Folding of peptides characterized by c3Val, a highly constrained analogue of valine (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
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Paper type: Journal Article,
Impact factor: 2.733, 5-year impact factor: 2.675
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037322818&partnerID=40&md5=af126fd9069374b33e779f5ff32d2eb1
Keywords: β-Bend, 310-Helix, Amino Acid Synthesis, Cα-Tetrasubstituted α-Amino Acids, Conformational Analysis, Cyclopropane Amino Acid, Ir Absorption, Peptide Synthesis, X-Ray Diffraction, Fourier Transform Infrared Spectroscopy, Synthesis (chemical), X Ray Diffraction, Chirality, Amino Acid Derivative, Glycine, Valine, Article, Biosynthesis, Crystal Structure, Enantiomer, Intermethod Comparison, Methylation, Protein Analysis, Protein Folding, Protein Structure, Crystallography, Models, Molecular, Molecular Conformation, Oligopeptides, Protein Conformation, ß-Bend, Ca-Tetrasubstituted A-Amino Acids,
Affiliations:
*** IBB - CNR ***
Institute of Biomolecular Chemistry, Department of Organic Chemistry, University of Padova, 35131 Padova, Italy
DSM Fine Chemicals, Advanced Synthesis and Catalysis, P. O. Box 18, 6160 MD Geleen, Netherlands
Inst. of Biostructures/Bioimaging, Department of Chemistry, University of Naples Federico II, 80134 Naples, Italy
References:
Toniolo, C., Benedetti, E., (1991) Macromolecules, 24, pp. 4004-400
Toniolo, C., Crisma, M., Formaggio, F., Peggion, C., (2001) Biopolymers (Pept Sci), 60, pp. 396-419
Toniolo, C., (1980) CRC Crit Rev Biochem, 9, pp. 1-44
Venkatachalam, C.M., (1968) Biopolymers, 6, pp. 1425-1436
Rose, G.D., Gierasch, L.M., Smith, J.A., (1985) Adv Protein Chem, 37, pp. 1-109
Bolin, K.A., Millhauser, G.L., (1999) Acc Chem Res, 32, pp. 1027-1033
Valle, G., Crisma, M., Toniolo, C., Polinelli, S., Boesten, W.H.J., Schoemaker, H.E., Meijer, E.M., Kamphuis, J., (1991) Int J Pept Protein Res, 37, pp. 521-527
Formaggio, F., Pantano, M., Valle, G., Crisma, M., Bonora, G.M., Mammi, S., Peggion, E., Kamphuis, J., (1993) Macromolecules, 26, pp. 1848-1852
Polese, A., Formaggio, F., Crisma, M., Valle, G., Toniolo, C., Bonora, G.M., Broxterman, Q.B., Kamphuis, J., (1996) Chem Eur J, 2, pp. 1104-1111
Lapeña, Y., Lopez, P., Cativiela, C., Kaptein, B., Broxterman, Q.B., Kamphuis, J., Mossel, E., Toniolo, C., (2000) J Chem Soc, Perkin Trans 2, pp. 631-636
Mossel, E., Formaggio, F., Valle, G., Crisma, M., Toniolo, C., Doi, M., Ishida, T., Kamphuis, J., (1998) Lett Pept Sci, 5, pp. 223-225
Indian Academy of Sciences: Bangalore, India
Benedetti, E., Di Blasio, B., Pavone, V., Pedone, C., Santini, A., Crisma, M., Valle, G., Toniolo, C., (1989) Biopolymers, 28, pp. 175-184
Barone, V., Fraternali, F., Cristinziano, P.L., Lelj, F., Rosa, A., (1988) Biopolymers, 26, pp. 1673-1685
Balaji, V.N., Ramnarayan, K., Chan, M.F., Rao, S.N., (1994) Pept Res, 7, pp. 60-71
Aleman, C., (1997) J Phys Chem, B101, pp. 5046-5050
Aleman, C., Casanovas, J., Galembeck, S.E., (1998) J Comput-Aided Mol Design, 12, pp. 259-273
Varughese, K.I., Srinivasan, A.R., Stammer, C.H., (1985) Int J Pept Protein Res, 26, pp. 242-251
Mapelli, C., Elrod, L.F., Switzer, F.L., Stammer, C.H., Holt, E.M., (1989) Biopolymers, 28, pp. 123-128
Burgess, K., Ho, K.-K., Pettitt, B.M., (1995) J Am Chem Soc, 117, pp. 54-65
Burgess, K., Ke, C.-Y., (1996) J Org Chem, 61, pp. 8627-8631
Burgess, K., Li, W., Lim, D., Moye-Sherman, D., (1997) Biopolymers, 42, pp. 439-453
Burgess, K., Lim, D., (1997) J Am Chem Soc, 119, pp. 9632-9640
Moye-Sherman, D., Jin, S., Li, S., Welch, M.B., Reibenspies, J., Burgess, K., (1999) Chem Eur J, 5, pp. 2730-2739
Jiménez, A.I., Vanderesse, R., Marraud, M., Aubry, A., Cativiela, C., (1997) Tetrahedron Lett, 38, pp. 7559-7562
Jiménez, A.I., Cativiela, C., Aubry, A., Marraud, M., (1998) J Am Chem Soc, 120, pp. 9452-9459
Sheldrick, G.M., (1997) SHELXS 97. Program for the Solution of Crystal Structures, , University of Göttingen: Göttingen, Germany
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Polidori, G., (1997) SIR 97. A Program for the Automatic Solution and Refinement of Crystal Structures, , University of Bari: Bari, Italy
Cromer, D.T., Waber, J.T., International Tables for X-Ray Crystallography, 4. , Table 2.2 B
Kynoch Press:, Birmingham, UK (now distributed by D. Reidel Publ. Co.)
Ramage, G.R., Simonsen, J.L., (1935) J Chem Soc, pp. 532-533
Cativiela, C., Díaz-de-Villegas, M.D., Jiménez, A.I., (1995) Tetrahedron: Asymmetry, 6, pp. 177-182
Moroder, L., Hallet, A., Wünsch, E., Keller, O., Wersin, G., (1976) Hoppe-Seyler's Z. Physiol Chem, 357, pp. 1651-1653
Burk, M.J., Allen, J.G., (1997) J Org Chem, 62, pp. 7054-7057
Minguillón, C., Franco, P., Oliveros, L., López, P., (1996) J Chromatogr A, 728, pp. 407-414
Easton, C.J., Fryer, N.L., Ivory, A.J., Tiekink, E.R.T., (1998) J Chem Soc, Perkin Trans 1, pp. 3725-3729
Chinchilla, R., Nájera, C., García-Granda, S., Menéndez-Velázquez, A., (1993) Tetrahedron Lett, 34, pp. 5799-5802
Kruizinga, W.H., Bolster, J., Kellogg, R.M., Kamphuis, J., Boesten, W.H.J., Meijer, E.M., Schoemaker, H.E., (1988) J Org Chem, 53, pp. 1826-1827
Kaptein, B., Boesten, W.H.J., Broxterman, Q.B., Peters, P.J.H., Schoemaker, H.E., Kamphuis, J., (1993) Tetrahedron: Asymmetry, 4, pp. 1113-1116
Carpino, L.A., (1993) J Am Chem Soc, 115, pp. 4397-4398
Leplawy, M.T., Jones, D.S., Kenner, G.W., Sheppard, R.C., (1960) Tetrahedron, 11, pp. 39-51
Valle, G., Formaggio, F., Crisma, M., Bonora, G.M., Toniolo, C., Bavoso, A., Benedetti, E., Pedone, C., (1986) J Chem Soc, Perkin Trans II, pp. 1371-1376
Schröder, E., Lübke, K., (1962) Liebigs Ann Chem, 655, pp. 211-218
Toniolo, C., Valle, G., Bonora, G.M., Crisma, M., Formaggio, F., Bavoso, A., Benedetti, E., Pedone, C., (1986) Biopolymers, 25, pp. 2237-2253
Cung, M.T., Marraud, M., Neél, J., (1972) Ann Chim, pp. 183-209
Bonora, G.M., Mapelli, C., Toniolo, C., Wilkening, R.R., Stevens, E.S., (1984) Int J Biol Macromol, 6, pp. 179-188
Némethy, G., Printz, M.P., (1972) Macromolecules, 5, pp. 755-758
Kopple, K.D., Ohnishi, M., Go, A., (1969) Biochemistry, 8, pp. 4087-4095
Martin, D., Hauthal, H.G., (1975) Dimethyl Sulphoxide, , van Nostrand-Reinhold: Wokingham, England
Kopple, K.D., Schamper, T.J., (1972) J Am Chem Soc, 94, pp. 3644-3646
(1970) Biochemistry, 9, pp. 3471-3479
Schweizer, W.B., Dunitz, J.D., (1982) Helv Chim Acta, 65, pp. 1547-1554
Benedetti, E., (1982) Chemistry and Biochemistry of Amino Acids, Peptides and Proteins, 6, pp. 105-184. , Weinstein, B., Ed.
Ashida, T., Tsunogae, Y., Tanaka, I., Yamane, T., (1987) Acta Crystallogr, B43, pp. 212-218
Paterson, Y., Rumsey, S.M., Benedetti, E., Némethy, G., Scheraga, H.A., (1981) J Am Chem Soc, 103, pp. 2947-2955
Zimmerman, S.S., Pottle, M.S., Némethy, G., Scheraga, H.A., (1977) Macromolecules, 10, pp. 1-9
Ramakrishnan, C., Prasad, N., (1971) Int J Protein Res, 3, pp. 209-231
Taylor, R., Kennard, O., Versichel, W., (1984) Acta Crystallogr, B40, pp. 280-288
Görbitz, C.H., (1989) Acta Crystallogr, B45, pp. 390-395
Dunitz, J.D., Strickler, P., (1968) Structural Chemistry and Molecular Biology, pp. 595-602. , Rich, A., Davidson, N., Eds.
Freeman: San Francisco
Marshall, G.R., (1971) Intra-Science Chemistry Report, pp. 305-316. , Kharasch, N., Ed.
Gordon & Breach: New York
Karle, I.L., Balaram, P., (1990) Biochemistry, 29, pp. 6747-6756
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.733, 5-year impact factor: 2.675
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037322818&partnerID=40&md5=af126fd9069374b33e779f5ff32d2eb1
Keywords: β-Bend, 310-Helix, Amino Acid Synthesis, Cα-Tetrasubstituted α-Amino Acids, Conformational Analysis, Cyclopropane Amino Acid, Ir Absorption, Peptide Synthesis, X-Ray Diffraction, Fourier Transform Infrared Spectroscopy, Synthesis (chemical), X Ray Diffraction, Chirality, Amino Acid Derivative, Glycine, Valine, Article, Biosynthesis, Crystal Structure, Enantiomer, Intermethod Comparison, Methylation, Protein Analysis, Protein Folding, Protein Structure, Crystallography, Models, Molecular, Molecular Conformation, Oligopeptides, Protein Conformation, ß-Bend, Ca-Tetrasubstituted A-Amino Acids,
Affiliations:
*** IBB - CNR ***
Institute of Biomolecular Chemistry, Department of Organic Chemistry, University of Padova, 35131 Padova, Italy
DSM Fine Chemicals, Advanced Synthesis and Catalysis, P. O. Box 18, 6160 MD Geleen, Netherlands
Inst. of Biostructures/Bioimaging, Department of Chemistry, University of Naples Federico II, 80134 Naples, Italy
References:
Toniolo, C., Benedetti, E., (1991) Macromolecules, 24, pp. 4004-400
Toniolo, C., Crisma, M., Formaggio, F., Peggion, C., (2001) Biopolymers (Pept Sci), 60, pp. 396-419
Toniolo, C., (1980) CRC Crit Rev Biochem, 9, pp. 1-44
Venkatachalam, C.M., (1968) Biopolymers, 6, pp. 1425-1436
Rose, G.D., Gierasch, L.M., Smith, J.A., (1985) Adv Protein Chem, 37, pp. 1-109
Bolin, K.A., Millhauser, G.L., (1999) Acc Chem Res, 32, pp. 1027-1033
Valle, G., Crisma, M., Toniolo, C., Polinelli, S., Boesten, W.H.J., Schoemaker, H.E., Meijer, E.M., Kamphuis, J., (1991) Int J Pept Protein Res, 37, pp. 521-527
Formaggio, F., Pantano, M., Valle, G., Crisma, M., Bonora, G.M., Mammi, S., Peggion, E., Kamphuis, J., (1993) Macromolecules, 26, pp. 1848-1852
Polese, A., Formaggio, F., Crisma, M., Valle, G., Toniolo, C., Bonora, G.M., Broxterman, Q.B., Kamphuis, J., (1996) Chem Eur J, 2, pp. 1104-1111
Lapeña, Y., Lopez, P., Cativiela, C., Kaptein, B., Broxterman, Q.B., Kamphuis, J., Mossel, E., Toniolo, C., (2000) J Chem Soc, Perkin Trans 2, pp. 631-636
Mossel, E., Formaggio, F., Valle, G., Crisma, M., Toniolo, C., Doi, M., Ishida, T., Kamphuis, J., (1998) Lett Pept Sci, 5, pp. 223-225
Indian Academy of Sciences: Bangalore, India
Benedetti, E., Di Blasio, B., Pavone, V., Pedone, C., Santini, A., Crisma, M., Valle, G., Toniolo, C., (1989) Biopolymers, 28, pp. 175-184
Barone, V., Fraternali, F., Cristinziano, P.L., Lelj, F., Rosa, A., (1988) Biopolymers, 26, pp. 1673-1685
Balaji, V.N., Ramnarayan, K., Chan, M.F., Rao, S.N., (1994) Pept Res, 7, pp. 60-71
Aleman, C., (1997) J Phys Chem, B101, pp. 5046-5050
Aleman, C., Casanovas, J., Galembeck, S.E., (1998) J Comput-Aided Mol Design, 12, pp. 259-273
Varughese, K.I., Srinivasan, A.R., Stammer, C.H., (1985) Int J Pept Protein Res, 26, pp. 242-251
Mapelli, C., Elrod, L.F., Switzer, F.L., Stammer, C.H., Holt, E.M., (1989) Biopolymers, 28, pp. 123-128
Burgess, K., Ho, K.-K., Pettitt, B.M., (1995) J Am Chem Soc, 117, pp. 54-65
Burgess, K., Ke, C.-Y., (1996) J Org Chem, 61, pp. 8627-8631
Burgess, K., Li, W., Lim, D., Moye-Sherman, D., (1997) Biopolymers, 42, pp. 439-453
Burgess, K., Lim, D., (1997) J Am Chem Soc, 119, pp. 9632-9640
Moye-Sherman, D., Jin, S., Li, S., Welch, M.B., Reibenspies, J., Burgess, K., (1999) Chem Eur J, 5, pp. 2730-2739
Jiménez, A.I., Vanderesse, R., Marraud, M., Aubry, A., Cativiela, C., (1997) Tetrahedron Lett, 38, pp. 7559-7562
Jiménez, A.I., Cativiela, C., Aubry, A., Marraud, M., (1998) J Am Chem Soc, 120, pp. 9452-9459
Sheldrick, G.M., (1997) SHELXS 97. Program for the Solution of Crystal Structures, , University of Göttingen: Göttingen, Germany
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Polidori, G., (1997) SIR 97. A Program for the Automatic Solution and Refinement of Crystal Structures, , University of Bari: Bari, Italy
Cromer, D.T., Waber, J.T., International Tables for X-Ray Crystallography, 4. , Table 2.2 B
Kynoch Press:, Birmingham, UK (now distributed by D. Reidel Publ. Co.)
Ramage, G.R., Simonsen, J.L., (1935) J Chem Soc, pp. 532-533
Cativiela, C., Díaz-de-Villegas, M.D., Jiménez, A.I., (1995) Tetrahedron: Asymmetry, 6, pp. 177-182
Moroder, L., Hallet, A., Wünsch, E., Keller, O., Wersin, G., (1976) Hoppe-Seyler's Z. Physiol Chem, 357, pp. 1651-1653
Burk, M.J., Allen, J.G., (1997) J Org Chem, 62, pp. 7054-7057
Minguillón, C., Franco, P., Oliveros, L., López, P., (1996) J Chromatogr A, 728, pp. 407-414
Easton, C.J., Fryer, N.L., Ivory, A.J., Tiekink, E.R.T., (1998) J Chem Soc, Perkin Trans 1, pp. 3725-3729
Chinchilla, R., Nájera, C., García-Granda, S., Menéndez-Velázquez, A., (1993) Tetrahedron Lett, 34, pp. 5799-5802
Kruizinga, W.H., Bolster, J., Kellogg, R.M., Kamphuis, J., Boesten, W.H.J., Meijer, E.M., Schoemaker, H.E., (1988) J Org Chem, 53, pp. 1826-1827
Kaptein, B., Boesten, W.H.J., Broxterman, Q.B., Peters, P.J.H., Schoemaker, H.E., Kamphuis, J., (1993) Tetrahedron: Asymmetry, 4, pp. 1113-1116
Carpino, L.A., (1993) J Am Chem Soc, 115, pp. 4397-4398
Leplawy, M.T., Jones, D.S., Kenner, G.W., Sheppard, R.C., (1960) Tetrahedron, 11, pp. 39-51
Valle, G., Formaggio, F., Crisma, M., Bonora, G.M., Toniolo, C., Bavoso, A., Benedetti, E., Pedone, C., (1986) J Chem Soc, Perkin Trans II, pp. 1371-1376
Schröder, E., Lübke, K., (1962) Liebigs Ann Chem, 655, pp. 211-218
Toniolo, C., Valle, G., Bonora, G.M., Crisma, M., Formaggio, F., Bavoso, A., Benedetti, E., Pedone, C., (1986) Biopolymers, 25, pp. 2237-2253
Cung, M.T., Marraud, M., Neél, J., (1972) Ann Chim, pp. 183-209
Bonora, G.M., Mapelli, C., Toniolo, C., Wilkening, R.R., Stevens, E.S., (1984) Int J Biol Macromol, 6, pp. 179-188
Némethy, G., Printz, M.P., (1972) Macromolecules, 5, pp. 755-758
Kopple, K.D., Ohnishi, M., Go, A., (1969) Biochemistry, 8, pp. 4087-4095
Martin, D., Hauthal, H.G., (1975) Dimethyl Sulphoxide, , van Nostrand-Reinhold: Wokingham, England
Kopple, K.D., Schamper, T.J., (1972) J Am Chem Soc, 94, pp. 3644-3646
(1970) Biochemistry, 9, pp. 3471-3479
Schweizer, W.B., Dunitz, J.D., (1982) Helv Chim Acta, 65, pp. 1547-1554
Benedetti, E., (1982) Chemistry and Biochemistry of Amino Acids, Peptides and Proteins, 6, pp. 105-184. , Weinstein, B., Ed.
Ashida, T., Tsunogae, Y., Tanaka, I., Yamane, T., (1987) Acta Crystallogr, B43, pp. 212-218
Paterson, Y., Rumsey, S.M., Benedetti, E., Némethy, G., Scheraga, H.A., (1981) J Am Chem Soc, 103, pp. 2947-2955
Zimmerman, S.S., Pottle, M.S., Némethy, G., Scheraga, H.A., (1977) Macromolecules, 10, pp. 1-9
Ramakrishnan, C., Prasad, N., (1971) Int J Protein Res, 3, pp. 209-231
Taylor, R., Kennard, O., Versichel, W., (1984) Acta Crystallogr, B40, pp. 280-288
Görbitz, C.H., (1989) Acta Crystallogr, B45, pp. 390-395
Dunitz, J.D., Strickler, P., (1968) Structural Chemistry and Molecular Biology, pp. 595-602. , Rich, A., Davidson, N., Eds.
Freeman: San Francisco
Marshall, G.R., (1971) Intra-Science Chemistry Report, pp. 305-316. , Kharasch, N., Ed.
Gordon & Breach: New York
Karle, I.L., Balaram, P., (1990) Biochemistry, 29, pp. 6747-6756
Folding of peptides characterized by c3Val, a highly constrained analogue of valine
Using a combined chemical/chiral chromatographic approach we synthesized an N-protected derivative of (R)-c3Val, a severely conformationally restricted Cα-tetrasubstituted α-amino acid characterized by a Cβ,β-dimethylated cyclopropane system. A set of terminally protected derivatives and model peptides (to the heptamer level), containing one or two (R)-c3Val residues in combination with either Aib or Gly residues, was prepared by solution methods. A detailed solution and crystal-state conformational investigation, based on Fourier transform infrared (FTIR) absorption, 1H-NMR, and x-ray diffraction techniques, performed in comparison with a similar study on related derivatives and peptides rich in (αMe)Val, the prototype of Cα-tetrasubstituted α-amino acids of this subfamily, allowed us to conclude the following: (a) c3Val is a good β-bend and helix former, although less efficient than (αMe)Val. (b) The relationship between α-carbon chirality and screw sense of the folded structure formed is the same as that of (αMe)Val, i.e., the (R)-enantiomer has a strong left-handed bias. (c) c3Val seems more prone than (αMe)Val to fold into a γ-bend conformation. The conformational propensities of Cβ,β-disubstituted Ac3c residues are also discussed in comparison with those of the parent cyclopropane residue. © 2002 Wiley Periodicals, Inc.
Using a combined chemical/chiral chromatographic approach we synthesized an N-protected derivative of (R)-c3Val, a severely conformationally restricted Cα-tetrasubstituted α-amino acid characterized by a Cβ,β-dimethylated cyclopropane system. A set of terminally protected derivatives and model peptides (to the heptamer level), containing one or two (R)-c3Val residues in combination with either Aib or Gly residues, was prepared by solution methods. A detailed solution and crystal-state conformational investigation, based on Fourier transform infrared (FTIR) absorption, 1H-NMR, and x-ray diffraction techniques, performed in comparison with a similar study on related derivatives and peptides rich in (αMe)Val, the prototype of Cα-tetrasubstituted α-amino acids of this subfamily, allowed us to conclude the following: (a) c3Val is a good β-bend and helix former, although less efficient than (αMe)Val. (b) The relationship between α-carbon chirality and screw sense of the folded structure formed is the same as that of (αMe)Val, i.e., the (R)-enantiomer has a strong left-handed bias. (c) c3Val seems more prone than (αMe)Val to fold into a γ-bend conformation. The conformational propensities of Cβ,β-disubstituted Ac3c residues are also discussed in comparison with those of the parent cyclopropane residue. © 2002 Wiley Periodicals, Inc.
Folding of peptides characterized by c3Val, a highly constrained analogue of valine
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Folding of peptides characterized by c3Val, a highly constrained analogue of valine
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Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (457 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (460 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (331 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
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Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
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Langella E, Rega N, Improta R, Crescenzi O, Barone V
* Conformational analysis of the tyrosine dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (292 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Apr 30; 23(6): 650-661.
Impact Factor: 2.931
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (512 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
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Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
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* NMR spectroscopy in the conformational analysis of peptides: an overview (91 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(14): 2729-2782.
Impact Factor: 4.184
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Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M
* Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues (416 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Nov 17; 17(22): 2179-2188.
Impact Factor: 2.847
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Synthesis of a thymine-functionalized nucleoamino acid for the solid phase assembly of cationic nucleopeptides (485 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2013 Oct; 45(4): 779-784.
Impact Factor: 3.653
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (527 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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Roviello GN, Mottola A, Musumeci D, Bucci EM, Pedone C
* Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid (423 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Oct; 43(4): 1465-1470.
Impact Factor: 3.914
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (367 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (492 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (457 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (460 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (331 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
View Export to BibTeX Export to EndNote
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
View Export to BibTeX Export to EndNote
Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
View Export to BibTeX Export to EndNote
Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
View Export to BibTeX Export to EndNote
Langella E, Rega N, Improta R, Crescenzi O, Barone V
* Conformational analysis of the tyrosine dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (292 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Apr 30; 23(6): 650-661.
Impact Factor: 2.931
View Export to BibTeX Export to EndNote
Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (512 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
View Export to BibTeX Export to EndNote
Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
22 Records (22 excluding Abstracts).
Total impact factor: 65.332 (65.332 excluding Abstracts).
Total 5 year impact factor: 71.452 (71.452 excluding Abstracts).
Total impact factor: 65.332 (65.332 excluding Abstracts).
Total 5 year impact factor: 71.452 (71.452 excluding Abstracts).
413 views. Last view on Monday 13 March 2023, 19:55:50
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