A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.992, 5-year impact factor: 3.307
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875561&partnerID=40&md5=e794bb44603ee52f7e685fb17ff9a655
Keywords: Binding Studies, Cck Analogues, Conformation Analysis, Cyclic Peptides, Ligand Design, Cholecystokinin A Receptor, Cholecystokinin Derivative, Cyclopeptide, Dodecylphosphorylcholine, Methionine, Tryptophan, Water, Amino Terminal Sequence, Aqueous Solution, Article, Carboxy Terminal Sequence, Dissociation Constant, Fluorescence Spectroscopy, Human, Human Cell, Micelle, Nuclear Magnetic Resonance Spectroscopy, Priority Journal, Receptor Binding, Spatial Orientation, Cultured, Drug Design, Models, Molecular, Molecular Structure, Peptide Fragments, Protein Binding, Protein Conformation, Chemical Synthesis, Chemistry, Pharmacology, Metabolism,
Affiliations:
*** IBB - CNR ***
CIRPeB, Ist. Biostrutture/Bioimmagini CNR, Via Mezzocannone, 6/8, 80134 Napoli, Italy
Dipto. di Biochimica e Biofisica, Seconda Università di Napoli, Via Costantinopoli, 16, 80138 Napoli, Italy
Bioindustry Park del Canavese, Via Ribes, 5, 10010 Colleretto Giacosa (TO), Italy
Centro Interuniversitario per la Ricerca sui Peptidi Bioattivi (CIRPeB), & Istituto di Biostrutture e Bioimmagini del CNR, Via Mezzocannone 6/8, 80134 Naples, Italy.,
References:
Rehfeld, J.F., Van Soulinge, W.W., (1994) Adv. Cancer. Res., 63, pp. 295-34
Deschenes, R.J., Lorenz, L.J., Haun, R.S., Roos, B.A., Collier, K.J., Dixon, J.E., (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 726-730
Wank, S.A., (1995) Amer. J. Physiol., 269, pp. G628-G646
De Tullio, P., Delarge, J., Piroette, B., (1999) Curr. Med. Chem., 6, pp. 433-455
Escherich, A., Lutz, J., Escrieut, C., Fourmy, D., Van Neuren, A.S., Mueller, G., Schafferhans, A., Moroder, L., (2001) Biopolymers, 56, pp. 55-76
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., (2001) Biochemistry, 40, pp. 3804-3809
Garner, J.D., Walker, M.D., Martinez, J., Priestly, G.P., Natarayan, S., Bodanszky, M., (1980) Biochim. Biophys. Acta, 630, pp. 323-329
Gigioux, V., Maigret, B., Escrieut, C., Silvente-Poirot, S., Bouisson, M., Fehrentz, J., Moroder, L., Fourmy, D., (1999) Protein Sci., 8, pp. 2347-2354
Kitagawa, K., Aida, C., Fujiwara, H., Tagami, T., Futaki, S., Kogire, M., Ida, J., Inoue, K., (2001) J. Org. Chem., 66, pp. 1-10
Mohamadi, F., Richards, N.G.J., Guida, W.C., Liskamp, R., Lipton, M., Caufield, C., Chang, G., Still, W.C., (1990) J. Comput. Chem., 11, pp. 440-467
Ragone, R., De Luca, S., Tesauro, D., Pedone, C., Morelli, G., (2001) Biopolymers, 56, pp. 47-53
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., (1981) Anal. Biochem., 115, pp. 278-286
Esposito, C., Colicchio, P., Facchiano, A., Ragone, R., (1998) J. Colloid Interface Sci., 200, pp. 310-312
Charpentier, B., Dor, A., Roy, P., England, P., Pham, H., Durieux, C., Roques, B.P., (1989) J. Med. Chem., 32, pp. 1184-1190
Noble, F., Roques, B.P., (1999) Prog. Neurobiol., 58, pp. 349-379
Lifson, S., Hagler, A.T., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5111-5121
Hagler, A.T., Lifson, S., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Piotto, M., Saudek, V., Sklenar, V., (1992) J. Biomol. NMR, 2, pp. 661-666
Sklenar, V., Piotto, M., Leppik, R., Saudek, V., (1993) J. Magn. Reson., A102, pp. 241-245
Braunschweiler, L., Ernst, R.R., (1983) J. Magn. Reson., 53, pp. 521-528
Bax, A., Davis, D.G., (1985) J. Magn. Reson., 65, pp. 355-360
Jeener, J., Meier, B.H., Bachmann, P., Ernst, R.R., (1979) J. Chem. Phys., 71, pp. 4546-4553
Piantini, U., Sørensen, O.W., Ernst, R.R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C.H., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley and Sons, New York
Güntert, P., Mumenthaler, C., Wüthrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., (1996) J. Mol. Graphics, 14, pp. 51-55
Güntert, P., (1998) Quart. Rev. Biophys., 31, pp. 145-237
Nèmethy, G., Pottle, M.S., Scheraga, H.A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D.Q., Still, W.C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Gill, S.C., Von Hippel, P.H., (1989) Anal. Biochem., 182, pp. 319-326
Eftink, M.R., (1997) Methods Enzymol., 278, pp. 221-257
Kennedy, K., Escrieut, C., Dufresne, M., Clerc, P., Vaysse, N., Fourmy, D., (1995) Biochem. Biophys. Res. Commun., 213, pp. 845-852
Aloj, L., Panico, M.R., Caraco, C., Zannetti, A., Del Vecchio, S., Di Nuzzo, C., Arra, C., Salvatore, M., (2003) Biopolymers, 66, pp. 370-380
Rehfeld, J. F., Van Soulinge, W. W., (1994) Adv. Cancer. Res., 63, pp. 295-34
Deschenes, R. J., Lorenz, L. J., Haun, R. S., Roos, B. A., Collier, K. J., Dixon, J. E., (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 726-730
Wank, S. A., (1995) Amer. J. Physiol., 269, pp. G628-G646
Garner, J. D., Walker, M. D., Martinez, J., Priestly, G. P., Natarayan, S., Bodanszky, M., (1980) Biochim. Biophys. Acta, 630, pp. 323-329
Hagler, A. T., Lifson, S., Dauber, P. J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Bax, A., Davis, D. G., (1985) J. Magn. Reson., 65, pp. 355-360
Piantini, U., S rensen, O. W., Ernst, R. R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C. H., Xia, T. -H., Billeter, M., G ntert, P., W thrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley and Sons, New York
G ntert, P., Mumenthaler, C., W thrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
G ntert, P., (1998) Quart. Rev. Biophys., 31, pp. 145-237
N methy, G., Pottle, M. S., Scheraga, H. A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D. Q., Still, W. C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Gill, S. C., Von Hippel, P. H., (1989) Anal. Biochem., 182, pp. 319-326
Eftink, M. R., (1997) Methods Enzymol., 278, pp. 221-257
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.992, 5-year impact factor: 3.307
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875561&partnerID=40&md5=e794bb44603ee52f7e685fb17ff9a655
Keywords: Binding Studies, Cck Analogues, Conformation Analysis, Cyclic Peptides, Ligand Design, Cholecystokinin A Receptor, Cholecystokinin Derivative, Cyclopeptide, Dodecylphosphorylcholine, Methionine, Tryptophan, Water, Amino Terminal Sequence, Aqueous Solution, Article, Carboxy Terminal Sequence, Dissociation Constant, Fluorescence Spectroscopy, Human, Human Cell, Micelle, Nuclear Magnetic Resonance Spectroscopy, Priority Journal, Receptor Binding, Spatial Orientation, Cultured, Drug Design, Models, Molecular, Molecular Structure, Peptide Fragments, Protein Binding, Protein Conformation, Chemical Synthesis, Chemistry, Pharmacology, Metabolism,
Affiliations:
*** IBB - CNR ***
CIRPeB, Ist. Biostrutture/Bioimmagini CNR, Via Mezzocannone, 6/8, 80134 Napoli, Italy
Dipto. di Biochimica e Biofisica, Seconda Università di Napoli, Via Costantinopoli, 16, 80138 Napoli, Italy
Bioindustry Park del Canavese, Via Ribes, 5, 10010 Colleretto Giacosa (TO), Italy
Centro Interuniversitario per la Ricerca sui Peptidi Bioattivi (CIRPeB), & Istituto di Biostrutture e Bioimmagini del CNR, Via Mezzocannone 6/8, 80134 Naples, Italy.,
References:
Rehfeld, J.F., Van Soulinge, W.W., (1994) Adv. Cancer. Res., 63, pp. 295-34
Deschenes, R.J., Lorenz, L.J., Haun, R.S., Roos, B.A., Collier, K.J., Dixon, J.E., (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 726-730
Wank, S.A., (1995) Amer. J. Physiol., 269, pp. G628-G646
De Tullio, P., Delarge, J., Piroette, B., (1999) Curr. Med. Chem., 6, pp. 433-455
Escherich, A., Lutz, J., Escrieut, C., Fourmy, D., Van Neuren, A.S., Mueller, G., Schafferhans, A., Moroder, L., (2001) Biopolymers, 56, pp. 55-76
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., (2001) Biochemistry, 40, pp. 3804-3809
Garner, J.D., Walker, M.D., Martinez, J., Priestly, G.P., Natarayan, S., Bodanszky, M., (1980) Biochim. Biophys. Acta, 630, pp. 323-329
Gigioux, V., Maigret, B., Escrieut, C., Silvente-Poirot, S., Bouisson, M., Fehrentz, J., Moroder, L., Fourmy, D., (1999) Protein Sci., 8, pp. 2347-2354
Kitagawa, K., Aida, C., Fujiwara, H., Tagami, T., Futaki, S., Kogire, M., Ida, J., Inoue, K., (2001) J. Org. Chem., 66, pp. 1-10
Mohamadi, F., Richards, N.G.J., Guida, W.C., Liskamp, R., Lipton, M., Caufield, C., Chang, G., Still, W.C., (1990) J. Comput. Chem., 11, pp. 440-467
Ragone, R., De Luca, S., Tesauro, D., Pedone, C., Morelli, G., (2001) Biopolymers, 56, pp. 47-53
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., (1981) Anal. Biochem., 115, pp. 278-286
Esposito, C., Colicchio, P., Facchiano, A., Ragone, R., (1998) J. Colloid Interface Sci., 200, pp. 310-312
Charpentier, B., Dor, A., Roy, P., England, P., Pham, H., Durieux, C., Roques, B.P., (1989) J. Med. Chem., 32, pp. 1184-1190
Noble, F., Roques, B.P., (1999) Prog. Neurobiol., 58, pp. 349-379
Lifson, S., Hagler, A.T., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5111-5121
Hagler, A.T., Lifson, S., Dauber, P.J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Piotto, M., Saudek, V., Sklenar, V., (1992) J. Biomol. NMR, 2, pp. 661-666
Sklenar, V., Piotto, M., Leppik, R., Saudek, V., (1993) J. Magn. Reson., A102, pp. 241-245
Braunschweiler, L., Ernst, R.R., (1983) J. Magn. Reson., 53, pp. 521-528
Bax, A., Davis, D.G., (1985) J. Magn. Reson., 65, pp. 355-360
Jeener, J., Meier, B.H., Bachmann, P., Ernst, R.R., (1979) J. Chem. Phys., 71, pp. 4546-4553
Piantini, U., Sørensen, O.W., Ernst, R.R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C.H., Xia, T.-H., Billeter, M., Güntert, P., Wüthrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley and Sons, New York
Güntert, P., Mumenthaler, C., Wüthrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., (1996) J. Mol. Graphics, 14, pp. 51-55
Güntert, P., (1998) Quart. Rev. Biophys., 31, pp. 145-237
Nèmethy, G., Pottle, M.S., Scheraga, H.A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D.Q., Still, W.C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Gill, S.C., Von Hippel, P.H., (1989) Anal. Biochem., 182, pp. 319-326
Eftink, M.R., (1997) Methods Enzymol., 278, pp. 221-257
Kennedy, K., Escrieut, C., Dufresne, M., Clerc, P., Vaysse, N., Fourmy, D., (1995) Biochem. Biophys. Res. Commun., 213, pp. 845-852
Aloj, L., Panico, M.R., Caraco, C., Zannetti, A., Del Vecchio, S., Di Nuzzo, C., Arra, C., Salvatore, M., (2003) Biopolymers, 66, pp. 370-380
Rehfeld, J. F., Van Soulinge, W. W., (1994) Adv. Cancer. Res., 63, pp. 295-34
Deschenes, R. J., Lorenz, L. J., Haun, R. S., Roos, B. A., Collier, K. J., Dixon, J. E., (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 726-730
Wank, S. A., (1995) Amer. J. Physiol., 269, pp. G628-G646
Garner, J. D., Walker, M. D., Martinez, J., Priestly, G. P., Natarayan, S., Bodanszky, M., (1980) Biochim. Biophys. Acta, 630, pp. 323-329
Hagler, A. T., Lifson, S., Dauber, P. J., (1979) J. Am. Chem. Soc., 101, pp. 5122-5130
Bax, A., Davis, D. G., (1985) J. Magn. Reson., 65, pp. 355-360
Piantini, U., S rensen, O. W., Ernst, R. R., (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
Bartels, C. H., Xia, T. -H., Billeter, M., G ntert, P., W thrich, K., (1995) J. Biomol. NMR, 6, pp. 1-10
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley and Sons, New York
G ntert, P., Mumenthaler, C., W thrich, K., (1997) J. Mol. Biol., 273, pp. 283-298
G ntert, P., (1998) Quart. Rev. Biophys., 31, pp. 145-237
N methy, G., Pottle, M. S., Scheraga, H. A., (1983) J. Phys. Chem., 87, pp. 1883-1887
Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Chio, C., Alagona, G., Profeta, S., Weiner, P., (1984) J. Am. Chem. Soc., 106, pp. 765-784
McDonald, D. Q., Still, W. C., (1992) Tetrahedron Lett., 33, pp. 7743-7746
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Gill, S. C., Von Hippel, P. H., (1989) Anal. Biochem., 182, pp. 319-326
Eftink, M. R., (1997) Methods Enzymol., 278, pp. 221-257
A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements
A cyclic CCK8 analogue, cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 (Dpr=L-2,3-diaminopropionic acid), has been designed on the basis of the NMR structure of the bimolecular complex between the N-terminal fragment of the CCK(A) receptor and its natural ligand CCK8. The conformational features of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 have been determined by NMR spectroscopy in aqueous solution and in water containing DPC-d(38) micelles (DPC=dodecylphosphocholine). The structure of the cyclic peptide in aqueous solution is found to be in a relaxed conformation, with the backbone and Dpr29 side chain atoms making a planar ring and the N-terminal tripeptide extending approximately along the plane of this ring. In DPC/water, the cyclic peptide adopts a "boat-shaped" conformation, which is more compact than that found in aqueous solution. The cyclic constraint between the Dpr29 side chain and the CCK8 carboxyl terminus (Lys34) introduces a restriction in the backbone conformational freedom. However, the interaction of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 with the micelles still plays an important role in the stabilisation of the bioactive conformation. A careful comparison of the NMR structure of the cyclic peptide in a DPC micelle aqueous solution with the structure of the rationally designed model underlines that the turn-like conformation in the Trp30-Met31 region is preserved, such that the Trp30 and Met31 side chains can adopt the proper spatial orientation to interact with the CCK(A) receptor. The binding properties of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 to the N-terminal receptor fragment have been investigated by fluorescence spectroscopy in a micellar environment. Estimates of the apparent dissociation constant, K(d), were in the range of 70-150 nM, with a mean value of 120+/-27 nM. Preliminary nuclear medicine studies on cell lines transfected with the CCK(A) receptor indicate that the sulfated-Tyr derivative of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 displaces the natural ligand with an IC(50) value of 15 microM.
A cyclic CCK8 analogue, cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 (Dpr=L-2,3-diaminopropionic acid), has been designed on the basis of the NMR structure of the bimolecular complex between the N-terminal fragment of the CCK(A) receptor and its natural ligand CCK8. The conformational features of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 have been determined by NMR spectroscopy in aqueous solution and in water containing DPC-d(38) micelles (DPC=dodecylphosphocholine). The structure of the cyclic peptide in aqueous solution is found to be in a relaxed conformation, with the backbone and Dpr29 side chain atoms making a planar ring and the N-terminal tripeptide extending approximately along the plane of this ring. In DPC/water, the cyclic peptide adopts a "boat-shaped" conformation, which is more compact than that found in aqueous solution. The cyclic constraint between the Dpr29 side chain and the CCK8 carboxyl terminus (Lys34) introduces a restriction in the backbone conformational freedom. However, the interaction of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 with the micelles still plays an important role in the stabilisation of the bioactive conformation. A careful comparison of the NMR structure of the cyclic peptide in a DPC micelle aqueous solution with the structure of the rationally designed model underlines that the turn-like conformation in the Trp30-Met31 region is preserved, such that the Trp30 and Met31 side chains can adopt the proper spatial orientation to interact with the CCK(A) receptor. The binding properties of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 to the N-terminal receptor fragment have been investigated by fluorescence spectroscopy in a micellar environment. Estimates of the apparent dissociation constant, K(d), were in the range of 70-150 nM, with a mean value of 120+/-27 nM. Preliminary nuclear medicine studies on cell lines transfected with the CCK(A) receptor indicate that the sulfated-Tyr derivative of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 displaces the natural ligand with an IC(50) value of 15 microM.
A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements
A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (526 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (494 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (470 views)
Patent, 2010; PctWo2011092575: Pct-Pct.
Impact Factor: 0
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (408 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (436 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (430 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (568 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (437 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Oliva R, Leone M, Falcigno L, D'Auria G, Dettin M, Scarinci C, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (499 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002 Mar 15; 8(6): 1467-1473.
Impact Factor: 4.238
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Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (498 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
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Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (722 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
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D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
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Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (514 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
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Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
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* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (150 views)
Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (261 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
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Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (365 views)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
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Avitabile C, D'Andrea LD, Saviano M, Olivieri M, Cimmino A, Romanelli A
* Binding studies of antimicrobial peptides to Escherichia coli cells (389 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2016 Sep 09; 478(1): 149-153.
Impact Factor: 2.466
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Roviello GN, Musumeci D
* Synthetic approaches to nucleopeptides containing all the four nucleobases, and nucleic acid-binding studies on a mixed-sequence nucleo-oligolysine (435 views)
Rsc Adv (ISSN: 2046-2069), 2016 Jun; 6: 63578-63585.
Impact Factor: 3.108
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Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (457 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2014 Sep 17; 4(1): 73-81.
Impact Factor: 3.088
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Basile L, Pappalardo M, Guccione S, Milardi D, Ramsay RR
* Computational comparison of imidazoline association with the I2 binding site in human monoamine oxidases (359 views)
J Chem Inf Model (ISSN: 1549-9596), 2014 Apr 28; 54(4): 1200-1207.
Impact Factor: 3.738
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (575 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (469 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2193 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (526 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (494 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (470 views)
Patent, 2010; PctWo2011092575: Pct-Pct.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (408 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (436 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (430 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
View Export to BibTeX Export to EndNote
De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
View Export to BibTeX Export to EndNote
Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (568 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
View Export to BibTeX Export to EndNote
Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (437 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
Oliva R, Leone M, Falcigno L, D'Auria G, Dettin M, Scarinci C, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (499 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002 Mar 15; 8(6): 1467-1473.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (498 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (722 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
View Export to BibTeX Export to EndNote
D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (514 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
33 Records (33 excluding Abstracts).
Total impact factor: 95.096 (95.096 excluding Abstracts).
Total 5 year impact factor: 94.183 (94.183 excluding Abstracts).
Total impact factor: 95.096 (95.096 excluding Abstracts).
Total 5 year impact factor: 94.183 (94.183 excluding Abstracts).
472 views. Last view on Tuesday 28 February 2023, 5:03:38
ibb.cnr.it
