Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (796 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.296, 5-year impact factor: 2.957
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-20444391320&partnerID=40&md5=b32bdfa88209280ff987ec9c2110536d
Keywords: β-Amyloid Toxicity, Cortical Neurons, Glial-Neuronal Interaction, Nicergoline, Alpha Adrenergic Receptor Blocking Agent, Amyloid Beta Protein[25-35], Glial Cell Line Derived Neurotrophic Factor, Methysergide, Prazosin, Protein Bax, Protein Bcl 2, Serotonin Antagonist, Transforming Growth Factor Beta, Alzheimer Disease, Animal Experiment, Animal Tissue, Apoptosis, Article, Astrocyte, Brain Cortex, Brain Slice, Cell Culture, Cognitive Defect, Controlled Study, Culture Medium, Drug Withdrawal, Nerve Cell Necrosis, Nerve Degeneration, Neuroprotection, Neurotoxicity, Nonhuman, Priority Journal, Amyloid Beta-Protein, Bcl-2-Associated X Protein, Cell Communication, Cerebral Cortex, Coculture Techniques, Cognition Disorders, Memory Disorders, Nerve Growth Factors, Neuroprotective Agents, Peptide Fragments, Proto-Oncogene Proteins C-Bcl-2, Sprague-Dawley, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
DISCAFF, University of Piemonte Orientale, Italy
CNS Medical Department, Pfizer Italia, Rome, Italy
I.N.M. Neuromed, Pozzilli, Italy
IRCCS Oasi Maria SS, Troina, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
IBB, CNR, Catania, Italy
I. N. M. Neuromed, Pozzilli, Italy
References:
Arcamone, F., Glasser, A.G., Grafnetterova, J., Minghetti, A., Nicolella, V., Studies on the metabolism of ergoline derivatives. Metabolism of nicergoline in man and in animals (1972) Biochem. Pharmacol., 21, pp. 2205-221
Barger, S.W., Horster, D., Furukawa, K., Goodman, Y., Krieglstein, J., Mattson, M.P., Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 9328-9332
Battaglia, G., Fornai, F., Busceti, C.L., Lembo, G., Nicoletti, F., De Blasi, A., Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity (2003) J. Neurochem., 86, pp. 413-421
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Canonico, P.L., Sortino, M.A., Carfagna, N., Cavallaro, S., Pamparana, F., Annoni, K., Wong, E., Post, C., Pharmacological basis for the clinical effects of nicergoline in dementia (1998) Geriatria, 5 (8 SUPPL.), pp. 24-48
Caputi, A., Di Luca, M., Pastorino, L., Colciaghi, F., Carfagna, N., Wong, E., Post, C., Cattabeni, F., Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas (1998) Neurosci. Res. Commun., 23, pp. 159-167
Carfagna, N., Di Clemente, A., Cavanus, S., Damiani, D., Gerna, M., Salmoiraghi, P., Cattaneo, B., Post, C., Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats (1995) Neurosci. Lett., 197, pp. 195-198
Carfagna, N., Cavanus, S., Damiani, D., Salmoiraghi, P., Fariello, R., Post, C., Modulation of phosphoinositide turnover by chronic nicergoline in rat brain (1996) Neurosci. Lett., 209, pp. 189-192
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Cedano-Minguez, A., Bonecchi, L., Winblad, B., Post, C., Wong, E.H.F., Cowborn, R.F., Benfatti, L., Nicergoline stimulates protein kinase C-mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells (1999) Neurochem. Int., 35, pp. 307-315
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J., 16, pp. 2006-2008
Crook, T.H., Nicergoline: Parallel evolution of clinical trial methodology and drug development in dementias (1998) Dement. Geriatr. Cogn. Disord., 8 (1 SUPPL.), pp. 22-26
D'Onofrio, M., Cuomo, L., Battaglia, G., Ngomba, R.T., Storto, M., Kingston, A.E., Orzi, F., Bruno, V., Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways (2001) J. Neurochem., 78, pp. 435-445
Frasca, G., Chiechio, S., Vancheri, C., Nicoletti, F., Copani, A., Sortino, M.A., Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway (2004) J. Mol. Neurosci., 22, pp. 231-236
Ghribi, O., Herman, M.M., Pramoonjago, P., Spaulding, N.K., Savory, J., GDNF regulates the a beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases (2004) Neurobiol. Dis., 16, pp. 417-427
Giardino, L., Giuliani, A., Battaglia, A., Carfagna, N., Aloe, L., Calza'L, Neuroprotection and aging of the cholinergic system: A role for the ergoline derivative nicergoline (Sermion) (2002) Neuroscience, 109, pp. 487-497
Guo, Q., Sopher, B.L., Furukawa, K., Pham, D.G., Robinson, N., Martin, G.M., Mattson, M.P., Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals (1997) J. Neurosci., 17, pp. 4212-4222
Hagen, J.D., Pierce, P.A., Peroutka, S.J., Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors (1994) Biol. Signals, 3, pp. 223-229
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Heitz, C., Descombes, J.J., Miller, R.C., Stoclet, J.C., Alpha-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta (1986) Eur. J. Pharmacol., 123, pp. 279-285
Herrmann, W.M., Stephan, K., Gaede, K., Apeceche, M.A., A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia (1987) Dement. Geriatr. Cogn. Disord., 8, pp. 9-17
Iwata, E., Miyazaki, I., Asanuma, M., Iida, A., Ogawa, N., Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line (1998) Neurosci. Lett., 251, pp. 49-52
Le Poncin-Lafitte, M., Grosdemouge, C., Duterte, D., Rapin, J.R., Simultaneous study of haemodynamic, metabolic and behavioural sequelae in a model of cerebral ischaemia in aged rats: Effects of nicergoline (1984) Gerontology, 30, pp. 109-119
Lombet, A., Zujovic, V., Kandouz, M., Billardon, C., Carvajal-Gonzalez, S., Gompel, A., Rostene, W., Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family (2001) Eur. J. Biochem., 268, pp. 1352-1362
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 7951-7955
Mark, R.J., Lovell, M.A., Markesbery, W.R., Uchida, K., Mattson, M.P., A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide (1997) J. Neurochem., 68, pp. 255-264
Miccheli, A., Puccetti, C., Capuani, G., Di Cocco, M.E., Giardino, L., Calza, L., Battaglia, A., Conti, F., [1-13C]Glucose entry in neuronal and astrocytic intermediary metabolism of aged rats. a study of the effects of nicergoline treatment by 13C NMR spectroscopy (2003) Brain Res., 966, pp. 116-125
Prehn, J.H., Bindokas, V.P., Jordan, J., Galindo, M.F., Ghadge, G.D., Roos, R.P., Boise, L.H., Miller, R.J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Saletu, B., Paulus, E., Linzmayer, L., Anderer, P., Semlitsch, H.V., Grunberger, J., Wicke, L., Podreka, I., Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: A double-blind, placebo-controlled, clinical and EEG/ERP mapping study (1995) Psychopharmacology (Berl), 117, pp. 385-395
Shintomi, K., Pharmacological study of nicergoline
Effects on regional cerebral blood flows and arterial carbon dioxide and oxygen pressure and pH in rats under cyanide-induced histotoxic anoxia (1991) Arzheim.-Forsch. Drug Res., 41, pp. 885-890
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Hortonjr, W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp. Neurol., 133, pp. 225-230
Sortino, M.A., Battaglia, A., Pamparana, F., Carfagna, N., Post, C., Canonico, P.L., Neuroprotective effects of nicergoline in immortalized neurons (1999) Eur. J. Pharmacol., 368, pp. 285-290
Sortino, M.A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P.L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Su, J.H., Anderson, A.J., Cummings, B.J., Cotman, C.W., Immunohistochemical evidence for apoptosis in Alzheimer's disease (1994) NeuroReport, 5, pp. 2529-2533
Tanaka, M., Yoshida, T., Okamoto, K., Hirai, S., Antioxidant properties of nicergoline
Inhibition of brain auto-oxidation and superoxide production of neutrophils in rats (1998) Neurosci. Lett., 248, pp. 68-72
Vairetti, M., Feletti, F., Battaglia, A., Pamparana, F., Canonico, P.L., Richelmi, P., Berte, F., Haloperidol-induced changes in glutathione and energy metabolism: Effect of nicergoline (1999) Eur. J. Pharmacol., 367, pp. 67-72
Vairetti, M., Battaglia, A., Carfagna, N., Canonico, P.L., Berte, F., Richelmi, P., Antioxidant properties of MDL and MMDL, two nicergoline metabolites, during chronic administration of haloperidol (2002) Eur. J. Pharmacol., 453, pp. 69-73
Xie, J., Guo, Q., Zhu, H., Wooten, M.W., Mattson, M.P., Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide (2000) Brain Res. Mol. Brain Res., 82, pp. 107-113
Winblad, B., Carfagna, N., Bonura, L., Rossini, B.M., Wong, E.H.F., Battaglia, A., Nicergoline in dementia. a review of its pharmacological properties and therapeutic potential (2000) CNS Drugs, 14, pp. 1-22
Barger, S. W., Horster, D., Furukawa, K., Goodman, Y., Krieglstein, J., Mattson, M. P., Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 9328-9332
Canonico, P. L., Sortino, M. A., Carfagna, N., Cavallaro, S., Pamparana, F., Annoni, K., Wong, E., Post, C., Pharmacological basis for the clinical effects of nicergoline in dementia (1998) Geriatria, 5 (8 SUPPL.), pp. 24-48
Crook, T. H., Nicergoline: Parallel evolution of clinical trial methodology and drug development in dementias (1998) Dement. Geriatr. Cogn. Disord., 8 (1 SUPPL.), pp. 22-26
Hagen, J. D., Pierce, P. A., Peroutka, S. J., Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors (1994) Biol. Signals, 3, pp. 223-229
Herrmann, W. M., Stephan, K., Gaede, K., Apeceche, M. A., A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia (1987) Dement. Geriatr. Cogn. Disord., 8, pp. 9-17
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 7951-7955
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., Mattson, M. P., A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide (1997) J. Neurochem., 68, pp. 255-264
Prehn, J. H., Bindokas, V. P., Jordan, J., Galindo, M. F., Ghadge, G. D., Roos, R. P., Boise, L. H., Miller, R. J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Sortino, M. A., Battaglia, A., Pamparana, F., Carfagna, N., Post, C., Canonico, P. L., Neuroprotective effects of nicergoline in immortalized neurons (1999) Eur. J. Pharmacol., 368, pp. 285-290
Sortino, M. A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P. L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Su, J. H., Anderson, A. J., Cummings, B. J., Cotman, C. W., Immunohistochemical evidence for apoptosis in Alzheimer's disease (1994) NeuroReport, 5, pp. 2529-2533
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.296, 5-year impact factor: 2.957
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-20444391320&partnerID=40&md5=b32bdfa88209280ff987ec9c2110536d
Keywords: β-Amyloid Toxicity, Cortical Neurons, Glial-Neuronal Interaction, Nicergoline, Alpha Adrenergic Receptor Blocking Agent, Amyloid Beta Protein[25-35], Glial Cell Line Derived Neurotrophic Factor, Methysergide, Prazosin, Protein Bax, Protein Bcl 2, Serotonin Antagonist, Transforming Growth Factor Beta, Alzheimer Disease, Animal Experiment, Animal Tissue, Apoptosis, Article, Astrocyte, Brain Cortex, Brain Slice, Cell Culture, Cognitive Defect, Controlled Study, Culture Medium, Drug Withdrawal, Nerve Cell Necrosis, Nerve Degeneration, Neuroprotection, Neurotoxicity, Nonhuman, Priority Journal, Amyloid Beta-Protein, Bcl-2-Associated X Protein, Cell Communication, Cerebral Cortex, Coculture Techniques, Cognition Disorders, Memory Disorders, Nerve Growth Factors, Neuroprotective Agents, Peptide Fragments, Proto-Oncogene Proteins C-Bcl-2, Sprague-Dawley, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Viale A. Doria, 6, 95125, Catania, Italy
DISCAFF, University of Piemonte Orientale, Italy
CNS Medical Department, Pfizer Italia, Rome, Italy
I.N.M. Neuromed, Pozzilli, Italy
IRCCS Oasi Maria SS, Troina, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
IBB, CNR, Catania, Italy
I. N. M. Neuromed, Pozzilli, Italy
References:
Arcamone, F., Glasser, A.G., Grafnetterova, J., Minghetti, A., Nicolella, V., Studies on the metabolism of ergoline derivatives. Metabolism of nicergoline in man and in animals (1972) Biochem. Pharmacol., 21, pp. 2205-221
Barger, S.W., Horster, D., Furukawa, K., Goodman, Y., Krieglstein, J., Mattson, M.P., Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 9328-9332
Battaglia, G., Fornai, F., Busceti, C.L., Lembo, G., Nicoletti, F., De Blasi, A., Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity (2003) J. Neurochem., 86, pp. 413-421
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Canonico, P.L., Sortino, M.A., Carfagna, N., Cavallaro, S., Pamparana, F., Annoni, K., Wong, E., Post, C., Pharmacological basis for the clinical effects of nicergoline in dementia (1998) Geriatria, 5 (8 SUPPL.), pp. 24-48
Caputi, A., Di Luca, M., Pastorino, L., Colciaghi, F., Carfagna, N., Wong, E., Post, C., Cattabeni, F., Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas (1998) Neurosci. Res. Commun., 23, pp. 159-167
Carfagna, N., Di Clemente, A., Cavanus, S., Damiani, D., Gerna, M., Salmoiraghi, P., Cattaneo, B., Post, C., Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats (1995) Neurosci. Lett., 197, pp. 195-198
Carfagna, N., Cavanus, S., Damiani, D., Salmoiraghi, P., Fariello, R., Post, C., Modulation of phosphoinositide turnover by chronic nicergoline in rat brain (1996) Neurosci. Lett., 209, pp. 189-192
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Cedano-Minguez, A., Bonecchi, L., Winblad, B., Post, C., Wong, E.H.F., Cowborn, R.F., Benfatti, L., Nicergoline stimulates protein kinase C-mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells (1999) Neurochem. Int., 35, pp. 307-315
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J., 16, pp. 2006-2008
Crook, T.H., Nicergoline: Parallel evolution of clinical trial methodology and drug development in dementias (1998) Dement. Geriatr. Cogn. Disord., 8 (1 SUPPL.), pp. 22-26
D'Onofrio, M., Cuomo, L., Battaglia, G., Ngomba, R.T., Storto, M., Kingston, A.E., Orzi, F., Bruno, V., Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways (2001) J. Neurochem., 78, pp. 435-445
Frasca, G., Chiechio, S., Vancheri, C., Nicoletti, F., Copani, A., Sortino, M.A., Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway (2004) J. Mol. Neurosci., 22, pp. 231-236
Ghribi, O., Herman, M.M., Pramoonjago, P., Spaulding, N.K., Savory, J., GDNF regulates the a beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases (2004) Neurobiol. Dis., 16, pp. 417-427
Giardino, L., Giuliani, A., Battaglia, A., Carfagna, N., Aloe, L., Calza'L, Neuroprotection and aging of the cholinergic system: A role for the ergoline derivative nicergoline (Sermion) (2002) Neuroscience, 109, pp. 487-497
Guo, Q., Sopher, B.L., Furukawa, K., Pham, D.G., Robinson, N., Martin, G.M., Mattson, M.P., Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals (1997) J. Neurosci., 17, pp. 4212-4222
Hagen, J.D., Pierce, P.A., Peroutka, S.J., Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors (1994) Biol. Signals, 3, pp. 223-229
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Heitz, C., Descombes, J.J., Miller, R.C., Stoclet, J.C., Alpha-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta (1986) Eur. J. Pharmacol., 123, pp. 279-285
Herrmann, W.M., Stephan, K., Gaede, K., Apeceche, M.A., A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia (1987) Dement. Geriatr. Cogn. Disord., 8, pp. 9-17
Iwata, E., Miyazaki, I., Asanuma, M., Iida, A., Ogawa, N., Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line (1998) Neurosci. Lett., 251, pp. 49-52
Le Poncin-Lafitte, M., Grosdemouge, C., Duterte, D., Rapin, J.R., Simultaneous study of haemodynamic, metabolic and behavioural sequelae in a model of cerebral ischaemia in aged rats: Effects of nicergoline (1984) Gerontology, 30, pp. 109-119
Lombet, A., Zujovic, V., Kandouz, M., Billardon, C., Carvajal-Gonzalez, S., Gompel, A., Rostene, W., Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family (2001) Eur. J. Biochem., 268, pp. 1352-1362
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 7951-7955
Mark, R.J., Lovell, M.A., Markesbery, W.R., Uchida, K., Mattson, M.P., A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide (1997) J. Neurochem., 68, pp. 255-264
Miccheli, A., Puccetti, C., Capuani, G., Di Cocco, M.E., Giardino, L., Calza, L., Battaglia, A., Conti, F., [1-13C]Glucose entry in neuronal and astrocytic intermediary metabolism of aged rats. a study of the effects of nicergoline treatment by 13C NMR spectroscopy (2003) Brain Res., 966, pp. 116-125
Prehn, J.H., Bindokas, V.P., Jordan, J., Galindo, M.F., Ghadge, G.D., Roos, R.P., Boise, L.H., Miller, R.J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Saletu, B., Paulus, E., Linzmayer, L., Anderer, P., Semlitsch, H.V., Grunberger, J., Wicke, L., Podreka, I., Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: A double-blind, placebo-controlled, clinical and EEG/ERP mapping study (1995) Psychopharmacology (Berl), 117, pp. 385-395
Shintomi, K., Pharmacological study of nicergoline
Effects on regional cerebral blood flows and arterial carbon dioxide and oxygen pressure and pH in rats under cyanide-induced histotoxic anoxia (1991) Arzheim.-Forsch. Drug Res., 41, pp. 885-890
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Hortonjr, W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp. Neurol., 133, pp. 225-230
Sortino, M.A., Battaglia, A., Pamparana, F., Carfagna, N., Post, C., Canonico, P.L., Neuroprotective effects of nicergoline in immortalized neurons (1999) Eur. J. Pharmacol., 368, pp. 285-290
Sortino, M.A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P.L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Su, J.H., Anderson, A.J., Cummings, B.J., Cotman, C.W., Immunohistochemical evidence for apoptosis in Alzheimer's disease (1994) NeuroReport, 5, pp. 2529-2533
Tanaka, M., Yoshida, T., Okamoto, K., Hirai, S., Antioxidant properties of nicergoline
Inhibition of brain auto-oxidation and superoxide production of neutrophils in rats (1998) Neurosci. Lett., 248, pp. 68-72
Vairetti, M., Feletti, F., Battaglia, A., Pamparana, F., Canonico, P.L., Richelmi, P., Berte, F., Haloperidol-induced changes in glutathione and energy metabolism: Effect of nicergoline (1999) Eur. J. Pharmacol., 367, pp. 67-72
Vairetti, M., Battaglia, A., Carfagna, N., Canonico, P.L., Berte, F., Richelmi, P., Antioxidant properties of MDL and MMDL, two nicergoline metabolites, during chronic administration of haloperidol (2002) Eur. J. Pharmacol., 453, pp. 69-73
Xie, J., Guo, Q., Zhu, H., Wooten, M.W., Mattson, M.P., Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide (2000) Brain Res. Mol. Brain Res., 82, pp. 107-113
Winblad, B., Carfagna, N., Bonura, L., Rossini, B.M., Wong, E.H.F., Battaglia, A., Nicergoline in dementia. a review of its pharmacological properties and therapeutic potential (2000) CNS Drugs, 14, pp. 1-22
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Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity
Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against β-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of β-amyloid peptide (βAP25-35) and toxicity was assessed after 24 h. Micromolar concentrations of nicergoline or its metabolite, MDL, attenuated βAP25-35-induced neuronal death, whereas MMDL (another metabolite of nicergoline), the α1- adrenergic receptor antagonist, prazosin, or the serotonin 5HT-2 receptor antagonist, methysergide, were inactive. Nicergoline increased the basal levels of Bcl-2 and reduced the increase in Bax levels induced by β-amyloid, indicating that the drug inhibits the execution of an apoptotic program in cortical neurons. In mixed cultures of rat cortical cells containing both neurons and astrocytes, nicergoline and MDL were more efficacious than in pure neuronal cultures in reducing β-amyloid neurotoxicity. Experiments carried out in pure cultures of astrocytes showed that a component of neuroprotection was mediated by a mechanism of glial-neuronal interaction. The conditioned medium of cultured astrocytes treated with nicergoline or MDL for 72-96 h (collected 24 h after drug withdrawal) was neuroprotective when transferred to pure neuronal cultures challenged with β-amyloid. In cultured astrocytes, nicergoline increased the intracellular levels of transforming-growth factor-β and glial-derived neurotrophic factor, two trophic factors that are known to protect neurons against β-amyloid toxicity. These results raise the possibility that nicergoline reduces neurodegeneration in the Alzheimer's brain. © 2005 Elsevier B.V. All rights reserved.
Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against β-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of β-amyloid peptide (βAP25-35) and toxicity was assessed after 24 h. Micromolar concentrations of nicergoline or its metabolite, MDL, attenuated βAP25-35-induced neuronal death, whereas MMDL (another metabolite of nicergoline), the α1- adrenergic receptor antagonist, prazosin, or the serotonin 5HT-2 receptor antagonist, methysergide, were inactive. Nicergoline increased the basal levels of Bcl-2 and reduced the increase in Bax levels induced by β-amyloid, indicating that the drug inhibits the execution of an apoptotic program in cortical neurons. In mixed cultures of rat cortical cells containing both neurons and astrocytes, nicergoline and MDL were more efficacious than in pure neuronal cultures in reducing β-amyloid neurotoxicity. Experiments carried out in pure cultures of astrocytes showed that a component of neuroprotection was mediated by a mechanism of glial-neuronal interaction. The conditioned medium of cultured astrocytes treated with nicergoline or MDL for 72-96 h (collected 24 h after drug withdrawal) was neuroprotective when transferred to pure neuronal cultures challenged with β-amyloid. In cultured astrocytes, nicergoline increased the intracellular levels of transforming-growth factor-β and glial-derived neurotrophic factor, two trophic factors that are known to protect neurons against β-amyloid toxicity. These results raise the possibility that nicergoline reduces neurodegeneration in the Alzheimer's brain. © 2005 Elsevier B.V. All rights reserved.
Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity
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Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity
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D'Errico S, Greco F, Falanga AP, Tedeschi V, Piccialli I, Marzano M, Terracciano M, Secondo A, Roviello GN, Oliviero G, Borbone N
* Probing the Ca2+ Mobilizing Properties on Primary Cortical Neurons of a New Stable cADPR Mimic (18 views)
Bioorg Chem (ISSN: 0045-2068linking), 2021 Oct 2; 117: 105401-105411.
Impact Factor: 5.275
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Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 201 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
* Probing the Ca2+ Mobilizing Properties on Primary Cortical Neurons of a New Stable cADPR Mimic (18 views)
Bioorg Chem (ISSN: 0045-2068linking), 2021 Oct 2; 117: 105401-105411.
Impact Factor: 5.275
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 201 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 14.576 (14.576 excluding Abstracts).
Total 5 year impact factor: 7.97 (7.97 excluding Abstracts).
Total impact factor: 14.576 (14.576 excluding Abstracts).
Total 5 year impact factor: 7.97 (7.97 excluding Abstracts).
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