Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.633, 5-year impact factor: 3.104
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33645658734&partnerID=40&md5=32b9d63d499e6078a35f6a60ec37dfe1
Keywords: Amino Acids, Biotechnology, Cytology, Enzymes, Bioinformatics Analysis, Inflammatory Cytokines, Structural Explanation, Synthetic Peptides, Molecular Dynamics, Alanine, Chemokine, Cyclopeptide, Glycine, Interleukin 6, Mitogen Activated Protein Kinase P38, Porin, Stress Activated Protein Kinase, Tumor Necrosis Factor Alpha, Amino Acid Sequence, Article, Bacterial Infection, Bacterial Membrane, Circular Dichroism, Cytokine Release, Enzyme Activation, Haemophilus Influenzae, Haemophilus Influenzae Type B, Human, Human Cell, Inflammation, Mutation, Nonhuman, Nucleotide Sequence, Pathogenesis, Priority Journal, Signal Transduction, Structure Activity Relation, Amino Acid Motifs, Bacterial Proteins, Computer Simulation, Inflammation Mediators, Map Kinase Kinase 1, Map Kinase Signaling System, Protein Structure, Secondary, Structure-Activity Relationship, Tumor Necrosis Factor-Alpha, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Naples, Italy
Department of Biological Sciences, University of Naples Federico II, Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Istituto di Chimica Biomolecolare-CNR, Sede di Pozzuoli, Comprensorio Olivetti, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
References:
Dufrene, Y.F., Using nanotechniques to explore microbial surfaces (2004) Nat. Rev. Microbiol., 2, pp. 451-46
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol. Lett., 199, pp. 1-7
Galdiero, M., Cipollaro De L'Ero, G., Donnarumma, G., Marcatili, A., Galdiero, F., Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins (1995) Immunology, 86, pp. 612-619
Galdiero, M., De Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro De L'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology, 94, pp. 5-13
Yi, K., Murphy, T.F., Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Sikkema, D.J., Murphy, T.F., Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae (1992) Infect. Immun., 60, pp. 5204-5211
Bell, J., Grass, S., Jeanteur, D., Munson Jr., R.S., Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates (1994) Infect. Immun., 62, pp. 2639-2643
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect. Immun., 71, pp. 2798-2809
Srikumar, R., Dahan, D., Gras, M.F., Ratcliffe, M.J., Van Alphen, L., Coulton, J.W., Antigenic sites on porin of Haemophilus influenzae type b: Mapping with synthetic peptides and evaluation of structure predictions (1992) J. Bacteriol., 174, pp. 4007-4016
Saint, N., Lou, K.L., Widmer, C., Luckey, M., Schirmer, T., Rosenbusch, J.P., Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization (1996) J. Biol. Chem., 271, pp. 20676-20680
Dinarello, C.A., The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome (1991) J. Infect. Dis., 163, pp. 1177-1184
Van Snick, J., Interleukin-6: An overview (1990) Annu. Rev. Immunol., 8, pp. 253-278
Van Amersfoort, E.S., Van Berkel, T.J., Kuiper, J., Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock (2003) Clin. Microbiol. Rev., 16, pp. 379-414
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med. Microbiol. Immunol., 194, pp. 13-23
Rawadi, G., Dussurget, O., Advances in PCR-based detection of mycoplasmas contaminating cell cultures (1995) PCR Methods Appl., 4, pp. 199-208
Coulton, J.W., Wan, I.F., The outer membrane of Haemophilus influenzae type b: Cell envelope associations of major proteins (1983) Can. J. Microbiol., 29, pp. 280-287
Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., Tortora, A., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect. Immun., 69, pp. 221-227
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Polin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., Bradshaw, R.A., Wessler, S., Luderity, O., Sarmiento, M.F., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid a from Gram-negative bacteria (1972) Biochim. Blophys. Acta, 261, pp. 284-289
Nikaido, H., Rosenberg, E.Y., Porin channels in Escherichia coli: Studies with liposomes reconstituted from purified proteins (1983) J. Bacteriol., 153, pp. 241-252
Bonny, C., Oberson, A., Negri, S., Sauser, C., Schorderet, D.F., Cell-permeable peptide inhibitors of JNK: Novel blockers of beta-cell death (2001) Diabetes, 50, pp. 77-82
Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Yang, P.R., Lee, J.C., SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 (1995) FEBS Lett., 364, pp. 229-233
Singh, J., Chuaqui, C.E., Boriack-Sjodin, P.A., Lee, W.C., Pontz, T., Corbley, M.J., Cheung, H.K., Ling, L.E., Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI) (2003) Bioorg. Med. Chem. Lett., 13, pp. 4355-4359
Chakrabartty, A., Kortemme, T., Baldwin, R.L., Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions (1994) Protein Sci., 3, pp. 843-852
Simmerling, C.L., Darden, T.A., Merz, K.M., Stanton, R.V., Cheng, A.L., Vincent, J.J., Crowley, M., Duan, Y., (1999) AMBER 6, , University of California, San Francisco, CA
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 51-55
Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res., 25, pp. 3389-3402
Cornell, W.D., Cieplak, P., Bayly, C.I., Gould, I.R., Merz Jr., K.M., Ferguson, D.M., Spellmeyer, D.C., Kollman, P.A., A second generation force field for the simulation of proteins, nucleic acids, and organic molecules (1995) J. Am. Chem. Soc., 117, pp. 5179-5197
Saviano, G., Benedetti, E., Cozzolino, R., De Capua, A., Laccetti, P., Palladino, P., Zanotti, G., Rossi, F., Influence of conformational flexibility on biological activity in cyclic astin analogues (2004) Biopolymers, 76, pp. 477-484
Jorgensen, W.L., Chandrasekhar, J., Madura, J., Klein, M.L., Comparison of simple potential functions for simulating liquid water (1983) J. Chem. Phys., 79, pp. 926-935
Vitale, R.M., Zaccaro, L., Di Blasio, B., Fattorusso, R., Isernia, C., Amodeo, P., Pedone, C., Saviano, M., Conformational features of human melanin-concentrating hormone: An NMR and computational analysis (2003) ChemBioChem, 4, pp. 73-81
Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N., Bourne, P.E., The protein data bank (2000) Nucleic Acids Res., 28, pp. 235-242
Hutchinson, E.G., Thornton, J.M., A revised set of potentials for beta-turn formation in proteins (1994) Protein Sci., 3, pp. 2207-2216
Abad-Zapatero, C., Goldman, R., Muchmore, S.W., Hutchins, C., Stewart, K., Navaza, J., Payne, C.D., Ray, T.L., Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: Implications for the design of antifungal agents (1996) Protein Sci., 5, pp. 640-652
Li, S., Kelly, S.J., Lamani, E., Ferraroni, M., Jedrzejas, M.J., Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase (2000) EMBO J., 19, pp. 1228-1240
Singh, S.K., Matsuno, K., LaPorte, D.C., Banaszak, L.J., Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 Å. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase (2001) J. Biol. Chem., 276, pp. 26154-26163
Muller, D.J., Engel, A., Voltage and pH-induced channel closure of porin OmpF visualized by atomic force microscopy (1999) J. Mol. Biol., 285, pp. 1347-1351
Massari, P., Ram, S., Macleod, H., Wetzler, L.M., The role of porins in neisserial pathogenesis and immunity (2003) Trends Microbiol., 11, pp. 87-93
Dufrene, Y. F., Using nanotechniques to explore microbial surfaces (2004) Nat. Rev. Microbiol., 2, pp. 451-46
Yi, K., Murphy, T. F., Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Sikkema, D. J., Murphy, T. F., Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae (1992) Infect. Immun., 60, pp. 5204-5211
Saint, N., Lou, K. L., Widmer, C., Luckey, M., Schirmer, T., Rosenbusch, J. P., Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization (1996) J. Biol. Chem., 271, pp. 20676-20680
Dinarello, C. A., The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome (1991) J. Infect. Dis., 163, pp. 1177-1184
Van Amersfoort, E. S., Van Berkel, T. J., Kuiper, J., Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock (2003) Clin. Microbiol. Rev., 16, pp. 379-414
Coulton, J. W., Wan, I. F., The outer membrane of Haemophilus influenzae type b: Cell envelope associations of major proteins (1983) Can. J. Microbiol., 29, pp. 280-287
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Polin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E. T., Galanos, C., Kinsky, S., Bradshaw, R. A., Wessler, S., Luderity, O., Sarmiento, M. F., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid a from Gram-negative bacteria (1972) Biochim. Blophys. Acta, 261, pp. 284-289
Simmerling, C. L., Darden, T. A., Merz, K. M., Stanton, R. V., Cheng, A. L., Vincent, J. J., Crowley, M., Duan, Y., (1999) AMBER 6, , University of California, San Francisco, CA
Altschul, S. F., Madden, T. L., Sch ffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res., 25, pp. 3389-3402
Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz Jr., K. M., Ferguson, D. M., Spellmeyer, D. C., Kollman, P. A., A second generation force field for the simulation of proteins, nucleic acids, and organic molecules (1995) J. Am. Chem. Soc., 117, pp. 5179-5197
Jorgensen, W. L., Chandrasekhar, J., Madura, J., Klein, M. L., Comparison of simple potential functions for simulating liquid water (1983) J. Chem. Phys., 79, pp. 926-935
Vitale, R. M., Zaccaro, L., Di Blasio, B., Fattorusso, R., Isernia, C., Amodeo, P., Pedone, C., Saviano, M., Conformational features of human melanin-concentrating hormone: An NMR and computational analysis (2003) ChemBioChem, 4, pp. 73-81
Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., Bourne, P. E., The protein data bank (2000) Nucleic Acids Res., 28, pp. 235-242
Hutchinson, E. G., Thornton, J. M., A revised set of potentials for beta-turn formation in proteins (1994) Protein Sci., 3, pp. 2207-2216
Li, S., Kelly, S. J., Lamani, E., Ferraroni, M., Jedrzejas, M. J., Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase (2000) EMBO J., 19, pp. 1228-1240
Singh, S. K., Matsuno, K., LaPorte, D. C., Banaszak, L. J., Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1. 55. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase (2001) J. Biol. Chem., 276, pp. 26154-26163
Muller, D. J., Engel, A., Voltage and pH-induced channel closure of porin OmpF visualized by atomic force microscopy (1999) J. Mol. Biol., 285, pp. 1347-1351
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.633, 5-year impact factor: 3.104
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33645658734&partnerID=40&md5=32b9d63d499e6078a35f6a60ec37dfe1
Keywords: Amino Acids, Biotechnology, Cytology, Enzymes, Bioinformatics Analysis, Inflammatory Cytokines, Structural Explanation, Synthetic Peptides, Molecular Dynamics, Alanine, Chemokine, Cyclopeptide, Glycine, Interleukin 6, Mitogen Activated Protein Kinase P38, Porin, Stress Activated Protein Kinase, Tumor Necrosis Factor Alpha, Amino Acid Sequence, Article, Bacterial Infection, Bacterial Membrane, Circular Dichroism, Cytokine Release, Enzyme Activation, Haemophilus Influenzae, Haemophilus Influenzae Type B, Human, Human Cell, Inflammation, Mutation, Nonhuman, Nucleotide Sequence, Pathogenesis, Priority Journal, Signal Transduction, Structure Activity Relation, Amino Acid Motifs, Bacterial Proteins, Computer Simulation, Inflammation Mediators, Map Kinase Kinase 1, Map Kinase Signaling System, Protein Structure, Secondary, Structure-Activity Relationship, Tumor Necrosis Factor-Alpha, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Naples, Italy
Department of Biological Sciences, University of Naples Federico II, Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Istituto di Chimica Biomolecolare-CNR, Sede di Pozzuoli, Comprensorio Olivetti, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
References:
Dufrene, Y.F., Using nanotechniques to explore microbial surfaces (2004) Nat. Rev. Microbiol., 2, pp. 451-46
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol. Lett., 199, pp. 1-7
Galdiero, M., Cipollaro De L'Ero, G., Donnarumma, G., Marcatili, A., Galdiero, F., Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins (1995) Immunology, 86, pp. 612-619
Galdiero, M., De Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro De L'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology, 94, pp. 5-13
Yi, K., Murphy, T.F., Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Sikkema, D.J., Murphy, T.F., Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae (1992) Infect. Immun., 60, pp. 5204-5211
Bell, J., Grass, S., Jeanteur, D., Munson Jr., R.S., Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates (1994) Infect. Immun., 62, pp. 2639-2643
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect. Immun., 71, pp. 2798-2809
Srikumar, R., Dahan, D., Gras, M.F., Ratcliffe, M.J., Van Alphen, L., Coulton, J.W., Antigenic sites on porin of Haemophilus influenzae type b: Mapping with synthetic peptides and evaluation of structure predictions (1992) J. Bacteriol., 174, pp. 4007-4016
Saint, N., Lou, K.L., Widmer, C., Luckey, M., Schirmer, T., Rosenbusch, J.P., Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization (1996) J. Biol. Chem., 271, pp. 20676-20680
Dinarello, C.A., The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome (1991) J. Infect. Dis., 163, pp. 1177-1184
Van Snick, J., Interleukin-6: An overview (1990) Annu. Rev. Immunol., 8, pp. 253-278
Van Amersfoort, E.S., Van Berkel, T.J., Kuiper, J., Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock (2003) Clin. Microbiol. Rev., 16, pp. 379-414
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med. Microbiol. Immunol., 194, pp. 13-23
Rawadi, G., Dussurget, O., Advances in PCR-based detection of mycoplasmas contaminating cell cultures (1995) PCR Methods Appl., 4, pp. 199-208
Coulton, J.W., Wan, I.F., The outer membrane of Haemophilus influenzae type b: Cell envelope associations of major proteins (1983) Can. J. Microbiol., 29, pp. 280-287
Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., Tortora, A., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect. Immun., 69, pp. 221-227
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Polin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., Bradshaw, R.A., Wessler, S., Luderity, O., Sarmiento, M.F., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid a from Gram-negative bacteria (1972) Biochim. Blophys. Acta, 261, pp. 284-289
Nikaido, H., Rosenberg, E.Y., Porin channels in Escherichia coli: Studies with liposomes reconstituted from purified proteins (1983) J. Bacteriol., 153, pp. 241-252
Bonny, C., Oberson, A., Negri, S., Sauser, C., Schorderet, D.F., Cell-permeable peptide inhibitors of JNK: Novel blockers of beta-cell death (2001) Diabetes, 50, pp. 77-82
Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Yang, P.R., Lee, J.C., SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 (1995) FEBS Lett., 364, pp. 229-233
Singh, J., Chuaqui, C.E., Boriack-Sjodin, P.A., Lee, W.C., Pontz, T., Corbley, M.J., Cheung, H.K., Ling, L.E., Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI) (2003) Bioorg. Med. Chem. Lett., 13, pp. 4355-4359
Chakrabartty, A., Kortemme, T., Baldwin, R.L., Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions (1994) Protein Sci., 3, pp. 843-852
Simmerling, C.L., Darden, T.A., Merz, K.M., Stanton, R.V., Cheng, A.L., Vincent, J.J., Crowley, M., Duan, Y., (1999) AMBER 6, , University of California, San Francisco, CA
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 51-55
Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res., 25, pp. 3389-3402
Cornell, W.D., Cieplak, P., Bayly, C.I., Gould, I.R., Merz Jr., K.M., Ferguson, D.M., Spellmeyer, D.C., Kollman, P.A., A second generation force field for the simulation of proteins, nucleic acids, and organic molecules (1995) J. Am. Chem. Soc., 117, pp. 5179-5197
Saviano, G., Benedetti, E., Cozzolino, R., De Capua, A., Laccetti, P., Palladino, P., Zanotti, G., Rossi, F., Influence of conformational flexibility on biological activity in cyclic astin analogues (2004) Biopolymers, 76, pp. 477-484
Jorgensen, W.L., Chandrasekhar, J., Madura, J., Klein, M.L., Comparison of simple potential functions for simulating liquid water (1983) J. Chem. Phys., 79, pp. 926-935
Vitale, R.M., Zaccaro, L., Di Blasio, B., Fattorusso, R., Isernia, C., Amodeo, P., Pedone, C., Saviano, M., Conformational features of human melanin-concentrating hormone: An NMR and computational analysis (2003) ChemBioChem, 4, pp. 73-81
Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N., Bourne, P.E., The protein data bank (2000) Nucleic Acids Res., 28, pp. 235-242
Hutchinson, E.G., Thornton, J.M., A revised set of potentials for beta-turn formation in proteins (1994) Protein Sci., 3, pp. 2207-2216
Abad-Zapatero, C., Goldman, R., Muchmore, S.W., Hutchins, C., Stewart, K., Navaza, J., Payne, C.D., Ray, T.L., Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: Implications for the design of antifungal agents (1996) Protein Sci., 5, pp. 640-652
Li, S., Kelly, S.J., Lamani, E., Ferraroni, M., Jedrzejas, M.J., Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase (2000) EMBO J., 19, pp. 1228-1240
Singh, S.K., Matsuno, K., LaPorte, D.C., Banaszak, L.J., Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 Å. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase (2001) J. Biol. Chem., 276, pp. 26154-26163
Muller, D.J., Engel, A., Voltage and pH-induced channel closure of porin OmpF visualized by atomic force microscopy (1999) J. Mol. Biol., 285, pp. 1347-1351
Massari, P., Ram, S., Macleod, H., Wetzler, L.M., The role of porins in neisserial pathogenesis and immunity (2003) Trends Microbiol., 11, pp. 87-93
Dufrene, Y. F., Using nanotechniques to explore microbial surfaces (2004) Nat. Rev. Microbiol., 2, pp. 451-46
Yi, K., Murphy, T. F., Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Sikkema, D. J., Murphy, T. F., Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae (1992) Infect. Immun., 60, pp. 5204-5211
Saint, N., Lou, K. L., Widmer, C., Luckey, M., Schirmer, T., Rosenbusch, J. P., Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization (1996) J. Biol. Chem., 271, pp. 20676-20680
Dinarello, C. A., The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome (1991) J. Infect. Dis., 163, pp. 1177-1184
Van Amersfoort, E. S., Van Berkel, T. J., Kuiper, J., Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock (2003) Clin. Microbiol. Rev., 16, pp. 379-414
Coulton, J. W., Wan, I. F., The outer membrane of Haemophilus influenzae type b: Cell envelope associations of major proteins (1983) Can. J. Microbiol., 29, pp. 280-287
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Polin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
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Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae
Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children, characterized by inflammation mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. Synthetic peptides corresponding to loops L5, L6, and L7 activate JNK and p38 mitogen-activated protein kinase (MAPK) pathways, L7 being the most active peptide. Therefore, sequence-activity relationships and key residues were identified by elongating sequence to different extents, designing cyclic peptides, and performing an alanine scan of L7. The ability of mutant peptides to induce activation of signal transduction pathways and release of TNF-alpha and IL-6 has been determined, and, in conjunction with CD spectra, bioinformatics analysis, and molecular dynamics data, showed that 6 out of 8 amino acids contribute significantly to the overall activity. Molecular dynamics showed that L7 modifications increased loop rigidity and helicity after Gly6 mutation, thus, providing a possible structural explanation for observed loss of bioactivity. This work provides insights into essential molecular details of P2 that may impact on the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.
Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children, characterized by inflammation mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. Synthetic peptides corresponding to loops L5, L6, and L7 activate JNK and p38 mitogen-activated protein kinase (MAPK) pathways, L7 being the most active peptide. Therefore, sequence-activity relationships and key residues were identified by elongating sequence to different extents, designing cyclic peptides, and performing an alanine scan of L7. The ability of mutant peptides to induce activation of signal transduction pathways and release of TNF-alpha and IL-6 has been determined, and, in conjunction with CD spectra, bioinformatics analysis, and molecular dynamics data, showed that 6 out of 8 amino acids contribute significantly to the overall activity. Molecular dynamics showed that L7 modifications increased loop rigidity and helicity after Gly6 mutation, thus, providing a possible structural explanation for observed loss of bioactivity. This work provides insights into essential molecular details of P2 that may impact on the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.
Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae
Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (853 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Lucignani G, Salvatore M
* Biotechnology in molecular and cellular imaging (312 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009; 21(1): 1-3.
Impact Factor: 0.268
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (512 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (553 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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De Simone A, Berisio R, Zagari A, Vitagliano L
* Limited Tendency Of Alpha-Helical Residues To Form Disulfide Bridges: A Structural Explanation (485 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 740-747.
Impact Factor: 1.801
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (493 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (597 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
Impact Factor: 3.633
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (484 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* A new spot test for sulfhydryl-containing compounds (450 views)
Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
Impact Factor: 2.305
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (738 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
Impact Factor: 3.633
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Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
* Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (388 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (575 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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De Luca S, Della Moglie R, De Capua A, Morelli G
* New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides (447 views)
Tetrahedron Lett (ISSN: 0040-4039), 2005 Sep 26; 46(39): 6637-6640.
Impact Factor: 2.477
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Improta R, Antonello S, Formaggio F, Maran F, Rega N, Barone V
* Understanding Electron Transfer across Negatively-Charged Aib Oligopeptides (575 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2005 Jan 20; 109(2): 1023-1033.
Impact Factor: 4.033
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (419 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (375 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, Amodeo P, Tancredi T, Laccetti P, Corbier C, Benedetti E
* New antitumour cyclic astin analogues: Synthesis, conformation and bioactivity (445 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 Feb; 10(2): 92-102.
Impact Factor: 1.652
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Zarivach R, Bashan A, Berisio R, Harms J, Auerbach T, Schluenzen F, Bartels H, Baram D, Pyetan E, Sittner A, Amit M, Hansen HAS, Kessler M, Liebe C, Wolff A, Agmon I, Yonath A
* Functional aspects of ribosomal architecture: Symmetry, chirality and regulation (475 views)
J Phys Org Chem (ISSN: 0894-3230), 2004; 17(11): 901-912.
Impact Factor: 1.211
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Formaggio F, Crisma M, Toniolo C, Broxterman QB, Kaptein B, Corbier C, Saviano M, Palladino P, Benedetti E
* Cα-Methyl, Cα-n-Propylglycine Homo-oligomers (306 views)
Macromolecules (ISSN: 0024-9297), 2003; 36(21): 8164-8170.
Impact Factor: 3.621
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D'Amore M, Improta R, Barone V
* Conformational behavior and magnetic properties of a nitroxide amino acid derivative in vacuo and in aqueous solution (238 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2003; 107(32): 6264-6269.
Impact Factor: 2.792
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Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Impact Factor: 2.733
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1283 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (512 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
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Pavone V, Lombardi A, Saviano M, De Simone G, Nastri F, Maglio O, Omote Y, Yamanaka Y, Yamada T
Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues (407 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 161-168.
Impact Factor: 2.405
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De Simone G, Lombardi A, Galdiero S, Nastri F, Di Costanzo L, Gohda S, Sano A, Yamada T, Pavone V
The crystal structure of a Dcp-containing peptide (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 182-188.
Impact Factor: 2.405
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Lombardi A, De Simone G, Galdiero S, Nastri F, Di Costanzo L, Makihiara K, Yamada T, Pavone V
The crystal structure of Afc-containing peptide (427 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 150-160.
Impact Factor: 2.405
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Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (533 views)
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
Impact Factor: 0.406
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Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
Impact Factor: 1.311
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Campagna T, Grasso G, Rizzarelli E, Vecchio G
L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (333 views)
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
Impact Factor: 1.454
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Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (313 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
Impact Factor: 0.557
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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Bonomo RP, Pedotti S, Vecchio G, Rizzarelli E
Molecular Recognition of Amino Acids by Copper(II) Complexes of 6A, 6X-Diamino-6A, 6 X-dideoxy-β-cyclodextrin (X = B, C, D) (254 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Nov 6; 35(23): 6873-6877.
Impact Factor: 2.736
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Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (512 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
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Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (400 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
Impact Factor: 2.425
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Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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Pavone V, Di Blasio B, Lombardi A, Maglio O, Isernia C, Pedone C, Benedetti E, Altmann E, Mutter M
Non coded C alpha, alpha-disubstituted amino acids. X-ray diffraction analysis of a dipeptide containing (S)-alpha-methylserine (370 views)
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print, 0367-8377linking), 1993 Jan; 41(1): 15-20.
Impact Factor: 1.255
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Lombardi A, Maglio O, Pavone B, Di Blasio V, Saviano M, Nastri F, Pedone C, Benedetti E
Pt(II) Complexes of Amino Acids and Peptides. III. X-Ray Diffraction Study of trans-[Cl-(Ph3P)-Pt-(H-Aib-O-)] (414 views)
Inorg Chim Acta, 1993; 204: 87-92.
Impact Factor: 0
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Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (429 views)
Inorg Chim Acta, 1992; 196: 241-246.
Impact Factor: 0
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Della Ragione F, Oliva A, Gragnaniello V, Russo GL, Palumbo R, Zappia V
Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase (26 views) (PDF 8 views)
J Biol Chem (ISSN: 0021-9258linking), 1990 Apr 15; 265(11): 6241-6246.
Impact Factor: 5.328
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Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2114 views)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
Impact Factor: 0
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Gomez Palacios LR, Bracamonte AG
Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation (1 views)
Rsc Adv (ISSN: 2046-2069electronic), N/D; 12 (20 ): 12806-12822.
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* Synthesis, Characterization, and Study of Catalytic Activity of Chiral Cu(II) and Ni(II) Salen Complexes in the α-Amino Acid C-α Alkylation Reaction (6 views)
Molecules, 2023 Jan 25; 28: 1180-1196.
Impact Factor: 4.927
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Baker S, Gilhen-baker M, Roviello GN
* The Role of Nutrition and Forest-Bathing in the Physical Rehabilitation of Physically Inactive Patients: From the Molecular Aspects to New Nature-Inspired Techniques (20 views)
International Journal Of Environmental Research And Public Health, 2023 Jan; 20: 793-805.
Impact Factor: 4.614
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 13; 13(16): N/D-N/D.
Impact Factor: 6.126
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Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
* Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity (209 views) (PDF 75 views)
Spectrochim Acta A (ISSN: 1386-1425linking), 2020 Mar 15; 229: 117884-117884.
Impact Factor: 3.232
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Doti N, Caporale A, Monti A, Sandomenico A, Selis F, Ruvo M
* A recent update on the use of microbial transglutaminase for the generation of biotherapeutics (88 views)
World J Microbiol Biotechnol (ISSN: 0959-3993linking), 2020 Mar 14; 36(4): 53-53.
Impact Factor: 2.477
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Vincenzi M, Mercurio FA, Leone M
* About TFE: Old and New Findings (101 views)
Curr Protein Pept Sci (ISSN: 1389-2037linking), 2019; 20 (5 ): 425-451.
Impact Factor: 3.011
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Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (279 views)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
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Zambrano G, Ruggiero E, Malafronte A, Chino M, Maglio O, Pavone V, Nastri F, Lombardi A
* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (242 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Impact Factor: 3.687
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (364 views)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
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Grage SL, Kara S, Bordessa A, Doan V, Rizzolo F, Putzu M, Kubar T, Papini AM, Chaume G, Brigaud T, Afonin S, Ulrich AS
* Orthogonal (19) F-Labeling for Solid-State NMR Spectroscopy Reveals the Conformation and Orientation of Short Peptaibols in Membranes (347 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Jan 11; N/D: N/D-N/D.
Impact Factor: 5.476
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Magri A, Pietropaolo A, Tabbì G, La Mendola D, Rizzarelli E
* From Peptide Fragments to Whole Protein: Copper(II) Load and Coordination Features of IAPP (600 views) (PDF 116 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Dec 19; 23(71): 17898-17902.
Impact Factor: 5.16
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Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (416 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
* Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications (406 views) (PDF 160 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Dec 8; 180: 89-100.
Impact Factor: 3.063
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (389 views) (PDF 179 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
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Calce E, De Luca S
* The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences (400 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Aug 19; 22: 1-11.
Impact Factor: 5.317
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (392 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (503 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
Impact Factor: 3.108
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Merlino F, Brancaccio D, Yousif AM, Piras L, Campiglia P, Gomez-monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Carotenuto A, Grieco P
* Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position9 (378 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2016; N/D: N/D-N/D.
Impact Factor: 3.225
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Cerutti E, Viale A, Nervi C, Gobetto R, Aime S
* The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids (215 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2015 Nov 19; 119(46): 11271-11279.
Impact Factor: 2.883
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Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
* An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (447 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 22; 13(17): 4859-4868.
Impact Factor: 3.559
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Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (630 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
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Guaragna A, Roviello GN, D'Errico S, Paolella C, Palumbo G, D'Alonzo D
* Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy (421 views)
Tetrahedron Lett (ISSN: 0040-4039), 2015 Feb 4; 56(6): 775-778.
Impact Factor: 2.347
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (1089 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
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Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (531 views)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
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Caso JV, Russo L, Palmieri M, Malgieri G, Galdiero S, Falanga A, Isernia C, Iacovino R
* Investigating the inclusion properties of aromatic amino acids complexing beta-cyclodextrins in model peptides (418 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; N/D: N/D-N/D.
Impact Factor: 3.196
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Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
* Probing the molecular origin of native-state flexibility in repeat proteins (353 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
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Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
* Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (411 views)
Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
Impact Factor: 3.289
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Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (490 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Giuffrida A, Maccarrone G, Cucinotta V, Orlandini S, Contino A
* Recent advances in chiral separation of amino acids using capillary electromigration techniques (178 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2014 Oct 10; 1363: 41-50.
Impact Factor: 4.169
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1013 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (523 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (356 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
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Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (368 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
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Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (425 views)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (357 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (503 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
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Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
* RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (478 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2011 Apr 14; 54(7): 2095-2101.
Impact Factor: 5.248
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Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (357 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M
* Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (464 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183.
Impact Factor: 3.607
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (507 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
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Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A
* Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry (481 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Apr; 38(4): 1031-1041.
Impact Factor: 4.106
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Mazzaglia A, Micali N, Scolaro LM, Attanasio F, Magrí A, Pappalardo G, Villari V
* Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: A comparative study with two PEG-conjugated variants of the human sequence (440 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Jan 21; 114(2): 705-713.
Impact Factor: 3.603
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Erratum: Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (Amino Acids DOI: 10. 1007/s00726-009-0324-x) (311 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010; 38(5): 1311-1312.
Impact Factor: 4.106
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (853 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Lucignani G, Salvatore M
* Biotechnology in molecular and cellular imaging (312 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009; 21(1): 1-3.
Impact Factor: 0.268
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (512 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (553 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
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De Simone A, Berisio R, Zagari A, Vitagliano L
* Limited Tendency Of Alpha-Helical Residues To Form Disulfide Bridges: A Structural Explanation (485 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 740-747.
Impact Factor: 1.801
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (493 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (597 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
Impact Factor: 3.633
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (484 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* A new spot test for sulfhydryl-containing compounds (450 views)
Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
Impact Factor: 2.305
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (738 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
Impact Factor: 3.633
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Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
* Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (388 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (575 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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De Luca S, Della Moglie R, De Capua A, Morelli G
* New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides (447 views)
Tetrahedron Lett (ISSN: 0040-4039), 2005 Sep 26; 46(39): 6637-6640.
Impact Factor: 2.477
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Improta R, Antonello S, Formaggio F, Maran F, Rega N, Barone V
* Understanding Electron Transfer across Negatively-Charged Aib Oligopeptides (575 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2005 Jan 20; 109(2): 1023-1033.
Impact Factor: 4.033
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (419 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (375 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, Amodeo P, Tancredi T, Laccetti P, Corbier C, Benedetti E
* New antitumour cyclic astin analogues: Synthesis, conformation and bioactivity (445 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 Feb; 10(2): 92-102.
Impact Factor: 1.652
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Zarivach R, Bashan A, Berisio R, Harms J, Auerbach T, Schluenzen F, Bartels H, Baram D, Pyetan E, Sittner A, Amit M, Hansen HAS, Kessler M, Liebe C, Wolff A, Agmon I, Yonath A
* Functional aspects of ribosomal architecture: Symmetry, chirality and regulation (475 views)
J Phys Org Chem (ISSN: 0894-3230), 2004; 17(11): 901-912.
Impact Factor: 1.211
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Formaggio F, Crisma M, Toniolo C, Broxterman QB, Kaptein B, Corbier C, Saviano M, Palladino P, Benedetti E
* Cα-Methyl, Cα-n-Propylglycine Homo-oligomers (306 views)
Macromolecules (ISSN: 0024-9297), 2003; 36(21): 8164-8170.
Impact Factor: 3.621
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D'Amore M, Improta R, Barone V
* Conformational behavior and magnetic properties of a nitroxide amino acid derivative in vacuo and in aqueous solution (238 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2003; 107(32): 6264-6269.
Impact Factor: 2.792
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Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Impact Factor: 2.733
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1283 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (512 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
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Pavone V, Lombardi A, Saviano M, De Simone G, Nastri F, Maglio O, Omote Y, Yamanaka Y, Yamada T
Conformational behavior of C(α, α)-diphenyl glycine: Extended conformation in tripeptides containing consecutive Dφg residues (407 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 161-168.
Impact Factor: 2.405
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De Simone G, Lombardi A, Galdiero S, Nastri F, Di Costanzo L, Gohda S, Sano A, Yamada T, Pavone V
The crystal structure of a Dcp-containing peptide (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 182-188.
Impact Factor: 2.405
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Lombardi A, De Simone G, Galdiero S, Nastri F, Di Costanzo L, Makihiara K, Yamada T, Pavone V
The crystal structure of Afc-containing peptide (427 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 150-160.
Impact Factor: 2.405
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Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (533 views)
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
Impact Factor: 0.406
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Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
Impact Factor: 1.311
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Campagna T, Grasso G, Rizzarelli E, Vecchio G
L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (333 views)
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
Impact Factor: 1.454
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Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (313 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
Impact Factor: 0.557
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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Bonomo RP, Pedotti S, Vecchio G, Rizzarelli E
Molecular Recognition of Amino Acids by Copper(II) Complexes of 6A, 6X-Diamino-6A, 6 X-dideoxy-β-cyclodextrin (X = B, C, D) (254 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Nov 6; 35(23): 6873-6877.
Impact Factor: 2.736
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Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (512 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
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Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (400 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
Impact Factor: 2.425
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Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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Pavone V, Di Blasio B, Lombardi A, Maglio O, Isernia C, Pedone C, Benedetti E, Altmann E, Mutter M
Non coded C alpha, alpha-disubstituted amino acids. X-ray diffraction analysis of a dipeptide containing (S)-alpha-methylserine (370 views)
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print, 0367-8377linking), 1993 Jan; 41(1): 15-20.
Impact Factor: 1.255
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Lombardi A, Maglio O, Pavone B, Di Blasio V, Saviano M, Nastri F, Pedone C, Benedetti E
Pt(II) Complexes of Amino Acids and Peptides. III. X-Ray Diffraction Study of trans-[Cl-(Ph3P)-Pt-(H-Aib-O-)] (414 views)
Inorg Chim Acta, 1993; 204: 87-92.
Impact Factor: 0
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Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (429 views)
Inorg Chim Acta, 1992; 196: 241-246.
Impact Factor: 0
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Della Ragione F, Oliva A, Gragnaniello V, Russo GL, Palumbo R, Zappia V
Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase (26 views) (PDF 8 views)
J Biol Chem (ISSN: 0021-9258linking), 1990 Apr 15; 265(11): 6241-6246.
Impact Factor: 5.328
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Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2114 views)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
Impact Factor: 0
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Gomez Palacios LR, Bracamonte AG
Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation (1 views)
Rsc Adv (ISSN: 2046-2069electronic), N/D; 12 (20 ): 12806-12822.
Impact Factor:
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106 Records (105 excluding Abstracts).
Total impact factor: 350.732 (347.849 excluding Abstracts).
Total 5 year impact factor: 351.348 (348.639 excluding Abstracts).
Total impact factor: 350.732 (347.849 excluding Abstracts).
Total 5 year impact factor: 351.348 (348.639 excluding Abstracts).
514 views. Last view on Friday 24 February 2023, 6:50:40
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