Keywords: Computational Protein Design, De Novo Protein Design, Diiron Protein, Metalloprotein, Structure, Biopolymers, Construction, Mathematical Models, Molecular Structure, Polypeptides, Artificial Diiron Proteins, Structure Determination, Unclassified Drug, Protein Family, Protein Function, Protein Synthesis, Review, Structure Analysis, Amino Acid Sequence, Catalytic Domain, Dimerization, Electrostatics, Molecular Sequence Data, Protein Conformation, Protein Structure, Quaternary, Thermodynamics,
Affiliations: *** IBB - CNR ***
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, United States
Department of Chemistry, University of Pennsylvania, 231 South 34 Street, Philadelphia, PA 19104, United States
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 6, 80134 Napoli, Italy
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Artificial diiron proteins: From structure to function
De novo protein design provides an attractive approach,for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins. (c) 2005 Wiley Periodicals, Inc.
Artificial diiron proteins: From structure to function