Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling(462 views) Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
Keywords: Glucose, Insulin, Insulin Receptor, Phenylalanine, Phosphatidylinositide, Phosphatidylinositol 3 Kinase, Phosphoinositide Dependent Kinase 1, Protein Kinase B, Protein Tyrosine Kinase, Threonine, Unclassified Drug, Amino Acid Substitution, Animal Cell, Article, Carboxy Terminal Sequence, Controlled Study, Enzyme Activation, Gene Deletion, Glucose Metabolism, Glucose Transport, In Vitro Study, Insulin Metabolism, Myoblast, Nonhuman, Priority Journal, Protein Expression, Protein Phosphorylation, Signal Transduction, Cultured, Intracellular Signaling Peptides And Proteins, Phosphoproteins, Protein-Serine-Threonine Kinases, Sequence Deletion,
Affiliations: *** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini del CNR, Naples, Italy
Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
Mammalian Cell Technology, Novo Nordisk A/S, DK 2880 Bagsvaerd, Denmark
References: Alessi, D.R., Kozlowski, M.T., Weng, Q.P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K.E., Coadwell, J., Stephens, L.R., Hawkins, P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Belham, C., Wu, S., Avruch, J., Intracellular signalling: PDK-1-a kinase at the hub of things (1999) Curr. Biol., 9, pp. R93-R96
Cantrell, D.A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Caruso, M., Miele, C., Oriente, F., Maitan, M.A., Bifulco, G., Andreozzi, F., Condorelli, G., Beguinot, F., In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and transactivates the insulin receptor kinase (1999) J. Biol. Chem., 274, pp. 28637-28644
Caruso, M., Maitan, M.A., Bifulco, G., Miele, C., Vigliotta, G., Oriente, F., Formisano, P., Beguinot, F., Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells (2001) J. Biol. Chem., 276, pp. 45088-45097
Casamayor, A., Morrice, N.A., Alessi, D.R., Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo (1999) Biochem. J., 342, pp. 287-292
Chou, M.M., Hou, W., Johnson, J., Graham, L.K., Lee, M.H., Chen, C.S., Newton, A.C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L.Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L.Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E.M., Toker, A., Newton, A.C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Filippa, N., Sable, C.L., Hemmings, B.A., Van Obberghen, E., Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation (2000) Mol. Cell. Biol., 20, pp. 5712-5721
Fiory, F., Oriente, F., Miele, C., Romano, C., Trencia, A., Alberobello, A.T., Esposito, I., Formisano, P., Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting (2004) J. Biol. Chem., 279, pp. 11137-11145
Formisano, P., Oriente, F., Miele, C., Caruso, M., Auricchio, R., Vigliotta, G., Condorelli, G., Beguinot, F., In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing (1998) J. Biol. Chem., 273, pp. 13197-13202
Formisano, P., Sohn, K.J., Miele, C., Di Finizio, B., Petruzziello, A., Riccardi, G., Beguinot, L., Beguinot, F., Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action (1993) J. Biol. Chem., 268, pp. 5241-5248
Foukas, L.C., Shepherd, P.R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel, Y., Tanti, J.F., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide- dependent protein kinase-1 potential involvement of src kinase (2000) Eur. J. Biochem., 267, pp. 6642-6649
Hresko, R.C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E.S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A., Williams, L.T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (1996) Mol. Cell. Biol., 16, pp. 4117-4127
Kobayashi, T., Cohen, P., Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 (1999) Biochem. J., 339, pp. 319-328
Levy-Toledano, R., Taouis, M., Blaettler, D.H., Gorden, P., Taylor, S.I., Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells (1994) J. Biol. Chem., 269, pp. 31178-31182
Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Ullrich, A., Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects (1988) J. Biol. Chem., 263, pp. 8912-8917
McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S., Alessi, D.R., The in vivo role of PtdIns(3,4,5)P(3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
More, A., Komander, D., Van Aalten, D.M., Alessi, D.R., PDK1, the master regulator of AGC kinase signal transduction (2004) Semin. Cell Dev. Biol., 15, pp. 161-170
Myers, M.G., Backer, J.M., Siddle, K., White, M.F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M.M., Hess, D., Brazil, D.P., Hofsteenge, J., Hemmings, B.A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Prasad, N., Topping, R.S., Zhou, D., Decker, S.J., Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1) (2000) Biochemistry, 39, pp. 6929-6935
