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33750941974&partnerID=40&md5=d869a957875a5f604577f6b4ee32ef7a
Keywords: Antiretrovirus Agent, Cd40 Ligand, Spiramycin, Zidovudine, Antigen Expression, Cd4+ T Lymphocyte, Cd8+ T Lymphocyte, Clinical Article, Conference Paper, Controlled Study, Highly Active Antiretroviral Therapy, Human, Human Immunodeficiency Virus Infection, Immune Response, Immunostimulation, Infant, Peripheral Blood Mononuclear Cell, Postnatal Care, Prenatal Care, T Lymphocyte Activation, Toxoplasmosis, Treatment Outcome, Vertical Transmission, Virus Transmission, Cd4-Positive T-Lymphocytes, Cd8-Positive T-Lymphocytes, Child, Preschool, Disease Transmission, Female, Hiv Infections, Hiv Seropositivity, Newborn, Pregnancy, Pregnancy Complications, Viral Load,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Medical Biotechnologies, Federico II Medical School, Naples University, Naples, Italy
Department of Pediatrics, Federico II Medical School, Naples University, Naples, Italy
Institute of Biostructure and Bioimaging-National Research Council (CNR), Naples, Italy
Institute of Child Health, University College London, London, United Kingdom
References:
Not available.
Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis
Although prevention of mother-to-child HIV transmission by antiretroviral drugs has been shown to be effective, the short- and long-term effects of treatment are not well known. Several reports suggest that antiretroviral drugs act not only by inhibiting viral replication, but also by improving antiviral immunity. In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes. The present study investigated potential immunostimulatory effects of antiretroviral treatment (ART) in uninfected HIV-exposed infants, receiving either ante- or postnatal therapy to reduce the transmission rate. To this end, we analyzed CD40L expression in unstimulated lymphocytes from peripheral blood samples of uninfected infants vertically exposed to HIV and subjected to ART. The CD45 PanLeucogating strategy was applied in flow cytometry to analyze the lymphocytes of 41 cases and 64 age-matched infants, taken as control. We found increased CD154 expression on both CD4+ and CD8+ lymphocytes in ART-treated infants, compared with the controls. CD154 was apparently functional, because the expression of CD86 on monocytes was enhanced; moreover, inhibition of the CD40-CD40L interaction produced downmodulation of CD86. From these results, we conclude that CD4+ and CD8+ lymphocytes of HIV-exposed noninfected infants, who have been exposed to antiretroviral drugs in fetal and early life, display enhanced CD154 expression and costimulatory activity. © Mary Ann Liebert, Inc.
Although prevention of mother-to-child HIV transmission by antiretroviral drugs has been shown to be effective, the short- and long-term effects of treatment are not well known. Several reports suggest that antiretroviral drugs act not only by inhibiting viral replication, but also by improving antiviral immunity. In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes. The present study investigated potential immunostimulatory effects of antiretroviral treatment (ART) in uninfected HIV-exposed infants, receiving either ante- or postnatal therapy to reduce the transmission rate. To this end, we analyzed CD40L expression in unstimulated lymphocytes from peripheral blood samples of uninfected infants vertically exposed to HIV and subjected to ART. The CD45 PanLeucogating strategy was applied in flow cytometry to analyze the lymphocytes of 41 cases and 64 age-matched infants, taken as control. We found increased CD154 expression on both CD4+ and CD8+ lymphocytes in ART-treated infants, compared with the controls. CD154 was apparently functional, because the expression of CD86 on monocytes was enhanced; moreover, inhibition of the CD40-CD40L interaction produced downmodulation of CD86. From these results, we conclude that CD4+ and CD8+ lymphocytes of HIV-exposed noninfected infants, who have been exposed to antiretroviral drugs in fetal and early life, display enhanced CD154 expression and costimulatory activity. © Mary Ann Liebert, Inc.
Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis
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Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis
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Lanzillo R, Carbone F, Quarantelli M, Bruzzese D, Carotenuto A, De RosaV, Colamatteo A, Micillo T, De Luca Picione C, Saccà F, De Rosa A, Moccia M, Brescia Morra V, Matarese G
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Berisio R, Corti N, Pfister P, Yonath A, Böttger EC
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* Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a (529 views)
Clin Immunol (ISSN: 1521-6616, 1521-6616linking), 2017 Oct; 183: 249-253.
Impact Factor: 3.557
View Export to BibTeX Export to EndNote
Berisio R, Corti N, Pfister P, Yonath A, Böttger EC
* 23S rRNA 2058A→G alteration mediates ketolide resistance in combination with deletion in L22 (761 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2006 Nov; 50(11): 3816-3823.
Impact Factor: 4.153
View Export to BibTeX Export to EndNote
2 Records (2 excluding Abstracts).
Total impact factor: 7.71 (7.71 excluding Abstracts).
Total 5 year impact factor: 8.528 (8.528 excluding Abstracts).
Total impact factor: 7.71 (7.71 excluding Abstracts).
Total 5 year impact factor: 8.528 (8.528 excluding Abstracts).
370 views. Last view on Friday 11 October 2024, 21:12:31
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