Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (532 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
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Paper type: Journal Article,
Impact factor: 1.844, 5-year impact factor: 1.193
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-32044434958&partnerID=40&md5=4dfcd54745ec51e20d1f8d3fa158dfea
Keywords: Gene Therapy, Gene Transcription, Peptide Nucleic Acids (pna), Pna-Dna Chimeras, Transcription Factor Decoy, Urokinase-Type Plasminogen Activator Receptor (upar), Firefly Luciferase, Transcription Factor Sp1, Urokinase Receptor, Article, Breast Cancer, Cancer Cell Culture, Cancer Invasion, Cell Strain Hepg2, Colon Cancer, Controlled Study, Gene Expression, Genetic Transcription, Human, Human Cell, Lung Cancer, Melanoma, Metastasis Potential, Priority Journal, Protein Expression, Reporter Gene, Carcinoma, Hepatocellular, Gene Expression Regulation, Neoplastic, Liver Neoplasms, Mannose-Binding Lectins, Membrane Glycoproteins, Promoter Regions (genetics), Cell Surface, Sp1 Transcription Factor, Tumor Cells,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Molecular Biology, Section of Molecular Biology, Ferrara University, Ferrara, Italy
Department of Cancer Biology, M.D. Anderson Cancer Center, University of Texas, Houston, TX, United States
Institute of Biostructures and Bioimages, CNR, Napoli, Italy
Department of Biological Sciences, University of Naples Frederico II, Naples, Italy
Biotechnology Centre, Ferrara University, Ferrara, Italy
References:
Not available.
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.844, 5-year impact factor: 1.193
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-32044434958&partnerID=40&md5=4dfcd54745ec51e20d1f8d3fa158dfea
Keywords: Gene Therapy, Gene Transcription, Peptide Nucleic Acids (pna), Pna-Dna Chimeras, Transcription Factor Decoy, Urokinase-Type Plasminogen Activator Receptor (upar), Firefly Luciferase, Transcription Factor Sp1, Urokinase Receptor, Article, Breast Cancer, Cancer Cell Culture, Cancer Invasion, Cell Strain Hepg2, Colon Cancer, Controlled Study, Gene Expression, Genetic Transcription, Human, Human Cell, Lung Cancer, Melanoma, Metastasis Potential, Priority Journal, Protein Expression, Reporter Gene, Carcinoma, Hepatocellular, Gene Expression Regulation, Neoplastic, Liver Neoplasms, Mannose-Binding Lectins, Membrane Glycoproteins, Promoter Regions (genetics), Cell Surface, Sp1 Transcription Factor, Tumor Cells,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Molecular Biology, Section of Molecular Biology, Ferrara University, Ferrara, Italy
Department of Cancer Biology, M.D. Anderson Cancer Center, University of Texas, Houston, TX, United States
Institute of Biostructures and Bioimages, CNR, Napoli, Italy
Department of Biological Sciences, University of Naples Frederico II, Naples, Italy
Biotechnology Centre, Ferrara University, Ferrara, Italy
References:
Not available.
Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter
The expression levels of urokinase-type plasminogen activator receptor (uPAR) are strongly correlated with metastatic potential in human cancer cell lines of melanoma, breast, lung, and colon. Therefore, targeting of uPAR could have practical implications in the treatment of neoplastic diseases. Because the expression of uPAR is regulated at the level of transcription in part by Sp1, we designed and tested transcription factors decoy molecules targeting Sp1 with the aim of inhibiting uPAR gene expression. The main objective of the present study was to determine whether decoy molecules based on peptide nucleic acids (PNA)-DNA chimeras mimicking Sp1 binding sites might be proposed as useful reagents to alter expression of Sp1-regulated genes involved in tumor invasion and metastasis. The results obtained firmly indicate that Sp1 binding molecules based on PNA-DNA-PNA chimeras are powerful decoys, as they efficiently inhibit the interactions between Sp1 and the uPAR promoter elements. Experiments performed on hepatoma HepG2 cells transfected with a plasmid containing the firefly luciferase gene reporter under the control of the human uPAR promoter demonstrate that PNA-DNA-PNA-based decoy molecules are potent inhibitors of the transcriptional activity of the uPAR promoter. Our results suggest that these molecules warrant attention for the design of novel antimetastatic drugs.
The expression levels of urokinase-type plasminogen activator receptor (uPAR) are strongly correlated with metastatic potential in human cancer cell lines of melanoma, breast, lung, and colon. Therefore, targeting of uPAR could have practical implications in the treatment of neoplastic diseases. Because the expression of uPAR is regulated at the level of transcription in part by Sp1, we designed and tested transcription factors decoy molecules targeting Sp1 with the aim of inhibiting uPAR gene expression. The main objective of the present study was to determine whether decoy molecules based on peptide nucleic acids (PNA)-DNA chimeras mimicking Sp1 binding sites might be proposed as useful reagents to alter expression of Sp1-regulated genes involved in tumor invasion and metastasis. The results obtained firmly indicate that Sp1 binding molecules based on PNA-DNA-PNA chimeras are powerful decoys, as they efficiently inhibit the interactions between Sp1 and the uPAR promoter elements. Experiments performed on hepatoma HepG2 cells transfected with a plasmid containing the firefly luciferase gene reporter under the control of the human uPAR promoter demonstrate that PNA-DNA-PNA-based decoy molecules are potent inhibitors of the transcriptional activity of the uPAR promoter. Our results suggest that these molecules warrant attention for the design of novel antimetastatic drugs.
Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter
| ▼ Evaluation of gene expression and test of new therapies by preclinical imaging in murine models |
Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter
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View Export to BibTeX Export to EndNote
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Impact Factor: 12.563
View Export to BibTeX Export to EndNote
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* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (1080 views)
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Impact Factor: 6.482
View Export to BibTeX Export to EndNote
Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (549 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
View Export to BibTeX Export to EndNote
Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (387 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
View Export to BibTeX Export to EndNote
Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (579 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
View Export to BibTeX Export to EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (617 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (361 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (665 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
View Export to BibTeX Export to EndNote
19 Records (16 excluding Abstracts).
Total impact factor: 87.523 (80.965 excluding Abstracts).
Total 5 year impact factor: 95.024 (87.67 excluding Abstracts).
Total impact factor: 87.523 (80.965 excluding Abstracts).
Total 5 year impact factor: 95.024 (87.67 excluding Abstracts).
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