Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
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Paper type: Journal Article,
Impact factor: 2.767, 5-year impact factor: 3.497
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037318794&partnerID=40&md5=e9d967b9f008d2e531a080c7e96d6392
Keywords: Angiopeptin, Glucose, Growth Hormone, Insulin, Octreotide, Somatomedin C, Somatostatin Derivative, Acromegaly, Adult, Angiography, Article, Cardiomyopathy, Clinical Article, Controlled Study, Diastole, Disease Control, Disease Duration, Drug Efficacy, Early Diagnosis, Echocardiography, Exercise Tolerance, Female, Follow Up, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Function, Heart Left Ventricle Hypertrophy, Hemodynamics, Human, Oral Glucose Tolerance Test, Priority Journal, Remission, Time Series Analysis, Treatment Outcome, Age Factors, Antineoplastic Agents, Case-Control Studies, Chi-Square Distribution, Delayed-Action Preparations, Doppler, Pulsed, Exercise Test, Left Ventricular, Immunoradiometric Assay, Insulin-Like Growth Factor I, Middle Aged, Prospective Studies, Radionuclide Angiography, Statistics, Nonparametric, Stroke Volume, Time Factors,
Affiliations:
*** IBB - CNR ***
Dept. Molec./Clin. Endocrinol./O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Dept. Biomorphological/Funct. Sci., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Int. Med. I 'Federico II' Univ. N., Pozzilli, Italy
Sci. Inst. for Res./Care Neuromed, Pozzilli, Italy
Dept. Molec. /Clin. Endocrinol. /O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
References:
Baldelli, R., Ferretti, E., Jaffrain-Rea, M.L., Iacobellis, G., Minniti, G., Caracciolo, B., Moroni, C., Tamburrano, G., Cardiac effects of lanreotide, a slow release somatostatin analog, in acromegalic patients (1999) Journal of Clinical Endocrinology and Metabolism, 84, pp. 575-53
Bates, A.S., Van't Hoff, W., Jones, J.M., Clayton, R.N., An audit of outcome of treatment in acromegaly (1993) Quarterly Journal of Medicine, 86, pp. 293-299
Bengtsson, B., Eden, S., Ernest, I., Oden, A., Sjogren, B., Epidemiology and long term survival in acromegaly (1988) Acta Medica Scandinavica, 223, pp. 327-335
Colao, A., Baldelli, R., Marzullo, P., Ferretti, E., Ferone, D., Gargiulo, P., Petretta, M., Liuzzi, A., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 193-199
Colao, A., Cuocolo, A., Marzullo, P., Nicolai, E., Ferone, D., Della Morte, A.M., Pivonello, R., Lombardi, G., Is the acromegalic cardiomyopathy reversible? Effect of 5 year normalization of growth hormone and insulin-like growth factor-I levels on cardiac performance (2001) Journal of Clinical Endocrinology Metabolism, 86, pp. 1551-1557
Colao, A., Ferone, D., Lastoria, S., Marzullo, P., Cerbone, G., Di Sarno, A., Longobardi, S., Lombardi, G., Prediction of efficacy of octreotide therapy in patients with acromegaly (1996) Journal of Clinical Endocrinology Metabolism, 81, pp. 2356-2362
Colao, A., Lombardi, G., Growth hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Colao, A., Marzullo, P., Di Somma, C., Lombardi, G., Growth hormone and the heart (2001) Clinical Endocrinology, 54, pp. 137-154
Colao, A., Merola, B., Ferone, D., Lombardi, G., Extensive personal experience: Acromegaly (1997) Journal of Clinical Endocrinology and Metabolism, 82, pp. 2777-2781
Colao, A., Spinelli, L., Cuocolo, A., Spiezia, S., Pivonello, R., Di Somma, C., Bonaduce, D., Lombardi, G., Cardiovascular consequences of early-onset growth hormone excess (2002) Journal of Clinical Endocrinology Metabolism, 87, pp. 3097-3104
Fazio, S., Cittadini, A., Biondi, B., Palmieri, E.A., Riccio, G., Bonè, F., Oliviero, U., Saccà, L., Cardiovascular effects of short-term growth hormone hypersecretion (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 179-182
Giustina, A., Barkan, A., Casanueva, F.F., Cavagnini, F., Frohman, L., Ho, K., Veldhuis, J., Melmed, S., Criteria for cure of acromegaly: A consensus statement (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 526-529
Hayward, R.P., Emanuel, R.W., Nabarro, J.D.N., Acromegalic heart disease: Influence of treatment of the acromegaly on the heart (1987) Quarterly Journal of Medicine, 62, pp. 41-58
Hejtmancik, M.R., Bradfield, J.Y., Herrmann, G.R., Acromegaly and the heart: A clinical and pathologic study (1951) Annals of Internal Medicine, 34, pp. 1445-1456
Hradec, J., Kral, J., Janota, T., Krsek, M., Hana, V., Marek, J., Malik, M., Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow-release somatostatin analog) (1999) American Journal of Cardiology, 83, pp. 1506-1509
Lancranjan, I., Atkinson, A.B., Results of a European multicentre study with sandostatin LAR in acromegalic patients (1999) Pituitary, 1, pp. 105-114
Lie, J.T., Grossman, S.J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) American Heart Journal, 100, pp. 41-52
Lim, M.J., Barkan, A.L., Buda, A.J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Annals of Internal Medicine, 117, pp. 719-726
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Villa, E., Sancho, J.M., Moya-Mur, J.L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) Journal of Clinical Endocrinology Metabolism, 82, pp. 1047-1053
McGuffin W.L., Jr., Sherman, B.M., Roth, J., Gorden, P., Kahn, C.R., Roberts, W.C., Frommer, P.L., Acromegaly and cardiovascular disorders: A prospective study (1974) Annals of Internal Medicine, 81, pp. 11-18
Merola, B., Cittadini, A., Colao, A., Ferone, D., Fazio, S., Sabatini, D., Biondi, B., Lombardi, G., Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly (1993) Journal of Clinical Endocrinology and Metabolism, 77, pp. 790-793
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Baldelli, R., Ferretti, E., Cassone, R., Gulino, A., Tamburrano, G., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clinical Endocrinology, 49, pp. 101-106
Morvan, D., Komajda, M., Grimaldi, A., Turpin, G., Grosgogeat, Y., Cardiac hypertrophy and function in asymptomatic acromegaly (1991) European Heart Journal, 12, pp. 666-672
Orme, S.M., McNally, R.J., Cartwright, R.A., Belchetz, P.E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 2730-2734. , United Kingdom Acromegaly Study Group
Pereira, J., Rodriguez-Puras, M.J., Leal-Cerro, A., Martinez, A., Garcial-Luna, P.P., Gavilan, I., Pumar, A., Astorga, R., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) Journal of Endocrinological Investigation, 14, pp. 17-23
Rajasoorya, C., Holdaway, I.M., Wrightson, P., Scott, D.J., Ibbertson, H.K., Determinants of clinical outcome and survival in acromegaly (1994) Clinical Endocrinology, 41, pp. 95-102
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Savage, D.D., Henry, W.L., Eastman, R.C., Borer, J.S., Gorden, P., Echocardiographic assessment of cardiac anatomy and function in patients (1979) American Journal of Medicine, 67, pp. 823-829
Smallridge, R.C., Rajfer, S., Davia, J., Schaaf, M., Acromegaly and the heart. An echocardiographic study (1979) American Journal of Medicine, 66, pp. 22-27
Thuesen, L., Christensen, S.E., Weeke, J., Orskov, H., Henningsen, P., A hyperkinetic heart in uncomplicated active acromegaly. Explanation of hypertension in acromegalic patients? (1988) Acta Medica Scandinavica, 223, pp. 337-343
Tokgözoglu, S.L., Erbas, T., Aytemir, K., Akalin, S., Kes, S., Oram, E., Effects of octreotide on left ventricular mass in acromegaly (1994) American Journal of Cardiology, 74, pp. 1072-1074
Wright, A.D., Hill, D.M., Lowy, C., Fraser, T.R., Mortality in acromegaly (1970) Quarterly Journal of Medicine, 39, pp. 1-16
Bates, A. S., Van't Hoff, W., Jones, J. M., Clayton, R. N., An audit of outcome of treatment in acromegaly (1993) Quarterly Journal of Medicine, 86, pp. 293-299
Hayward, R. P., Emanuel, R. W., Nabarro, J. D. N., Acromegalic heart disease: Influence of treatment of the acromegaly on the heart (1987) Quarterly Journal of Medicine, 62, pp. 41-58
Hejtmancik, M. R., Bradfield, J. Y., Herrmann, G. R., Acromegaly and the heart: A clinical and pathologic study (1951) Annals of Internal Medicine, 34, pp. 1445-1456
Lie, J. T., Grossman, S. J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) American Heart Journal, 100, pp. 41-52
Lim, M. J., Barkan, A. L., Buda, A. J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Annals of Internal Medicine, 117, pp. 719-726
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Villa, E., Sancho, J. M., Moya-Mur, J. L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) Journal of Clinical Endocrinology Metabolism, 82, pp. 1047-1053
McGuffin W. L., Jr., Sherman, B. M., Roth, J., Gorden, P., Kahn, C. R., Roberts, W. C., Frommer, P. L., Acromegaly and cardiovascular disorders: A prospective study (1974) Annals of Internal Medicine, 81, pp. 11-18
Orme, S. M., McNally, R. J., Cartwright, R. A., Belchetz, P. E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 2730-2734. , United Kingdom Acromegaly Study Group
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Savage, D. D., Henry, W. L., Eastman, R. C., Borer, J. S., Gorden, P., Echocardiographic assessment of cardiac anatomy and function in patients (1979) American Journal of Medicine, 67, pp. 823-829
Smallridge, R. C., Rajfer, S., Davia, J., Schaaf, M., Acromegaly and the heart. An echocardiographic study (1979) American Journal of Medicine, 66, pp. 22-27
Tokg zoglu, S. L., Erbas, T., Aytemir, K., Akalin, S., Kes, S., Oram, E., Effects of octreotide on left ventricular mass in acromegaly (1994) American Journal of Cardiology, 74, pp. 1072-1074
Wright, A. D., Hill, D. M., Lowy, C., Fraser, T. R., Mortality in acromegaly (1970) Quarterly Journal of Medicine, 39, pp. 1-16
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.767, 5-year impact factor: 3.497
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037318794&partnerID=40&md5=e9d967b9f008d2e531a080c7e96d6392
Keywords: Angiopeptin, Glucose, Growth Hormone, Insulin, Octreotide, Somatomedin C, Somatostatin Derivative, Acromegaly, Adult, Angiography, Article, Cardiomyopathy, Clinical Article, Controlled Study, Diastole, Disease Control, Disease Duration, Drug Efficacy, Early Diagnosis, Echocardiography, Exercise Tolerance, Female, Follow Up, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Function, Heart Left Ventricle Hypertrophy, Hemodynamics, Human, Oral Glucose Tolerance Test, Priority Journal, Remission, Time Series Analysis, Treatment Outcome, Age Factors, Antineoplastic Agents, Case-Control Studies, Chi-Square Distribution, Delayed-Action Preparations, Doppler, Pulsed, Exercise Test, Left Ventricular, Immunoradiometric Assay, Insulin-Like Growth Factor I, Middle Aged, Prospective Studies, Radionuclide Angiography, Statistics, Nonparametric, Stroke Volume, Time Factors,
Affiliations:
*** IBB - CNR ***
Dept. Molec./Clin. Endocrinol./O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Dept. Biomorphological/Funct. Sci., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Int. Med. I 'Federico II' Univ. N., Pozzilli, Italy
Sci. Inst. for Res./Care Neuromed, Pozzilli, Italy
Dept. Molec. /Clin. Endocrinol. /O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
References:
Baldelli, R., Ferretti, E., Jaffrain-Rea, M.L., Iacobellis, G., Minniti, G., Caracciolo, B., Moroni, C., Tamburrano, G., Cardiac effects of lanreotide, a slow release somatostatin analog, in acromegalic patients (1999) Journal of Clinical Endocrinology and Metabolism, 84, pp. 575-53
Bates, A.S., Van't Hoff, W., Jones, J.M., Clayton, R.N., An audit of outcome of treatment in acromegaly (1993) Quarterly Journal of Medicine, 86, pp. 293-299
Bengtsson, B., Eden, S., Ernest, I., Oden, A., Sjogren, B., Epidemiology and long term survival in acromegaly (1988) Acta Medica Scandinavica, 223, pp. 327-335
Colao, A., Baldelli, R., Marzullo, P., Ferretti, E., Ferone, D., Gargiulo, P., Petretta, M., Liuzzi, A., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 193-199
Colao, A., Cuocolo, A., Marzullo, P., Nicolai, E., Ferone, D., Della Morte, A.M., Pivonello, R., Lombardi, G., Is the acromegalic cardiomyopathy reversible? Effect of 5 year normalization of growth hormone and insulin-like growth factor-I levels on cardiac performance (2001) Journal of Clinical Endocrinology Metabolism, 86, pp. 1551-1557
Colao, A., Ferone, D., Lastoria, S., Marzullo, P., Cerbone, G., Di Sarno, A., Longobardi, S., Lombardi, G., Prediction of efficacy of octreotide therapy in patients with acromegaly (1996) Journal of Clinical Endocrinology Metabolism, 81, pp. 2356-2362
Colao, A., Lombardi, G., Growth hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Colao, A., Marzullo, P., Di Somma, C., Lombardi, G., Growth hormone and the heart (2001) Clinical Endocrinology, 54, pp. 137-154
Colao, A., Merola, B., Ferone, D., Lombardi, G., Extensive personal experience: Acromegaly (1997) Journal of Clinical Endocrinology and Metabolism, 82, pp. 2777-2781
Colao, A., Spinelli, L., Cuocolo, A., Spiezia, S., Pivonello, R., Di Somma, C., Bonaduce, D., Lombardi, G., Cardiovascular consequences of early-onset growth hormone excess (2002) Journal of Clinical Endocrinology Metabolism, 87, pp. 3097-3104
Fazio, S., Cittadini, A., Biondi, B., Palmieri, E.A., Riccio, G., Bonè, F., Oliviero, U., Saccà, L., Cardiovascular effects of short-term growth hormone hypersecretion (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 179-182
Giustina, A., Barkan, A., Casanueva, F.F., Cavagnini, F., Frohman, L., Ho, K., Veldhuis, J., Melmed, S., Criteria for cure of acromegaly: A consensus statement (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 526-529
Hayward, R.P., Emanuel, R.W., Nabarro, J.D.N., Acromegalic heart disease: Influence of treatment of the acromegaly on the heart (1987) Quarterly Journal of Medicine, 62, pp. 41-58
Hejtmancik, M.R., Bradfield, J.Y., Herrmann, G.R., Acromegaly and the heart: A clinical and pathologic study (1951) Annals of Internal Medicine, 34, pp. 1445-1456
Hradec, J., Kral, J., Janota, T., Krsek, M., Hana, V., Marek, J., Malik, M., Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow-release somatostatin analog) (1999) American Journal of Cardiology, 83, pp. 1506-1509
Lancranjan, I., Atkinson, A.B., Results of a European multicentre study with sandostatin LAR in acromegalic patients (1999) Pituitary, 1, pp. 105-114
Lie, J.T., Grossman, S.J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) American Heart Journal, 100, pp. 41-52
Lim, M.J., Barkan, A.L., Buda, A.J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Annals of Internal Medicine, 117, pp. 719-726
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Villa, E., Sancho, J.M., Moya-Mur, J.L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) Journal of Clinical Endocrinology Metabolism, 82, pp. 1047-1053
McGuffin W.L., Jr., Sherman, B.M., Roth, J., Gorden, P., Kahn, C.R., Roberts, W.C., Frommer, P.L., Acromegaly and cardiovascular disorders: A prospective study (1974) Annals of Internal Medicine, 81, pp. 11-18
Merola, B., Cittadini, A., Colao, A., Ferone, D., Fazio, S., Sabatini, D., Biondi, B., Lombardi, G., Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly (1993) Journal of Clinical Endocrinology and Metabolism, 77, pp. 790-793
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Baldelli, R., Ferretti, E., Cassone, R., Gulino, A., Tamburrano, G., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clinical Endocrinology, 49, pp. 101-106
Morvan, D., Komajda, M., Grimaldi, A., Turpin, G., Grosgogeat, Y., Cardiac hypertrophy and function in asymptomatic acromegaly (1991) European Heart Journal, 12, pp. 666-672
Orme, S.M., McNally, R.J., Cartwright, R.A., Belchetz, P.E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 2730-2734. , United Kingdom Acromegaly Study Group
Pereira, J., Rodriguez-Puras, M.J., Leal-Cerro, A., Martinez, A., Garcial-Luna, P.P., Gavilan, I., Pumar, A., Astorga, R., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) Journal of Endocrinological Investigation, 14, pp. 17-23
Rajasoorya, C., Holdaway, I.M., Wrightson, P., Scott, D.J., Ibbertson, H.K., Determinants of clinical outcome and survival in acromegaly (1994) Clinical Endocrinology, 41, pp. 95-102
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Savage, D.D., Henry, W.L., Eastman, R.C., Borer, J.S., Gorden, P., Echocardiographic assessment of cardiac anatomy and function in patients (1979) American Journal of Medicine, 67, pp. 823-829
Smallridge, R.C., Rajfer, S., Davia, J., Schaaf, M., Acromegaly and the heart. An echocardiographic study (1979) American Journal of Medicine, 66, pp. 22-27
Thuesen, L., Christensen, S.E., Weeke, J., Orskov, H., Henningsen, P., A hyperkinetic heart in uncomplicated active acromegaly. Explanation of hypertension in acromegalic patients? (1988) Acta Medica Scandinavica, 223, pp. 337-343
Tokgözoglu, S.L., Erbas, T., Aytemir, K., Akalin, S., Kes, S., Oram, E., Effects of octreotide on left ventricular mass in acromegaly (1994) American Journal of Cardiology, 74, pp. 1072-1074
Wright, A.D., Hill, D.M., Lowy, C., Fraser, T.R., Mortality in acromegaly (1970) Quarterly Journal of Medicine, 39, pp. 1-16
Bates, A. S., Van't Hoff, W., Jones, J. M., Clayton, R. N., An audit of outcome of treatment in acromegaly (1993) Quarterly Journal of Medicine, 86, pp. 293-299
Hayward, R. P., Emanuel, R. W., Nabarro, J. D. N., Acromegalic heart disease: Influence of treatment of the acromegaly on the heart (1987) Quarterly Journal of Medicine, 62, pp. 41-58
Hejtmancik, M. R., Bradfield, J. Y., Herrmann, G. R., Acromegaly and the heart: A clinical and pathologic study (1951) Annals of Internal Medicine, 34, pp. 1445-1456
Lie, J. T., Grossman, S. J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) American Heart Journal, 100, pp. 41-52
Lim, M. J., Barkan, A. L., Buda, A. J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Annals of Internal Medicine, 117, pp. 719-726
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Villa, E., Sancho, J. M., Moya-Mur, J. L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) Journal of Clinical Endocrinology Metabolism, 82, pp. 1047-1053
McGuffin W. L., Jr., Sherman, B. M., Roth, J., Gorden, P., Kahn, C. R., Roberts, W. C., Frommer, P. L., Acromegaly and cardiovascular disorders: A prospective study (1974) Annals of Internal Medicine, 81, pp. 11-18
Orme, S. M., McNally, R. J., Cartwright, R. A., Belchetz, P. E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 2730-2734. , United Kingdom Acromegaly Study Group
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Savage, D. D., Henry, W. L., Eastman, R. C., Borer, J. S., Gorden, P., Echocardiographic assessment of cardiac anatomy and function in patients (1979) American Journal of Medicine, 67, pp. 823-829
Smallridge, R. C., Rajfer, S., Davia, J., Schaaf, M., Acromegaly and the heart. An echocardiographic study (1979) American Journal of Medicine, 66, pp. 22-27
Tokg zoglu, S. L., Erbas, T., Aytemir, K., Akalin, S., Kes, S., Oram, E., Effects of octreotide on left ventricular mass in acromegaly (1994) American Journal of Cardiology, 74, pp. 1072-1074
Wright, A. D., Hill, D. M., Lowy, C., Fraser, T. R., Mortality in acromegaly (1970) Quarterly Journal of Medicine, 39, pp. 1-16
Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
BACKGROUND: Cardiovascular disease is the most frequent cause of death of patients with acromegaly. AIM To investigate whether young patients with a presumed short disease duration are more likely to reverse the acromegalic cardiomyopathy than older patients with longer disease duration. DESIGN: An open prospective design. PATIENTS: Ten young (aged < 40 years), and 12 middle-aged (41-59 years) patients with active acromegaly well controlled after 12 months of treatment with the depot formulation of octreotide (OCT-LAR); 22 sex- and age-matched healthy subjects as controls. METHODS: Left ventricular (LV) mass (LVM) by echocardiography and performance by equilibrium radionuclide angiography were measured before and after 12 months of OCT-LAR treatment. RESULTS: At study entry, none of the controls and 14 patients (63.4%) of whom six were young (χ2 = 17.7; P < 0.0001) had LV hypertrophy (LVH); none of the controls and four patients of whom one was young had insufficient LV ejection fraction (LVEF) at rest (< 50%); one control and 13 patients (59.1%) of whom five were young (χ2= 12.7; P < 0.0001) had inadequate LVEF at peak exercise (ΔLVEF; < 5% increase of baseline). After 12 months, no change in haemodynamic and diastolic parameters was observed in both groups, except for a significant decrease in heart rate at peak exercise in young patients (P < 0.0001). The LVM index decreased significantly in both young (124.4 ± 5.8 vs. 103.4 ± 3.9 g/m2; P = 0.01) and middle-aged patients (140.9 ± 7.9 vs. 117.8 ± 6.6 g/m2; P= 0.03). LVH disappeared in 10 of 14 patients (71.4%): all six young and four of eight middle-aged patients (50%). LVEF at rest and at peak exercise increased significantly in both groups but ΔLVEF increased significantly only in young patients (1.5 ± 2.9 vs. 13.7 ± 5.2%, P= 0.04); it normalized in nine of 13 patients (69.2%), four of five young (80%) and four of eight middle-aged patients (50%). Exercise capacity (82.5 ± 5.3 vs. 110.0 ± 5.5 W, P= 0.005) and duration (7.3 ± 0.3 vs. 9.9 ± 0.4 min, P = 0.0003) also increased only in young patients. CONCLUSIONS: The acromegalic cardiomyopathy is reversed in most young patients with short disease duration and achieving disease control after OCT-LAR treatment for 12 months, indicating that early diagnosis and effective treatment are essential.
BACKGROUND: Cardiovascular disease is the most frequent cause of death of patients with acromegaly. AIM To investigate whether young patients with a presumed short disease duration are more likely to reverse the acromegalic cardiomyopathy than older patients with longer disease duration. DESIGN: An open prospective design. PATIENTS: Ten young (aged < 40 years), and 12 middle-aged (41-59 years) patients with active acromegaly well controlled after 12 months of treatment with the depot formulation of octreotide (OCT-LAR); 22 sex- and age-matched healthy subjects as controls. METHODS: Left ventricular (LV) mass (LVM) by echocardiography and performance by equilibrium radionuclide angiography were measured before and after 12 months of OCT-LAR treatment. RESULTS: At study entry, none of the controls and 14 patients (63.4%) of whom six were young (χ2 = 17.7; P < 0.0001) had LV hypertrophy (LVH); none of the controls and four patients of whom one was young had insufficient LV ejection fraction (LVEF) at rest (< 50%); one control and 13 patients (59.1%) of whom five were young (χ2= 12.7; P < 0.0001) had inadequate LVEF at peak exercise (ΔLVEF; < 5% increase of baseline). After 12 months, no change in haemodynamic and diastolic parameters was observed in both groups, except for a significant decrease in heart rate at peak exercise in young patients (P < 0.0001). The LVM index decreased significantly in both young (124.4 ± 5.8 vs. 103.4 ± 3.9 g/m2; P = 0.01) and middle-aged patients (140.9 ± 7.9 vs. 117.8 ± 6.6 g/m2; P= 0.03). LVH disappeared in 10 of 14 patients (71.4%): all six young and four of eight middle-aged patients (50%). LVEF at rest and at peak exercise increased significantly in both groups but ΔLVEF increased significantly only in young patients (1.5 ± 2.9 vs. 13.7 ± 5.2%, P= 0.04); it normalized in nine of 13 patients (69.2%), four of five young (80%) and four of eight middle-aged patients (50%). Exercise capacity (82.5 ± 5.3 vs. 110.0 ± 5.5 W, P= 0.005) and duration (7.3 ± 0.3 vs. 9.9 ± 0.4 min, P = 0.0003) also increased only in young patients. CONCLUSIONS: The acromegalic cardiomyopathy is reversed in most young patients with short disease duration and achieving disease control after OCT-LAR treatment for 12 months, indicating that early diagnosis and effective treatment are essential.
Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
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Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
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Impact Factor: 0.481
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
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Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
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Pisani A, Sabbatini M, Imbriaco M, Riccio E, Rubis N, Prinster A, Perna A, Liuzzi R, Spinelli L, Santangelo M, Remuzzi G, Ruggenenti P
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Impact Factor: 1.396
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Fonti R, Mainolfi C, Anzivino A, Camera L, Faggiano A, Colao A, Salvatore M, Del Vecchio S
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 5.114
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Impact Factor: 3.578
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Impact Factor: 1.799
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Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
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Impact Factor: 0
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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Impact Factor: 5.036
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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Impact Factor: 5.328
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
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Impact Factor: 3.669
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
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Impact Factor: 6.202
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
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Impact Factor: 8.172
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
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Impact Factor: 8.172
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
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Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
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Impact Factor: 4.708
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
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Impact Factor: 6.069
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Supuran CT, Di Fiore A, De Simone G
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Impact Factor: 3.08
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De Simone G, Di Fiore A, Supuran CT
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Impact Factor: 4.399
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
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Impact Factor: 0.481
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Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
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Impact Factor: 6.02
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
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Savastano S, Pivonello R, Acampa W, Salvatore M, Lombardi G, Colao A, Fenzi G
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
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Impact Factor: 5.778
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
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Impact Factor: 5.873
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
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Impact Factor: 1.621
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Impact Factor: 5.199
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
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Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
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Impact Factor: 5.16
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Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
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Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
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Impact Factor: 5.447
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Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
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Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
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Impact Factor: 5.805
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Impact Factor: 0.957
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Impact Factor: 5.805
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
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Impact Factor: 3.064
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
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Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
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Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
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Impact Factor: 0.481
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (358 views)
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Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
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Impact Factor: 2.125
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Diagnosis and treatment of thymoma by octreotide (234 views)
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Impact Factor: 0
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
IN-111 OCTREOTIDE UPTAKE LEVELS IN PITUITARY-ADENOMAS TO PREDICT THE RESPONSIVENESS TO CHRONIC OCTREOTIDE TREATMENT (240 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (267 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (293 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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59 Records (48 excluding Abstracts).
Total impact factor: 240.752 (200.304 excluding Abstracts).
Total 5 year impact factor: 202.844 (168.235 excluding Abstracts).
Total impact factor: 240.752 (200.304 excluding Abstracts).
Total 5 year impact factor: 202.844 (168.235 excluding Abstracts).
429 views. Last view on Saturday 14 January 2023, 19:47:30
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