Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease(329 views) Pellegrino T, Storto G, Filardi PP, Sorrentino AR, Silvestro A, Petretta M, Brevetti G, Chiariello M, Salvatore M, Cuocolo A
Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
Institute of Biostructure and Bioimages, National Council of Research, Napoli, Italy
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
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Kuvin, J. T., Karas, R. H., Clinical utility of endothelial function testing: Ready for prime-time? (2003) Circulation, 107, pp. 3243-3247
Anderson, T. J., Uehala, A., Gerhard, M. D., Close relation of endothelial function in the human coronary and peripheral circulations (1995) J Am Coll Cardiol, 26, pp. 1235-1241
Kuvin, J. T., Patel, A. R., Sliney, K. A., Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease (2001) J Am Coll Cardiol, 38, pp. 1843-1849
Pitkunen, O. P., Raitakari, O. T., Niinikoski, H., Coronary How reserve is impaired in young men with familial hypercholesterolemia (1996) J Am Coll Cardiol, 28, pp. 1705-1711
Bergmann, S. R., Fox, K. A., Rand, A. L., Quantification of regional myocardial blood flow in vivo with H2-15O (1984) Circulation, 70, pp. 724-733
Araujo, L. I., Lammertsma, A. A., Rhodes, C. G., Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography (1991) Circulation, 83, pp. 875-885
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force (2002) J Am Coll Cardiol, 39, pp. 257-265
Celermajer, D. S., Sorensen, K. E., Bull, C., Robinson, J., Deanfield, J. E., Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction (1994) J Am Coll Cardiol, 24, pp. 1468-1474
Vogel, R. A., Measurement of endothelial function by brachial artery flow-mediated vasodilation (2001) Am J Cardiol, 88, pp. 31E-34E
Gullberg, G. T., Di Bella, E. V., Sinusas, A. J., Estimation of coronary flow reserve: Can SPECT compete with other modalities? (2001) J Nucl Cardiol, 8, pp. 620-625
41: 1860-1862Suwaidi, J. A., Hamasaki, S., Higano, S. T., Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction (2000) Circulation, 101, pp. 948-954
Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease
The aim of this study was to assess the relationship between brachial artery flow-mediated dilation (FMD) and coronary flow reserve (CFR) in patients with peripheral artery disease (PAD). Methods: Thirty patients who had PAD, who showed no cardiac symptoms, and who had normal stress SPECT cardiac imaging results and 28 control subjects underwent brachial artery FMD assessment by ultrasound and dipyridamole 99mTc-sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first-transit counts in the pulmonary artery and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of MBF at stress to MBF at rest. Results: Patients with PAD were separated into 2 groups according to the median value of overall FMD (6.85%): group 1 (n = 15) with FMD above the median (mean ± SD, 8.78% ± 1.3%) and group 2 (n = 15) with FMD below the median (mean ± SD, 5.14% ± 0.94%). FMD was significantly higher in control subjects (11.4% ± 3.4%) than in both groups of PAD patients (P < 0.001 for both). In control subjects, estimated CFR was 2.2 ± 0.4-significantly higher than CFR in both groups of PAD patients (P < 0.001 for both). In addition, in PAD patients of group 1, estimated CFR was 1.5 ± 0.4-higher than CFR in group 2 (1.0 ± 0.4) (P < 0.01). When all PAD patients were considered, a significant correlation between FMD and estimated CFR was observed (r = 0.56, P < 0.005). Conclusion: Estimated CFR is significantly lower in patients with PAD than in control subjects, and CFR impairment correlates with the degree of peripheral endothelial dysfunction.
Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(692 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote