Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities(282 views) Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
Dept. of Investigative Radiology, Natl. Cardiovasc. Ctr. Res. Inst., Osaka, Japan
National Research Council, Biostructure and Bioimaging Inst., Naples, Italy
Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, United States
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Seibyl, J. P., Marek, K., Sheff, K., Test/retest reproducibility of iodine-123- -CIT SPECT brain measurement of dopamine transporters in Parkinson's patients (1997) J Nucl Med, 38, pp. 1453-1459
Van Dyck, C. H., Seibyl, J. P., Malison, R. T., Age-related decline in striatal dopamine transporter binding with iodine-123- -CIT SPECT (1995) J Nucl Med, 36, pp. 1175-1181
Stodilka, R. Z., Kemp, B. J., Msaki, P., The relative contributions of scatter and attenuation corrections toward improved brain SPECT quantification (1998) Phys Med Biol, 43, pp. 2991-3008
Hudson, H. M., Larkin, R. S., Accelerated image reconstruction using ordered subsets of projection data (1994) IEEE Trans Med Imaging, 13, pp. 601-609
Sorenson, J. A., Phelps, M. E., (1987) Physics in Nuclear Medicine 2nd Ed, , New York, NY. Grune & Stratton Inc
Jaszczak, R. J., Coleman, R. E., Whitehead FR Physical factors affecting quantitative measurements using camera-based single photon emission computed tomography (SPECT) (1981) IEEE Trans Nucl Sci, 28, pp. 69-80
Meikle, S. R., Hutton, B. F., Bailey, D. L., A transmission-dependent method for scatter correction in SPECT (1994) J Nucl Med, 35, pp. 360-367
Kim, K. M., Watebe, H., Shidahara, M., SPECT collimator dependency of scatter and validation of transmission-dependent scatter compensation methodologies (2001) IEEE Trans Nucl Sci, 48, pp. 689-696
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
Correction of scatter and attenuation is essential for quantitative SPECT. In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR), Methods: SPECT data were acquired from an 123I-containing phantom with a constant activity in the STR but differing background (BKG) activities, so as to simulate various STR/BKG ratios (19.7:1, 9.7:1, 4.8:1, 1.9:1, and 1:1). In a study of healthy humans (n = 6), a transmission scan followed by an emission scan was performed 24 h after injection of 123I-2β-carbomethoxy-3β- (4-iodophenyl)-tropane (123I-β-CIT). All SPECT data was reconstructed with ordered-subset expectation maximization. TDCS was applied for scatter correction. Values of activity in the STR and occipital lobe (for BKG) were used to calculate binding potential V3″ (= [STR - BKG]/BKG). The effect of SPECT collimator dependency on scatter correction was also evaluated for 6 collimators from 3 different SPECT cameras in the phantom experiment. Results: Scatter correction in the phantom experiment increased the measured values of STR activity (36.2%), resulting in a substantial increase in V3″ (66.1%). Scatter and attenuation corrections with recovery correction showed an overall bias of -7.3% for the STR, -4.0% for BKG activity, and -7.8% for V3″. TDCS corrections of phantom activities were relatively uniform for the 6 different collimators, with variabilities of <5.5% for the STR and <3.0% for BKG activities. TDCS correction of human 123I-β-CIT images was of a similar, although slightly larger, magnitude than for the phantom data, with increased V3″ values of 9.4 ± 2.3 and 4.9 ± 0.6, with and without scatter correction, respectively. Conclusion: The TDSC method significantly improved the accuracy of SPECT images with a nonuniform distribution of activity highly concentrated in central regions. The value of V3″ was significantly increased in phantom and human data, with most of the improvement derived from an increase in STR activity. This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities.
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
No results.
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities