Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (788 views)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
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Paper type: Journal Article,
Impact factor: 2.045, 5-year impact factor: 5.445
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038370949&partnerID=40&md5=e8b171b1dbb1ff05e361e8a229f5b5c5
Keywords: Avascular Necrosis, Bone Mineral Density, Fibroblast Colony-Forming Unit, Graft Versus Host Disease, Stem Cell Transplantation, Steroid Treatment, Alpha Interferon, Analgesic Agent, Asparaginase, Bleomycin, Busulfan, Carmustine, Chlorambucil, Cyclophosphamide, Cyclosporin, Cytarabine, Daunorubicin, Doxorubicin, Epirubicin, Etoposide, Fludarabine, Hydroxyurea, Idarubicin, Melphalan, Methotrexate, Methylprednisolone, Mitoxantrone, Vincristine, Adult, Autologous Bone Marrow Transplantation, Blood Disease, Cancer Surgery, Cancer Survival, Cell Growth, Colony Forming Unit, Controlled Study, Disease Course, Dual Energy X Ray Absorptiometry, Electromagnetic Radiation, Female, Femur Head, Follow Up, Graft Versus Host Reaction, Human, Human Tissue, In Vitro Study, Long Term Care, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Postoperative Complication, Priority Journal, Prospective Study, Review, Risk Factor, Total Hip Prosthesis, Article, Bone Density, Bone Necrosis, Case Control Study, Disease Free Survival, Italy, Leukemia, Mortality, Pathology, Prevalence, Case-Control Studies, Disease-Free Survival, Osteonecrosis, Prospective Studies, Survivors,
Affiliations:
*** IBB - CNR ***
Dept. of Molecular Endocrinology, Federico II University, Naples, Italy
Division of Hematology, Federico II University, Via S. Pansini 5, 80131 Naples, Italy
Department of Orthopedics, Federico II University, Naples, Italy
Dept. of Biomorphological Sciences, Federico II University, Naples, Italy
References:
Not available.
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.045, 5-year impact factor: 5.445
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038370949&partnerID=40&md5=e8b171b1dbb1ff05e361e8a229f5b5c5
Keywords: Avascular Necrosis, Bone Mineral Density, Fibroblast Colony-Forming Unit, Graft Versus Host Disease, Stem Cell Transplantation, Steroid Treatment, Alpha Interferon, Analgesic Agent, Asparaginase, Bleomycin, Busulfan, Carmustine, Chlorambucil, Cyclophosphamide, Cyclosporin, Cytarabine, Daunorubicin, Doxorubicin, Epirubicin, Etoposide, Fludarabine, Hydroxyurea, Idarubicin, Melphalan, Methotrexate, Methylprednisolone, Mitoxantrone, Vincristine, Adult, Autologous Bone Marrow Transplantation, Blood Disease, Cancer Surgery, Cancer Survival, Cell Growth, Colony Forming Unit, Controlled Study, Disease Course, Dual Energy X Ray Absorptiometry, Electromagnetic Radiation, Female, Femur Head, Follow Up, Graft Versus Host Reaction, Human, Human Tissue, In Vitro Study, Long Term Care, Major Clinical Study, Nuclear Magnetic Resonance Imaging, Postoperative Complication, Priority Journal, Prospective Study, Review, Risk Factor, Total Hip Prosthesis, Article, Bone Density, Bone Necrosis, Case Control Study, Disease Free Survival, Italy, Leukemia, Mortality, Pathology, Prevalence, Case-Control Studies, Disease-Free Survival, Osteonecrosis, Prospective Studies, Survivors,
Affiliations:
*** IBB - CNR ***
Dept. of Molecular Endocrinology, Federico II University, Naples, Italy
Division of Hematology, Federico II University, Via S. Pansini 5, 80131 Naples, Italy
Department of Orthopedics, Federico II University, Naples, Italy
Dept. of Biomorphological Sciences, Federico II University, Naples, Italy
References:
Not available.
Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review
BACKGROUND. The most debilitating skeletal complication of stem cell transplantation (SCT) is avascular necrosis (AVN). METHODS. Two hundred seven consecutive patients were evaluated prospectively for AVN. They survived disease free for more than 180 days after autologous or allogeneic SCT for hematologic malignancies. The diagnosis of AVN in suspicious cases was confirmed by magnetic resonance imaging. Possible correlations with treatments, bone mineral density (BMD), graft versus host disease (GVHD), and in vitro growth of fibroblast progenitors were investigated. Bone mineral density was evaluated by dual-energy X-ray absorptiometry in 100 transplanted patients, and the in vitro growth of fibroblast progenitors was monitored by a fibroblast colony-forming unit (CFU-F) assay in 30 patients after allogeneic SCT. RESULTS. Twelve patients developed AVN 3-114 months (median, 26 months) following SCT: 10 (10%) after allogeneic SCT and 2 (1.9%) after autologous SCT (P = 0.04). Twenty-five joints were affected by AVN. All patients had femoral head involvement, which was managed with hip replacement in six of them. All but one patient who developed AVN after allogeneic SCT suffered from chronic GVHD (cGVHD). Avascular necrosis occurred 1-4 months after exacerbation or progression of cGVHD. Cumulative dose of steroids was similar in both SCT groups (including steroids given pretransplant for the basic disease), whereas treatment duration was significantly longer in the allogeneic SCT group. Avascular necrosis was related to the decreased number of bone marrow CFU-F colonies in vitro, but not to BMD values. CONCLUSIONS. Avascular necrosis is a skeletal complication that occurs more often after allogeneic than after autologous SCT. Occurrence of AVN symptoms after clinical follow-p of cGVHD suggests that cGVHD requiring long-term steroid therapy is one of the main risk factors for AVN. Avascular necrosis may be facilitated by a severe deficit in the repopulating capacity of bone marrow stromal stem cells after SCT. © 2003 American Cancer Society.
BACKGROUND. The most debilitating skeletal complication of stem cell transplantation (SCT) is avascular necrosis (AVN). METHODS. Two hundred seven consecutive patients were evaluated prospectively for AVN. They survived disease free for more than 180 days after autologous or allogeneic SCT for hematologic malignancies. The diagnosis of AVN in suspicious cases was confirmed by magnetic resonance imaging. Possible correlations with treatments, bone mineral density (BMD), graft versus host disease (GVHD), and in vitro growth of fibroblast progenitors were investigated. Bone mineral density was evaluated by dual-energy X-ray absorptiometry in 100 transplanted patients, and the in vitro growth of fibroblast progenitors was monitored by a fibroblast colony-forming unit (CFU-F) assay in 30 patients after allogeneic SCT. RESULTS. Twelve patients developed AVN 3-114 months (median, 26 months) following SCT: 10 (10%) after allogeneic SCT and 2 (1.9%) after autologous SCT (P = 0.04). Twenty-five joints were affected by AVN. All patients had femoral head involvement, which was managed with hip replacement in six of them. All but one patient who developed AVN after allogeneic SCT suffered from chronic GVHD (cGVHD). Avascular necrosis occurred 1-4 months after exacerbation or progression of cGVHD. Cumulative dose of steroids was similar in both SCT groups (including steroids given pretransplant for the basic disease), whereas treatment duration was significantly longer in the allogeneic SCT group. Avascular necrosis was related to the decreased number of bone marrow CFU-F colonies in vitro, but not to BMD values. CONCLUSIONS. Avascular necrosis is a skeletal complication that occurs more often after allogeneic than after autologous SCT. Occurrence of AVN symptoms after clinical follow-p of cGVHD suggests that cGVHD requiring long-term steroid therapy is one of the main risk factors for AVN. Avascular necrosis may be facilitated by a severe deficit in the repopulating capacity of bone marrow stromal stem cells after SCT. © 2003 American Cancer Society.
Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review
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Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review
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Impact Factor: 5.078
View Export to BibTeX Export to EndNote
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9 Records (8 excluding Abstracts).
Total impact factor: 70.706 (61.363 excluding Abstracts).
Total 5 year impact factor: 68.492 (58.871 excluding Abstracts).
Total impact factor: 70.706 (61.363 excluding Abstracts).
Total 5 year impact factor: 68.492 (58.871 excluding Abstracts).
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