Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.02, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-24344475243&partnerID=40&md5=83da819b53ab4affd589688c47d3a1e7
Keywords: C Reactive Protein, Cortisone Acetate, Desmopressin, Estradiol, Estrogen, Fibrinogen, Gestagen, Growth Hormone, High Density Lipoprotein Cholesterol, Insulin, Levothyroxine, Progesterone, Somatomedin C, Testosterone Enantate, Adult, Artery Intima Proliferation, Artery Media, Article, Atherosclerosis, Blood Pressure, Body Mass, Cardiovascular Risk, Cholesterol Blood Level, Clinical Article, Clinical Trial, Common Carotid Artery, Controlled Clinical Trial, Controlled Study, Disease Severity, Drug Effect, Exercise, Female, Fibrinogen Blood Level, Functional Assessment, Functional Morphology, Gender, Glucose Homeostasis, Growth Hormone Deficiency, Heart Left Ventricle Contraction, Heart Left Ventricle Filling, Heart Left Ventricle Mass, Heart Left Ventricle Performance, Heart Rate, Hormone Substitution, Human, Hypogonadism, Hypopituitarism, Insulin Resistance, Prevalence, Priority Journal, Prospective Study, Protein Blood Level, Time Series Analysis, University Hospital, Anthropometry, Cardiovascular Diseases, Cardiovascular System, Case-Control Studies, Echocardiography, Exercise Test, Hormone Replacement Therapy, Human Growth Hormone, Insulin-Like Growth Factor I, Intracranial Arteriosclerosis, Prospective Studies, Recombinant Proteins, Risk Factors, Sex Factors, Steroid Metabolism, Inborn Errors,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Nuclear Medicine Centre of the National Council of Research, Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Emergency Unit, S. Maria degli Incurabili Hospital of Naples, Naples 80138, Italy
References:
Rosen, T., Bengtsson, B.-A., Premature mortality due to cardiovascular disease in hypopituitarism (1990) Lancet, 336, pp. 285-28
Bülow, B., Hagmar, L., Mikoczy, Z., Nordstroem, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Bates, A.S., Van't Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Tomlinson, J.W., Holden, N., Hills, R., Wheatley, K., Clayton, R.N., Bates, A.S., Sheppard, M.C., Stewart, P.M., Premature mortality in 1014 patients with hypopituitarism (2001) Lancet, 357, pp. 425-431
Beshyah, S.A., Johnston, D., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
McCallum, R.W., Petrie, J.R., Dominiczak, A.F., Connell, J.M.C., Growth hormone deficiency and vascular risk (2002) Clin Endocrinol, 57, pp. 11-24. , Oxf
Colao, A., Di Somma, C., Marzullo, P., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol, 54, pp. 137-154. , Oxf
Maison, P., Griffin, S., Nicoue-Beglah, M., Haddad, N., Balkau, B., Chanson, P., Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: A metaanalysis of blinded, randomized, placebo-controlled trials (2004) J Clin Endocrinol Metab, 89, pp. 2192-2199
Gola, M., Bonadonna, S., Doga, M., Giustina, A., Growth hormone (GH) and cardiovascular risk factors (2005) J Clin Endocrinol Metab, 90, pp. 1864-1870
Maison, P., Chanson, P., Cardiac effects of growth hormone in adults with growth hormone deficiency: A metaanalysis (2003) Circulation, 108, pp. 2648-2652
Markussis, V., Beshyah, S.A., Fisher, C., Sharp, P., Nicholaides, A.N., Johnston, D., Detection of premature atherosclerosis by high resolution ultrasonography in symptom free hypopituitary adults (1992) Lancet, 340, pp. 1188-1192
Murata, M., Kaji, H., Mizuno, I., Sakurai, T., Iida, K., Okimura, Y., Chihara, K., A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children (2003) Eur J Endocrinol, 148, pp. 333-338
Leonsson, M., Hulthe, J., Oscarsson, J., Johannsson, G., Wendelhag, I., Wikstrand, J., Bengtsson, B.A., Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: Relation to body mass index, gender, and other cardiovascular risk factors (2002) Clin Endocrinol, 57, pp. 751-759. , Oxf
Pfeifer, M., Verhovec, R., Zizek, B., Prezelj, J., Poredos, P., Clayton, R.N., Growth hormone treatment (GH) reverses early atherosclerotic changes in GH-deficient adults (1999) J Clin Endocrinol Metab, 84, pp. 453-457
Borson-Chazot, F., Serusclat, A., Kalfallah, Y., Ducottet, X., Sassolas, G., Bernard, S., Labrousse, F., Berthezéne, F., Decrease in carotid intima-media thickness after 1 year growth hormone (GH) treatment in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1329-1333
Gatford, K.L., Egan, A.R., Clarke, I.J., Owens, P.C., Sexual dimorphism of the somatotrophic axis (1998) J Endocrinol, 157, pp. 373-389
Burman, P., Johansson, A., Siegbahn, A., Vesby, B., Karlsson, F.A., Growth (GH)-deficient men are more responsive to GH replacement therapy than women (1997) J Clin Endocrinol Metab, 82, pp. 550-555
Johansson, A.G., Engstrom, B.E., Ljunghall, S., Karlsson, F.A., Burman, P., Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2002-2007
Span, J.P., Pieters, C.F., Sweep, F.G., Hermus, A.R., Smals, A.G., Gender difference in rhGH-induced changes in body composition in GH-deficient adults (2001) J Clin Endocrinol Metab, 86, pp. 4161-4165
Ezzat, S., Fear, S., Gaillard, R.-C., Gayle, C., Landy, H., Marcovitz, S., Mattioni, T., Svanberg, E., Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults (2002) J Clin Endocrinol Metab, 87, pp. 2725-2733
Jousilahti, P., Vartiainen, E., Tuomilehto, J., Puska, P., Sex, age, cardiovascular risk factors, and coronary heart disease. A prospective follow-up study of 14,786 middle-aged men and women in Finland (1999) Circulation, 99, pp. 1165-1172
Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Lombardi, G., The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Colao, A., Spiezia, S., Di Somma, C., Pivonello, R., Marzullo, P., Rota, F., Musella, T., Lombardi, G., Circulating insulin-like growth factor-I levels are correlated with the atherosclerotic profile in healthy subjects independently of age (2005) J Endocrinol Invest, 28, pp. 440-448
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Hypertension control. Report of a WHO expert committee (1996) World Health Organization Tech Rep Ser, 862, pp. 1-83
(1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part. 1. Diagnosis and Classification of Diabetes Mellitus, , Geneva: World Health Organization
Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28, pp. 412-419
Consensus conference: Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
The Expert Panel: Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (1988) Arch Intern Med, 148, pp. 36-39
Simon, A., Gariepy, J., Chironi, G., Megnien, J.-L., Levenson, J., Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk (2002) J Hypertens, 20, pp. 159-169
Belcaro, G., Laurora, G., Cesarone, M.R., Noninvasive ultrasonic biopsy: Evaluation of early arteriosclerotic lesions progression in normal asymptomatic, hyperlipidemic and diabetic subjects (1993) Angiology, 44, pp. 93-99
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R.B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (2 SUPPL.), pp. 19-26
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Ross, R., The pathogenesis of atherosclerosis: A perspective for the 1990s (1993) Nature, 362, pp. 801-809
Salonen, J.T., Salonen, R., Ultrasound B-mode imaging in observational studies of atherosis progression (1993) Circulation, 87 (2 SUPPL.), pp. 56-65
Bonithon-Kopp, C., Touboul, P.-J., Berr, C., Berr, C., Leroux, C., Mainard, F., Bourbon, D., Ducimetiere, P., Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The vascular aging (EVA) study (1996) Arterioscler Thromb Vasc Biol, 16, pp. 310-316
Abdu, T.A.M., Elhadd, T.A., Buch, H., Barton, D., Neary, R., Clayton, R.N., Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk (2004) Clin Endocrinol, 61, pp. 387-393. , Oxf
Valcavi, R., Gaddi, O., Zini, M., Iavicolli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adult with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Gibney, J., Wallace, J.D., Spinks, T., Schnorr, L., Ranicar, A., Cuneo, R.C., Lockhart, S., Russell-Jones, D., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Della Morte, A.M., Pivonello, R., Nicolai, E., Lombardi, G., Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (2000) Clin Endocrinol, 52, pp. 447-455. , Oxf
B low, B., Hagmar, L., Mikoczy, Z., Nordstroem, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Bates, A. S., Van't Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Tomlinson, J. W., Holden, N., Hills, R., Wheatley, K., Clayton, R. N., Bates, A. S., Sheppard, M. C., Stewart, P. M., Premature mortality in 1014 patients with hypopituitarism (2001) Lancet, 357, pp. 425-431
Beshyah, S. A., Johnston, D., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
McCallum, R. W., Petrie, J. R., Dominiczak, A. F., Connell, J. M. C., Growth hormone deficiency and vascular risk (2002) Clin Endocrinol, 57, pp. 11-24. , Oxf
Gatford, K. L., Egan, A. R., Clarke, I. J., Owens, P. C., Sexual dimorphism of the somatotrophic axis (1998) J Endocrinol, 157, pp. 373-389
Johansson, A. G., Engstrom, B. E., Ljunghall, S., Karlsson, F. A., Burman, P., Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2002-2007
Span, J. P., Pieters, C. F., Sweep, F. G., Hermus, A. R., Smals, A. G., Gender difference in rhGH-induced changes in body composition in GH-deficient adults (2001) J Clin Endocrinol Metab, 86, pp. 4161-4165
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
(1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part. 1. Diagnosis and Classification of Diabetes Mellitus, , Geneva: World Health Organization
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., Turner, R. C., Homeostasis model assessment: Insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28, pp. 412-419
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R. B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (2 SUPPL.), pp. 19-26
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Salonen, J. T., Salonen, R., Ultrasound B-mode imaging in observational studies of atherosis progression (1993) Circulation, 87 (2 SUPPL.), pp. 56-65
Abdu, T. A. M., Elhadd, T. A., Buch, H., Barton, D., Neary, R., Clayton, R. N., Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk (2004) Clin Endocrinol, 61, pp. 387-393. , Oxf
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.02, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-24344475243&partnerID=40&md5=83da819b53ab4affd589688c47d3a1e7
Keywords: C Reactive Protein, Cortisone Acetate, Desmopressin, Estradiol, Estrogen, Fibrinogen, Gestagen, Growth Hormone, High Density Lipoprotein Cholesterol, Insulin, Levothyroxine, Progesterone, Somatomedin C, Testosterone Enantate, Adult, Artery Intima Proliferation, Artery Media, Article, Atherosclerosis, Blood Pressure, Body Mass, Cardiovascular Risk, Cholesterol Blood Level, Clinical Article, Clinical Trial, Common Carotid Artery, Controlled Clinical Trial, Controlled Study, Disease Severity, Drug Effect, Exercise, Female, Fibrinogen Blood Level, Functional Assessment, Functional Morphology, Gender, Glucose Homeostasis, Growth Hormone Deficiency, Heart Left Ventricle Contraction, Heart Left Ventricle Filling, Heart Left Ventricle Mass, Heart Left Ventricle Performance, Heart Rate, Hormone Substitution, Human, Hypogonadism, Hypopituitarism, Insulin Resistance, Prevalence, Priority Journal, Prospective Study, Protein Blood Level, Time Series Analysis, University Hospital, Anthropometry, Cardiovascular Diseases, Cardiovascular System, Case-Control Studies, Echocardiography, Exercise Test, Hormone Replacement Therapy, Human Growth Hormone, Insulin-Like Growth Factor I, Intracranial Arteriosclerosis, Prospective Studies, Recombinant Proteins, Risk Factors, Sex Factors, Steroid Metabolism, Inborn Errors,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Nuclear Medicine Centre of the National Council of Research, Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Emergency Unit, S. Maria degli Incurabili Hospital of Naples, Naples 80138, Italy
References:
Rosen, T., Bengtsson, B.-A., Premature mortality due to cardiovascular disease in hypopituitarism (1990) Lancet, 336, pp. 285-28
Bülow, B., Hagmar, L., Mikoczy, Z., Nordstroem, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Bates, A.S., Van't Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Tomlinson, J.W., Holden, N., Hills, R., Wheatley, K., Clayton, R.N., Bates, A.S., Sheppard, M.C., Stewart, P.M., Premature mortality in 1014 patients with hypopituitarism (2001) Lancet, 357, pp. 425-431
Beshyah, S.A., Johnston, D., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
McCallum, R.W., Petrie, J.R., Dominiczak, A.F., Connell, J.M.C., Growth hormone deficiency and vascular risk (2002) Clin Endocrinol, 57, pp. 11-24. , Oxf
Colao, A., Di Somma, C., Marzullo, P., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol, 54, pp. 137-154. , Oxf
Maison, P., Griffin, S., Nicoue-Beglah, M., Haddad, N., Balkau, B., Chanson, P., Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: A metaanalysis of blinded, randomized, placebo-controlled trials (2004) J Clin Endocrinol Metab, 89, pp. 2192-2199
Gola, M., Bonadonna, S., Doga, M., Giustina, A., Growth hormone (GH) and cardiovascular risk factors (2005) J Clin Endocrinol Metab, 90, pp. 1864-1870
Maison, P., Chanson, P., Cardiac effects of growth hormone in adults with growth hormone deficiency: A metaanalysis (2003) Circulation, 108, pp. 2648-2652
Markussis, V., Beshyah, S.A., Fisher, C., Sharp, P., Nicholaides, A.N., Johnston, D., Detection of premature atherosclerosis by high resolution ultrasonography in symptom free hypopituitary adults (1992) Lancet, 340, pp. 1188-1192
Murata, M., Kaji, H., Mizuno, I., Sakurai, T., Iida, K., Okimura, Y., Chihara, K., A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children (2003) Eur J Endocrinol, 148, pp. 333-338
Leonsson, M., Hulthe, J., Oscarsson, J., Johannsson, G., Wendelhag, I., Wikstrand, J., Bengtsson, B.A., Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: Relation to body mass index, gender, and other cardiovascular risk factors (2002) Clin Endocrinol, 57, pp. 751-759. , Oxf
Pfeifer, M., Verhovec, R., Zizek, B., Prezelj, J., Poredos, P., Clayton, R.N., Growth hormone treatment (GH) reverses early atherosclerotic changes in GH-deficient adults (1999) J Clin Endocrinol Metab, 84, pp. 453-457
Borson-Chazot, F., Serusclat, A., Kalfallah, Y., Ducottet, X., Sassolas, G., Bernard, S., Labrousse, F., Berthezéne, F., Decrease in carotid intima-media thickness after 1 year growth hormone (GH) treatment in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1329-1333
Gatford, K.L., Egan, A.R., Clarke, I.J., Owens, P.C., Sexual dimorphism of the somatotrophic axis (1998) J Endocrinol, 157, pp. 373-389
Burman, P., Johansson, A., Siegbahn, A., Vesby, B., Karlsson, F.A., Growth (GH)-deficient men are more responsive to GH replacement therapy than women (1997) J Clin Endocrinol Metab, 82, pp. 550-555
Johansson, A.G., Engstrom, B.E., Ljunghall, S., Karlsson, F.A., Burman, P., Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2002-2007
Span, J.P., Pieters, C.F., Sweep, F.G., Hermus, A.R., Smals, A.G., Gender difference in rhGH-induced changes in body composition in GH-deficient adults (2001) J Clin Endocrinol Metab, 86, pp. 4161-4165
Ezzat, S., Fear, S., Gaillard, R.-C., Gayle, C., Landy, H., Marcovitz, S., Mattioni, T., Svanberg, E., Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults (2002) J Clin Endocrinol Metab, 87, pp. 2725-2733
Jousilahti, P., Vartiainen, E., Tuomilehto, J., Puska, P., Sex, age, cardiovascular risk factors, and coronary heart disease. A prospective follow-up study of 14,786 middle-aged men and women in Finland (1999) Circulation, 99, pp. 1165-1172
Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Lombardi, G., The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Colao, A., Spiezia, S., Di Somma, C., Pivonello, R., Marzullo, P., Rota, F., Musella, T., Lombardi, G., Circulating insulin-like growth factor-I levels are correlated with the atherosclerotic profile in healthy subjects independently of age (2005) J Endocrinol Invest, 28, pp. 440-448
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Hypertension control. Report of a WHO expert committee (1996) World Health Organization Tech Rep Ser, 862, pp. 1-83
(1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part. 1. Diagnosis and Classification of Diabetes Mellitus, , Geneva: World Health Organization
Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28, pp. 412-419
Consensus conference: Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
The Expert Panel: Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (1988) Arch Intern Med, 148, pp. 36-39
Simon, A., Gariepy, J., Chironi, G., Megnien, J.-L., Levenson, J., Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk (2002) J Hypertens, 20, pp. 159-169
Belcaro, G., Laurora, G., Cesarone, M.R., Noninvasive ultrasonic biopsy: Evaluation of early arteriosclerotic lesions progression in normal asymptomatic, hyperlipidemic and diabetic subjects (1993) Angiology, 44, pp. 93-99
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R.B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (2 SUPPL.), pp. 19-26
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Ross, R., The pathogenesis of atherosclerosis: A perspective for the 1990s (1993) Nature, 362, pp. 801-809
Salonen, J.T., Salonen, R., Ultrasound B-mode imaging in observational studies of atherosis progression (1993) Circulation, 87 (2 SUPPL.), pp. 56-65
Bonithon-Kopp, C., Touboul, P.-J., Berr, C., Berr, C., Leroux, C., Mainard, F., Bourbon, D., Ducimetiere, P., Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The vascular aging (EVA) study (1996) Arterioscler Thromb Vasc Biol, 16, pp. 310-316
Abdu, T.A.M., Elhadd, T.A., Buch, H., Barton, D., Neary, R., Clayton, R.N., Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk (2004) Clin Endocrinol, 61, pp. 387-393. , Oxf
Valcavi, R., Gaddi, O., Zini, M., Iavicolli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adult with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Gibney, J., Wallace, J.D., Spinks, T., Schnorr, L., Ranicar, A., Cuneo, R.C., Lockhart, S., Russell-Jones, D., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Della Morte, A.M., Pivonello, R., Nicolai, E., Lombardi, G., Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (2000) Clin Endocrinol, 52, pp. 447-455. , Oxf
B low, B., Hagmar, L., Mikoczy, Z., Nordstroem, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Bates, A. S., Van't Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Tomlinson, J. W., Holden, N., Hills, R., Wheatley, K., Clayton, R. N., Bates, A. S., Sheppard, M. C., Stewart, P. M., Premature mortality in 1014 patients with hypopituitarism (2001) Lancet, 357, pp. 425-431
Beshyah, S. A., Johnston, D., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
McCallum, R. W., Petrie, J. R., Dominiczak, A. F., Connell, J. M. C., Growth hormone deficiency and vascular risk (2002) Clin Endocrinol, 57, pp. 11-24. , Oxf
Gatford, K. L., Egan, A. R., Clarke, I. J., Owens, P. C., Sexual dimorphism of the somatotrophic axis (1998) J Endocrinol, 157, pp. 373-389
Johansson, A. G., Engstrom, B. E., Ljunghall, S., Karlsson, F. A., Burman, P., Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2002-2007
Span, J. P., Pieters, C. F., Sweep, F. G., Hermus, A. R., Smals, A. G., Gender difference in rhGH-induced changes in body composition in GH-deficient adults (2001) J Clin Endocrinol Metab, 86, pp. 4161-4165
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
(1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part. 1. Diagnosis and Classification of Diabetes Mellitus, , Geneva: World Health Organization
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., Turner, R. C., Homeostasis model assessment: Insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28, pp. 412-419
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R. B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (2 SUPPL.), pp. 19-26
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Salonen, J. T., Salonen, R., Ultrasound B-mode imaging in observational studies of atherosis progression (1993) Circulation, 87 (2 SUPPL.), pp. 56-65
Abdu, T. A. M., Elhadd, T. A., Buch, H., Barton, D., Neary, R., Clayton, R. N., Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk (2004) Clin Endocrinol, 61, pp. 387-393. , Oxf
Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency
Context: GH secretion and response to GH replacement are gender-related. Objective: The objective of this study was to investigate the effects of GH deficiency (GHD) and replacement on the cardiovascular system according to gender. Design: The design was open and prospective. Setting: The study was conducted at a university hospital. Subjects: Subjects included 36 severe adult-onset GHD patients (18 men, 20 women, aged < 45 yr); 36 gender-, age-, and body mass index-matched healthy subjects served as controls. Interventions: Subjects received GH replacement at a median dose of 6.5 μg/kg·d in men and 7.7 μg/kg·d in women for 2 yr. Main Outcome Measures: Homeostasis model assessment index, total to HDL cholesterol ratio, fibrinogen and C-reactive protein levels, left ventricular mass index, blood pressure, heart rate, diastolic filling, and systolic function at rest and at peak exercise and intimamedia thickness (IMT) at common carotid arteries were measured. Results: Basal prevalence and/or degree of insulin resistance, lipid alterations, compromised cardiac function, and IMT were similar in women and men. Diastolic dysfunction was more prevalent in men (61 vs. 25%, P = 0.036). After GH replacement, IGF-I levels normalized in all patients. Lipid profile, fibrinogen, and C-reactive protein levels normalized in all cases. The total to HDL ratio (P = 0.04) was higher in women than men. The homeostasis model assessment index persisted higher in GHD patients than controls and decreased only in GHD men (P = 0.017). Left ventricular mass index normalized during treatment in both women and men, abnormal diastolic function persisted in three women (P = 0.031), and abnormal systolic performance persisted in six women and one man (P = 0.13). IMT decreased similarly in women and men, persisting higher than in controls. Exercise performance normalized in all. Conclusions: Two-year GH replacement has similar beneficial effects on cardiac and exercise performance and atherosclerosis in women and men with severe GHD. Copyright © 2005 by The Endocrine Society.
Context: GH secretion and response to GH replacement are gender-related. Objective: The objective of this study was to investigate the effects of GH deficiency (GHD) and replacement on the cardiovascular system according to gender. Design: The design was open and prospective. Setting: The study was conducted at a university hospital. Subjects: Subjects included 36 severe adult-onset GHD patients (18 men, 20 women, aged < 45 yr); 36 gender-, age-, and body mass index-matched healthy subjects served as controls. Interventions: Subjects received GH replacement at a median dose of 6.5 μg/kg·d in men and 7.7 μg/kg·d in women for 2 yr. Main Outcome Measures: Homeostasis model assessment index, total to HDL cholesterol ratio, fibrinogen and C-reactive protein levels, left ventricular mass index, blood pressure, heart rate, diastolic filling, and systolic function at rest and at peak exercise and intimamedia thickness (IMT) at common carotid arteries were measured. Results: Basal prevalence and/or degree of insulin resistance, lipid alterations, compromised cardiac function, and IMT were similar in women and men. Diastolic dysfunction was more prevalent in men (61 vs. 25%, P = 0.036). After GH replacement, IGF-I levels normalized in all patients. Lipid profile, fibrinogen, and C-reactive protein levels normalized in all cases. The total to HDL ratio (P = 0.04) was higher in women than men. The homeostasis model assessment index persisted higher in GHD patients than controls and decreased only in GHD men (P = 0.017). Left ventricular mass index normalized during treatment in both women and men, abnormal diastolic function persisted in three women (P = 0.031), and abnormal systolic performance persisted in six women and one man (P = 0.13). IMT decreased similarly in women and men, persisting higher than in controls. Exercise performance normalized in all. Conclusions: Two-year GH replacement has similar beneficial effects on cardiac and exercise performance and atherosclerosis in women and men with severe GHD. Copyright © 2005 by The Endocrine Society.
Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency
No results. |
Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency
Other filter: ([btitle,keywords] "C Reactive Protein" ...
Troisi R, Balasco N, Santamaria A, Vitagliano L, Sica F
* Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin (26 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 Jun 30; 181: 858-867.
Impact Factor: 5.162
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (266 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
View Export to BibTeX Export to EndNote
Lanzillo R, Liuzzi R, Vallefuoco L, Moccia M, Amato L, Vacca G, Vacchiano V, Portella G, Brescia Morra V
* JC virus antibody index in natalizumab-treated patients: correlations with John Cunningham virus DNA and C-reactive protein level (325 views)
Ther Clin Risk Manag (ISSN: 1178-203x), 2014 Oct 9; 10: 807-814.
Impact Factor: 1.469
View Export to BibTeX Export to EndNote
Camera L, Sagnelli M, Guadagno P, Mainenti PP, Marra T, Scotto di Santolo M, Fei L, Salvatore M
* Colonic perforation by a transmural and transvalvular migrated retained sponge: Multi-detector computed tomography findings (358 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2014 Apr 21; 20(15): 4457-4461.
Impact Factor: 2.369
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1685 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Berisio R, Ciccarelli L, Squeglia F, De Simone A, Vitagliano L
* Structural and Dynamic properties of incomplete immunoglobulin-like fold domains (477 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1045-1053.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (778 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (611 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (395 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
View Export to BibTeX Export to EndNote
Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (445 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (445 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Pace L, Catalano L, Del Vecchio S, Di Gennaro F, De Renzo A, Sica G, Califano C, Tedesco N, Borrelli G, Rotoli B, Salvatore M
* Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up (410 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Mar; 28(3): 304-312.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (428 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
View Export to BibTeX Export to EndNote
Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
View Export to BibTeX Export to EndNote
Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
View Export to BibTeX Export to EndNote
* Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin (26 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 Jun 30; 181: 858-867.
Impact Factor: 5.162
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (266 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
View Export to BibTeX Export to EndNote
Lanzillo R, Liuzzi R, Vallefuoco L, Moccia M, Amato L, Vacca G, Vacchiano V, Portella G, Brescia Morra V
* JC virus antibody index in natalizumab-treated patients: correlations with John Cunningham virus DNA and C-reactive protein level (325 views)
Ther Clin Risk Manag (ISSN: 1178-203x), 2014 Oct 9; 10: 807-814.
Impact Factor: 1.469
View Export to BibTeX Export to EndNote
Camera L, Sagnelli M, Guadagno P, Mainenti PP, Marra T, Scotto di Santolo M, Fei L, Salvatore M
* Colonic perforation by a transmural and transvalvular migrated retained sponge: Multi-detector computed tomography findings (358 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2014 Apr 21; 20(15): 4457-4461.
Impact Factor: 2.369
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1685 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Berisio R, Ciccarelli L, Squeglia F, De Simone A, Vitagliano L
* Structural and Dynamic properties of incomplete immunoglobulin-like fold domains (477 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1045-1053.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (778 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (611 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (395 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
View Export to BibTeX Export to EndNote
Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (445 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (445 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Pace L, Catalano L, Del Vecchio S, Di Gennaro F, De Renzo A, Sica G, Califano C, Tedesco N, Borrelli G, Rotoli B, Salvatore M
* Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up (410 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Mar; 28(3): 304-312.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (428 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
View Export to BibTeX Export to EndNote
Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
View Export to BibTeX Export to EndNote
Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
View Export to BibTeX Export to EndNote
35 Records (31 excluding Abstracts).
Total impact factor: 153.045 (136.701 excluding Abstracts).
Total 5 year impact factor: 126.194 (111.796 excluding Abstracts).
Total impact factor: 153.045 (136.701 excluding Abstracts).
Total 5 year impact factor: 126.194 (111.796 excluding Abstracts).
422 views. Last view on Thursday 16 March 2023, 7:27:34
ibb.cnr.it
