Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (563 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
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Paper type: Journal Article,
Impact factor: 4.899, 5-year impact factor: 6.119
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038315472&partnerID=40&md5=4fd1f70a57dcd75a1e806e0d20ec048a
Keywords: 123i-2β-Carbomethoxy-3β-(4-Iodophenyl)-Tropane, Attenuation Correction, Binding Potential, Scatter Correction, Spect, 3beta (4 Iodophenyl) 2beta Tropanecarboxylic Acid Methyl Ester, Iodine 123, Cocaine, Diagnostic Agent, Drug Derivative, Radioactive Iodine, Radiopharmaceutical Agent, Accuracy, Article, Brain, Brain Region, Calculation, Camera, Collimator, Controlled Study, Corpus Striatum, Evaluation, Experiment, Human, Image Analysis, Image Reconstruction, Injection, Measurement, Occipital Lobe, Phantom, Priority Journal, Quantitative Analysis, Simulation, Single Photon Emission Computer Tomography, Adult, Clinical Trial, Comparative Study, Female, Image Enhancement, Image Quality, Image Subtraction, Methodology, Quality Control, Radiation Scattering, Reproducibility, Scintiscanning, Sensitivity And Specificity, Iodine Radioisotopes, Imaging, Reproducibility Of Results, Subtraction Technique, Emission-Computed, Single-Photon, 123i-2ß-Carbomethoxy-3ß-(4-Iodophenyl)-Tropane, 123i-2-Carbomethoxy-3-(4-Iodophenyl)-Tropane,
Affiliations:
*** IBB - CNR ***
Dept. of Investigative Radiology, Natl. Cardiovasc. Ctr. Res. Inst., Osaka, Japan
National Research Council, Biostructure and Bioimaging Inst., Naples, Italy
Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, United States
References:
Not available.
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.899, 5-year impact factor: 6.119
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038315472&partnerID=40&md5=4fd1f70a57dcd75a1e806e0d20ec048a
Keywords: 123i-2β-Carbomethoxy-3β-(4-Iodophenyl)-Tropane, Attenuation Correction, Binding Potential, Scatter Correction, Spect, 3beta (4 Iodophenyl) 2beta Tropanecarboxylic Acid Methyl Ester, Iodine 123, Cocaine, Diagnostic Agent, Drug Derivative, Radioactive Iodine, Radiopharmaceutical Agent, Accuracy, Article, Brain, Brain Region, Calculation, Camera, Collimator, Controlled Study, Corpus Striatum, Evaluation, Experiment, Human, Image Analysis, Image Reconstruction, Injection, Measurement, Occipital Lobe, Phantom, Priority Journal, Quantitative Analysis, Simulation, Single Photon Emission Computer Tomography, Adult, Clinical Trial, Comparative Study, Female, Image Enhancement, Image Quality, Image Subtraction, Methodology, Quality Control, Radiation Scattering, Reproducibility, Scintiscanning, Sensitivity And Specificity, Iodine Radioisotopes, Imaging, Reproducibility Of Results, Subtraction Technique, Emission-Computed, Single-Photon, 123i-2ß-Carbomethoxy-3ß-(4-Iodophenyl)-Tropane, 123i-2-Carbomethoxy-3-(4-Iodophenyl)-Tropane,
Affiliations:
*** IBB - CNR ***
Dept. of Investigative Radiology, Natl. Cardiovasc. Ctr. Res. Inst., Osaka, Japan
National Research Council, Biostructure and Bioimaging Inst., Naples, Italy
Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, United States
References:
Not available.
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
Correction of scatter and attenuation is essential for quantitative SPECT. In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR), Methods: SPECT data were acquired from an 123I-containing phantom with a constant activity in the STR but differing background (BKG) activities, so as to simulate various STR/BKG ratios (19.7:1, 9.7:1, 4.8:1, 1.9:1, and 1:1). In a study of healthy humans (n = 6), a transmission scan followed by an emission scan was performed 24 h after injection of 123I-2β-carbomethoxy-3β- (4-iodophenyl)-tropane (123I-β-CIT). All SPECT data was reconstructed with ordered-subset expectation maximization. TDCS was applied for scatter correction. Values of activity in the STR and occipital lobe (for BKG) were used to calculate binding potential V3″ (= [STR - BKG]/BKG). The effect of SPECT collimator dependency on scatter correction was also evaluated for 6 collimators from 3 different SPECT cameras in the phantom experiment. Results: Scatter correction in the phantom experiment increased the measured values of STR activity (36.2%), resulting in a substantial increase in V3″ (66.1%). Scatter and attenuation corrections with recovery correction showed an overall bias of -7.3% for the STR, -4.0% for BKG activity, and -7.8% for V3″. TDCS corrections of phantom activities were relatively uniform for the 6 different collimators, with variabilities of <5.5% for the STR and <3.0% for BKG activities. TDCS correction of human 123I-β-CIT images was of a similar, although slightly larger, magnitude than for the phantom data, with increased V3″ values of 9.4 ± 2.3 and 4.9 ± 0.6, with and without scatter correction, respectively. Conclusion: The TDSC method significantly improved the accuracy of SPECT images with a nonuniform distribution of activity highly concentrated in central regions. The value of V3″ was significantly increased in phantom and human data, with most of the improvement derived from an increase in STR activity. This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities.
Correction of scatter and attenuation is essential for quantitative SPECT. In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR), Methods: SPECT data were acquired from an 123I-containing phantom with a constant activity in the STR but differing background (BKG) activities, so as to simulate various STR/BKG ratios (19.7:1, 9.7:1, 4.8:1, 1.9:1, and 1:1). In a study of healthy humans (n = 6), a transmission scan followed by an emission scan was performed 24 h after injection of 123I-2β-carbomethoxy-3β- (4-iodophenyl)-tropane (123I-β-CIT). All SPECT data was reconstructed with ordered-subset expectation maximization. TDCS was applied for scatter correction. Values of activity in the STR and occipital lobe (for BKG) were used to calculate binding potential V3″ (= [STR - BKG]/BKG). The effect of SPECT collimator dependency on scatter correction was also evaluated for 6 collimators from 3 different SPECT cameras in the phantom experiment. Results: Scatter correction in the phantom experiment increased the measured values of STR activity (36.2%), resulting in a substantial increase in V3″ (66.1%). Scatter and attenuation corrections with recovery correction showed an overall bias of -7.3% for the STR, -4.0% for BKG activity, and -7.8% for V3″. TDCS corrections of phantom activities were relatively uniform for the 6 different collimators, with variabilities of <5.5% for the STR and <3.0% for BKG activities. TDCS correction of human 123I-β-CIT images was of a similar, although slightly larger, magnitude than for the phantom data, with increased V3″ values of 9.4 ± 2.3 and 4.9 ± 0.6, with and without scatter correction, respectively. Conclusion: The TDSC method significantly improved the accuracy of SPECT images with a nonuniform distribution of activity highly concentrated in central regions. The value of V3″ was significantly increased in phantom and human data, with most of the improvement derived from an increase in STR activity. This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities.
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
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Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
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Attenuation correction for myocardial perfusion SPECT imaging: still a controversial issue (1085 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Oct; 38(10): 1887-1889.
Impact Factor: 4.991
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Slomka PJ, Le Meunier L, Hayes SW, Acampa W, Oba M, Haemer GG, Berman DS, Germano G
* Comparison of Myocardial Perfusion (82)Rb PET Performed with CT- and Transmission CT-Based Attenuation Correction (1818 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2008 Dec; 49(12): 1992-1998.
Impact Factor: 6.662
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Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (900 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
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Kim KM, Watabe H, Varrone A, Fujita M, Innis RB, Iida H
* Evaluation of Two Scatter Correction Methods in Quantitative Brain SPECT with Dopaminergic Tracer (735 views)
Ieee Nucl Sci Symp Med Imaging Conf, 2002; 3: 1792-1796.
Impact Factor: 0.155
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Attenuation correction for myocardial perfusion SPECT imaging: still a controversial issue (1085 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Oct; 38(10): 1887-1889.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Slomka PJ, Le Meunier L, Hayes SW, Acampa W, Oba M, Haemer GG, Berman DS, Germano G
* Comparison of Myocardial Perfusion (82)Rb PET Performed with CT- and Transmission CT-Based Attenuation Correction (1818 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2008 Dec; 49(12): 1992-1998.
Impact Factor: 6.662
View Export to BibTeX Export to EndNote
Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (900 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
Kim KM, Watabe H, Varrone A, Fujita M, Innis RB, Iida H
* Evaluation of Two Scatter Correction Methods in Quantitative Brain SPECT with Dopaminergic Tracer (735 views)
Ieee Nucl Sci Symp Med Imaging Conf, 2002; 3: 1792-1796.
Impact Factor: 0.155
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 15.743 (15.743 excluding Abstracts).
Total 5 year impact factor: 15.907 (15.907 excluding Abstracts).
Total impact factor: 15.743 (15.743 excluding Abstracts).
Total 5 year impact factor: 15.907 (15.907 excluding Abstracts).
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