Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity(796 views) Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
DISCAFF, University of Piemonte Orientale, Italy
CNS Medical Department, Pfizer Italia, Rome, Italy
I.N.M. Neuromed, Pozzilli, Italy
IRCCS Oasi Maria SS, Troina, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
IBB, CNR, Catania, Italy
I. N. M. Neuromed, Pozzilli, Italy
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Canonico, P. L., Sortino, M. A., Carfagna, N., Cavallaro, S., Pamparana, F., Annoni, K., Wong, E., Post, C., Pharmacological basis for the clinical effects of nicergoline in dementia (1998) Geriatria, 5 (8 SUPPL.), pp. 24-48
Crook, T. H., Nicergoline: Parallel evolution of clinical trial methodology and drug development in dementias (1998) Dement. Geriatr. Cogn. Disord., 8 (1 SUPPL.), pp. 22-26
Hagen, J. D., Pierce, P. A., Peroutka, S. J., Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors (1994) Biol. Signals, 3, pp. 223-229
Herrmann, W. M., Stephan, K., Gaede, K., Apeceche, M. A., A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia (1987) Dement. Geriatr. Cogn. Disord., 8, pp. 9-17
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 7951-7955
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., Mattson, M. P., A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide (1997) J. Neurochem., 68, pp. 255-264
Prehn, J. H., Bindokas, V. P., Jordan, J., Galindo, M. F., Ghadge, G. D., Roos, R. P., Boise, L. H., Miller, R. J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Sortino, M. A., Battaglia, A., Pamparana, F., Carfagna, N., Post, C., Canonico, P. L., Neuroprotective effects of nicergoline in immortalized neurons (1999) Eur. J. Pharmacol., 368, pp. 285-290
Sortino, M. A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P. L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Su, J. H., Anderson, A. J., Cummings, B. J., Cotman, C. W., Immunohistochemical evidence for apoptosis in Alzheimer's disease (1994) NeuroReport, 5, pp. 2529-2533
Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity