Lung structure abnormalities, but normal lung function in pediatric bronchiectasis(431 views) Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
Department of Pediatrics, Federico II University, Naples, Italy
Department of Radiology, Federico II University, Naples, Italy
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Karakoc, G. B., Yilmaz, M., Altintas, D. U., Bronchiectasis: Still a problem (2001) Pediatr Pulmonol, 32, pp. 175-178
Callahan, C. W., Redding, G. J., Bronchiectasis in children: Orphan disease or persistent problem? (2002) Pediatr Pulmonol, 33, pp. 492-496
Chang, A. B., Boyce, N. C., Masters, I. B., Bronchoscopic findings in children with non-cystic flbrosis chronic suppurative lung disease (2002) Thorax, 57, pp. 935-938
Chang, A. B., Masel, J. P., Boyce, N. C., Non-CF bronchiectasis: Clinical and HRCT evaluation (2003) Pediatr Pulmonol, 35, pp. 477-483
Edwards, E. A., Metcalfe, R., Milne, D. G., Retrospective review of children presenting with non cystic fibrosis bronchiectasis: HRCT features and clinical relationships (2003) Pediatr Pulmonol, 36, pp. 87-93
Eastham, K. M., Fall, A. J., Mitchell, L., The need to redefine non-cystic fibrosis bronchiectasis in childhood (2004) Thorax, 59, pp. 324-327
Shah, R. M., Sexauer, W., Ostrum, B. J., High-resolution CT in the acute exacerbation of cystic fibrosis: Evaluation of acute findings, reversibility of those findings, and clinical correlation (1997) AJR Am J Roentgenol, 169, pp. 375-380
Helbich, T. H., Heinz-Peer, G., Eichler, I., Cystic fibrosis: CT assessment of lung involvement in children and adults (1999) Radiology, 213, pp. 537-544
Lynch, D. A., Newell, J., Hale, V., Correlation of CT findings with clinical evaluations in 261 patients with symptomatic bronchiectasis (1999) AJR Am J Roentgenol, 173, pp. 53-58
Roberts, H. R., Wells, A. U., Milne, D. G., Airflow obstruction in bronchiectasis: Correlation between computed tomography features and pulmonary function tests (2000) Thorax, 55, pp. 198-204
Sheehan, R. E., Wells, A. U., Copley, S. J., A comparison of serial computed tomography and functional change in bronchiectasis (2002) Eur Respir J, 20, pp. 581-587
Koulouris, N. G., Retsou, S., Kosmas, E., Tidal expiratory flow limitation, dyspnoea and exercise capacity in patients with bilateral bronchiectasis (2003) Eur Respir J, 21, pp. 743-748
De Jong, P. A., Nakano, Y., Lequin, M. H., Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis (2004) Eur Respir J, 23, pp. 93-97
Marchant, J. M., Masel, J. P., Dickinson, F. L., Application of chest high-resolution computed tomography in young children with cystic fibrosis (2001) Pediatr Pulmonol, 31, pp. 24-29
Brody, A. S., Klein, J. S., Molina, P. L., High-resolution computed tomography in young patients with cystic fibrosis: Distribution of abnormalities and correlation with pulmonary function tests (2004) J Pediatr, 145, pp. 32-38
Naidich, D. P., McCauley, D. I., Khouri, N. F., Computed tomography of bronchiectasis (1982) J Comput Assist Tomogr, 6, pp. 437-444
Wald, E. R., Recurrent and nonresolving pneumonia in children (1993) Semin Respir Infect, 8, pp. 46-58
Rosenstein, B. J., Cutting, G. R., The diagnosis of cystic fibrosis: A consensus statement (1998) J Pediatr, 132, pp. 589-595
Reiff, D. B., Wells, A. U., Carr, D. H., CT findings in bronchiectasis: Limited value in distinguishing between postinfectious and specific types (1995) AJR Am J Roentgenol, 165, pp. 261-267
Koran, L. M., The reliability of clinical methods, data and judgment (1975) N Engl J Med, 293, pp. 642-646
Tiddens, H. A., Pare, P. D., Hogg, J. C., Cartilaginous airway dimensions and airflow obstruction in human lungs (1995) Am J Respir Crit Care Med, 152, pp. 260-266
Barker, A. F., Bronchiectasis (2002) N Engl J Med, 346, pp. 1383-1393
O'Donnell, A. E., Barker, A. F., Ilowite, J. S., Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I (1998) Chest, 113, pp. 1329-1334
Nasr, S. Z., Kuhns, L. R., Brown, R. W., Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study (2001) Pediatr Pulmonol, 31, pp. 377-382
Robinson, T. E., Goris, M. L., Zhu, H. J., Dornase alfa reduces air trapping in children with mild cystic fibrosis lung disease: A quantitative analysis (2005) Chest, 128, pp. 2327-2335
Brown, M. A., Lemen, R. J., Bronchiectasis (1998) Kendig's Disorders of the Respiratory Tract in Children, pp. 538-552. , Chernick V, Boat TF, Kending EL Jr, eds. Philadelphia, PA: WB Saunders
Wilson, C. B., Jones, P. W., O'Leary, C. J., Systemic markers of inflammation in stable bronchiectasis (1998) Eur Respir J, 12, pp. 820-824
Edwards, E. A., Narang, I., Li, A., HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis (2004) Eur Respir J, 24, pp. 538-544
Tsang, K. W., Tipoe, G., Sun, J., Clinical value of ciliary assessment in bronchiectasis (2005) Lung, 183, pp. 73-86
Rang, E. Y., Miller, R. R., Muller, N. L., Bronchiectasis: Comparison of preoperative thin-section CT and pathologic findings in resected specimens (1995) Radiology, 195, pp. 649-654
Brody, A. S., Scoring system for CT in cystic fibrosis: Who cares? (2004) Radiology, 231, pp. 296-298
(1997) Workshop on Surrogate Markers for CF, , Bethesda, MD: National Institute of Health
Brody, A. S., Sucharew, H., Campbell, J. D., Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis (2005) Am J Respir Crit Care Med, 172, pp. 1128-1132
Field, C. E., Bronchiectasis. Third report on a follow-up study of medical and surgical cases from childhood (1969) Arch Dis Child, 44, pp. 551-561
Pitney, A. C., Callahan, C. W., Ruess, L., Reversal of bronchiectasis caused by chronic aspiration in cri du chat syndrome (2001) Arch Dis Child, 85, pp. 413-414
Verleden, G. M., Dupont, L. J., Vanhaecke, J., Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: A case report (2005) J Heart Lung Transplant, 24, pp. 1155-1158
Chang, A. B., Grimwood, K., Mulholland, E. K., Bronchiectasis in Indigenous children in remote Australian communities (2002) Med J Aust, 177, pp. 200-204
Ip, M. S., So, S. Y., Lam, W. K., High prevalence of asthma in patients with bronchiectasis in Hong Kong (1992) Eur Respir J, 5, pp. 418-423
Gold, D. R., Tager, I. B., Weiss, S. T., Acute lower respiratory illness in childhood as a predictor of lung function and chronic respiratory symptoms (1989) Am Rev Respir Dis, 140, pp. 877-884
Shaheen, S. O., Barker, D. J., Shiell, A. W., The relationship between pneumonia in early childhood an impaired lung function in late adult life (1994) Am J Respir Crit Care Med, 149, pp. 616-619
Johnston, I. D., Strachan, D. P., Anderson, H. R., Effect of pneumonia and whooping cough in childhood on adult lung function (1998) N Engl J Med, 338, pp. 581-587
MacIntyre, C. R., McIntyre, P. B., Cagney, M., Community-based estimates of incidence and risk factors for childhood pneumonia in Western Sydney (2003) Epidemiol Infect, 131, pp. 1091-1096
Lung structure abnormalities, but normal lung function in pediatric bronchiectasis
Background: Bronchiectasis is not considered to be uncommon in children anymore. The relationship between pulmonary function and severity of bronchiectasis is still controversial. Study objectives: To assess the extent and severity of bronchiectasis through high-resolution CT (HRCT) scan score, and to correlate it with clinical, microbiological, and functional data. Patients and methods: Forty-three white children with HRCT-diagnosed bronchiectasis were studied. Bronchiectasis extent, bronchial wall thickening severity, and bronchial wall dilatation severity were evaluated using the Reiff score. Clinical, microbiological, and spirometry results were related to total HRCT scan score and to subscores as well. Results: The percentages of affected lobes were as follows: right lower lobe, 65%; middle lobe, 56%; left lower lobe, 51%; right upper lobe, 37%; lingula, 30%; and left upper lobe, 30% (χ2 = 18.4; p = 0.002). The mean (± SEM) HRCT score was 20 ± 2.6. Total score or subscores of bronchiectasis extent, bronchial wall thickening severity, and bronchial wall dilatation severity were not significantly related to FEV1 and FVC. Seventy-four percent of patients had asthma. The age at the onset of cough correlated with age at the time of the HRCT scan (p = 0.004) and with the presence of asthma (p = 0.01). Positive findings of deep throat or sputum cultures were found more frequently in atopic patients (p = 0.02) and asthmatic (p < 0.01) patients, and in children who were < 2 years of age at the onset of cough (p < 0.01). Conclusions: Normal lung function may coexist with HRCT scan abnormalities and does not exclude damage to the bronchial structure. Pulmonary function is not an accurate method for assessing the severity of lung disease in children with bronchiectasis.
Lung structure abnormalities, but normal lung function in pediatric bronchiectasis
No results.
Lung structure abnormalities, but normal lung function in pediatric bronchiectasis
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Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, Banerjee AK, Hackett S, Hurst JR, Warnatz K, Gathmann B, Weidemann J, Berthold D, Baumann U, Schutz K, Alecsandru D, Grimbacher B, Haddock J, Bruining A, Driessen G, De Vries E, Van Hagen PM, Hartmann I, Fraioli F, Milito C, Mitrevski M, Quinti I, Serra G, Kelleher P, Loebinger M, Litzman J, Postranecka V, Thon V, Babar J, Condliffe AM, Exley A, Kumararatne D, Screaton N, Jones A, Bondioni MP, Lougaris V, Plebani A, Soresina A, Sirignano C, Spadaro G, Galal N, Gonzalez-granado LI, Dettmer S, Stirling R, Chapel H, Lucas M, Patel S, Farber CM, Meyts I, B * Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group(148 views)(PDF 6 views) J Clin Immunol (ISSN: 0271-9142linking, 1573-2592), 2019 Jan; 3939(2): 45-54. Impact Factor:2.654 ViewExport to BibTeXExport to EndNote