Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?(325 views) Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
Department of Pediatrics, Child Neurology Unit, Federico II University, Naples, Italy
Neuroradiology Department, S.Chiara Hospital, University of Pisa, Pisa, Italy
Biostructure and Bioimaging Institute, Department of Radiology, Federico II University, Naples, Italy
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Kaufman, A. S., Factor analysis of the WISC-R at 11 age levels between 61/2 and 161/2 years (1975) J Cons Clin Psychol, 43, pp. 135-147
Kaufman, A. S., (1990) Assessing Adolescent and Adult Intelligence, , Boston: Allyn and Bacon
Kim, S. K., Na, D. G., Byun, H. S., Focal cortical dysplasia: Comparison of MRI and FDG-PET (2000) J Comput Assist Tomogr, 24, pp. 296-302
Lawson, J. A., Birchansky, S., Pacheco, E., Distinct clinicopathologic subtypes of cortical dysplasia of Taylor (2005) Neurology, 64, pp. 55-61
Reynolds, C. R., Bigler, E. D., (1995) Test of Memory and Learning (TOMAL), , Trento: Erickson
Siegel, A. M., Cascino, G. D., Elger, C. E., Adult-onset epilepsy in focal cortical dysplasia of Taylor type (2005) Neurology, 64, pp. 1771-1774
Sisodiya, S. M., Lin, W. R., Harding, B. N., Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy (2002) Brain, 125, pp. 22-31
Stephen, L. J., Kwan, P., Brodie, M. J., Does the cause of localisation - related epilepsy influence the response to antiepileptic drug treatment? (2001) Epilepsia, 42, pp. 357-362
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment.
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
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Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?