Structural insight into the antibiotic action of telithromycin against resistant mutants
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Structural insight into the antibiotic action of telithromycin against resistant mutants (613 views)

Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HAS, Fucini P, Yonath A

J Bacteriol Journal Of Bacteriology (ISSN: 0021-9193, 1098-5530), 2003 Jul; 185(14): 4276-4279.

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Paper type: Journal Article,

Impact factor: 4.175, 5-year impact factor: 3.298

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038492422&partnerID=40&md5=46b4241b4cf7905242d3a5efe211743f

Keywords: Cethromycin, Erythromycin, Ketolide, Macrolide, Telithromycin, Antibiotic Resistance, Article, Bacterium Mutant, Binding Site, Crystal Structure, Deinococcus Radiodurans, Drug Mechanism, Drug Protein Binding, Drug Structure, Nonhuman, Priority Journal, Protein Domain, Protein Interaction, Ribosome, Anti-Bacterial Agents, Crystallization, Crystallography, X-Ray, Drug Resistance, Models, Molecular, Molecular Sequence Data, 23s, Bacteria (microorganisms), Posibacteria,

Affiliations:
*** IBB - CNR ***

Max-Planck-Res. U. Ribosomal Struct., Hamburg, Germany
Max-Planck-Inst. for Molec. Genet., Berlin, Germany
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Inst. of Biostructure and Bioimaging, CNR, Naples, Italy


References:
Not available.
Structural insight into the antibiotic action of telithromycin against resistant mutants

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
Structural insight into the antibiotic action of telithromycin against resistant mutants

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Structural insight into the antibiotic action of telithromycin against resistant mutants

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14 Records (14 excluding Abstracts).
Total impact factor: 52.753 (52.753 excluding Abstracts).
Total 5 year impact factor: 55.684 (55.684 excluding Abstracts).

Last modified by Rita Berisio on Sunday 12 July 2020, 13:15:11
613 views. Last view on Tuesday 10 December 2024, 10:46:43