Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (345 views)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
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Paper type: Journal Article, Case Reports,
Impact factor: 1.202, 5-year impact factor: 1.128
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845487882&partnerID=40&md5=2e3b9f4af20b86eeef0cfaa1dc372b18
Keywords: Cortical Dysplasia, Dysplastic Lesion, Natural Evolution, Taylor-Type Focal Cortical Dysplasia, Carbamazepine, Fluorodeoxyglucose, Gadolinium, Phenobarbital, Vigabatrin, Adolescent, Article, Brain Cortex Lesion, Case Report, Clinical Feature, Cognition, Epilepsy, Female, Follow Up, Human, Monotherapy, Motor Coordination, Neuroimaging, Neurologic Disease, Neurologic Examination, Neuropsychology, Nuclear Magnetic Resonance Imaging, Preschool Child, Priority Journal, Seizure, Single Photon Emission Computer Tomography, Working Memory, Anticonvulsants, Attention, Cerebral Cortex, Epilepsies, Partial, Psychomotor Performance, Remission, Spontaneous, Emission-Computed, Single-Photon, Therapeutic Use, Radiography, Abnormalities, Pathology, Drug Therapy, Parasitology, Physiopathology,
Affiliations:
*** IBB - CNR ***
Department of Pediatrics, Child Neurology Unit, Federico II University, Naples, Italy
Neuroradiology Department, S.Chiara Hospital, University of Pisa, Pisa, Italy
Biostructure and Bioimaging Institute, Department of Radiology, Federico II University, Naples, Italy
References:
Not available.
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Case Reports,
Impact factor: 1.202, 5-year impact factor: 1.128
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845487882&partnerID=40&md5=2e3b9f4af20b86eeef0cfaa1dc372b18
Keywords: Cortical Dysplasia, Dysplastic Lesion, Natural Evolution, Taylor-Type Focal Cortical Dysplasia, Carbamazepine, Fluorodeoxyglucose, Gadolinium, Phenobarbital, Vigabatrin, Adolescent, Article, Brain Cortex Lesion, Case Report, Clinical Feature, Cognition, Epilepsy, Female, Follow Up, Human, Monotherapy, Motor Coordination, Neuroimaging, Neurologic Disease, Neurologic Examination, Neuropsychology, Nuclear Magnetic Resonance Imaging, Preschool Child, Priority Journal, Seizure, Single Photon Emission Computer Tomography, Working Memory, Anticonvulsants, Attention, Cerebral Cortex, Epilepsies, Partial, Psychomotor Performance, Remission, Spontaneous, Emission-Computed, Single-Photon, Therapeutic Use, Radiography, Abnormalities, Pathology, Drug Therapy, Parasitology, Physiopathology,
Affiliations:
*** IBB - CNR ***
Department of Pediatrics, Child Neurology Unit, Federico II University, Naples, Italy
Neuroradiology Department, S.Chiara Hospital, University of Pisa, Pisa, Italy
Biostructure and Bioimaging Institute, Department of Radiology, Federico II University, Naples, Italy
References:
Not available.
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment.
Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment.
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
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Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
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Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
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* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (396 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
Impact Factor: 1.579
View Export to BibTeX Export to EndNote
Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (508 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
View Export to BibTeX Export to EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1056 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 8.674 (8.674 excluding Abstracts).
Total 5 year impact factor: 9.144 (9.144 excluding Abstracts).
Total impact factor: 8.674 (8.674 excluding Abstracts).
Total 5 year impact factor: 9.144 (9.144 excluding Abstracts).
345 views. Last view on Thursday 28 September 2023, 22:09:58
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