A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor(383 views) Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
Ist. di Biostrutture e Bioimmagini, Dipartimento di Chimica Biologica, Univ. Federico II di Napoli, Via Mezzocannone 6, 80134 Naples, Italy
Dipto. di Biochimica e Biofisica, C.R.I.S.C.E.B., Seconda Università di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
Gupta, S.K., Pillarisetti, K., Thomas, R.A., Aiyar, N., (2001) Immunol. Lett., 78, pp. 29-34
Ragone, R., De Luca, S., Tesauro, D., Pedone, C., Morelli, G., (2000) Biopolymers, 56, pp. 47-53
Kleinschmidt, J.H., Wiener, M.C., Tamm, L.K., (1999) Protein Sci., 8, pp. 2065-2071
Emerson, M.F., Holtzer, A., (1967) J. Phys. Chem., 71, pp. 1898-1907
Esposito, C., Colicchio, P., Facchiano, A., Ragone, R., (1998) J. Colloid Interface Sci., 200, pp. 310-312
Loetscher, P., Gong, J.-H., Dewald, B., Baggiolini, M., Clark-Lewis, I., (1998) J. Biol. Chem., 273, pp. 22279-22283
A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor
We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4 {29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4 {29-39}
A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor