Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET
Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET(463 views) He W, Acampa W, Mainolfi C, Menna F, Sorrentino AR, Petretta M, Cuocolo A
Dept. Biomorphol. Functional Sci., Institute of Internal Medicine, Univeristy Federico II, Via Pansini 5, 80131 Napoli, Italy
University of Federico II, Inst. of Biostructure and Bioimages, National Council of Research, Via Pansini 5, 80131 Napoli, Italy
IRCCS Neuromed, Pozzilli, Italy
Inst. Int. Med. Cardiol./Heart Surg., University Federico II, Via Pansini 5, 80131 Napoli, Italy
References: Not available.
Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET
Background. In patients with ischemic left ventricular (LV) dysfunction, myocardial perfusion imaging after nitrate administration may improve the identification of dysfunctional but viable myocardium. This study was designed to assess the relationship between tetrofosmin uptake after nitrate administration and metabolic activity as assessed by positron emission tomography (PET) in patients with ischemic LV dysfunction. Methods and Results. Thirty-six patients with chronic myocardial infarction and LV dysfunction (ejection fraction, 35% ± 6%) underwent resting technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging under control conditions (baseline) and after sublingual administration of 10 mg isosorbide dinitrate. Within 1 week, all patients underwent metabolic PET imaging with fluorine 18-fluorodeoxyglucose. Tetrofosmin uptake and metabolic activity were measured in 13 segments/patient. Regional LV function was assessed in corresponding segments by echocardiography. On baseline tetrofosmin imaging, 53 (40%) of the 131 akinetic or dyskinetic segments had reduced (
Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET
Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET