Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (362 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.415, 5-year impact factor: 3.47
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-18144387601&partnerID=40&md5=fb5daa0e2711e39a7ccc7b64493bbfb1
Keywords: Antitumor Activity, Domain Swapping, Protein Dimerization, Ribonuclease A, Ribonuclease Cytotoxicity, Ribonuclease Inhibitor, Esterase Inhibitor, Unclassified Drug, Antineoplastic Activity, Article, Complex Formation, Concentration Response, Cytosol, Drug Mechanism, Drug Protein Binding, Enzyme Activity, Enzyme Inhibition, Priority Journal, Animals, Cattle, Electrophoresis, Polyacrylamide Gel, Enzyme Inhibitors, Hydrogen-Ion Concentration, Kinetics, Models, Molecular, Pancreatic, Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Dipto. Biol. Strutturale Funzionale, Univ. di Napoli Federico II, Via Mezzocannone 16, I-80134 Napoli, Italy
Ist. di Biostrutture e Bioimmagini, CNR, CIRPEB, Via Mezzocannone 16, I-80134 Napoli, Italy
Dipartimento di Scienze Della Vita, Seconda Università di Napoli, Via Vivaldi 43, I-81110 Caserta, Italy
Dipto. Sci. Neurologiche Della V., Università di Verona, Strada Le Grazie 8, 37134 Verona, Italy
References:
Crestfield, A.M., Stein, W.H., Moore, S., On the aggregation of bovine pancreatic ribonuclease (1962) Arch. Biochem. Biophys., 1 (SUPPL.), pp. 217-22
Fruchter, R.G., Crestfield, A.M., Preparation and properties of two active forms of ribonuclease dimer (1965) J. Biol. Chem., 240, pp. 3868-3874
Libonati, M., Bertoldi, M., Sorrentino, S., The activity on double-stranded RNA of aggregates of ribonuclease a higher than dimers increases as a function of the size of the aggregates (1996) Biochem. J., 318, pp. 287-290
Gotte, G., Libonati, M., Two different forms of aggregated dimers of ribonuclease a (1998) Biochim. Biophys. Acta, 1386, pp. 106-112
Liu, Y., Hart, P.J., Schlunegger, M.P., Eisenberg, D., The crystal structure of a 3D domain-swapped dimer of RNase a at 2.1 Å resolution (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 3437-3442
Gotte, G., Bertoldi, M., Libonati, M., Structural versatility of bovine ribonuclease A. Distinct conformers of trimeric and tetrameric aggregates of the enzyme (1999) Eur. J. Biochem., 265, pp. 680-687
Sorrentino, S., Barone, R., Bucci, E., Gotte, G., Russo, N., Libonati, M., D'Alessio, G., The two dimeric forms of RNase a (2000) FEBS Lett., 466, pp. 35-39
Liu, Y., Gotte, G., Libonati, M., Eisenberg, D., A domain-swapped RNase a dimer with implications for amyloid formation (2001) Nat. Struct. Biol., 8, pp. 211-214
Gotte, G., Vottariello, F., Libonati, M., A contribution to the understanding of the role of 3D domain swapping in protein aggregation (2003) J. Biol. Chem., 278, pp. 10763-10769
Park, C., Raines, R.T., Dimer formation by a monomeric protein (2000) Protein Sci., 9, pp. 2026-2033
Rousseau, F., Schymkowitz, J., Itzhaki, L., The unfolding story of three-dimensional domain swapping (2003) Structure, 11, pp. 243-251
Libonati, M., Gotte, G., Oligomerization of bovine ribonuclease A: Structural and functional features of its multimers (2004) Biochem. J., 380, pp. 311-327
Matousek, J., Gotte, G., Pouckova, P., Soucek, J., Slavik, T., Vottariello, F., Libonati, M., Antitumor activity and other biological actions of oligomers of ribonuclease a (2003) J. Biol. Chem., 278, pp. 23817-23822
Murthy, B.S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Suzuki, M., Saxena, S., Boix, E., Prill, R., Vasandani, V., Ladner, J., Sung, C., Youle, R., Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction (1999) Nat. Biotechnol., 17, pp. 265-270
Leland, P.A., Schultz, L.W., Kim, B.-L., Raines, R.T., Ribonuclease a variants with potent cytotoxic activity (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 10407-10412
Antignani, A., Naddeo, M., Cubellis, M.V., Russo, A., D'Alessio, G., Antitumor action of seminal ribonuclease, its dimeric structure, and its resistance to the cytosolic ribonuclease inhibitor (2001) Biochemistry, 40, pp. 3492-3496
Haigis, M., Kurten, E., Abel, R., Raines, R.T., KFERQ sequence in ribonuclease A-mediated cytotoxicity (2002) J. Biol. Chem., 277, pp. 11576-11581
D'Alessio, G., Di Donato, A., Mazzarella, L., Piccoli, R., (1997) Ribonucleases: Structures and Functions, pp. 383-423. , G. D'Alessio J.F. Riordan Academic Press New York, NY
Lee, F., Vallee, B.L., Structure and action of mammalian ribonuclease (angiogenin) inhibitor (1993) Prog. Nucl. Acid Res. Mol. Biol., 44, pp. 1-30
Hofsteenge, J., (1997) Ribonucleases: Structures and Functions, pp. 621-658. , G. D'Alessio J.F. Riordan Academic Press San Diego, CA
Kobe, B., Deisenhofer, J., A structural basis of the interactions between leucine-rich repeats and protein ligands (1995) Nature, 374, pp. 183-186
Beintema, J.J., Kleinedam, R.G., The ribonuclease a superfamily: General discussion (1998) Cell. Mol. Life Sci., 54, pp. 825-832
Mosimann, S.C., Ardelt, W., James, M.N.G., Refined 1.7 a X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity (1994) J. Mol. Biol., 236, pp. 1141-1153
Youle, R.J., D'Alessio, G., (1997) Ribonucleases: Structures and Function, pp. 491-514. , G. D'Alessio J.F. Riordan Academic Press San Diego
Irie, M., Nitta, K., Nonaka, T., Biochemistry of frog ribonucleases (1998) Cell. Mol. Life Sci., 54, pp. 775-784
Monti, D.M., D'Alessio, G., Cytosolic RNase inhibitor only affects RNases with intrinsic cytotoxicity (2004) J. Biol. Chem., 279, pp. 39195-39198
Witzel, H., Barnard, E.A., Mechanism and binding sites in the ribonuclease reaction. II. Kinetic studies on the first step of the reaction (1962) Biochem. Biophys. Res. Commun., 7, pp. 295-299
Shapiro, R., Vallee, B.L., Interaction of human placental ribonuclease with placental ribonuclease inhibitor (1991) Biochemistry, 30, pp. 2246-2255
Lee, F., Shapiro, R., Vallee, B.L., Tight-binding inhibition of angiogenin and ribonuclease a by placental ribonuclease inhibitor (1989) Biochemistry, 28, pp. 225-230
Lee, F., Auld, D., Vallee, B.L., Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin (1989) Biochemistry, 28, pp. 219-224
Shapiro, R., Riordan, J.F., Vallee, B.L., Characteristic ribonucleolytic activity of human angiogenin (1986) Biochemistry, 25, pp. 3527-3532
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Jones, T.A., Zou, J.-Y., Cowan, S.W., Kjeldgaard, M., Improved methods for the building of protein models in electron density maps and the location of errors in these (1991) Acta Crystallogr., 47, pp. 110-119
Blackburn, P., Moore, S., (1982) The Enzymes, 15, pp. 317-433. , P.D. Boyer Academic Press New York
Merlino, A., Vitagliano, L., Ceruso, M.A., Mazzarella, L., Dynamic properties of the N-terminal swapped dimer of ribonuclease a (2004) Biophys. J., 86, pp. 2383-2391
Murthy, B.S., Sirdeshmukh, R., Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor (1992) Biochem. J., 281, pp. 343-348
Kim, J.S., Soucek, J., Matousek, J., Raines, R.T., Mechanism of ribonuclease cytotoxicity (1995) J. Biol. Chem., 270, pp. 31097-31102
Shapiro, R., Cytoplasmic ribonuclease inhibitor (2001) Meth. Enzymol., 341, pp. 611-628
Vescia, S., Tramontano, D., Augusti Tocco, G., D'Alessio, G., In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease (1980) Cancer Res., 40, pp. 3740-3744
Newton, D.L., Xue, Y., Boque, L., Wlodawer, A., Kung, H.F., Rybak, S.M., Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy (1997) Protein Eng., 10, pp. 463-470
Bosch, M., Benito, A., Ribò, M., Puig, T., Beaumelle, B., Vilanova, M., A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity (2004) Biochemistry, 43, pp. 2167-2177
Kraulis, P.J., Molscript - A program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 945-949
Merritt, E.A., Murphy, M.E.P., RASTER3D version 2.0: A program for photorealistic molecular graphics (1994) Acta Crystallogr., 50, pp. 869-873
Mazzarella, L., Capasso, S., Demasi, D., Di Lorenzo, G., Mattia, C.A., Zagari, A., Bovine seminal ribonuclease structure at 1.9 Å resolution (1993) Acta Crystallogr., 49, pp. 389-402
Crestfield, A. M., Stein, W. H., Moore, S., On the aggregation of bovine pancreatic ribonuclease (1962) Arch. Biochem. Biophys., 1 (SUPPL.), pp. 217-22
Fruchter, R. G., Crestfield, A. M., Preparation and properties of two active forms of ribonuclease dimer (1965) J. Biol. Chem., 240, pp. 3868-3874
Liu, Y., Hart, P. J., Schlunegger, M. P., Eisenberg, D., The crystal structure of a 3D domain-swapped dimer of RNase a at 2. 1 resolution (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 3437-3442
Murthy, B. S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P. A., Schultz, L. W., Kim, B. -L., Raines, R. T., Ribonuclease a variants with potent cytotoxic activity (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 10407-10412
Beintema, J. J., Kleinedam, R. G., The ribonuclease a superfamily: General discussion (1998) Cell. Mol. Life Sci., 54, pp. 825-832
Mosimann, S. C., Ardelt, W., James, M. N. G., Refined 1. 7 a X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity (1994) J. Mol. Biol., 236, pp. 1141-1153
Youle, R. J., D'Alessio, G., (1997) Ribonucleases: Structures and Function, pp. 491-514. , G. D'Alessio J. F. Riordan Academic Press San Diego
Monti, D. M., D'Alessio, G., Cytosolic RNase inhibitor only affects RNases with intrinsic cytotoxicity (2004) J. Biol. Chem., 279, pp. 39195-39198
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Jones, T. A., Zou, J. -Y., Cowan, S. W., Kjeldgaard, M., Improved methods for the building of protein models in electron density maps and the location of errors in these (1991) Acta Crystallogr., 47, pp. 110-119
Murthy, B. S., Sirdeshmukh, R., Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor (1992) Biochem. J., 281, pp. 343-348
Kim, J. S., Soucek, J., Matousek, J., Raines, R. T., Mechanism of ribonuclease cytotoxicity (1995) J. Biol. Chem., 270, pp. 31097-31102
Newton, D. L., Xue, Y., Boque, L., Wlodawer, A., Kung, H. F., Rybak, S. M., Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy (1997) Protein Eng., 10, pp. 463-470
Kraulis, P. J., Molscript - A program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 945-949
Merritt, E. A., Murphy, M. E. P., RASTER3D version 2. 0: A program for photorealistic molecular graphics (1994) Acta Crystallogr., 50, pp. 869-873
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.415, 5-year impact factor: 3.47
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-18144387601&partnerID=40&md5=fb5daa0e2711e39a7ccc7b64493bbfb1
Keywords: Antitumor Activity, Domain Swapping, Protein Dimerization, Ribonuclease A, Ribonuclease Cytotoxicity, Ribonuclease Inhibitor, Esterase Inhibitor, Unclassified Drug, Antineoplastic Activity, Article, Complex Formation, Concentration Response, Cytosol, Drug Mechanism, Drug Protein Binding, Enzyme Activity, Enzyme Inhibition, Priority Journal, Animals, Cattle, Electrophoresis, Polyacrylamide Gel, Enzyme Inhibitors, Hydrogen-Ion Concentration, Kinetics, Models, Molecular, Pancreatic, Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Dipto. Biol. Strutturale Funzionale, Univ. di Napoli Federico II, Via Mezzocannone 16, I-80134 Napoli, Italy
Ist. di Biostrutture e Bioimmagini, CNR, CIRPEB, Via Mezzocannone 16, I-80134 Napoli, Italy
Dipartimento di Scienze Della Vita, Seconda Università di Napoli, Via Vivaldi 43, I-81110 Caserta, Italy
Dipto. Sci. Neurologiche Della V., Università di Verona, Strada Le Grazie 8, 37134 Verona, Italy
References:
Crestfield, A.M., Stein, W.H., Moore, S., On the aggregation of bovine pancreatic ribonuclease (1962) Arch. Biochem. Biophys., 1 (SUPPL.), pp. 217-22
Fruchter, R.G., Crestfield, A.M., Preparation and properties of two active forms of ribonuclease dimer (1965) J. Biol. Chem., 240, pp. 3868-3874
Libonati, M., Bertoldi, M., Sorrentino, S., The activity on double-stranded RNA of aggregates of ribonuclease a higher than dimers increases as a function of the size of the aggregates (1996) Biochem. J., 318, pp. 287-290
Gotte, G., Libonati, M., Two different forms of aggregated dimers of ribonuclease a (1998) Biochim. Biophys. Acta, 1386, pp. 106-112
Liu, Y., Hart, P.J., Schlunegger, M.P., Eisenberg, D., The crystal structure of a 3D domain-swapped dimer of RNase a at 2.1 Å resolution (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 3437-3442
Gotte, G., Bertoldi, M., Libonati, M., Structural versatility of bovine ribonuclease A. Distinct conformers of trimeric and tetrameric aggregates of the enzyme (1999) Eur. J. Biochem., 265, pp. 680-687
Sorrentino, S., Barone, R., Bucci, E., Gotte, G., Russo, N., Libonati, M., D'Alessio, G., The two dimeric forms of RNase a (2000) FEBS Lett., 466, pp. 35-39
Liu, Y., Gotte, G., Libonati, M., Eisenberg, D., A domain-swapped RNase a dimer with implications for amyloid formation (2001) Nat. Struct. Biol., 8, pp. 211-214
Gotte, G., Vottariello, F., Libonati, M., A contribution to the understanding of the role of 3D domain swapping in protein aggregation (2003) J. Biol. Chem., 278, pp. 10763-10769
Park, C., Raines, R.T., Dimer formation by a monomeric protein (2000) Protein Sci., 9, pp. 2026-2033
Rousseau, F., Schymkowitz, J., Itzhaki, L., The unfolding story of three-dimensional domain swapping (2003) Structure, 11, pp. 243-251
Libonati, M., Gotte, G., Oligomerization of bovine ribonuclease A: Structural and functional features of its multimers (2004) Biochem. J., 380, pp. 311-327
Matousek, J., Gotte, G., Pouckova, P., Soucek, J., Slavik, T., Vottariello, F., Libonati, M., Antitumor activity and other biological actions of oligomers of ribonuclease a (2003) J. Biol. Chem., 278, pp. 23817-23822
Murthy, B.S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Suzuki, M., Saxena, S., Boix, E., Prill, R., Vasandani, V., Ladner, J., Sung, C., Youle, R., Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction (1999) Nat. Biotechnol., 17, pp. 265-270
Leland, P.A., Schultz, L.W., Kim, B.-L., Raines, R.T., Ribonuclease a variants with potent cytotoxic activity (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 10407-10412
Antignani, A., Naddeo, M., Cubellis, M.V., Russo, A., D'Alessio, G., Antitumor action of seminal ribonuclease, its dimeric structure, and its resistance to the cytosolic ribonuclease inhibitor (2001) Biochemistry, 40, pp. 3492-3496
Haigis, M., Kurten, E., Abel, R., Raines, R.T., KFERQ sequence in ribonuclease A-mediated cytotoxicity (2002) J. Biol. Chem., 277, pp. 11576-11581
D'Alessio, G., Di Donato, A., Mazzarella, L., Piccoli, R., (1997) Ribonucleases: Structures and Functions, pp. 383-423. , G. D'Alessio J.F. Riordan Academic Press New York, NY
Lee, F., Vallee, B.L., Structure and action of mammalian ribonuclease (angiogenin) inhibitor (1993) Prog. Nucl. Acid Res. Mol. Biol., 44, pp. 1-30
Hofsteenge, J., (1997) Ribonucleases: Structures and Functions, pp. 621-658. , G. D'Alessio J.F. Riordan Academic Press San Diego, CA
Kobe, B., Deisenhofer, J., A structural basis of the interactions between leucine-rich repeats and protein ligands (1995) Nature, 374, pp. 183-186
Beintema, J.J., Kleinedam, R.G., The ribonuclease a superfamily: General discussion (1998) Cell. Mol. Life Sci., 54, pp. 825-832
Mosimann, S.C., Ardelt, W., James, M.N.G., Refined 1.7 a X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity (1994) J. Mol. Biol., 236, pp. 1141-1153
Youle, R.J., D'Alessio, G., (1997) Ribonucleases: Structures and Function, pp. 491-514. , G. D'Alessio J.F. Riordan Academic Press San Diego
Irie, M., Nitta, K., Nonaka, T., Biochemistry of frog ribonucleases (1998) Cell. Mol. Life Sci., 54, pp. 775-784
