Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects(346 views) Ciampi Q, Betocchi S, Violante A, Lombardi R, Losi M, Storto G, Manganelli F, Tocchetti C, Aversa M, Pezzella E, Finizio F, Cuocolo A, Chiariello M
Department of Clinical Medicine, Federico II Univ. School of Medicine, Via S Pansini 5, I-80131 Naples, Italy
Dept. of Morphol./Functional Sci., Federico II Univ. School of Medicine, Via S Pansini 5, I-80131 Naples, Italy
Dept. of Morphol. /Functional Sci., Federico II Univ. School of Medicine, Via S Pansini 5, I-80131 Naples, Italy
References: Flamm, M.D., Harrison, D.C., Hancock, E.W., Muscular subaortic stenosis: Prevention of outflow obstruction with propranolol (1968) Circulation, 38, pp. 846-85
Harrison, D.C., Braunwald, E., Glick, G., Effects of beta adrenergic blockade on the circulation, with particular reference to observations in patients with hypertrophic subaortic stenosis (1964) Circulation, 29, pp. 84-98
Kluess, H.A., Wood, R.H., Welsch, M.A., Vagal modulation of the heart and central hemodynamics during handgrip exercise (2000) Am. J. Physiol. Heart Circ., 279, pp. H1648-H1652
Wigle, E.D., Rakowski, H., Kimball, B.P., Williams, W.G., Hypertrophic cardiomyopathy. Clinical spectrum and treatment (1995) Circulation, 92, pp. 1680-1692
Maron, B.J., Epstein, S.E., Hypertrophic cardiomyopathy: A discussion of nomenclature (1979) Am. J. Cardiol., 43, pp. 1242-1244
Sahn, D.J., DeMaria, A., Kisslo, J., Weiman, A., Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Spirito, P., Maron, B.J., Chiarella, F., Diastolic abnormalities in patients with hypertrophic cardiomyopathy: Relation to magnitude of left ventricular hypertrophy (1985) Circulation, 72, pp. 310-316
Helmcke, F., Nanda, N.C., Hsiung, M.C., Color Doppler assessment of mitral regurgitation with orthogonal planes (1987) Circulation, 75, pp. 175-183
Panza, J.A., Petrone, R.K., Fananapazir, L., Maron, B.J., Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy (1991) J. Am. Coll. Cardiol., 19, pp. 91-99
Betocchi, S., Piscione, F., Villari, B., Effects of induced asynchrony on left ventricular diastolic function in patients with coronary artery disease (1993) J. Am. Coll. Cardiol., 21, pp. 1124-1131
Pace, L., Cuocolo, A., Nappi, A., Accuracy and repeatability of left ventricle systolic and diastolic function measurements using an ambulatory radionuclide monitor (1992) Eur. J. Nucl. Med., 19, pp. 800-806
Wilson, R.A., Sullivan, P.J., Moore, R.H., An ambulatory ventricular function monitor: Validation and preliminary results (1983) Am. J. Cardiol., 52, pp. 601-606
Asmussen, E., Similarities and dissimilarities between static and dynamic exercise (1981) Circ. Res., 48 (SUPPL. 2), pp. 13-20
Jones, R.J., Lahiri, A., Cashman, P.M.M., Dore, C., Raftery, E.B., Left ventricular function during isometric handgrip and cold stress in normal subjects (1986) Br. Heart J., 55, pp. 246-252
Ludbrook, P.A., Byrne, J.D., Reed, F.R., McKnight, R.C., Modification of left ventricular diastolic behavior by isometric handgrip exercise (1980) Circulation, 62, pp. 357-370
Mizushige, K., Matsuo, H., Nokaki, S., Kwan, O.L., DeMaria, A.N., Differential responses in left ventricular diastolic filling dynamics with isometric handgrip versus isotonic treadmill exertion (1996) Am. Heart J., 131, pp. 131-137
Bodenheimer, M.M., Banka, V.S., Fooshee, C.M., Gillespie, J.A., Helfant, R.H., Detection of coronary heart disease using radionuclide determined regional ejection fraction at rest and during handgrip exercise: Correlation with coronary arteriography (1978) Circulation, 4, pp. 640-648
Peter, C.A., Jones, R.H., Effects of isometric handgrip and dynamic exercise on left-ventricle function (1980) J. Nucl. Med., 21, pp. 1131-1138
Cannon R.O. III, Rosing, D.R., Maron, B.J., Myocardial ischemia in patients with hypertrophic cardiomyopathy: Contribution of inadequate vasodilator reserve and elevated left ventricular filling pressure (1985) Circulation, 71, pp. 234-243
Imbriaco, M., Cuocolo, A., Pace, L., Repeatability of hemodynamic responses to cardiac stimulation by ambulatory monitoring of left ventricular function (1993) J. Nucl. Biol. Med., 37, pp. 238-244
Dilsizian, V., Bonow, R.O., Epstein, S.E., Fananapazir, L., Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy (1993) J. Am. Coll. Cardiol., 22, pp. 796-804
Yamada, M., Elliott, P.M., Kaski, J.C., Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy (1998) Eur. Heart J., 19, pp. 500-507
Cuocolo, A., Sax, F.L., Brush, J.E., Left ventricular hypertrophy and impaired diastolic filling in essential hypertension. Diastolic mechanisms for systolic dysfunction during exercise (1990) Circulation, 81, pp. 978-986
Gwathmey, J.K., Warren, S.E., Briggs, G.M., Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole (1991) J. Clin. Invest., 87, pp. 1023-1031
Little, W.C., Barr, W.K., Crawford, M.H., Altered effect of the Valsalva maneuver on left ventricular volume in patients with cardiomyopathy (1985) Circulation, 71, pp. 227-233
Wigle, E.D., Sasson, Z., Henderson, M.A., Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review (1985) Prog. Cardiovasc. Dis., 28, pp. 1-83
Spirito, P., Bellone, P., Harris, K.M., Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy (2000) N. Engl. J. Med., 342, pp. 1778-1785
Briguori, C., Betocchi, S., Romano, M., Exercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function (1999) Am. J. Cardiol., 84, pp. 309-315
Chigamori, T., Counhian, P.J., Doi, Y.L., Mechanisms of exercise limitation in hypertrophic cardiomyopathy (1992) J. Am. Coll. Cardiol., 19, pp. 507-512
Manganelli, F., Betocchi, S., Losi, M.A., Influence of left ventricular cavity size on clinical presentation in hypertrophic cardiomyopathy (1999) Am. J. Cardiol., 83, pp. 547-552
Flamm, M. D., Harrison, D. C., Hancock, E. W., Muscular subaortic stenosis: Prevention of outflow obstruction with propranolol (1968) Circulation, 38, pp. 846-85
Harrison, D. C., Braunwald, E., Glick, G., Effects of beta adrenergic blockade on the circulation, with particular reference to observations in patients with hypertrophic subaortic stenosis (1964) Circulation, 29, pp. 84-98
Kluess, H. A., Wood, R. H., Welsch, M. A., Vagal modulation of the heart and central hemodynamics during handgrip exercise (2000) Am. J. Physiol. Heart Circ., 279, pp. H1648-H1652
Wigle, E. D., Rakowski, H., Kimball, B. P., Williams, W. G., Hypertrophic cardiomyopathy. Clinical spectrum and treatment (1995) Circulation, 92, pp. 1680-1692
Maron, B. J., Epstein, S. E., Hypertrophic cardiomyopathy: A discussion of nomenclature (1979) Am. J. Cardiol., 43, pp. 1242-1244
Sahn, D. J., DeMaria, A., Kisslo, J., Weiman, A., Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Panza, J. A., Petrone, R. K., Fananapazir, L., Maron, B. J., Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy (1991) J. Am. Coll. Cardiol., 19, pp. 91-99
Wilson, R. A., Sullivan, P. J., Moore, R. H., An ambulatory ventricular function monitor: Validation and preliminary results (1983) Am. J. Cardiol., 52, pp. 601-606
Jones, R. J., Lahiri, A., Cashman, P. M. M., Dore, C., Raftery, E. B., Left ventricular function during isometric handgrip and cold stress in normal subjects (1986) Br. Heart J., 55, pp. 246-252
Ludbrook, P. A., Byrne, J. D., Reed, F. R., McKnight, R. C., Modification of left ventricular diastolic behavior by isometric handgrip exercise (1980) Circulation, 62, pp. 357-370
Bodenheimer, M. M., Banka, V. S., Fooshee, C. M., Gillespie, J. A., Helfant, R. H., Detection of coronary heart disease using radionuclide determined regional ejection fraction at rest and during handgrip exercise: Correlation with coronary arteriography (1978) Circulation, 4, pp. 640-648
Peter, C. A., Jones, R. H., Effects of isometric handgrip and dynamic exercise on left-ventricle function (1980) J. Nucl. Med., 21, pp. 1131-1138
Cannon R. O. III, Rosing, D. R., Maron, B. J., Myocardial ischemia in patients with hypertrophic cardiomyopathy: Contribution of inadequate vasodilator reserve and elevated left ventricular filling pressure (1985) Circulation, 71, pp. 234-243
Gwathmey, J. K., Warren, S. E., Briggs, G. M., Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole (1991) J. Clin. Invest., 87, pp. 1023-1031
Little, W. C., Barr, W. K., Crawford, M. H., Altered effect of the Valsalva maneuver on left ventricular volume in patients with cardiomyopathy (1985) Circulation, 71, pp. 227-233
Wigle, E. D., Sasson, Z., Henderson, M. A., Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review (1985) Prog. Cardiovasc. Dis., 28, pp. 1-83
Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects
Background. We assessed the hemodynamic effects of isometric exercise by an ambulatory radionuclide monitoring device (VEST) that measured left ventricular function in patients who had hypertrophic cardiomyopathy (HCM), with and without significant left ventricular outflow-tract obstruction at rest, compared with control subjects. Methods and results. We studied 10 patients with obstructive HCM, 25 patients with nonobstructive HCM, and 11 control subjects. During VEST monitoring, all patients gripped a dynamometer at 75% of maximal strength for up to 5 minutes. End-diastolic, end-systolic, and stroke volumes; cardiac output; and systemic vascular resistance were expressed as a percentage of baseline. The mean exercise duration was similar among the 3 groups. During handgrip, heart rate, systolic blood pressure, and cardiac output increased significantly and similarly in the 3 groups. There was a significant difference in the lung activity between obstructive and nonobstructive HCM patients and control subjects (P < .001), with a fall in control subjects and no change in HCM patients, irrespective of obstruction. Control subjects showed a decrease in end-systolic volume (P = .02) and an increase in ejection fraction (P = .003) and stroke volume (P = .009), whereas these parameters did not change in HCM patients, irrespective of obstruction. Systemic vascular resistance increased in obstructive (P = .02) and nonobstructive (P < .01) HCM patients but did not change in control subjects. Conclusions. Isometric exercise causes an abnormal and similar adaptation to load changes in obstructive and nonobstructive HCM patients, as compared with control subjects.
Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(692 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote