Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (650 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
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Paper type: Journal Article,
Impact factor: 2.767, 5-year impact factor: 3.497
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037318794&partnerID=40&md5=e9d967b9f008d2e531a080c7e96d6392
Keywords: Angiopeptin, Glucose, Growth Hormone, Insulin, Octreotide, Somatomedin C, Somatostatin Derivative, Acromegaly, Adult, Angiography, Article, Cardiomyopathy, Clinical Article, Controlled Study, Diastole, Disease Control, Disease Duration, Drug Efficacy, Early Diagnosis, Echocardiography, Exercise Tolerance, Female, Follow Up, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Function, Heart Left Ventricle Hypertrophy, Hemodynamics, Human, Oral Glucose Tolerance Test, Priority Journal, Remission, Time Series Analysis, Treatment Outcome, Age Factors, Antineoplastic Agents, Case-Control Studies, Chi-Square Distribution, Delayed-Action Preparations, Doppler, Pulsed, Exercise Test, Left Ventricular, Immunoradiometric Assay, Insulin-Like Growth Factor I, Middle Aged, Prospective Studies, Radionuclide Angiography, Statistics, Nonparametric, Stroke Volume, Time Factors,
Affiliations:
*** IBB - CNR ***
Dept. Molec./Clin. Endocrinol./O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Dept. Biomorphological/Funct. Sci., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Int. Med. I 'Federico II' Univ. N., Pozzilli, Italy
Sci. Inst. for Res./Care Neuromed, Pozzilli, Italy
Dept. Molec. /Clin. Endocrinol. /O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
References:
Not available.
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.767, 5-year impact factor: 3.497
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037318794&partnerID=40&md5=e9d967b9f008d2e531a080c7e96d6392
Keywords: Angiopeptin, Glucose, Growth Hormone, Insulin, Octreotide, Somatomedin C, Somatostatin Derivative, Acromegaly, Adult, Angiography, Article, Cardiomyopathy, Clinical Article, Controlled Study, Diastole, Disease Control, Disease Duration, Drug Efficacy, Early Diagnosis, Echocardiography, Exercise Tolerance, Female, Follow Up, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Function, Heart Left Ventricle Hypertrophy, Hemodynamics, Human, Oral Glucose Tolerance Test, Priority Journal, Remission, Time Series Analysis, Treatment Outcome, Age Factors, Antineoplastic Agents, Case-Control Studies, Chi-Square Distribution, Delayed-Action Preparations, Doppler, Pulsed, Exercise Test, Left Ventricular, Immunoradiometric Assay, Insulin-Like Growth Factor I, Middle Aged, Prospective Studies, Radionuclide Angiography, Statistics, Nonparametric, Stroke Volume, Time Factors,
Affiliations:
*** IBB - CNR ***
Dept. Molec./Clin. Endocrinol./O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Dept. Biomorphological/Funct. Sci., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
Int. Med. I 'Federico II' Univ. N., Pozzilli, Italy
Sci. Inst. for Res./Care Neuromed, Pozzilli, Italy
Dept. Molec. /Clin. Endocrinol. /O., Nucl. Med. Ctr. Natl. Cncl. Res., Pozzilli, Italy
References:
Not available.
Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
BACKGROUND: Cardiovascular disease is the most frequent cause of death of patients with acromegaly. AIM To investigate whether young patients with a presumed short disease duration are more likely to reverse the acromegalic cardiomyopathy than older patients with longer disease duration. DESIGN: An open prospective design. PATIENTS: Ten young (aged < 40 years), and 12 middle-aged (41-59 years) patients with active acromegaly well controlled after 12 months of treatment with the depot formulation of octreotide (OCT-LAR); 22 sex- and age-matched healthy subjects as controls. METHODS: Left ventricular (LV) mass (LVM) by echocardiography and performance by equilibrium radionuclide angiography were measured before and after 12 months of OCT-LAR treatment. RESULTS: At study entry, none of the controls and 14 patients (63.4%) of whom six were young (χ2 = 17.7; P < 0.0001) had LV hypertrophy (LVH); none of the controls and four patients of whom one was young had insufficient LV ejection fraction (LVEF) at rest (< 50%); one control and 13 patients (59.1%) of whom five were young (χ2= 12.7; P < 0.0001) had inadequate LVEF at peak exercise (ΔLVEF; < 5% increase of baseline). After 12 months, no change in haemodynamic and diastolic parameters was observed in both groups, except for a significant decrease in heart rate at peak exercise in young patients (P < 0.0001). The LVM index decreased significantly in both young (124.4 ± 5.8 vs. 103.4 ± 3.9 g/m2; P = 0.01) and middle-aged patients (140.9 ± 7.9 vs. 117.8 ± 6.6 g/m2; P= 0.03). LVH disappeared in 10 of 14 patients (71.4%): all six young and four of eight middle-aged patients (50%). LVEF at rest and at peak exercise increased significantly in both groups but ΔLVEF increased significantly only in young patients (1.5 ± 2.9 vs. 13.7 ± 5.2%, P= 0.04); it normalized in nine of 13 patients (69.2%), four of five young (80%) and four of eight middle-aged patients (50%). Exercise capacity (82.5 ± 5.3 vs. 110.0 ± 5.5 W, P= 0.005) and duration (7.3 ± 0.3 vs. 9.9 ± 0.4 min, P = 0.0003) also increased only in young patients. CONCLUSIONS: The acromegalic cardiomyopathy is reversed in most young patients with short disease duration and achieving disease control after OCT-LAR treatment for 12 months, indicating that early diagnosis and effective treatment are essential.
BACKGROUND: Cardiovascular disease is the most frequent cause of death of patients with acromegaly. AIM To investigate whether young patients with a presumed short disease duration are more likely to reverse the acromegalic cardiomyopathy than older patients with longer disease duration. DESIGN: An open prospective design. PATIENTS: Ten young (aged < 40 years), and 12 middle-aged (41-59 years) patients with active acromegaly well controlled after 12 months of treatment with the depot formulation of octreotide (OCT-LAR); 22 sex- and age-matched healthy subjects as controls. METHODS: Left ventricular (LV) mass (LVM) by echocardiography and performance by equilibrium radionuclide angiography were measured before and after 12 months of OCT-LAR treatment. RESULTS: At study entry, none of the controls and 14 patients (63.4%) of whom six were young (χ2 = 17.7; P < 0.0001) had LV hypertrophy (LVH); none of the controls and four patients of whom one was young had insufficient LV ejection fraction (LVEF) at rest (< 50%); one control and 13 patients (59.1%) of whom five were young (χ2= 12.7; P < 0.0001) had inadequate LVEF at peak exercise (ΔLVEF; < 5% increase of baseline). After 12 months, no change in haemodynamic and diastolic parameters was observed in both groups, except for a significant decrease in heart rate at peak exercise in young patients (P < 0.0001). The LVM index decreased significantly in both young (124.4 ± 5.8 vs. 103.4 ± 3.9 g/m2; P = 0.01) and middle-aged patients (140.9 ± 7.9 vs. 117.8 ± 6.6 g/m2; P= 0.03). LVH disappeared in 10 of 14 patients (71.4%): all six young and four of eight middle-aged patients (50%). LVEF at rest and at peak exercise increased significantly in both groups but ΔLVEF increased significantly only in young patients (1.5 ± 2.9 vs. 13.7 ± 5.2%, P= 0.04); it normalized in nine of 13 patients (69.2%), four of five young (80%) and four of eight middle-aged patients (50%). Exercise capacity (82.5 ± 5.3 vs. 110.0 ± 5.5 W, P= 0.005) and duration (7.3 ± 0.3 vs. 9.9 ± 0.4 min, P = 0.0003) also increased only in young patients. CONCLUSIONS: The acromegalic cardiomyopathy is reversed in most young patients with short disease duration and achieving disease control after OCT-LAR treatment for 12 months, indicating that early diagnosis and effective treatment are essential.
Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
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Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
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Impact Factor: 5.447
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Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
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Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
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Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
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Supuran CT, Di Fiore A, De Simone G
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De Simone G, Di Fiore A, Supuran CT
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
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Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
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Impact Factor: 2.922
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Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (354 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (446 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (443 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (438 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (507 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (358 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (904 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (387 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Diagnosis and treatment of thymoma by octreotide (240 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1995; 36(0): N/D-N/D.
Impact Factor: 0
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
IN-111 OCTREOTIDE UPTAKE LEVELS IN PITUITARY-ADENOMAS TO PREDICT THE RESPONSIVENESS TO CHRONIC OCTREOTIDE TREATMENT (240 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (283 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (293 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (267 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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59 Records (48 excluding Abstracts).
Total impact factor: 240.752 (200.304 excluding Abstracts).
Total 5 year impact factor: 202.844 (168.235 excluding Abstracts).
Total impact factor: 240.752 (200.304 excluding Abstracts).
Total 5 year impact factor: 202.844 (168.235 excluding Abstracts).
650 views. Last view on Wednesday 13 September 2023, 13:10:51
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