ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0242320345&partnerID=40&md5=9eb96544a5bb8a0bca00e1ba9288ec3f
Keywords: Adenovirus Vector, Dna Fragment, Doxorubicin, Onyx 015, Paclitaxel, Anaplastic Carcinoma, Anaplastic Thyroid Carcinoma, Antineoplastic Activity, Apoptosis, Article, Cancer Radiotherapy, Controlled Study, Cytopathogenic Effect, Cytotoxicity, Drug Potentiation, Human, Human Cell, Low Drug Dose, Nude Mouse, Priority Journal, Radiation Dose, Radiosensitivity, Tumor Xenograft, Virus Replication, Adenoviridae, Animals, Cell Death, Combined Modality Therapy, Dna Fragmentation, Mice, Radiation Tolerance, Thyroid Neoplasms, Tumor Cells, Cultured, Viral Vaccines, Xenograft Model Antitumor Assays, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipto. Diagnostica Immagini R., Univ. di Napoli Federico II, 80131 Naples, Italy
References:
Hedinger, C., Williams, E.D., Sobin, L.H., The WHO histological classification of thyroid tumours: A commentary on the second edition (1989) Cancer, 63, pp. 908-91
Wynford-Thomas, D., Origin and progression of thyroid epithelial tumours. Cellular and molecular mechanisms (1997) Horm Res, 47, pp. 145-157
Ain, K.B., Anaplastic thyroid carcinoma: A therapeutic challenge (1999) Semin Surg Oncol, 16, pp. 64-69
Bischott, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., McCormick, F., An adenovirus mutant that replicates selectively in p53 deficient human tumor cells (1996) Science, 274, pp. 373-376
Ries, S.J., Brandts, C.H., Chung, A.S., Biederer, C.H., Hann, B.C., Lipner, E.M., McCormick, F., Korn, W.M., Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) (2000) Nat Med, 6, pp. 1128-1133
Nemunaitis, J., Ganly, I., Khuri, F., Arseneau, J., Kuhn, J., McCarty, T., Landers, S., Kirn, D., Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial (2000) Cancer Res, 15, pp. 6359-6366
Ito, T., Seyama, T., Mizuno, T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Akiyama, M., Unique association of p53 mutations with undifferentiated but not differentiated carcinomas of the thyroid gland (1992) Cancer Res, 52, pp. 1369-1371
Fagin, J.A., Matsuo, K., Karmakar, A., Chen, D.L., Tang, S.H., Koeffler, H.P., High prevalence of mutations of p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Dobashi, Y., Sakamoto, A., Sugimura, H., Mernyei, M., Mori, M., Oyama, T., Machinami, R., Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma (1993) Am J Surg Pathol, 17, pp. 375-381
Donghi, R., Longoni, A., Pilotti, S., Michieli, P., Della Porta, G., Pierotti, M.A., p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland (1993) J Clin Invest, 91, pp. 1753-1760
Matias-Guiu, X., Cuatrecasas, M., Musulen, E., Prat, J., p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas (1994) J Clin Pathol, 47, pp. 337-339
Fusco, A., Santoro, M., Human thyroid carcinogenesis (1997) Forum, pp. 214-229. , 7.2
Khuri, F.R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I.F., Romel, L., Gore, M., Kirn, D.H., A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer patients (2000) Nat Med, 6, pp. 879-885
Nemunaitis, J., Khuri, F., Ganly, I., Arseneau, J., Posner, M., Vokes, E., Kuhn, J., Kirn, D., Phase II trial of intratumoral administration of ONYX-015, a replicationselective adenovirus, in patients with refractory head and neck cancer (2001) J Clin Oncol, 19, pp. 289-298
Habib, N.A., Mitry, R.R., Sarraf, C.E., Habib, N.A., Mitry, R.R., Sarraf, C.E., Jiao, L.R., Jensen, S.L., Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus (2002) Cancer Gene Ther, 9, pp. 414-420
Reid, T., Galanis, E., Abbruzzese, J., Sze, D., Wein, L.M., Andrews, J., Randlev, B., Kirn, D., Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints (2002) Cancer Res, 62, pp. 6070-6079
Mulvihill, S., Warren, R., Venook, A., Adler, A., Randlev, B., Heise, C., Kirn, D., Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial (2001) Gene Ther, 8, pp. 308-315
Portella, G., Scala, S., Vitagliano, D., Vecchio, G., Fusco, A., ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines (2002) J Clin Endocrinol Metab, 87, pp. 2525-2531
Nemunaitis, J., Cunningham, C., Buchanan, A., Blackburn, A., Edelman, G., Maples, P., Netto, G., Kirn, D., Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity (2001) Gene Ther, 8, pp. 746-759
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an aE1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents (1997) Nat Med, 3, pp. 639-1545
You, L., Yang, C., Jablons, D.M., ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients (2000) Cancer Res, 60, pp. 1009-1013
Pang, X.J., Hershman, M., Chung, M., Pekary, A.E., Characterization of tumor necrosis factor-α receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin (1989) Endocrinology, 125, pp. 1783-1788
Ain, K.B., Tofiq, S., Taylor, K.D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Rogulski, K.R., Freytag, S.O., Zhang, K., Gilbert, J.D., Paielli, D.L., Kim, J.H., Heise, C.C., Kirn, D.H., In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy (2000) Cancer Res, 60, pp. 1193-1196
Haigh, P.I., Anaplastic thyroid carcinoma (2000) Curr Treat Options Oncol, 1, pp. 353-357
Yeung, S.J., Xu, G., Pan, J., Christgen, M., Bamiagis, A., Manumycin enhances the cytotoxix effect of paclitaxel on anaplastic thyroid carcinoma cells (2000) Cancer Res, 60, pp. 650-656
Xu, G., Pan, J., Martin, C., Yeung, S.J., Angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma (2001) J Clin Endocrinol Metab, 86, pp. 1769-1777
Scala, S., Portella, G., Fedele, M., Chiappetta, G., Fusco, A., Adenovirus-mediated suppression of HMGI (Y) protein synthesis as potential therapy of human malignant neoplasias (2000) Proc Nat Acad Sci USA, 97, pp. 4256-4261
Lowe, S.W., Ruley, H.E., Jacks, T., Housman, D.E., p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) Cell, 74, pp. 957-967
Shao, R., Karunagaran, D., Zhou, B.P., Li, K., Lo, S.S., Deng, J., Chiao, P., Hung, M.C., Inhibition of nuclear factor-KB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis (1997) J Biol Chem, 272, pp. 32739-32742
Zhou, Z., Jia, S.F., Hung, M.C., Kleinerman, E.S., E1A sensitizes HER2/neu overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs (2001) Cancer Res, 61, pp. 3394-3398
Frisch, S., Mymryk, J., Adenovirus-5 E1A: Paradox and paradigm (2002) Nat Rev Mol Cell Biol, 6, pp. 441-452
Deng, J., Xia, W., Hung, M.C., Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo (1998) Oncogene, 17, pp. 2167-2175
Debbas, M., White, E., Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B (1993) Genes Dev, 7, pp. 546-554
Putzer, B.M., Stiewe, T., Parssanedjad, K., Rega, S., Esche, H., E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products (2000) Cell Death Differ, 7, pp. 177-188
Rothmann, T., Hengstermann, A., Whitaker, N.J., Scheffner, M., Zur Hausen, H., Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells (1998) J Virol, 72, pp. 9470-9478
Goodrum, F.D., Ornelles, D.A., p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lyric infection (1998) J Virol, 72, pp. 9479-9490
Wadler, S., Yu, B., Tan, J.Y., Kaleya, R., Rozenblit, A., Makower, D., Edelman, M., Horwitz, M., Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants (2003) Clin Cancer Res, 9, pp. 33-43
Ain, K. B., Anaplastic thyroid carcinoma: A therapeutic challenge (1999) Semin Surg Oncol, 16, pp. 64-69
Bischott, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., McCormick, F., An adenovirus mutant that replicates selectively in p53 deficient human tumor cells (1996) Science, 274, pp. 373-376
Ries, S. J., Brandts, C. H., Chung, A. S., Biederer, C. H., Hann, B. C., Lipner, E. M., McCormick, F., Korn, W. M., Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) (2000) Nat Med, 6, pp. 1128-1133
Fagin, J. A., Matsuo, K., Karmakar, A., Chen, D. L., Tang, S. H., Koeffler, H. P., High prevalence of mutations of p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Khuri, F. R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I. F., Romel, L., Gore, M., Kirn, D. H., A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer patients (2000) Nat Med, 6, pp. 879-885
Habib, N. A., Mitry, R. R., Sarraf, C. E., Habib, N. A., Mitry, R. R., Sarraf, C. E., Jiao, L. R., Jensen, S. L., Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus (2002) Cancer Gene Ther, 9, pp. 414-420
Pang, X. J., Hershman, M., Chung, M., Pekary, A. E., Characterization of tumor necrosis factor- receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin (1989) Endocrinology, 125, pp. 1783-1788
Ain, K. B., Tofiq, S., Taylor, K. D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Rogulski, K. R., Freytag, S. O., Zhang, K., Gilbert, J. D., Paielli, D. L., Kim, J. H., Heise, C. C., Kirn, D. H., In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy (2000) Cancer Res, 60, pp. 1193-1196
Haigh, P. I., Anaplastic thyroid carcinoma (2000) Curr Treat Options Oncol, 1, pp. 353-357
Yeung, S. J., Xu, G., Pan, J., Christgen, M., Bamiagis, A., Manumycin enhances the cytotoxix effect of paclitaxel on anaplastic thyroid carcinoma cells (2000) Cancer Res, 60, pp. 650-656
Lowe, S. W., Ruley, H. E., Jacks, T., Housman, D. E., p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) Cell, 74, pp. 957-967
Zhou, Z., Jia, S. F., Hung, M. C., Kleinerman, E. S., E1A sensitizes HER2/neu overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs (2001) Cancer Res, 61, pp. 3394-3398
Putzer, B. M., Stiewe, T., Parssanedjad, K., Rega, S., Esche, H., E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products (2000) Cell Death Differ, 7, pp. 177-188
Goodrum, F. D., Ornelles, D. A., p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lyric infection (1998) J Virol, 72, pp. 9479-9490
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0242320345&partnerID=40&md5=9eb96544a5bb8a0bca00e1ba9288ec3f
Keywords: Adenovirus Vector, Dna Fragment, Doxorubicin, Onyx 015, Paclitaxel, Anaplastic Carcinoma, Anaplastic Thyroid Carcinoma, Antineoplastic Activity, Apoptosis, Article, Cancer Radiotherapy, Controlled Study, Cytopathogenic Effect, Cytotoxicity, Drug Potentiation, Human, Human Cell, Low Drug Dose, Nude Mouse, Priority Journal, Radiation Dose, Radiosensitivity, Tumor Xenograft, Virus Replication, Adenoviridae, Animals, Cell Death, Combined Modality Therapy, Dna Fragmentation, Mice, Radiation Tolerance, Thyroid Neoplasms, Tumor Cells, Cultured, Viral Vaccines, Xenograft Model Antitumor Assays, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipto. Diagnostica Immagini R., Univ. di Napoli Federico II, 80131 Naples, Italy
References:
Hedinger, C., Williams, E.D., Sobin, L.H., The WHO histological classification of thyroid tumours: A commentary on the second edition (1989) Cancer, 63, pp. 908-91
Wynford-Thomas, D., Origin and progression of thyroid epithelial tumours. Cellular and molecular mechanisms (1997) Horm Res, 47, pp. 145-157
Ain, K.B., Anaplastic thyroid carcinoma: A therapeutic challenge (1999) Semin Surg Oncol, 16, pp. 64-69
Bischott, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., McCormick, F., An adenovirus mutant that replicates selectively in p53 deficient human tumor cells (1996) Science, 274, pp. 373-376
Ries, S.J., Brandts, C.H., Chung, A.S., Biederer, C.H., Hann, B.C., Lipner, E.M., McCormick, F., Korn, W.M., Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) (2000) Nat Med, 6, pp. 1128-1133
Nemunaitis, J., Ganly, I., Khuri, F., Arseneau, J., Kuhn, J., McCarty, T., Landers, S., Kirn, D., Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial (2000) Cancer Res, 15, pp. 6359-6366
Ito, T., Seyama, T., Mizuno, T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Akiyama, M., Unique association of p53 mutations with undifferentiated but not differentiated carcinomas of the thyroid gland (1992) Cancer Res, 52, pp. 1369-1371
Fagin, J.A., Matsuo, K., Karmakar, A., Chen, D.L., Tang, S.H., Koeffler, H.P., High prevalence of mutations of p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Dobashi, Y., Sakamoto, A., Sugimura, H., Mernyei, M., Mori, M., Oyama, T., Machinami, R., Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma (1993) Am J Surg Pathol, 17, pp. 375-381
Donghi, R., Longoni, A., Pilotti, S., Michieli, P., Della Porta, G., Pierotti, M.A., p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland (1993) J Clin Invest, 91, pp. 1753-1760
Matias-Guiu, X., Cuatrecasas, M., Musulen, E., Prat, J., p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas (1994) J Clin Pathol, 47, pp. 337-339
Fusco, A., Santoro, M., Human thyroid carcinogenesis (1997) Forum, pp. 214-229. , 7.2
Khuri, F.R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I.F., Romel, L., Gore, M., Kirn, D.H., A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer patients (2000) Nat Med, 6, pp. 879-885
Nemunaitis, J., Khuri, F., Ganly, I., Arseneau, J., Posner, M., Vokes, E., Kuhn, J., Kirn, D., Phase II trial of intratumoral administration of ONYX-015, a replicationselective adenovirus, in patients with refractory head and neck cancer (2001) J Clin Oncol, 19, pp. 289-298
Habib, N.A., Mitry, R.R., Sarraf, C.E., Habib, N.A., Mitry, R.R., Sarraf, C.E., Jiao, L.R., Jensen, S.L., Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus (2002) Cancer Gene Ther, 9, pp. 414-420
Reid, T., Galanis, E., Abbruzzese, J., Sze, D., Wein, L.M., Andrews, J., Randlev, B., Kirn, D., Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints (2002) Cancer Res, 62, pp. 6070-6079
Mulvihill, S., Warren, R., Venook, A., Adler, A., Randlev, B., Heise, C., Kirn, D., Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial (2001) Gene Ther, 8, pp. 308-315
Portella, G., Scala, S., Vitagliano, D., Vecchio, G., Fusco, A., ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines (2002) J Clin Endocrinol Metab, 87, pp. 2525-2531
Nemunaitis, J., Cunningham, C., Buchanan, A., Blackburn, A., Edelman, G., Maples, P., Netto, G., Kirn, D., Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity (2001) Gene Ther, 8, pp. 746-759
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an aE1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents (1997) Nat Med, 3, pp. 639-1545
You, L., Yang, C., Jablons, D.M., ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients (2000) Cancer Res, 60, pp. 1009-1013
Pang, X.J., Hershman, M., Chung, M., Pekary, A.E., Characterization of tumor necrosis factor-α receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin (1989) Endocrinology, 125, pp. 1783-1788
Ain, K.B., Tofiq, S., Taylor, K.D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Rogulski, K.R., Freytag, S.O., Zhang, K., Gilbert, J.D., Paielli, D.L., Kim, J.H., Heise, C.C., Kirn, D.H., In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy (2000) Cancer Res, 60, pp. 1193-1196
Haigh, P.I., Anaplastic thyroid carcinoma (2000) Curr Treat Options Oncol, 1, pp. 353-357
Yeung, S.J., Xu, G., Pan, J., Christgen, M., Bamiagis, A., Manumycin enhances the cytotoxix effect of paclitaxel on anaplastic thyroid carcinoma cells (2000) Cancer Res, 60, pp. 650-656
Xu, G., Pan, J., Martin, C., Yeung, S.J., Angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma (2001) J Clin Endocrinol Metab, 86, pp. 1769-1777
Scala, S., Portella, G., Fedele, M., Chiappetta, G., Fusco, A., Adenovirus-mediated suppression of HMGI (Y) protein synthesis as potential therapy of human malignant neoplasias (2000) Proc Nat Acad Sci USA, 97, pp. 4256-4261
Lowe, S.W., Ruley, H.E., Jacks, T., Housman, D.E., p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) Cell, 74, pp. 957-967
Shao, R., Karunagaran, D., Zhou, B.P., Li, K., Lo, S.S., Deng, J., Chiao, P., Hung, M.C., Inhibition of nuclear factor-KB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis (1997) J Biol Chem, 272, pp. 32739-32742
Zhou, Z., Jia, S.F., Hung, M.C., Kleinerman, E.S., E1A sensitizes HER2/neu overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs (2001) Cancer Res, 61, pp. 3394-3398
Frisch, S., Mymryk, J., Adenovirus-5 E1A: Paradox and paradigm (2002) Nat Rev Mol Cell Biol, 6, pp. 441-452
Deng, J., Xia, W., Hung, M.C., Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo (1998) Oncogene, 17, pp. 2167-2175
Debbas, M., White, E., Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B (1993) Genes Dev, 7, pp. 546-554
Putzer, B.M., Stiewe, T., Parssanedjad, K., Rega, S., Esche, H., E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products (2000) Cell Death Differ, 7, pp. 177-188
Rothmann, T., Hengstermann, A., Whitaker, N.J., Scheffner, M., Zur Hausen, H., Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells (1998) J Virol, 72, pp. 9470-9478
Goodrum, F.D., Ornelles, D.A., p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lyric infection (1998) J Virol, 72, pp. 9479-9490
Wadler, S., Yu, B., Tan, J.Y., Kaleya, R., Rozenblit, A., Makower, D., Edelman, M., Horwitz, M., Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants (2003) Clin Cancer Res, 9, pp. 33-43
Ain, K. B., Anaplastic thyroid carcinoma: A therapeutic challenge (1999) Semin Surg Oncol, 16, pp. 64-69
Bischott, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., McCormick, F., An adenovirus mutant that replicates selectively in p53 deficient human tumor cells (1996) Science, 274, pp. 373-376
Ries, S. J., Brandts, C. H., Chung, A. S., Biederer, C. H., Hann, B. C., Lipner, E. M., McCormick, F., Korn, W. M., Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) (2000) Nat Med, 6, pp. 1128-1133
Fagin, J. A., Matsuo, K., Karmakar, A., Chen, D. L., Tang, S. H., Koeffler, H. P., High prevalence of mutations of p53 gene in poorly differentiated human thyroid carcinomas (1993) J Clin Invest, 91, pp. 179-184
Khuri, F. R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I. F., Romel, L., Gore, M., Kirn, D. H., A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer patients (2000) Nat Med, 6, pp. 879-885
Habib, N. A., Mitry, R. R., Sarraf, C. E., Habib, N. A., Mitry, R. R., Sarraf, C. E., Jiao, L. R., Jensen, S. L., Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus (2002) Cancer Gene Ther, 9, pp. 414-420
Pang, X. J., Hershman, M., Chung, M., Pekary, A. E., Characterization of tumor necrosis factor- receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin (1989) Endocrinology, 125, pp. 1783-1788
Ain, K. B., Tofiq, S., Taylor, K. D., Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo (1996) J Clin Endocrinol Metab, 81, pp. 3650-3653
Rogulski, K. R., Freytag, S. O., Zhang, K., Gilbert, J. D., Paielli, D. L., Kim, J. H., Heise, C. C., Kirn, D. H., In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy (2000) Cancer Res, 60, pp. 1193-1196
Haigh, P. I., Anaplastic thyroid carcinoma (2000) Curr Treat Options Oncol, 1, pp. 353-357
Yeung, S. J., Xu, G., Pan, J., Christgen, M., Bamiagis, A., Manumycin enhances the cytotoxix effect of paclitaxel on anaplastic thyroid carcinoma cells (2000) Cancer Res, 60, pp. 650-656
Lowe, S. W., Ruley, H. E., Jacks, T., Housman, D. E., p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) Cell, 74, pp. 957-967
Zhou, Z., Jia, S. F., Hung, M. C., Kleinerman, E. S., E1A sensitizes HER2/neu overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs (2001) Cancer Res, 61, pp. 3394-3398
Putzer, B. M., Stiewe, T., Parssanedjad, K., Rega, S., Esche, H., E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products (2000) Cell Death Differ, 7, pp. 177-188
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ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells
ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early gene and therefore is designed to replicate preferentially in p53-mutated cells causing their death. We previously demonstrated that the ONYX-015 virus kills anaplastic thyroid carcinoma (ATC) cells and enhances the anti-neoplastic effects of doxorubicin and paclitaxel. Here we report that ONYX-015 increased the cytopathic effect of radiotherapy in three ATC cell lines. In fact, ONYX-015 and radiation induced a significant cytopathic effect on ATC cells. DNA fragmentation analysis showed that ATC ONYX-015-treated cells were very sensitive to radiation-induced apoptosis. In addition, low doses of ONYX-015 associated with a single radiation dose of 10 Gy delayed the growth of a xenograft tumor induced by ARO cells in athymic mice. Our results suggest that the combination of ONYX-015 and radiotherapy should be considered for experimental trials in patients with anaplastic thyroid carcinoma.
ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early gene and therefore is designed to replicate preferentially in p53-mutated cells causing their death. We previously demonstrated that the ONYX-015 virus kills anaplastic thyroid carcinoma (ATC) cells and enhances the anti-neoplastic effects of doxorubicin and paclitaxel. Here we report that ONYX-015 increased the cytopathic effect of radiotherapy in three ATC cell lines. In fact, ONYX-015 and radiation induced a significant cytopathic effect on ATC cells. DNA fragmentation analysis showed that ATC ONYX-015-treated cells were very sensitive to radiation-induced apoptosis. In addition, low doses of ONYX-015 associated with a single radiation dose of 10 Gy delayed the growth of a xenograft tumor induced by ARO cells in athymic mice. Our results suggest that the combination of ONYX-015 and radiotherapy should be considered for experimental trials in patients with anaplastic thyroid carcinoma.
ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells
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ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (328 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (299 views)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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* GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[(18)F]F-FDG-PET (12 views)
Mol Imaging Biol (ISSN: 1536-1632linking), 2021 Aug 12; N/D: N/D-N/D.
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Cusano AM, Aliberti A, Cusano A, Ruvo M
* Detection of small DNA fragments by biolayer interferometry (79 views)
Anal Biochem (ISSN: 0003-2697linking, 1096-0309electronic), 2020 Oct 15; 607: 113898-113898.
Impact Factor: 2.219
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Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
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Impact Factor: 7.581
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (413 views)
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Impact Factor: 4.122
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (446 views)
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Impact Factor: 4.521
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Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (331 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
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Crisci V, Mainenti PP, Corvino F, Lauria R, Maurea S
* Bone involvement by adenocarcinoma of the uterine cervix: a rare entity (284 views)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Feb 14; 80(1): 81-84.
Impact Factor: 0.567
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Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
* Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (470 views)
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (524 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (451 views)
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Impact Factor: 1.951
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Insabato L, Natella V, Somma A, Persico M, Camera L, Losito NS, Masone S
* Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue (300 views)
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Impact Factor: 0.782
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (531 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (378 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (586 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
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Impact Factor: 5.48
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (484 views)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
Impact Factor: 1.554
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (464 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (408 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Accardo A, Ringhieri P, Tesauro D, Morelli G
* Liposomes derivatized with tetrabranched neurotensin peptides via click chemistry reactions (397 views)
New J Chem (ISSN: 1144-0546), 2013; 37(11): 3528-3534.
Impact Factor: 3.159
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (491 views) (PDF 236 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F
* Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (394 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Impact Factor: 2.057
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (457 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (440 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (353 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (347 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (457 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (399 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (429 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (233 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (580 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (354 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (246 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (277 views)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (255 views) (PDF 220 views)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (399 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (328 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (299 views)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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63 Records (60 excluding Abstracts).
Total impact factor: 245.807 (232.547 excluding Abstracts).
Total 5 year impact factor: 262.568 (248.7 excluding Abstracts).
Total impact factor: 245.807 (232.547 excluding Abstracts).
Total 5 year impact factor: 262.568 (248.7 excluding Abstracts).
467 views. Last view on Monday 06 March 2023, 6:32:03
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