Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (579 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
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Paper type: Journal Article,
Impact factor: 1.496, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23344454963&partnerID=40&md5=984ec2eb70e02d812cc69aa5a2a25691
Keywords: Nse, Octreoscan, Octreotide Lar, Ovarian Carcinoma, Poorly Differentiated Neuroendocrine Carcinoma, Thyroid Carcinoma, Cisplatin, Etoposide, Antineoplastic Agent, Antineoplastic Hormone Agonists And Antagonists, Article, Case Report, Clinical Feature, Dyspnea, Endocrine Gland, Female, Goiter, Histology, Human, Human Tissue, Immunohistochemistry, Liver Metastasis, Liver Polycystic Disease, Lymph Node, Neuroendocrine Tumor, Pericardium, Small Cell Carcinoma, Thyroid Nodule, Trachea Muscle, Tumor Differentiation, Tumor Localization, Adrenal Tumor, Liver Tumor, Lymph Node Metastasis, Ovary Tumor, Pathology, Treatment Outcome, Adrenal Gland Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Liver Neoplasms, Lymphatic Metastasis, Unknown Primary, Ovarian Neoplasms,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
Department of Anatomical Pathology and Cytology, Federico II University of Naples, Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, Naples, Italy
References:
Not available.
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.496, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23344454963&partnerID=40&md5=984ec2eb70e02d812cc69aa5a2a25691
Keywords: Nse, Octreoscan, Octreotide Lar, Ovarian Carcinoma, Poorly Differentiated Neuroendocrine Carcinoma, Thyroid Carcinoma, Cisplatin, Etoposide, Antineoplastic Agent, Antineoplastic Hormone Agonists And Antagonists, Article, Case Report, Clinical Feature, Dyspnea, Endocrine Gland, Female, Goiter, Histology, Human, Human Tissue, Immunohistochemistry, Liver Metastasis, Liver Polycystic Disease, Lymph Node, Neuroendocrine Tumor, Pericardium, Small Cell Carcinoma, Thyroid Nodule, Trachea Muscle, Tumor Differentiation, Tumor Localization, Adrenal Tumor, Liver Tumor, Lymph Node Metastasis, Ovary Tumor, Pathology, Treatment Outcome, Adrenal Gland Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Liver Neoplasms, Lymphatic Metastasis, Unknown Primary, Ovarian Neoplasms,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
Department of Anatomical Pathology and Cytology, Federico II University of Naples, Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, Naples, Italy
References:
Not available.
Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR
Neuroendocrine tumors represent a heterogeneous category of neoplasm, with conflicting diagnostic and therapeutic demands. We here describe the case of a 72-yr-old woman with evidence of a poorly differentiated small-cell neuroendocrine carcinoma (NEC) localized in different endocrine glands and other non-endocrine organs. In particular, a large ovarian mass, multinodular thyroid goiter, right adrenal mass, cystic liver metastases and anterior mediastinum lymph node metastasis were present. The largest thyroid nodule caused tracheal restriction and dyspnea. Diagnosis of poorly differentiated metastasized NEC of unknown origin was made on the basis of histological and immunohistochemical findings, and treatment with etoposide (1100 mg/m(2) in days 1, 2 and 3) and cisplatinum (45 mg/m(2) in days 2 and 3) was initiated. Simultaneously, im administration of octreotide LAR 20 mg every 28 days was started, according to the presence of SS receptors at In-111-octreotide scan. Rapid improvement of dyspnea and a reduction of the largest thyroid nodule, liver metastases and adrenal mass by 50% were observed after 3 months of treatment; the dimensions remained stable thereafter, while the pericardial lymph node disappeared. In conclusion, poorly differentiated NEC of unknown primary site is a well-recognized category, usually with an aggressive behavior, rapid growth rate and wide dissemination. Median survival of these patients is 6 months if left untreated. Our patient is alive 18 months after beginning the treatment, reporting good general condition and quality of life over the whole follow-up period. (c) 2005, Editrice Kurtis.
Neuroendocrine tumors represent a heterogeneous category of neoplasm, with conflicting diagnostic and therapeutic demands. We here describe the case of a 72-yr-old woman with evidence of a poorly differentiated small-cell neuroendocrine carcinoma (NEC) localized in different endocrine glands and other non-endocrine organs. In particular, a large ovarian mass, multinodular thyroid goiter, right adrenal mass, cystic liver metastases and anterior mediastinum lymph node metastasis were present. The largest thyroid nodule caused tracheal restriction and dyspnea. Diagnosis of poorly differentiated metastasized NEC of unknown origin was made on the basis of histological and immunohistochemical findings, and treatment with etoposide (1100 mg/m(2) in days 1, 2 and 3) and cisplatinum (45 mg/m(2) in days 2 and 3) was initiated. Simultaneously, im administration of octreotide LAR 20 mg every 28 days was started, according to the presence of SS receptors at In-111-octreotide scan. Rapid improvement of dyspnea and a reduction of the largest thyroid nodule, liver metastases and adrenal mass by 50% were observed after 3 months of treatment; the dimensions remained stable thereafter, while the pericardial lymph node disappeared. In conclusion, poorly differentiated NEC of unknown primary site is a well-recognized category, usually with an aggressive behavior, rapid growth rate and wide dissemination. Median survival of these patients is 6 months if left untreated. Our patient is alive 18 months after beginning the treatment, reporting good general condition and quality of life over the whole follow-up period. (c) 2005, Editrice Kurtis.
Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR
| ▼ Clinical Oncology |
Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR
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Orlandella FM, Mariniello RM, Iervolino PLC, Auletta L, De Stefano AE, Ugolini C, Greco A, Mirabelli P, Pane K, Franzese M, Denaro M, Basolo F, Salvatore G
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Mazziotti G, Formenti AM, Panarotto MB, Arvat E, Chiti A, Cuocolo A, Dottorini ME, Durante C, Agate L, Filetti S, Felicetti F, Filice A, Pace L, Pellegrino T, Rodari M, Salvatori M, Tranfaglia C, Versari A, Viola D, Frara S, Berruti A, Giustina A, Giubbini R
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Greco A, Albanese S, Auletta L, Mirabelli P, Zannetti A, D'Alterio C, Di Maro G, Orlandella FM, Salvatore G, Soricelli A, Salvatore M
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De Luca S, Fonti R, Camera L, Salvatore B, Faggiano A, Ciarmiello A, Segreto S, Colao A, Salvatore M, Del Vecchio S
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Albanese S, Auletta L, Zannetti A, Di Maro G, Mirabelli P, D'Alterio C, Salvatore G, Soricelli A, Salvatore M, Greco A
* High Frequency Ultrasound for the development of an Orthotopic mouse model of Human Follicular Thyroid Carcinoma (614 views)
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Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
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Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M
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Fonti R, Mainolfi C, Anzivino A, Camera L, Faggiano A, Colao A, Salvatore M, Del Vecchio S
* 18F-FDG-PET/CT and 111In-Octreotide SPECT in Patients with Metastatic Medullary Thyroid Carcinoma (590 views)
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Gallicchio R, Giacomobono S, Capacchione D, Nardelli A, Barbato F, Nappi A, Pellegrino T, Storto G
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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Impact Factor: 5.036
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Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
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Salvatore B, Paone G, Klain M, Storto G, Nicolai E, D'Amico D, Della Morte AM, Pace L, Salvatore M
* Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and 131I ablation (1015 views)
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Impact Factor: 1.724
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Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (747 views)
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Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
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Impact Factor: 0
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Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (602 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
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Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
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Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
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Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Sacca L
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
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* Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 alpha/beta pathways (445 views)
Mol Carcinog (ISSN: 0899-1987linking), 2019 Mar 4; 58(7): 1181-1193.
Impact Factor: 3.851
View Export to BibTeX Export to EndNote
Mazziotti G, Formenti AM, Panarotto MB, Arvat E, Chiti A, Cuocolo A, Dottorini ME, Durante C, Agate L, Filetti S, Felicetti F, Filice A, Pace L, Pellegrino T, Rodari M, Salvatori M, Tranfaglia C, Versari A, Viola D, Frara S, Berruti A, Giustina A, Giubbini R
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Impact Factor: 3.179
View Export to BibTeX Export to EndNote
Russo M, Malandrino P, Moleti M, Vermiglio F, Violi MA, Marturano I, Minaldi E, Vigneri R, Pellegriti G, Regalbuto C
* Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods (613 views)
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Impact Factor: 3.166
View Export to BibTeX Export to EndNote
Greco A, Albanese S, Auletta L, Mirabelli P, Zannetti A, D'Alterio C, Di Maro G, Orlandella FM, Salvatore G, Soricelli A, Salvatore M
* High-frequency ultrasound-guided injection for the generation of a novel orthotopic mouse model of human thyroid carcinoma (1013 views)
Thyroid (ISSN: 1050-7256, 1050-7256linking), 2016 Feb 4; 26(4): 552-558.
Impact Factor: 5.515
View Export to BibTeX Export to EndNote
De Luca S, Fonti R, Camera L, Salvatore B, Faggiano A, Ciarmiello A, Segreto S, Colao A, Salvatore M, Del Vecchio S
* Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma (699 views)
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Impact Factor: 1.396
View Export to BibTeX Export to EndNote
Albanese S, Auletta L, Zannetti A, Di Maro G, Mirabelli P, D'Alterio C, Salvatore G, Soricelli A, Salvatore M, Greco A
* High Frequency Ultrasound for the development of an Orthotopic mouse model of Human Follicular Thyroid Carcinoma (614 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S416-S416.
Impact Factor: 5.537
View Export to BibTeX Export to EndNote
Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
* Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (574 views)
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Impact Factor: 0.782
View Export to BibTeX Export to EndNote
Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M
* Multimetastatic medullary thyroid carcinoma to the breast: PET/CT--mammographic-US and MR findings (665 views)
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Impact Factor: 1.411
View Export to BibTeX Export to EndNote
Fonti R, Mainolfi C, Anzivino A, Camera L, Faggiano A, Colao A, Salvatore M, Del Vecchio S
* 18F-FDG-PET/CT and 111In-Octreotide SPECT in Patients with Metastatic Medullary Thyroid Carcinoma (590 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Gallicchio R, Giacomobono S, Capacchione D, Nardelli A, Barbato F, Nappi A, Pellegrino T, Storto G
* Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation? (769 views)
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Impact Factor: 3.527
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (912 views)
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Impact Factor: 4.907
View Export to BibTeX Export to EndNote
D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (614 views)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
View Export to BibTeX Export to EndNote
Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (887 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (482 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Dec; 114(8): 1385-1385.
Impact Factor: 1.454
View Export to BibTeX Export to EndNote
Salvatore B, Paone G, Klain M, Storto G, Nicolai E, D'Amico D, Della Morte AM, Pace L, Salvatore M
* Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and 131I ablation (1015 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2008 Mar; 52(1): 2-8.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Caleo O, Maurea S, Klain M, Salvatore B, Storto G, Mancini M, Pace L, Salvatore M
* Postsurgical diagnostic evaluation of patients with differentiated thyroid carcinoma: Comparison of ultrasound, iodine-131 scintigraphy and PET with fluorine-18 fluorodeoxyglucose (747 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2008 Mar; 113(2): 278-288.
Impact Factor: 0.955
View Export to BibTeX Export to EndNote
Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
* Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (792 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
Impact Factor: 0
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Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (602 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (685 views)
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Impact Factor: 3.883
View Export to BibTeX Export to EndNote
Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (778 views)
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Impact Factor: 5.108
View Export to BibTeX Export to EndNote
Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (829 views)
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Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (703 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (672 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Sacca L
Impaired cardiac reserve and exercise capacity in patients receiving long-term thyrotropin suppressive therapy with levothyroxine (600 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1996 Dec; 81(12): 4224-4228.
Impact Factor: 4.575
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (736 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (785 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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26 Records (23 excluding Abstracts).
Total impact factor: 88.969 (82.298 excluding Abstracts).
Total 5 year impact factor: 82.641 (76.443 excluding Abstracts).
Total impact factor: 88.969 (82.298 excluding Abstracts).
Total 5 year impact factor: 82.641 (76.443 excluding Abstracts).
579 views. Last view on Friday 18 April 2025, 22:11:22
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