Ribosomal crystallography: Peptide bond formation and its inhibition (603 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.733, 5-year impact factor: 2.675
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-10744220564&partnerID=40&md5=b319d9712d7d3360f8811658e7eb404e
Keywords: Elongation Arrest, Peptide-Bond Formation, Ribosomes, Translocation, Tunnel Gating, Biosynthesis, Polypeptides, Proteins, Cellular Organelles, Crystallography, Antibiotic Agent, Azithromycin, Chloramphenicol, Clarithromycin, Clindamycin, Erythromycin, Ketolide, Lincomycin, Macrolide, Nucleotide, Protein Subunit, Protein Synthesis Inhibitor, Puromycin, Ribosome Rna, Roxithromycin, Sparsomycin, Tetracycline, Transfer Rna, Troleandomycin, Article, Binding Site, Catalysis, Cell Organelle, Channel Gating, Enzyme Active Site, Enzyme Substrate, Eubacterium, Genetic Code, Geometry, Molecular Dynamics, Molecular Weight, Orientation, Process Monitoring, Protein Assembly, Protein Binding, Protein Rna Binding, Protein Structure, Protein Synthesis Inhibition, Reaction Analysis, Ribosome Subunit, Rna Translation, Rna Transport, Rotation, Anti-Bacterial Agents, Catalytic Domain, X-Ray, Models, Molecular Conformation, Nucleic Acid Conformation, Peptidyl Transferases, Protein Conformation, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
Max-Planck-Res. U. Ribosomal Struct., 22603 Hamburg, Germany
FB Biologie, Chemie, Pharmazie, Frei Uni. Berlin, 14195 Berlin, Germany
Max-Planck-Inst. for Molec. Genet., 14195 Berlin, Germany
Inst. of Biostructure and Bioimage, CNR, 80138 Napoli, Italy
References:
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Trakhanov, S. D., Yusupov, M. M., Agalarov, S. C., Garber, M. B., Ryazantsev, S. N., Tischenko, S. V., Shirokov, V. A., (1987) FEBS Lett, 220, pp. 319-322
Wimberly, B. T., Brodersen, D. E., Clemons W. M., Jr., Morgan-Warren, R. J., Carter, A. P., Vonrhein, C., Hartsch, T., Ramakrishnan, V., (2000) Nature, 407, pp. 327-339
Lake, J. A., (1985) Annu Rev Biochem, 54, pp. 507-530
Garrett, R. A., Rodriguez-Fonseca, C., (1995) Ribosomal RNA: Structure, Evolution, Processing & Function, pp. 327-355. , Zimmermann, R. A., Dahlberg, A. E., Eds.
Noller, H. F., Hoffarth, V., Zimniak, L., (1992) Science, 256, pp. 1416-1419
Samaha, R. R., Green, R., Noller, H. F., (1995) Nature, 377, pp. 309-314
Milligan, R. A., Unwin, P. N., (1986) Nature, 319, pp. 693-695
Malkin, L. I., Rich, A., (1967) J Mol Biol, 26, pp. 329-346
Sabatini, D. D., Blobel, G., (1970) J Cell Biol, 45, pp. 146-157
Bayfield, M. A., Dahlberg, A. E., Schulmeister, U., Dorner, S., Barta, A., (2001) Proc Natl Acad Sci USA, 98, pp. 10096-10101
Spahn, C. M., Prescott, C. D., (1996) J Mol Med, 74, pp. 423-439
Carter, A. P., Clemons, W. M., Brodersen, D. E., Morgan-Warren, R. J., Wimberly, B. T., Ramakrishnan, V., (2000) Nature, 407, pp. 340-348
Hansen, J. L., Ippolito, J. A., Ban, N., Nissen, P., Moore, P. B., Steitz, T. A., (2002) Mol Cell, 10, pp. 117-128
Traut, R. R., Monro, R. E., (1964) J Mol Biol, 10, pp. 63-72
Porse, B. T., Garrett, R. A., (1995) J Mol Biol, 249, pp. 1-10
Porse, B. T., Kirillov, S. V., Awayez, M. J., Ottenheijm, H. C., Garrett, R. A., (1999) Proc Natl Acad Sci USA, 96, pp. 9003-9008
Tan, G. T., DeBlasio, A., Mankin, A. S., (1996) J Mol Biol, 261, pp. 222-230
Chepkwony, H. K., Roets, E., Hoogmartens, J., (2001) J Chromatogr A, 914, pp. 53-58
Hansen, J. L., Schmeing, T. M., Moore, P. B., Steitz, T. A., (2002) Proc Natl Acad Sci USA, 16, p. 16
Gabashvili, I. S., Gregory, S. T., Valle, M., Grassucci, R., Worbs, M., Wahl, M. C., Dahlberg, A. E., Frank, J., (2001) Mol Cell, 8, pp. 181-188
Mankin, A. S., (1997) J Mol Biol, 274, pp. 8-15
Cooperman, B. S., (1977) Adv Exp Med Biol, pp. 595-609
Krayevsky, A. A., Kukhanova, M. K., (1979) Prog Nucleic Acid Res Mol Biol, 23, pp. 1-51
Nierhaus, K. H., Schulze, H., Cooperman, B. S., (1980) Biochem Int, 1, pp. 185-192
Wilson, K. S., Noller, H. F., (1998) Cell, 92, pp. 337-349
Parnell, K. M., Seila, A. C., Strobel, S. A., (2002) Proc Natl Acad Sci USA, 16, p. 16
Schmeing, T. M., Seila, A. C., Hansen, J. L., Freeborn, B., Soukup, J. K., Scaringe, S. A., Strobel, S. A., Steitz, T. A., (2002) Nat Struct Biol, 9, pp. 225-230
Goldberg, I. H., Mitsugi, K., (1966) Biochem Biophys Res Commun, 23, pp. 453-459
Agrawal, R. K., Heagle, A. B., Penczek, P., Grassucci, R. A., Frank, J., (1999) Nat Struct Biol, 6, pp. 643-647
Kim, D. F., Green, R., (1999) Mol Cell, 4, pp. 859-864
Rodnina, M. V., Wintermeyer, W., (2001) Trends Biochem Sci, 26, pp. 124-130
Lu, M., Steitz, T. A., (2000) Proc Natl Acad Sci USA, 97, pp. 2023-2028
Stroud, R. M., Walter, P., (1999) Curr Opin Struct Biol, 9, pp. 754-759
Morris, D. R., Geballe, A. P., (2000) Mol Cell Biol, 20, pp. 8635-8642
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.733, 5-year impact factor: 2.675
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-10744220564&partnerID=40&md5=b319d9712d7d3360f8811658e7eb404e
Keywords: Elongation Arrest, Peptide-Bond Formation, Ribosomes, Translocation, Tunnel Gating, Biosynthesis, Polypeptides, Proteins, Cellular Organelles, Crystallography, Antibiotic Agent, Azithromycin, Chloramphenicol, Clarithromycin, Clindamycin, Erythromycin, Ketolide, Lincomycin, Macrolide, Nucleotide, Protein Subunit, Protein Synthesis Inhibitor, Puromycin, Ribosome Rna, Roxithromycin, Sparsomycin, Tetracycline, Transfer Rna, Troleandomycin, Article, Binding Site, Catalysis, Cell Organelle, Channel Gating, Enzyme Active Site, Enzyme Substrate, Eubacterium, Genetic Code, Geometry, Molecular Dynamics, Molecular Weight, Orientation, Process Monitoring, Protein Assembly, Protein Binding, Protein Rna Binding, Protein Structure, Protein Synthesis Inhibition, Reaction Analysis, Ribosome Subunit, Rna Translation, Rna Transport, Rotation, Anti-Bacterial Agents, Catalytic Domain, X-Ray, Models, Molecular Conformation, Nucleic Acid Conformation, Peptidyl Transferases, Protein Conformation, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Department of Structural Biology, Weizmann Institute, 76100 Rehovot, Israel
Max-Planck-Res. U. Ribosomal Struct., 22603 Hamburg, Germany
FB Biologie, Chemie, Pharmazie, Frei Uni. Berlin, 14195 Berlin, Germany
Max-Planck-Inst. for Molec. Genet., 14195 Berlin, Germany
Inst. of Biostructure and Bioimage, CNR, 80138 Napoli, Italy
References:
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Bashan, A., Agmon, I., Zarivach, R., Schluenzen, F., Harms, J., Berisio, R., Bartels, H., Yonath, A., (2003) Mol Cell, 11, pp. 91-102
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Hansen, H.A., Volkmann, N., Piefke, J., Glotz, C., Weinstein, S., Makowski, I., Meyer, S., Yonath, A., (1990) Biochim Biophys Acta, 1050, pp. 1-7
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Levin-Zaidman, S., Englander, J., Shimoni, E., Sharma, A.K., Minton, K.W., Minsky, A., (2003) Science, 299, pp. 254-256
Hope, H., Frolow, F., Von Bohlen, K., Makowski, I., Kratky, C., Halfon, Y., Danz, H., Wittmann, H.G., (1989) Acta Crystallogr B, 45, pp. 190-199
Yonath, A., Leonard, K.R., Weinstein, S., Wittmann, H.G., (1987) Cold Spring Harb Symp Quant Biol, 52, pp. 729-741
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Ribosomal crystallography: Peptide bond formation and its inhibition
Ribosomes, the universal cellular organelles catalyzing the translation of genetic code into proteins, are protein/RNA assemblies, of a molecular weight 2.5 mega Daltons or higher. They are built of two subunits that associate for performing protein biosynthesis. The large subunit creates the peptide bond and provides the path for emerging proteins. The small has key roles in initiating the process and controlling its fidelity. Crystallographic studies on complexes of the small and the large eubacterial ribosomal subunits with substrate analogs, antibiotics, and inhibitors confirmed that the ribosomal RNA governs most of its activities, and indicated that the main catalytic contribution of the ribosome is the precise positioning and alignment of its substrates, the tRNA molecules. A symmetry-related region of a significant size, containing about two hundred nucleotides, was revealed in all known structures of the large ribosomal subunit, despite the asymmetric nature of the ribosome. The symmetry rotation axis, identified in the middle of the peptide-bond formation site, coincides with the bond connecting the tRNA double-helical features with its single-stranded 3′ end, which is the moiety carrying the amino acids. This thus implies sovereign movements of tRNA features and suggests that tRNA translocation involves a rotatory motion within the ribosomal active site. This motion is guided and anchored by ribosomal nucleotides belonging to the active site walls, and results in geometry suitable for peptide-bond formation with no significant rearrangements. The sole geometrical requirement for this proposed mechanism is that the initial P-site tRNA adopts the flipped orientation. The rotatory motion is the major component of unified machinery for peptide-bond formation, translocation, and nascent protein progression, since its spiral nature ensures the entrance of the nascent peptide into the ribosomal exit tunnel. This tunnel, assumed to be a passive path for the growing chains, was found to be involved dynamically in gating and discrimination. © 2003 Wiley Periodicals, Inc.
Ribosomes, the universal cellular organelles catalyzing the translation of genetic code into proteins, are protein/RNA assemblies, of a molecular weight 2.5 mega Daltons or higher. They are built of two subunits that associate for performing protein biosynthesis. The large subunit creates the peptide bond and provides the path for emerging proteins. The small has key roles in initiating the process and controlling its fidelity. Crystallographic studies on complexes of the small and the large eubacterial ribosomal subunits with substrate analogs, antibiotics, and inhibitors confirmed that the ribosomal RNA governs most of its activities, and indicated that the main catalytic contribution of the ribosome is the precise positioning and alignment of its substrates, the tRNA molecules. A symmetry-related region of a significant size, containing about two hundred nucleotides, was revealed in all known structures of the large ribosomal subunit, despite the asymmetric nature of the ribosome. The symmetry rotation axis, identified in the middle of the peptide-bond formation site, coincides with the bond connecting the tRNA double-helical features with its single-stranded 3′ end, which is the moiety carrying the amino acids. This thus implies sovereign movements of tRNA features and suggests that tRNA translocation involves a rotatory motion within the ribosomal active site. This motion is guided and anchored by ribosomal nucleotides belonging to the active site walls, and results in geometry suitable for peptide-bond formation with no significant rearrangements. The sole geometrical requirement for this proposed mechanism is that the initial P-site tRNA adopts the flipped orientation. The rotatory motion is the major component of unified machinery for peptide-bond formation, translocation, and nascent protein progression, since its spiral nature ensures the entrance of the nascent peptide into the ribosomal exit tunnel. This tunnel, assumed to be a passive path for the growing chains, was found to be involved dynamically in gating and discrimination. © 2003 Wiley Periodicals, Inc.
Ribosomal crystallography: Peptide bond formation and its inhibition
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Ribosomal crystallography: Peptide bond formation and its inhibition
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (393 views)
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Impact Factor: 2.082
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
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Impact Factor: 6.692
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Lanzillo R, Orefice G, Prinster A, Ventrella G, Liuzzi R, Scarano V, Florio C, Vacca G, Brunetti A, Alfano B, Brescia Morra V, Bonavita V
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Impact Factor: 1.315
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
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Impact Factor: 0.506
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Berisio R, Ruggiero A, Vitagliano L
* Elongation Factors Efia And Ef-Tu: Their Role In Translation And Beyond (579 views)
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Impact Factor: 2.561
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
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Impact Factor: 1.849
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
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Impact Factor: 2.572
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Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A
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Impact Factor: 1.807
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
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Impact Factor: 1.621
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Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (496 views)
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Impact Factor: 4.399
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
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Impact Factor: 0.645
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
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Impact Factor: 5.115
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Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
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Impact Factor: 3.415
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
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Impact Factor: 0.84
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
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Impact Factor: 3.843
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
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Impact Factor: 2.019
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
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Impact Factor: 1.938
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Zarivach R, Bashan A, Berisio R, Harms J, Auerbach T, Schluenzen F, Bartels H, Baram D, Pyetan E, Sittner A, Amit M, Hansen HAS, Kessler M, Liebe C, Wolff A, Agmon I, Yonath A
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Impact Factor: 1.211
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (433 views)
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Impact Factor: 2.248
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
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Impact Factor: 2.863
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Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C
* Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli (342 views)
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Impact Factor: 2.208
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Agmon I, Auerbach T, Baram D, Bartels H, Bashan A, Berisio R, Fucini P, Hansen HA, Harms J, Kessler M, Peretz M, Schluenzen F, Yonath A, Zarivach R
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Impact Factor: 3.06
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Berisio R, Schluenzen F, Harms J, Bashan A, Auerbach T, Baram D, Yonath A
* Structural insight into the role of the ribosomal tunnel in cellular regulation (379 views)
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Impact Factor: 11.579
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
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Impact Factor: 3.992
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
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Impact Factor: 16.835
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Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
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Impact Factor: 2.733
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
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Impact Factor: 1.218
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
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Impact Factor: 7.258
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
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Impact Factor: 1.451
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
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Impact Factor: 2.579
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
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Impact Factor: 4.293
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Oliva A, Della Ragione F, Fratta M, Marrone G, Palumbo R, Zappia V
Effect of retinoic acid on osteocalcin gene expression in human osteoblasts (271 views)
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Impact Factor: 2.671
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Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (441 views)
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Impact Factor: 2.364
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Margotta V, Fonti R, Palladini G, Filoni S, Lauro GM
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts (484 views)
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* The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis (247 views)
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Impact Factor: 2.863
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Lama A, Annunziata C, Coretti L, Pirozzi C, Di Guida F, Nitrato Izzo A, Cristiano C, Mollica MP, Chiariotti L, Pelagalli A, Lembo F, Meli R, Mattace Raso G
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Impact Factor: 5.078
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Leggio L, Guarino F, Magrì A, Accardi-gheit R, Reina S, Specchia V, Damiano F, Tomasello MF, Tommasino M, Messina A
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Impact Factor: 4.259
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Salvatore B, Klain M, Nicolai E, D'Amico D, De Matteis G, Raddi M, Fonti R, Pellegrino T, Storto G, Cuocolo A, Pace L
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
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Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, Del Giudice C, Ciccarelli M, Franco A, Crola C, Campiglia P, Sala M, Gomez-Monterrey I, De Luca N, Trimarco B, Iaccarino G, Illario M
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Impact Factor: 3.057
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Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
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Impact Factor: 3.057
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
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Impact Factor: 2.332
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
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Impact Factor: 7.232
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
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Impact Factor: 2.551
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De Rosa L, Russomanno A, Romanelli A, D'Andrea LD
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Impact Factor: 2.095
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Musumeci D, Roviello GN, Montesarchio D, Sapio R, Valente M, Anr V, Bucci EM
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Impact Factor: 3.708
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
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Impact Factor: 5.466
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Martucci NM, Lamberti A, Vitagliano L, Cantiello P, Ruggiero I, Arcari P, Masullo M
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Impact Factor: 2.203
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Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
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Impact Factor: 2.406
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
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Impact Factor: 3.35
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
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Impact Factor: 6.873
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De Rosa L, Cortajarena AL, Romanelli A, Regan L, D'Andrea LD
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Impact Factor: 3.568
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (393 views)
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Impact Factor: 2.082
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
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Impact Factor: 6.692
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Lanzillo R, Orefice G, Prinster A, Ventrella G, Liuzzi R, Scarano V, Florio C, Vacca G, Brunetti A, Alfano B, Brescia Morra V, Bonavita V
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Impact Factor: 1.315
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (408 views)
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Impact Factor: 0.506
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Berisio R, Ruggiero A, Vitagliano L
* Elongation Factors Efia And Ef-Tu: Their Role In Translation And Beyond (579 views)
Israel Journal Of Chemistry, 2010 Jun; 50(1): 71-79.
Impact Factor: 2.561
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
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Impact Factor: 1.849
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
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Impact Factor: 2.572
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Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A
* Ribosome's mode of function: Myths, facts and recent results (395 views)
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Impact Factor: 1.807
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (446 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (496 views)
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Impact Factor: 4.399
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (729 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
* A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (391 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Jun 13; 579(15): 3207-3213.
Impact Factor: 3.415
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (362 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Zarivach R, Bashan A, Berisio R, Harms J, Auerbach T, Schluenzen F, Bartels H, Baram D, Pyetan E, Sittner A, Amit M, Hansen HAS, Kessler M, Liebe C, Wolff A, Agmon I, Yonath A
* Functional aspects of ribosomal architecture: Symmetry, chirality and regulation (504 views)
J Phys Org Chem (ISSN: 0894-3230), 2004; 17(11): 901-912.
Impact Factor: 1.211
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (433 views)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C
* Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli (342 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Oct; 59(10): 1846-1848.
Impact Factor: 2.208
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Agmon I, Auerbach T, Baram D, Bartels H, Bashan A, Berisio R, Fucini P, Hansen HA, Harms J, Kessler M, Peretz M, Schluenzen F, Yonath A, Zarivach R
* On Peptide Bond Formation, Translocation, Nascent Protein Progression And The Regulatory Properties Of Ribosomes. Derived On 20 October 2002 At The 28th Febs Meeting In Istanbul (308 views)
Chembiochem, 2003 Jun; 270(12): 2543-2556.
Impact Factor: 3.06
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Berisio R, Schluenzen F, Harms J, Bashan A, Auerbach T, Baram D, Yonath A
* Structural insight into the role of the ribosomal tunnel in cellular regulation (379 views)
Nat Struct Biol (ISSN: 1072-8368), 2003 May; 10(5): 366-370.
Impact Factor: 11.579
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (430 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
* Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression (465 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2003 Jan; 11(1): 91-102.
Impact Factor: 16.835
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Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (429 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Impact Factor: 2.733
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1313 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (624 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (517 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
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Oliva A, Della Ragione F, Fratta M, Marrone G, Palumbo R, Zappia V
Effect of retinoic acid on osteocalcin gene expression in human osteoblasts (271 views)
Biochem Biophys Res Commun (ISSN: 0006-291xprint, 0006-291xlinking), 1993 Mar 31; 191(3): 908-914.
Impact Factor: 2.671
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Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (441 views)
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
Impact Factor: 2.364
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Margotta V, Fonti R, Palladini G, Filoni S, Lauro GM
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts (484 views)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(4): 485-490.
Impact Factor: 0
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54 Records (53 excluding Abstracts).
Total impact factor: 192.009 (190.071 excluding Abstracts).
Total 5 year impact factor: 206.342 (201.372 excluding Abstracts).
Total impact factor: 192.009 (190.071 excluding Abstracts).
Total 5 year impact factor: 206.342 (201.372 excluding Abstracts).
603 views. Last view on Tuesday 30 May 2023, 17:30:22
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