Monti, D.M., D'Alessio, G., Cytosolic RNase inhibitor only affects RNases with intrinsic cytotoxicity (2004) J. Biol. Chem., 279, pp. 39195-39198
Witzel, H., Barnard, E.A., Mechanism and binding sites in the ribonuclease reaction. II. Kinetic studies on the first step of the reaction (1962) Biochem. Biophys. Res. Commun., 7, pp. 295-299
Shapiro, R., Vallee, B.L., Interaction of human placental ribonuclease with placental ribonuclease inhibitor (1991) Biochemistry, 30, pp. 2246-2255
Lee, F., Shapiro, R., Vallee, B.L., Tight-binding inhibition of angiogenin and ribonuclease a by placental ribonuclease inhibitor (1989) Biochemistry, 28, pp. 225-230
Lee, F., Auld, D., Vallee, B.L., Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin (1989) Biochemistry, 28, pp. 219-224
Shapiro, R., Riordan, J.F., Vallee, B.L., Characteristic ribonucleolytic activity of human angiogenin (1986) Biochemistry, 25, pp. 3527-3532
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Jones, T.A., Zou, J.-Y., Cowan, S.W., Kjeldgaard, M., Improved methods for the building of protein models in electron density maps and the location of errors in these (1991) Acta Crystallogr., 47, pp. 110-119
Blackburn, P., Moore, S., (1982) The Enzymes, 15, pp. 317-433. , P.D. Boyer Academic Press New York
Merlino, A., Vitagliano, L., Ceruso, M.A., Mazzarella, L., Dynamic properties of the N-terminal swapped dimer of ribonuclease a (2004) Biophys. J., 86, pp. 2383-2391
Murthy, B.S., Sirdeshmukh, R., Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor (1992) Biochem. J., 281, pp. 343-348
Kim, J.S., Soucek, J., Matousek, J., Raines, R.T., Mechanism of ribonuclease cytotoxicity (1995) J. Biol. Chem., 270, pp. 31097-31102
Shapiro, R., Cytoplasmic ribonuclease inhibitor (2001) Meth. Enzymol., 341, pp. 611-628
Vescia, S., Tramontano, D., Augusti Tocco, G., D'Alessio, G., In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease (1980) Cancer Res., 40, pp. 3740-3744
Newton, D.L., Xue, Y., Boque, L., Wlodawer, A., Kung, H.F., Rybak, S.M., Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy (1997) Protein Eng., 10, pp. 463-470
Bosch, M., Benito, A., Ribò, M., Puig, T., Beaumelle, B., Vilanova, M., A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity (2004) Biochemistry, 43, pp. 2167-2177
Kraulis, P.J., Molscript - A program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 945-949
Merritt, E.A., Murphy, M.E.P., RASTER3D version 2.0: A program for photorealistic molecular graphics (1994) Acta Crystallogr., 50, pp. 869-873
Mazzarella, L., Capasso, S., Demasi, D., Di Lorenzo, G., Mattia, C.A., Zagari, A., Bovine seminal ribonuclease structure at 1.9 Å resolution (1993) Acta Crystallogr., 49, pp. 389-402
Crestfield, A. M., Stein, W. H., Moore, S., On the aggregation of bovine pancreatic ribonuclease (1962) Arch. Biochem. Biophys., 1 (SUPPL.), pp. 217-22
Fruchter, R. G., Crestfield, A. M., Preparation and properties of two active forms of ribonuclease dimer (1965) J. Biol. Chem., 240, pp. 3868-3874
Liu, Y., Hart, P. J., Schlunegger, M. P., Eisenberg, D., The crystal structure of a 3D domain-swapped dimer of RNase a at 2. 1 resolution (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 3437-3442
Murthy, B. S., De Lorenzo, C., Piccoli, R., D'Alessio, G., Sirdeshmukh, R., Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase (1996) Biochemistry, 35, pp. 3880-3885
Leland, P. A., Schultz, L. W., Kim, B. -L., Raines, R. T., Ribonuclease a variants with potent cytotoxic activity (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 10407-10412
Beintema, J. J., Kleinedam, R. G., The ribonuclease a superfamily: General discussion (1998) Cell. Mol. Life Sci., 54, pp. 825-832
Mosimann, S. C., Ardelt, W., James, M. N. G., Refined 1. 7 a X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity (1994) J. Mol. Biol., 236, pp. 1141-1153
Youle, R. J., D'Alessio, G., (1997) Ribonucleases: Structures and Function, pp. 491-514. , G. D'Alessio J. F. Riordan Academic Press San Diego
Monti, D. M., D'Alessio, G., Cytosolic RNase inhibitor only affects RNases with intrinsic cytotoxicity (2004) J. Biol. Chem., 279, pp. 39195-39198
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Jones, T. A., Zou, J. -Y., Cowan, S. W., Kjeldgaard, M., Improved methods for the building of protein models in electron density maps and the location of errors in these (1991) Acta Crystallogr., 47, pp. 110-119
Murthy, B. S., Sirdeshmukh, R., Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor (1992) Biochem. J., 281, pp. 343-348
Kim, J. S., Soucek, J., Matousek, J., Raines, R. T., Mechanism of ribonuclease cytotoxicity (1995) J. Biol. Chem., 270, pp. 31097-31102
Newton, D. L., Xue, Y., Boque, L., Wlodawer, A., Kung, H. F., Rybak, S. M., Expression and characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy (1997) Protein Eng., 10, pp. 463-470
Kraulis, P. J., Molscript - A program to produce both detailed and schematic plots of protein structures (1991) J. Appl. Crystallogr., 24, pp. 945-949
Merritt, E. A., Murphy, M. E. P., RASTER3D version 2. 0: A program for photorealistic molecular graphics (1994) Acta Crystallogr., 50, pp. 869-873
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
Ribonuclease A (RNase A) dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biological activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape the neutralizing action of the cytosolic RNase inhibitor (cRI). However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were found to bind cRI with high affinity and to form tight complexes. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Ribonuclease A (RNase A) dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biological activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape the neutralizing action of the cytosolic RNase inhibitor (cRI). However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were found to bind cRI with high affinity and to form tight complexes. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
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Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
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Calvanese L, Squeglia F, Romano M, D'Auria G, Falcigno L, Berisio R
* Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence (216 views) (PDF 10 views)
J Biomol Struct Dyn (ISSN: 0739-1102linking, 1538-0254electronic), 2020; N/D: 1-19.
Impact Factor: 3.11
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Smaldone G, Ruggiero A, Balasco N, Abuhammad A, Autiero I, Caruso D, Esposito D, Ferraro G, Gelardi E, L , M , Moreira M, Quareshy M, Romano M, Saaret A, Selvam I, Squeglia F, Troisi R, Kroon-batenburg L, M , J , Esposito L, Berisio R, Vitagliano L
* The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima (140 views)
Acta Crystallogr F Struct Biol Commun, 2019 Nov; 75(Pt11): 707-713.
Impact Factor: 0.968
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Esposito L, Donnarumma F, Ruggiero A, Leone S, Vitagliano L, Picone D
* Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera (292 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jul 15; 133: 1125-1133.
Impact Factor: 4.784
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Ruggiero A, Garcia-ortega L, Moreira M, Ragucci S, Landi N, Di Maro A, Berisio R
* Binding and enzymatic properties of Ageritin, a fungal ribotoxin with novel zinc-dependent function (196 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jun 18; 136: 625-631.
Impact Factor: 4.78
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Ruggiero A, Garcia-ortega L, Ragucci S, Russo R, Landi N, Berisio R, Di Maro A
* Structural and enzymatic properties of Ageritin, a novel metal-dependent ribotoxin-like protein with antitumor activity (271 views)
Bba-Gen Subjects (ISSN: 1872-8006electronic, 0304-4165linking, 0304-4165print), 2018 Sep 18; 1862(12): 2888-2894.
Impact Factor: 3.679
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Smaldone G, Berisio R, Balasco N, D'Auria S, Vitagliano L, Ruggiero A
* Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization (248 views)
Bba-Gen Subjects (ISSN: 1570-9639print, 1570-9639linking, 0005-2728), 2018 May 31; 1866(9): 952-962.
Impact Factor: 2.773
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Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (306 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
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Messori L, Marzo T, Merlino A
* Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (312 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
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Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
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Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (328 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (876 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Balasco N, Esposito L, De Simone A, Vitagliano L
* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (353 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.
Impact Factor: 2.861
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Balasco N, Esposito L, De Simone A, Vitagliano L
* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (523 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.
Impact Factor: 2.861
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Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (280 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (478 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (351 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (406 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (417 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (365 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (438 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (811 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
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Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (383 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Dynamic properties of the N-terminal swapped dimer of ribonuclease (373 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Apr; 86(4): 2383-2391.
Impact Factor: 4.585
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Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L
* Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease (383 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Nov 6; 554(1-2): 105-110.
Impact Factor: 3.609
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Subtle functional collective motions in pancreatic-like ribonucleases: From ribonuclease A to angiogenin (386 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Oct 1; 53(1): 101-110.
Impact Factor: 4.313
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (340 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (411 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Berisio R, Sica F, Lamzin VS, Wilson KS, Zagari A, Mazzarella L
* Atomic resolution structures of ribonuclease A at six pH values (548 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002; 58(3): 441-450.
Impact Factor: 1.76
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Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Effect of deamidation on folding of ribonuclease (385 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
Impact Factor: 3.869
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Esposito L, Vitagliano L, Zagari A, Mazzarella L
Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (301 views)
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
Impact Factor: 2.442
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Vitagliano L, Merlino A, Zagari A, Mazzarella L
Productive and nonproductive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2 ', 5 ')guanosine (524 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Jun; 9(6): 1217-1225.
Impact Factor: 3.869
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (679 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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ZagariA, Berisio R, Merlino A, Sica F, Vitagliano L, Mazzarella L
Reversible domain motions induced by substrate binding in ribonuclease (298 views)
Acta Crystallographica Section A, 2000; 56: 263-263.
Impact Factor: 2.33
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Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (380 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
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Berisio R, Lamzin VS, Sica F, Wilson KS, Zagari A, Mazzarella L
Protein titration in the crystal state (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 1; 292(4): 845-854.
Impact Factor: 5.501
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Sica F, Adinolfi S, Berisio R, De Lorenzo C, Mazzarella L, Piccoli R, Vitagliano L, Zagari A
Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state (282 views)
J Cryst Growth (ISSN: 0022-0248), 1999; 196(2-4): 305-312.
Impact Factor: 1.492
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Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (425 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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Adinolfi S, Piccoli R, Sica F, Mazzarella L
BS-RNase tetramers: An example of domain-swapped oligomers (421 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1996 Dec 2; 398(2-3): 326-332.
Impact Factor: 3.504
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (479 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
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* Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence (216 views) (PDF 10 views)
J Biomol Struct Dyn (ISSN: 0739-1102linking, 1538-0254electronic), 2020; N/D: 1-19.
Impact Factor: 3.11
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Smaldone G, Ruggiero A, Balasco N, Abuhammad A, Autiero I, Caruso D, Esposito D, Ferraro G, Gelardi E, L , M , Moreira M, Quareshy M, Romano M, Saaret A, Selvam I, Squeglia F, Troisi R, Kroon-batenburg L, M , J , Esposito L, Berisio R, Vitagliano L
* The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima (140 views)
Acta Crystallogr F Struct Biol Commun, 2019 Nov; 75(Pt11): 707-713.
Impact Factor: 0.968
View Export to BibTeX Export to EndNote
Esposito L, Donnarumma F, Ruggiero A, Leone S, Vitagliano L, Picone D
* Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera (292 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jul 15; 133: 1125-1133.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Ruggiero A, Garcia-ortega L, Moreira M, Ragucci S, Landi N, Di Maro A, Berisio R
* Binding and enzymatic properties of Ageritin, a fungal ribotoxin with novel zinc-dependent function (196 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jun 18; 136: 625-631.
Impact Factor: 4.78
View Export to BibTeX Export to EndNote
Ruggiero A, Garcia-ortega L, Ragucci S, Russo R, Landi N, Berisio R, Di Maro A
* Structural and enzymatic properties of Ageritin, a novel metal-dependent ribotoxin-like protein with antitumor activity (271 views)
Bba-Gen Subjects (ISSN: 1872-8006electronic, 0304-4165linking, 0304-4165print), 2018 Sep 18; 1862(12): 2888-2894.
Impact Factor: 3.679
View Export to BibTeX Export to EndNote
Smaldone G, Berisio R, Balasco N, D'Auria S, Vitagliano L, Ruggiero A
* Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization (248 views)
Bba-Gen Subjects (ISSN: 1570-9639print, 1570-9639linking, 0005-2728), 2018 May 31; 1866(9): 952-962.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (306 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
View Export to BibTeX Export to EndNote
Messori L, Marzo T, Merlino A
* Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (312 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
View Export to BibTeX Export to EndNote
Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
View Export to BibTeX Export to EndNote
Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (328 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (876 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Balasco N, Esposito L, De Simone A, Vitagliano L
* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (353 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.
Impact Factor: 2.861
View Export to BibTeX Export to EndNote
Balasco N, Esposito L, De Simone A, Vitagliano L
* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (523 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.
Impact Factor: 2.861
View Export to BibTeX Export to EndNote
Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (280 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (478 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (351 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (406 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
View Export to BibTeX Export to EndNote
Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (417 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
View Export to BibTeX Export to EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (365 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (438 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (811 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
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Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (383 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Dynamic properties of the N-terminal swapped dimer of ribonuclease (373 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Apr; 86(4): 2383-2391.
Impact Factor: 4.585
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Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L
* Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease (383 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Nov 6; 554(1-2): 105-110.
Impact Factor: 3.609
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Merlino A, Vitagliano L, Ceruso MA, Mazzarella L
* Subtle functional collective motions in pancreatic-like ribonucleases: From ribonuclease A to angiogenin (386 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Oct 1; 53(1): 101-110.
Impact Factor: 4.313
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (340 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (411 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Berisio R, Sica F, Lamzin VS, Wilson KS, Zagari A, Mazzarella L
* Atomic resolution structures of ribonuclease A at six pH values (548 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002; 58(3): 441-450.
Impact Factor: 1.76
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Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Effect of deamidation on folding of ribonuclease (385 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
Impact Factor: 3.869
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Esposito L, Vitagliano L, Zagari A, Mazzarella L
Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (301 views)
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
Impact Factor: 2.442
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Vitagliano L, Merlino A, Zagari A, Mazzarella L
Productive and nonproductive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2 ', 5 ')guanosine (524 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Jun; 9(6): 1217-1225.
Impact Factor: 3.869
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (679 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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ZagariA, Berisio R, Merlino A, Sica F, Vitagliano L, Mazzarella L
Reversible domain motions induced by substrate binding in ribonuclease (298 views)
Acta Crystallographica Section A, 2000; 56: 263-263.
Impact Factor: 2.33
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Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (380 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
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Berisio R, Lamzin VS, Sica F, Wilson KS, Zagari A, Mazzarella L
Protein titration in the crystal state (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 1; 292(4): 845-854.
Impact Factor: 5.501
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Sica F, Adinolfi S, Berisio R, De Lorenzo C, Mazzarella L, Piccoli R, Vitagliano L, Zagari A
Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state (282 views)
J Cryst Growth (ISSN: 0022-0248), 1999; 196(2-4): 305-312.
Impact Factor: 1.492
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Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (425 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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Adinolfi S, Piccoli R, Sica F, Mazzarella L
BS-RNase tetramers: An example of domain-swapped oligomers (421 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1996 Dec 2; 398(2-3): 326-332.
Impact Factor: 3.504
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (479 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
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45 Records (43 excluding Abstracts).
Total impact factor: 172.016 (163.642 excluding Abstracts).
Total 5 year impact factor: 174.169 (165.795 excluding Abstracts).
Total impact factor: 172.016 (163.642 excluding Abstracts).
Total 5 year impact factor: 174.169 (165.795 excluding Abstracts).
362 views. Last view on Saturday 14 January 2023, 19:42:31
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