Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (669 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.426, 5-year impact factor: 2.947
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-24144495221&partnerID=40&md5=c8524bc914729799b2d5b29a51b6a9db
Keywords: Catechin, Ferric Ion, Ferulic Acid, Gallic Acid, Peroxide, Polyphenol, Quercetin, Resveratrol, Antioxidant Activity, Apoptosis, Article, Beer, Cancer, Cancer Cell Culture, Cell Strain Hl 60, Cell Viability, Chemoprophylaxis, Controlled Study, Culture Medium, Cytotoxicity, Freeze Drying, Human, Human Cell, Leukemia Cell Line, Anticarcinogenic Agents, Caspase 3, Cell Division, Chromatography, High Pressure Liquid, Dose-Response Relationship, Flavonoids, Flow Cytometry, Hl-60 Cells, L-Lactate Dehydrogenase, Lipid Peroxidation, Oxidation-Reduction, Animalia,
Affiliations:
*** IBB - CNR ***
Istituto di Scienze dell'Alimentazione, Consiglio Nazionale Delle Ricerche, 83100 Avellino, Italy
References:
Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research (1999) Cancer Res, 59, pp. 4743-475
Sporn, M.B., Suh, N., Chemoprevention: An essential approach to controlling cancer (2002) Nat Rev Cancer, 2, pp. 537-543
Surh, Y.J., Cancer chemoprevention with dietary phytochemicals (2003) Nat Rev Cancer, 3, pp. 768-780
Go, V.L., Butrum, R.R., Wong, D.A., Diet, nutrition, and cancer prevention: The postgenomic era (2003) J Nutr, 133, pp. 3830S-3836S
Bingham, S., Riboli, E., Diet and cancer - The European prospective investigation into cancer and nutrition (2004) Nat Rev Cancer, 4, pp. 206-215
Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer (2002) Am J Med, 113, pp. 71S-88S
Weisburger, J.H., Approaches for chronic disease prevention based on current understanding of underlying mechanisms (2000) Am J Clin Nutr, 71, pp. 1710S-1714S
Yang, C.S., Landau, J.M., Huang, M.T., Newmark, H.L., Inhibition of carcinogenesis by dietary polyphenolic compounds (2001) Annu Rev Nutr, 21, pp. 381-406
Middleton, E.J., Kandaswami, C., The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer (1993) The Flavonoid: Advance Research since 1986, pp. 619-652. , Hairbone JH (eds). New York: CRC Press
Brash, D.E., Havre, P.A., New careers for antioxidants (2002) Proc Natl Acad Sci U S A, 99, pp. 13969-13971
Weisburger, J.H., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea (1999) Food Chem Toxicol, 37, pp. 943-948
Rietveld, A., Wiseman, S., Antioxidant effects of tea: Evidence from human clinical trials (2003) J Nutr, 133, pp. 3285S-3292S
Bushman, J.L., Green tea and cancer in humans: A review of the literature (1998) Nutr Cancer, 31, pp. 151-159
Goldfinger, T.M., Beyond the French paradox: The impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease (2003) Cardiol Clin, 21, pp. 449-457
Rehm, J., Sempos, C.T., Trevisan, M., Alcohol and cardiovascular disease-more than one paradox to consider. Average volume of alcohol consumption, patterns of drinking and risk of coronary heart disease - A review (2003) J Cardiovasc Risk, 10, pp. 15-20
Di Castelnuovo, A., Rotondo, S., Iacoviello, L., Donati, M.B., De Gaetano, G., Meta-analysis of wine and beer consumption in relation to vascular risk (2002) Circulation, 105, pp. 2836-2844
Ruf, J.C., Overview of epidemiological studies on wine, health and mortality (2003) Drugs Exp Clin Res, 29, pp. 173-179
Truelsen, T., Gronbaek, M., Schnohr, P., Boysen, G., Intake of beer, wine, and spirits and risk of stroke: The Copenhagen city heart study (1998) Stroke, 29, pp. 2467-2472
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Cleophas, T.J., Wine, beer and spirits and the risk of myocardial infarction: A systematic review (1999) Biomed Pharmacother, 53, pp. 417-423
Innes, G., Cost-effectiveness of beer versus red wine for the prevention of symptomatic coronary artery disease (1998) CMAJ, 159, pp. 1463-1466
Ghiselli, A., Natella, F., Guidi, A., Montanari, L., Fantozzi, P., Beer increases plasma antioxidant capacity in humans (2000) J Nutr Biochem, 11, pp. 76-80
Vinson, J.A., Mandarano, M., Hirst, M., Trevithick, J.R., Bose, P., Phenol antioxidant quantity and quality in foods: Beers and the effect of two types of beer on an animal model of atherosclerosis (2003) J Agric Food Chem, 51, pp. 5528-5533
Pedersen, A., Johansen, C., Gronbaek, M., Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study (2003) Gut, 52, pp. 861-867
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Hou, D.X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr Mol Med, 3, pp. 149-159
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Sovak, M., Grape extract, resveratrol, and its analogs: A review (2001) J Med Food, 4, pp. 93-105
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Miranda, C.L., Stevens, J.F., Helmrich, A., Henderson, M.C., Rodriguez, R.J., Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines (1999) Food Chem Toxicol, 37, pp. 271-285
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Ahmad, K.A., Clement, M.V., Hanif, I.M., Pervaiz, S., Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution (2004) Cancer Res, 64, pp. 1452-1459
Wang, I.K., Lin-Shiau, S.Y., Lin, J.K., Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells (1999) Eur J Cancer, 35, pp. 1517-1525
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Sporn, M. B., Suh, N., Chemoprevention: An essential approach to controlling cancer (2002) Nat Rev Cancer, 2, pp. 537-543
Surh, Y. J., Cancer chemoprevention with dietary phytochemicals (2003) Nat Rev Cancer, 3, pp. 768-780
Go, V. L., Butrum, R. R., Wong, D. A., Diet, nutrition, and cancer prevention: The postgenomic era (2003) J Nutr, 133, pp. 3830S-3836S
Kris-Etherton, P. M., Hecker, K. D., Bonanome, A., Coval, S. M., Binkoski, A. E., Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer (2002) Am J Med, 113, pp. 71S-88S
Weisburger, J. H., Approaches for chronic disease prevention based on current understanding of underlying mechanisms (2000) Am J Clin Nutr, 71, pp. 1710S-1714S
Yang, C. S., Landau, J. M., Huang, M. T., Newmark, H. L., Inhibition of carcinogenesis by dietary polyphenolic compounds (2001) Annu Rev Nutr, 21, pp. 381-406
Middleton, E. J., Kandaswami, C., The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer (1993) The Flavonoid: Advance Research since 1986, pp. 619-652. , Hairbone JH (eds). New York: CRC Press
Brash, D. E., Havre, P. A., New careers for antioxidants (2002) Proc Natl Acad Sci U S A, 99, pp. 13969-13971
Bushman, J. L., Green tea and cancer in humans: A review of the literature (1998) Nutr Cancer, 31, pp. 151-159
Goldfinger, T. M., Beyond the French paradox: The impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease (2003) Cardiol Clin, 21, pp. 449-457
Ruf, J. C., Overview of epidemiological studies on wine, health and mortality (2003) Drugs Exp Clin Res, 29, pp. 173-179
Denke, M. A., Nutritional and health benefits of beer (2000) Am J Med Sci, 320, pp. 320-326
Cleophas, T. J., Wine, beer and spirits and the risk of myocardial infarction: A systematic review (1999) Biomed Pharmacother, 53, pp. 417-423
Vinson, J. A., Mandarano, M., Hirst, M., Trevithick, J. R., Bose, P., Phenol antioxidant quantity and quality in foods: Beers and the effect of two types of beer on an animal model of atherosclerosis (2003) J Agric Food Chem, 51, pp. 5528-5533
Hou, D. X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr Mol Med, 3, pp. 149-159
Aziz, M. H., Kumar, R., Ahmad, N., Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (2003) Int J Oncol, 23, pp. 17-28
Goldberg, D. M., Yan, J., Soleas, G. J., Absorption of three wine-related polyphenols in three different matrices by healthy subjects (2003) Clin Biochem, 36, pp. 79-87
Miranda, C. L., Aponso, G. L., Stevens, J. F., Deinzer, M. L., Buhler, D. R., Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells (2000) Cancer Lett, 149, pp. 21-29
Chen, W. J., Lin, J. K., Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades (2004) J Agric Food Chem, 52, pp. 55-64
Miranda, C. L., Stevens, J. F., Helmrich, A., Henderson, M. C., Rodriguez, R. J., Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines (1999) Food Chem Toxicol, 37, pp. 271-285
Andersen, M. L., Outtrup, H., Skibsted, L. H., Potential antioxidants in beer assessed by ESR spin trapping (2000) J Agric Food Chem, 48, pp. 3106-3111
Singleton, S. L., Rossi, J. A., Colorimetry of total phenolics and phosphomolybdic-phosphotungstic acid reagents (1965) Am J Enol Vitic, 16, pp. 144-158
Benzie, I. F., Strain, J. J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay (1996) Anal Biochem, 239, pp. 70-76
Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-254
Hough, J. S., (1991) The Biotechnology of Malting and Brewing, , New York: Cambridge University Press
Collins, S. J., Gallo, R. C., Gallagher, R. E., Continuous growth and differentiation of human myeloid leukemic cells in suspension culture (1977) Nature, 270, pp. 347-349
Long, L. H., Clement, M. V., Halliwell, B., Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-) -epigallocatechin, (-) -epigallocatechin gallate, (+) -catechin, and quercetin to commonly used cell culture media (2000) Biochem Biophys Res Commun, 273, pp. 50-53
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Telford, W. G., King, L. E., Fraker, P. J., Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry (1992) Cytometty, 13, pp. 137-143
Lamson, D. W., Brignall, M. S., Antioxidants and cancer, part 3: Quercetin (2000) Altern Med Rev, 5, pp. 196-208
Sporn, M. B., Hobson's choice and the need for combinations of new agents for the prevention and treatment of breast cancer (2002) J Natl Cancer Inst, 94, pp. 242-243
Liu, R. H., Sun, J., Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation (2003) J Agric Food Chem, 51, pp. 1718-1723
Eberhardt, M. V., Lee, C. Y., Liu, R. H., Antioxidant activity of fresh apples (2000) Nature, 405, pp. 903-904
Kang, J. H., Park, Y. H., Choi, S. W., Yang, E. K., Lee, W. J., Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells (2003) Exp Mol Med, 35, pp. 467-474
Ahmad, K. A., Clement, M. V., Hanif, I. M., Pervaiz, S., Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution (2004) Cancer Res, 64, pp. 1452-1459
Wang, I. K., Lin-Shiau, S. Y., Lin, J. K., Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells (1999) Eur J Cancer, 35, pp. 1517-1525
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.426, 5-year impact factor: 2.947
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-24144495221&partnerID=40&md5=c8524bc914729799b2d5b29a51b6a9db
Keywords: Catechin, Ferric Ion, Ferulic Acid, Gallic Acid, Peroxide, Polyphenol, Quercetin, Resveratrol, Antioxidant Activity, Apoptosis, Article, Beer, Cancer, Cancer Cell Culture, Cell Strain Hl 60, Cell Viability, Chemoprophylaxis, Controlled Study, Culture Medium, Cytotoxicity, Freeze Drying, Human, Human Cell, Leukemia Cell Line, Anticarcinogenic Agents, Caspase 3, Cell Division, Chromatography, High Pressure Liquid, Dose-Response Relationship, Flavonoids, Flow Cytometry, Hl-60 Cells, L-Lactate Dehydrogenase, Lipid Peroxidation, Oxidation-Reduction, Animalia,
Affiliations:
*** IBB - CNR ***
Istituto di Scienze dell'Alimentazione, Consiglio Nazionale Delle Ricerche, 83100 Avellino, Italy
References:
Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research (1999) Cancer Res, 59, pp. 4743-475
Sporn, M.B., Suh, N., Chemoprevention: An essential approach to controlling cancer (2002) Nat Rev Cancer, 2, pp. 537-543
Surh, Y.J., Cancer chemoprevention with dietary phytochemicals (2003) Nat Rev Cancer, 3, pp. 768-780
Go, V.L., Butrum, R.R., Wong, D.A., Diet, nutrition, and cancer prevention: The postgenomic era (2003) J Nutr, 133, pp. 3830S-3836S
Bingham, S., Riboli, E., Diet and cancer - The European prospective investigation into cancer and nutrition (2004) Nat Rev Cancer, 4, pp. 206-215
Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer (2002) Am J Med, 113, pp. 71S-88S
Weisburger, J.H., Approaches for chronic disease prevention based on current understanding of underlying mechanisms (2000) Am J Clin Nutr, 71, pp. 1710S-1714S
Yang, C.S., Landau, J.M., Huang, M.T., Newmark, H.L., Inhibition of carcinogenesis by dietary polyphenolic compounds (2001) Annu Rev Nutr, 21, pp. 381-406
Middleton, E.J., Kandaswami, C., The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer (1993) The Flavonoid: Advance Research since 1986, pp. 619-652. , Hairbone JH (eds). New York: CRC Press
Brash, D.E., Havre, P.A., New careers for antioxidants (2002) Proc Natl Acad Sci U S A, 99, pp. 13969-13971
Weisburger, J.H., Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea (1999) Food Chem Toxicol, 37, pp. 943-948
Rietveld, A., Wiseman, S., Antioxidant effects of tea: Evidence from human clinical trials (2003) J Nutr, 133, pp. 3285S-3292S
Bushman, J.L., Green tea and cancer in humans: A review of the literature (1998) Nutr Cancer, 31, pp. 151-159
Goldfinger, T.M., Beyond the French paradox: The impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease (2003) Cardiol Clin, 21, pp. 449-457
Rehm, J., Sempos, C.T., Trevisan, M., Alcohol and cardiovascular disease-more than one paradox to consider. Average volume of alcohol consumption, patterns of drinking and risk of coronary heart disease - A review (2003) J Cardiovasc Risk, 10, pp. 15-20
Di Castelnuovo, A., Rotondo, S., Iacoviello, L., Donati, M.B., De Gaetano, G., Meta-analysis of wine and beer consumption in relation to vascular risk (2002) Circulation, 105, pp. 2836-2844
Ruf, J.C., Overview of epidemiological studies on wine, health and mortality (2003) Drugs Exp Clin Res, 29, pp. 173-179
Truelsen, T., Gronbaek, M., Schnohr, P., Boysen, G., Intake of beer, wine, and spirits and risk of stroke: The Copenhagen city heart study (1998) Stroke, 29, pp. 2467-2472
Denke, M.A., Nutritional and health benefits of beer (2000) Am J Med Sci, 320, pp. 320-326
Brenner, H., Rothenbacher, D., Bode, G., Marz, W., Hoffmeister, A., Coronary heart disease risk reduction in a predominantly beer-drinking population (2001) Epidemiology, 12, pp. 390-395
Cleophas, T.J., Wine, beer and spirits and the risk of myocardial infarction: A systematic review (1999) Biomed Pharmacother, 53, pp. 417-423
Innes, G., Cost-effectiveness of beer versus red wine for the prevention of symptomatic coronary artery disease (1998) CMAJ, 159, pp. 1463-1466
Ghiselli, A., Natella, F., Guidi, A., Montanari, L., Fantozzi, P., Beer increases plasma antioxidant capacity in humans (2000) J Nutr Biochem, 11, pp. 76-80
Vinson, J.A., Mandarano, M., Hirst, M., Trevithick, J.R., Bose, P., Phenol antioxidant quantity and quality in foods: Beers and the effect of two types of beer on an animal model of atherosclerosis (2003) J Agric Food Chem, 51, pp. 5528-5533
Pedersen, A., Johansen, C., Gronbaek, M., Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study (2003) Gut, 52, pp. 861-867
Bianchini, F., Vainio, H., Wine and resveratrol: Mechanisms of cancer prevention? (2003) Eur J Cancer Prev, 12, pp. 417-425
Hou, D.X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr Mol Med, 3, pp. 149-159
Lopez-Velez, M., Martinez-Martinez, F., Del Valle-Ribes, C., The study of phenolic compounds as natural antioxidants in wine (2003) Crit Rev Food Sci Nutr, 43, pp. 233-244
Sovak, M., Grape extract, resveratrol, and its analogs: A review (2001) J Med Food, 4, pp. 93-105
Roemer, K., Mahyar-Roemer, M., The basis for the chemopreventive action of resveratrol (2002) Drugs Today (Barc), 38, pp. 571-580
Aziz, M.H., Kumar, R., Ahmad, N., Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (2003) Int J Oncol, 23, pp. 17-28
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Long, L. H., Clement, M. V., Halliwell, B., Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-) -epigallocatechin, (-) -epigallocatechin gallate, (+) -catechin, and quercetin to commonly used cell culture media (2000) Biochem Biophys Res Commun, 273, pp. 50-53
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Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line
An impressive number of studies have suggested that red wine can be considered the protective beverage of choice against chronic and degenerative pathologies. Only few and controversial data are available on a potential, similar role for beer, which represents a more cost-effective, safe, and widely available beverage. Starting from the evidence that many antioxidant compounds present in red wine are also present at similar or even higher concentrations in beers, we first screened 48 commercially available beers and selected one (Mrt-HP) with very high polyphenol concentration and antioxidant activity estimated by ferric reducing antioxidant power. We demonstrated that a lyophilized preparation of Mrt-HP beer was cytotoxic with respect to a beer with low polyphenolic content (Trt-LP) when assayed on HL-60 human leukemia cell line. We measured a 60% decrease in cell viability at a polyphenol concentration of 250 μM quercetin equivalents. We also demonstrated that Mrt-HP cytotoxicity was not an artifact due to cell growth conditions because addition of Mrt-HP extracts to cell medium generated peroxide levels indistinguishable from controls. By means of cytofluorimetric analysis of pre-G1 population and caspase 3 activation, we demonstrated that Mrt-HP extracts activated apoptosis in HL-60 cell line. Finally, we found that the concentration of quercetin, resveratrol, and gallic acid in Mrt-HP was 10, 4.6, and 4.6-fold higher, respectively, than in Trt-LP, suggesting that the presence of these molecules might be responsible for the observed cytotoxicity. These data, together with the low in vivo beer toxicity reported in the literature, suggest a possible chemopreventive role for this beverage that requires further studies in animal models. Copyright © 2005, Lawrence Erlbaum Associates, Inc.
An impressive number of studies have suggested that red wine can be considered the protective beverage of choice against chronic and degenerative pathologies. Only few and controversial data are available on a potential, similar role for beer, which represents a more cost-effective, safe, and widely available beverage. Starting from the evidence that many antioxidant compounds present in red wine are also present at similar or even higher concentrations in beers, we first screened 48 commercially available beers and selected one (Mrt-HP) with very high polyphenol concentration and antioxidant activity estimated by ferric reducing antioxidant power. We demonstrated that a lyophilized preparation of Mrt-HP beer was cytotoxic with respect to a beer with low polyphenolic content (Trt-LP) when assayed on HL-60 human leukemia cell line. We measured a 60% decrease in cell viability at a polyphenol concentration of 250 μM quercetin equivalents. We also demonstrated that Mrt-HP cytotoxicity was not an artifact due to cell growth conditions because addition of Mrt-HP extracts to cell medium generated peroxide levels indistinguishable from controls. By means of cytofluorimetric analysis of pre-G1 population and caspase 3 activation, we demonstrated that Mrt-HP extracts activated apoptosis in HL-60 cell line. Finally, we found that the concentration of quercetin, resveratrol, and gallic acid in Mrt-HP was 10, 4.6, and 4.6-fold higher, respectively, than in Trt-LP, suggesting that the presence of these molecules might be responsible for the observed cytotoxicity. These data, together with the low in vivo beer toxicity reported in the literature, suggest a possible chemopreventive role for this beverage that requires further studies in animal models. Copyright © 2005, Lawrence Erlbaum Associates, Inc.
Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line
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Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (653 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Miniaturized hemoproteins (423 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
Impact Factor: 2.086
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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* Resveratrol Reverts Tolerance and Restores Susceptibility to Chlorhexidine and Benzalkonium in Gram-Negative Bacteria, Gram-Positive Bacteria and Yeasts (6 views)
Antibiotics (ISSN: 2079-6382linking), 2022 Jul 18; 11(7): N/D-N/D.
Impact Factor: 4.64
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Migliaccio A, Esposito EP, Bagattini M, Berisio R, Triassi M, De Gregorio E, Zarrilli R
* Inhibition of AdeB, AceI, and AmvA Efflux Pumps Restores Chlorhexidine and Benzalkonium Susceptibility in Acinetobacter baumannii ATCC 19606 (5 views)
Front Microbiol (ISSN: 1664-302xlinking), 2022 Feb 7; 12: 790263-790263.
Impact Factor: 6.1
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Perrella F, Coppola F, Petrone A, Platella C, Montesarchio D, Stringaro A, Ravagnan G, Fuggetta MP, Rega N, Musumeci D
* Interference of Polydatin/Resveratrol in the ACE2: Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays (15 views)
Biomolecules (ISSN: 2218-273xlinking), 2021 Jul 16; 11(7): N/D-N/D.
Impact Factor: 4.57
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Tito A, Colantuono C, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F
* Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs (41 views) (PDF 18 views)
Front Chem (ISSN: 2296-2646linking), 2021 Apr 28; 9: 638187-638187.
Impact Factor: 3.693
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Platella C, Raucci U, Rega N, D’atri S, Levati L, Roviello GN, Fuggetta MP, Musumeci D, Montesarchio D
* Shedding light on the interaction of polydatin and resveratrol with G-quadruplex and duplex DNA: a biophysical, computational and biological approach (204 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2020 May 15; 151: 1163-1172.
Impact Factor: 5.162
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Costabile G, Vitale M, Luongo D, Naviglio D, Vetrani C, Ciciola P, Tura A, Castello F, Mena P, Del Rio D, Capaldo B, Rivellese AA, Riccardi G, Giacco R
* Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study (209 views)
Clin Nutr (ISSN: 0261-5614linking), 2019 Dec; 38(6): 2727-2734.
Impact Factor: 0.5
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Gallo M, Formato A, Giacco R, Riccardi G, Luongo D, Formato G, Amoresano A, Naviglio D
* Mathematical optimization of the green extraction of polyphenols from grape peels through a cyclic pressurization process (112 views) (PDF 63 views)
Helyon, 2019 May; N/D: N/D-N/D.
Impact Factor: 0.572
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Castello F, Costabile G, Bresciania L, Tassottia M, Naviglio D, Luongo D, Ciciola P, Vitale M, Vetrani C, Galaverna G, Brighenti F, Giacco R, Del Rio D, Mena P
* Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans (206 views) (PDF 148 views)
Arch Bioch Bioph (ISSN: 0003-9861linking), 2018 May 15; 646: 1-9.
Impact Factor: 3.165
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Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D
* A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage (297 views) (PDF 115 views)
Bba-Gen Subjects (ISSN: 0005-2736print, 0005-2736linking), 2018 Mar 17; N/D: 1793-1902.
Impact Factor: 4.647
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (290 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
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Milardi D
Associazione di derivati di Resveratrolo per la prevenzione e il trattamento di malattie da disordine conformazionale proteico (364 views)
Italian Patent - Brevetto Italiano, 2016 Jul; N/D: 102016000073131-102016000073131.
Impact Factor: 0
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Lolicato F, Raudino A, Milardi D, La Rosa C
* Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (558 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 92: 876-881.
Impact Factor: 3.902
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (571 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (509 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (474 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
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Sciacca MF, Chillemi R, Sciuto S, Pappalardo M, La Rosa C, Grasso D, Milardi D
* Interactions of two O-phosphorylresveratrol derivatives with model membranes (337 views)
Arch Biochem Biophys (ISSN: 1096-0384, 0003-3986), 2012 May; 521(1-2): 111-116.
Impact Factor: 0
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (880 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1217 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
* Influence of Yeast on Polyphenol Composition of Wine (243 views)
Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
Impact Factor: 0.475
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (653 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Miniaturized hemoproteins (423 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
Impact Factor: 2.086
View Export to BibTeX Export to EndNote
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
26 Records (25 excluding Abstracts).
Total impact factor: 110.51 (106.817 excluding Abstracts).
Total 5 year impact factor: 120.884 (117.045 excluding Abstracts).
Total impact factor: 110.51 (106.817 excluding Abstracts).
Total 5 year impact factor: 120.884 (117.045 excluding Abstracts).
669 views. Last view on Friday 24 March 2023, 16:16:28
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