Piper, R.C., Hess, L.J., James, D.E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Romanelli, A., Dreisbach, V.C., Blenis, J., Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 (2002) J. Biol. Chem., 277, pp. 40281-40289
Ruderman, N.B., Kapeller, R., White, M.F., Cantley, L.C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sakaue, H., Nishizawa, A., Ogawa, W., Teshigawara, K., Mori, T., Takashima, Y., Noda, T., Kasuga, M., Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes (2003) J. Biol. Chem., 278, pp. 38870-38874
Sarbassov, D.D., Guertin, D.A., Ali, S.M., Sabatini, D.M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I.A., Yver, D.R., Hissin, P.J., Wardzala, L.J., Karnieli, E., Salans, L.B., Cushman, S.W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Storz, P., Toker, A., 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling (2002) Front Biosci., 7, pp. 886-902
Vanhaesebroeck, B., Alessi, D.R., The PI3K-PDK1 connection: More than just a road to PKB (2000) Biochem. J., 346, pp. 561-576
Van Horn, D.J., Myers Jr., M.G., Backer, J.M., Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Mol. Cell. Biol., 24, pp. 5005-5015
Wei, Q., Xia, Y., Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90 (2005) J. Biol. Chem., 280, pp. 18081-18086
Wick, K.L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M.R., Arthur, J.S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D.R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) Curr. Biol., 8, pp. 69-8
Anderson, K. E., Coadwell, J., Stephens, L. R., Hawkins, P. T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) Curr. Biol., 8, pp. 684-691
Cantrell, D. A., Phosphoinositide 3-kinase signalling pathways (2001) J. Cell Sci., 114, pp. 1439-1445
Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Toker, A., Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 (1998) Curr. Biol., 8, pp. 1069-1077
Dong, L. Q., Liu, F., PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle (2005) Am. J. Physiol. Endocrinol. Metab., 289, pp. E187-E196
Dong, L. Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., Liu, F., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase C (1999) J. Biol. Chem., 274, pp. 8117-8122
Dutil, E. M., Toker, A., Newton, A. C., Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) (1998) Curr. Biol., 8, pp. 1366-1375
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Foukas, L. C., Shepherd, P. R., Phosphoinositide 3-kinase: The protein kinase that time forgot (2004) Biochem. Soc. Trans., 32, pp. 330-331
Hresko, R. C., Murata, H., Mueckler, M., Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes (2003) J. Biol. Chem., 278, pp. 21615-21622
Kandel, E. S., Hay, N., The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB (1999) Exp. Cell Res., 253, pp. 210-229
McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S., Alessi, D. R., The in vivo role of PtdIns (3, 4, 5) P (3) binding to PDK1 PH domain defined by knockin mutation (2004) EMBO J., 23, pp. 2071-2082
Myers, M. G., Backer, J. M., Siddle, K., White, M. F., The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus (1991) J. Biol. Chem., 266, pp. 10616-10623
Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., Hemmings, B. A., Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity (2001) J. Biol. Chem., 276, pp. 37459-37471
Piper, R. C., Hess, L. J., James, D. E., Differential sorting of two glucose transporters expressed in insulin-sensitive cells (1991) Am. J. Physiol., 260, pp. C570-C580
Ruderman, N. B., Kapeller, R., White, M. F., Cantley, L. C., Activation of phosphatidylinositol 3-kinase by insulin (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 1411-1415
Sarbassov, D. D., Guertin, D. A., Ali, S. M., Sabatini, D. M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex (2005) Science, 307, pp. 1098-1101
Simpson, I. A., Yver, D. R., Hissin, P. J., Wardzala, L. J., Karnieli, E., Salans, L. B., Cushman, S. W., Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions (1983) Biochim. Biophys. Acta, 763, pp. 393-407
Van Horn, D. J., Myers Jr., M. G., Backer, J. M., Direct activation of the phosphatidylinositol 3 -kinase by the insulin receptor (1994) J. Biol. Chem., 269, pp. 29-32
Wick, K. L., Liu, F., A new molecular target of insulin action: Regulating the pivotal PDK1 (2001) Curr. Drug Targets Immune Endocr. Metabol. Disord., 1, pp. 209-221
Williams, M. R., Arthur, J. S., Balendran, A., Van Der Kaay, J., Poli, V., Cohen, P., Alessi, D. R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) Curr. Biol., 10, pp. 439-448
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling