A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (725 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.359, 5-year impact factor: 3.795
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-18444375552&partnerID=40&md5=25192b66e186ec7d3b9e4b121251ac2d
Keywords: A-Kinase Anchor Proteins, Mitochondria, Mitotic Spindles, S-Akap84 Akap121, Cyclic Amp Dependent Protein Kinase, Cyclic Amp Dependent Protein Kinase Anchoring Protein, Green Fluorescent Protein, Hybrid Protein, Isoprotein, Mutant Protein, Tissue Extract, Tubulin, Unclassified Drug, Amino Terminal Sequence, Animal Cell, Animal Cell Culture, Animal Tissue, Article, Cellular Distribution, Controlled Study, Deletion Mutant, Germ Cell, Immunohistochemistry, Immunoprecipitation, Interphase, Microtubule, Mitosis Spindle, Mouse, Nonhuman, Priority Journal, Protein Binding, Protein Domain, Protein Localization, Protein Motif, Protein Purification, Site Directed Mutagenesis, Testis, Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Amino Acid Sequence, Base Sequence, Carrier Proteins, Cell Line, Cyclic Amp-Dependent Protein Kinases, Complementary, Membrane Proteins, Mitotic Spindle Apparatus, Molecular Sequence Data, Site-Directed, Recombinant Fusion Proteins, Sequence Deletion, Spermatozoa, Two-Hybrid System Techniques,
Affiliations:
*** IBB - CNR ***
Dipartimento Di Biologia E Patologia Molecolare E Cellulare, BioGem Consortium, Universitá Federico II, via S. Pansini 5, 80131 Naples, Italy
Institute of Cancer Research, Columbia University, New York, NY 10032, United States
Centro Studi Biocristallografia CNR, via Mezzocannone 6, Naples, Italy
Department of Molecular Pharmacology, Atran Laboratories, Albert Einstein College of Medicine, Bronx, NY 10461, United States
References:
Edelman, A.M., Blumenthal, D.K., Krebs, E.G., Protein serine/threonine kinases (1987) Annu. Rev. Biochem., 56, pp. 567-61
Taylor, S., Buechler, J.A., Yonemoto, Y., Structural framework for the protein kinase family (1990) Annu. Rev. Biochem., 59, pp. 971-1005
Rubin, C.S., A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP (1994) Biochim. Biophys. Acta, 1224, pp. 467-479
Smith, F.D., Scott, J.D., Signaling complexes: Junctions on the intracellular information super highway (2002) Curr. Biol., 12, pp. R32-R40
Diviani, D., Scott, J.D., AKAP signaling complexes at the cytoskeleton (2001) J. Cell Sci., 114, pp. 1431-1437
Feliciello, A., Gottesman, M.E., Avvedimento, V.E., The biological function of A-kinase anchor proteins (2001) J. Mol. Biol., 308, pp. 99-114
Miki, K., Eddy, E.M., Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins (1999) J. Biol. Chem., 274, pp. 29057-29062
Angelo, R.G., Rubin, C.S., Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms (2000) J. Biol. Chem., 275, pp. 4351-4362
Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M., Scott, J.D., Association of protein kinase A and protein phosphatase 2B with a common anchoring protein (1995) Science, 267, pp. 108-111
Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., Scott, J.D., Coordination of three signaling enzymes by AKAP79, a mammalian scaffold-protein (1996) Science, 271, pp. 1589-1592
Schillace, R.V., Scott, J.D., Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 (1999) Curr. Biol., 9, pp. 321-324
Westphal, R.S., Tavalin, S.J., Lin, J.W., Alto, N.M., Fraser, I.D., Langeberg, L.K., Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex (1999) Science, 285, pp. 93-96
Steen, R.L., Martins, S.B., Tasken, K., Collas, P., Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly (2000) J. Cell Biol., 150, pp. 1251-1262
Feliciello, A., Giuliano, P., Porcellini, A., Garbi, C., Obici, S., Mele, E., The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein kinase IIbeta (1996) J. Biol. Chem., 271, pp. 25350-25359
Feliciello, A., Avvedimento, V.E., Li, Y., Gottesman, M.E., Rubin, C.S., A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus (1997) Curr. Biol., 7, pp. 1011-1014
Lester, L.B., Langeberg, L.K., Scott, J.D., Anchoring of protein kinase A facilitates hormone-mediated insulin secretion (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 14942-14947
Gray, P.C., Scott, J.D., Catterall, W.A., Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins (1998) Curr. Opin. Neurobiol., 8, pp. 330-334
Paolillo, M., Feliciello, A., Porcellini, A., Garbi, C., Bifulco, M., Schinelli, S., The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells (1999) J. Biol. Chem., 274, pp. 6546-6552
Westphal, R.S., Soderling, S.H., Alto, N.M., Langeberg, L.K., Scott, J.D., Scar/WAVE-1, a wiskott-aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold (2000) EMBO J., 19, pp. 4589-4600
Colledge, M., Dean, R.A., Scott, G.K., Langeberg, L.K., Huganir, R.L., Scott, J.D., Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex (2000) Neuron, 27, pp. 107-119
Feliciello, A., Gallo, A., Mele, E., Porcellini, A., Troncone, G., Garbi, C., The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells (2000) J. Biol. Chem., 275, pp. 303-311
Lester, L.B., Faux, M.C., Nauert, J.B., Scott, J.D., Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation (2001) Endocrinology, 142, pp. 1218-1227
Fink, M.A., Zakhary, D.R., Mackey, J.A., Desnoyer, R.W., Apperson-Hansen, C., Damron, D.S., Bond, M., AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes (2001) Circ. Res., 88, pp. 291-297
Lin, R., Moss, S.B., Rubin, C.S., Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells (1995) J. Biol. Chem., 270, pp. 27804-27811
Chen, Q., Lin, R., Rubin, C.S., Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria (1997) J. Biol. Chem., 272, pp. 15247-15257
Trendelenburg, G., Hummel, M., Riecken, E.O., Hanski, C., Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain (1996) Biochem. Biophys. Res. Commun., 225, pp. 313-319
Huang, L.J., Durick, K., Weiner, J.A., Chun, J., Taylor, S.S., Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits (1997) J. Biol. Chem., 272, pp. 8057-8064
Feliciello, A., Rubin, C.S., Avvedimento, E.V., Gottesman, M.E., Expression of A kinase anchor protein121 is regulated by hormones in thyroid and testicular germ cells (1998) J. Biol. Chem., 273, pp. 23361-23366
Huang, L.J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T.J., NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum (1999) J. Cell Biol., 145, pp. 951-959
Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L.J., Taylor, S.S., Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A (1999) Mol. Cell, 4, pp. 413-422
Feliciello, A., Cardone, L., Garbi, C., Ginsberg, M.D., Varrone, S., Rubin, C.S., Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II (1999) FEBS Letters, 464, pp. 174-178
Kelley, L.A., MacCallum, R.M., Sternberg, M.J.E., Enhanced genome annotation using structural profiles in the program 3D-PSSM (2000) J. Mol. Biol., 299, pp. 499-520
Hahne, K., Haucke, V., Ramage, L., Schatz, G., Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments (1994) Cell, 79, pp. 829-839
Weisiger, R.A., Fridovich, I., Mitochondrial superoxide dismutase. Site of synthesis and intra-mitochondrial localization (1973) J. Biol. Chem., 24, pp. 4793-4796
Yaffe, M., The machinery of mitochondrial inheritance and behavior (1999) Science, 283, pp. 1493-1497
Straight, A.F., Field, C.M., Microtubules, membranes and cytokinesis (2000) Curr. Biol., 10, pp. R760-R770
Piel, M., Nordberg, J., Euteneuer, U., Bornens, M., Centrosome-dependent exit of cytokinesis in animal cells (2001) Science, 291, pp. 1550-1553
Nogales, E., Structural insights into microtubule function (2000) Annu. Rev. Biochem., 69, pp. 277-302
Downing, K.H., Nogales, E., New insights into microtubule structure and function from the atomic model of tubulin (1998) Eur. Biophys. J., 27, pp. 431-436
Rubino, H.M., Dammerman, M., Shafit-Zagardo, B., Erlichman, J., Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2 (1989) Neuron, 3, pp. 631-638
Vallee, R.B., DiBartolomeis, M.J., Theurkauf, W.E., A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2) (1981) J. Cell Biol., 90, pp. 568-576
Diviani, D., Langeberg, L.K., Doxsey, S.J., Scott, J.D., Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain (2000) Curr. Biol., 10, pp. 417-420
Bernier-Valentin, F., Rousset, B., Interaction of tubulin with rat liver mitochondria (1982) J. Biol. Chem., 257, pp. 7092-7099
Jung, D., Filliol, D., Miehe, M., Rendon, A., Interaction of brain mitochondria with microtubules reconstituted from brain tubulin and MAP2 or TAU (1993) Cell Motil. Cytoskel., 24, pp. 245-255
Langford, G., Actin- and microtubule-dependent organelle motors: Interrelationships between the two motility systems (1995) Curr. Opin. Cell. Biol., 7, pp. 82-88
Wolkolwicz, M.J., Coonrod, S.M., Reddi, P.P., Millan, J.C., Hofmann, M.C., Herr, J.R., Refinement of the differentiated phenotype of the spermatogenic cell line GC-2spd(ts) (1996) Biol. Reprod., 55, pp. 923-932
Sambrook, J., Fritsch, E.F., Maniatis, T., (1989) Molecular Cloning: A Laboratory Manual, 2nd edit., , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
Williams, R.C., Lee, J.C., Preparation of tubulin from brain (1982) Methods Enzymol., 85, pp. 376-408
Edelman, A. M., Blumenthal, D. K., Krebs, E. G., Protein serine/threonine kinases (1987) Annu. Rev. Biochem., 56, pp. 567-61
Rubin, C. S., A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP (1994) Biochim. Biophys. Acta, 1224, pp. 467-479
Smith, F. D., Scott, J. D., Signaling complexes: Junctions on the intracellular information super highway (2002) Curr. Biol., 12, pp. R32-R40
Miki, K., Eddy, E. M., Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins (1999) J. Biol. Chem., 274, pp. 29057-29062
Angelo, R. G., Rubin, C. S., Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms (2000) J. Biol. Chem., 275, pp. 4351-4362
Coghlan, V. M., Perrino, B. A., Howard, M., Langeberg, L. K., Hicks, J. B., Gallatin, W. M., Scott, J. D., Association of protein kinase A and protein phosphatase 2B with a common anchoring protein (1995) Science, 267, pp. 108-111
Klauck, T. M., Faux, M. C., Labudda, K., Langeberg, L. K., Jaken, S., Scott, J. D., Coordination of three signaling enzymes by AKAP79, a mammalian scaffold-protein (1996) Science, 271, pp. 1589-1592
Schillace, R. V., Scott, J. D., Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 (1999) Curr. Biol., 9, pp. 321-324
Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, I. D., Langeberg, L. K., Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex (1999) Science, 285, pp. 93-96
Steen, R. L., Martins, S. B., Tasken, K., Collas, P., Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly (2000) J. Cell Biol., 150, pp. 1251-1262
Lester, L. B., Langeberg, L. K., Scott, J. D., Anchoring of protein kinase A facilitates hormone-mediated insulin secretion (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 14942-14947
Gray, P. C., Scott, J. D., Catterall, W. A., Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins (1998) Curr. Opin. Neurobiol., 8, pp. 330-334
Westphal, R. S., Soderling, S. H., Alto, N. M., Langeberg, L. K., Scott, J. D., Scar/WAVE-1, a wiskott-aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold (2000) EMBO J., 19, pp. 4589-4600
Lester, L. B., Faux, M. C., Nauert, J. B., Scott, J. D., Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation (2001) Endocrinology, 142, pp. 1218-1227
Fink, M. A., Zakhary, D. R., Mackey, J. A., Desnoyer, R. W., Apperson-Hansen, C., Damron, D. S., Bond, M., AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes (2001) Circ. Res., 88, pp. 291-297
Lin, R., Moss, S. B., Rubin, C. S., Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells (1995) J. Biol. Chem., 270, pp. 27804-27811
Huang, L. J., Durick, K., Weiner, J. A., Chun, J., Taylor, S. S., Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits (1997) J. Biol. Chem., 272, pp. 8057-8064
Huang, L. J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T. J., NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum (1999) J. Cell Biol., 145, pp. 951-959
Kelley, L. A., MacCallum, R. M., Sternberg, M. J. E., Enhanced genome annotation using structural profiles in the program 3D-PSSM (2000) J. Mol. Biol., 299, pp. 499-520
Weisiger, R. A., Fridovich, I., Mitochondrial superoxide dismutase. Site of synthesis and intra-mitochondrial localization (1973) J. Biol. Chem., 24, pp. 4793-4796
Straight, A. F., Field, C. M., Microtubules, membranes and cytokinesis (2000) Curr. Biol., 10, pp. R760-R770
Downing, K. H., Nogales, E., New insights into microtubule structure and function from the atomic model of tubulin (1998) Eur. Biophys. J., 27, pp. 431-436
Rubino, H. M., Dammerman, M., Shafit-Zagardo, B., Erlichman, J., Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2 (1989) Neuron, 3, pp. 631-638
Vallee, R. B., DiBartolomeis, M. J., Theurkauf, W. E., A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2) (1981) J. Cell Biol., 90, pp. 568-576
Wolkolwicz, M. J., Coonrod, S. M., Reddi, P. P., Millan, J. C., Hofmann, M. C., Herr, J. R., Refinement of the differentiated phenotype of the spermatogenic cell line GC-2spd (ts) (1996) Biol. Reprod., 55, pp. 923-932
Williams, R. C., Lee, J. C., Preparation of tubulin from brain (1982) Methods Enzymol., 85, pp. 376-408
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.359, 5-year impact factor: 3.795
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-18444375552&partnerID=40&md5=25192b66e186ec7d3b9e4b121251ac2d
Keywords: A-Kinase Anchor Proteins, Mitochondria, Mitotic Spindles, S-Akap84 Akap121, Cyclic Amp Dependent Protein Kinase, Cyclic Amp Dependent Protein Kinase Anchoring Protein, Green Fluorescent Protein, Hybrid Protein, Isoprotein, Mutant Protein, Tissue Extract, Tubulin, Unclassified Drug, Amino Terminal Sequence, Animal Cell, Animal Cell Culture, Animal Tissue, Article, Cellular Distribution, Controlled Study, Deletion Mutant, Germ Cell, Immunohistochemistry, Immunoprecipitation, Interphase, Microtubule, Mitosis Spindle, Mouse, Nonhuman, Priority Journal, Protein Binding, Protein Domain, Protein Localization, Protein Motif, Protein Purification, Site Directed Mutagenesis, Testis, Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Amino Acid Sequence, Base Sequence, Carrier Proteins, Cell Line, Cyclic Amp-Dependent Protein Kinases, Complementary, Membrane Proteins, Mitotic Spindle Apparatus, Molecular Sequence Data, Site-Directed, Recombinant Fusion Proteins, Sequence Deletion, Spermatozoa, Two-Hybrid System Techniques,
Affiliations:
*** IBB - CNR ***
Dipartimento Di Biologia E Patologia Molecolare E Cellulare, BioGem Consortium, Universitá Federico II, via S. Pansini 5, 80131 Naples, Italy
Institute of Cancer Research, Columbia University, New York, NY 10032, United States
Centro Studi Biocristallografia CNR, via Mezzocannone 6, Naples, Italy
Department of Molecular Pharmacology, Atran Laboratories, Albert Einstein College of Medicine, Bronx, NY 10461, United States
References:
Edelman, A.M., Blumenthal, D.K., Krebs, E.G., Protein serine/threonine kinases (1987) Annu. Rev. Biochem., 56, pp. 567-61
Taylor, S., Buechler, J.A., Yonemoto, Y., Structural framework for the protein kinase family (1990) Annu. Rev. Biochem., 59, pp. 971-1005
Rubin, C.S., A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP (1994) Biochim. Biophys. Acta, 1224, pp. 467-479
Smith, F.D., Scott, J.D., Signaling complexes: Junctions on the intracellular information super highway (2002) Curr. Biol., 12, pp. R32-R40
Diviani, D., Scott, J.D., AKAP signaling complexes at the cytoskeleton (2001) J. Cell Sci., 114, pp. 1431-1437
Feliciello, A., Gottesman, M.E., Avvedimento, V.E., The biological function of A-kinase anchor proteins (2001) J. Mol. Biol., 308, pp. 99-114
Miki, K., Eddy, E.M., Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins (1999) J. Biol. Chem., 274, pp. 29057-29062
Angelo, R.G., Rubin, C.S., Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms (2000) J. Biol. Chem., 275, pp. 4351-4362
Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M., Scott, J.D., Association of protein kinase A and protein phosphatase 2B with a common anchoring protein (1995) Science, 267, pp. 108-111
Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., Scott, J.D., Coordination of three signaling enzymes by AKAP79, a mammalian scaffold-protein (1996) Science, 271, pp. 1589-1592
Schillace, R.V., Scott, J.D., Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 (1999) Curr. Biol., 9, pp. 321-324
Westphal, R.S., Tavalin, S.J., Lin, J.W., Alto, N.M., Fraser, I.D., Langeberg, L.K., Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex (1999) Science, 285, pp. 93-96
Steen, R.L., Martins, S.B., Tasken, K., Collas, P., Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly (2000) J. Cell Biol., 150, pp. 1251-1262
Feliciello, A., Giuliano, P., Porcellini, A., Garbi, C., Obici, S., Mele, E., The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein kinase IIbeta (1996) J. Biol. Chem., 271, pp. 25350-25359
Feliciello, A., Avvedimento, V.E., Li, Y., Gottesman, M.E., Rubin, C.S., A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus (1997) Curr. Biol., 7, pp. 1011-1014
Lester, L.B., Langeberg, L.K., Scott, J.D., Anchoring of protein kinase A facilitates hormone-mediated insulin secretion (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 14942-14947
Gray, P.C., Scott, J.D., Catterall, W.A., Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins (1998) Curr. Opin. Neurobiol., 8, pp. 330-334
Paolillo, M., Feliciello, A., Porcellini, A., Garbi, C., Bifulco, M., Schinelli, S., The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells (1999) J. Biol. Chem., 274, pp. 6546-6552
Westphal, R.S., Soderling, S.H., Alto, N.M., Langeberg, L.K., Scott, J.D., Scar/WAVE-1, a wiskott-aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold (2000) EMBO J., 19, pp. 4589-4600
Colledge, M., Dean, R.A., Scott, G.K., Langeberg, L.K., Huganir, R.L., Scott, J.D., Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex (2000) Neuron, 27, pp. 107-119
Feliciello, A., Gallo, A., Mele, E., Porcellini, A., Troncone, G., Garbi, C., The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells (2000) J. Biol. Chem., 275, pp. 303-311
Lester, L.B., Faux, M.C., Nauert, J.B., Scott, J.D., Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation (2001) Endocrinology, 142, pp. 1218-1227
Fink, M.A., Zakhary, D.R., Mackey, J.A., Desnoyer, R.W., Apperson-Hansen, C., Damron, D.S., Bond, M., AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes (2001) Circ. Res., 88, pp. 291-297
Lin, R., Moss, S.B., Rubin, C.S., Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells (1995) J. Biol. Chem., 270, pp. 27804-27811
Chen, Q., Lin, R., Rubin, C.S., Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria (1997) J. Biol. Chem., 272, pp. 15247-15257
Trendelenburg, G., Hummel, M., Riecken, E.O., Hanski, C., Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain (1996) Biochem. Biophys. Res. Commun., 225, pp. 313-319
Huang, L.J., Durick, K., Weiner, J.A., Chun, J., Taylor, S.S., Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits (1997) J. Biol. Chem., 272, pp. 8057-8064
Feliciello, A., Rubin, C.S., Avvedimento, E.V., Gottesman, M.E., Expression of A kinase anchor protein121 is regulated by hormones in thyroid and testicular germ cells (1998) J. Biol. Chem., 273, pp. 23361-23366
Huang, L.J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T.J., NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum (1999) J. Cell Biol., 145, pp. 951-959
Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L.J., Taylor, S.S., Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A (1999) Mol. Cell, 4, pp. 413-422
Feliciello, A., Cardone, L., Garbi, C., Ginsberg, M.D., Varrone, S., Rubin, C.S., Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II (1999) FEBS Letters, 464, pp. 174-178
Kelley, L.A., MacCallum, R.M., Sternberg, M.J.E., Enhanced genome annotation using structural profiles in the program 3D-PSSM (2000) J. Mol. Biol., 299, pp. 499-520
Hahne, K., Haucke, V., Ramage, L., Schatz, G., Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments (1994) Cell, 79, pp. 829-839
Weisiger, R.A., Fridovich, I., Mitochondrial superoxide dismutase. Site of synthesis and intra-mitochondrial localization (1973) J. Biol. Chem., 24, pp. 4793-4796
Yaffe, M., The machinery of mitochondrial inheritance and behavior (1999) Science, 283, pp. 1493-1497
Straight, A.F., Field, C.M., Microtubules, membranes and cytokinesis (2000) Curr. Biol., 10, pp. R760-R770
Piel, M., Nordberg, J., Euteneuer, U., Bornens, M., Centrosome-dependent exit of cytokinesis in animal cells (2001) Science, 291, pp. 1550-1553
Nogales, E., Structural insights into microtubule function (2000) Annu. Rev. Biochem., 69, pp. 277-302
Downing, K.H., Nogales, E., New insights into microtubule structure and function from the atomic model of tubulin (1998) Eur. Biophys. J., 27, pp. 431-436
Rubino, H.M., Dammerman, M., Shafit-Zagardo, B., Erlichman, J., Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2 (1989) Neuron, 3, pp. 631-638
Vallee, R.B., DiBartolomeis, M.J., Theurkauf, W.E., A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2) (1981) J. Cell Biol., 90, pp. 568-576
Diviani, D., Langeberg, L.K., Doxsey, S.J., Scott, J.D., Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain (2000) Curr. Biol., 10, pp. 417-420
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A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs
A-kinase anchor proteins (AKAPs) assemble multi-enzyme signaling complexes in proximity to substrate/effector proteins, thus directing and amplifying membrane-generated signals. S-AKAP84 and AKAP121 are alternative splicing products with identical NH2 termini. These AKAPs bind and target protein kinase A (PKA) to the outer mitochondrial membrane. Tubulin was identified as a binding partner of S-AKAP84 in a yeast two-hybrid screen. Immunoprecipitation and co-sedimentation experiments in rat testis extracts confirmed the interaction between microtubules and S-AKAP84. In situ immunostaining of testicular germ cells (GC2) shows that AKAP121 concentrates on mitochondria in interphase and on mitotic spindles during M phase. Purified tubulin binds directly to S-AKAP84 but not to a deletion mutant lacking the mitochondrial targeting domain (MT) at residues 1-30. The MT is predicted to form a highly hydrophobic α-helical wheel that might also mediate interaction with tubulin. Disruption of the wheel by site-directed mutagenesis abolished tubulin binding and reduced mitochondrial attachment of an MT-GFP fusion protein. Some MT mutants retain tubulin binding but do not localize to mitochondria. Thus, the tubulin-binding motif lies within the mitochondrial attachment motif. Our findings indicate that S-AKAP84/AKAP121 use overlapping targeting motifs to localize signaling enzymes to mitochondrial and cytoskeletal compartments. © 2002 Elsevier Science Ltd. All rights reserved.
A-kinase anchor proteins (AKAPs) assemble multi-enzyme signaling complexes in proximity to substrate/effector proteins, thus directing and amplifying membrane-generated signals. S-AKAP84 and AKAP121 are alternative splicing products with identical NH2 termini. These AKAPs bind and target protein kinase A (PKA) to the outer mitochondrial membrane. Tubulin was identified as a binding partner of S-AKAP84 in a yeast two-hybrid screen. Immunoprecipitation and co-sedimentation experiments in rat testis extracts confirmed the interaction between microtubules and S-AKAP84. In situ immunostaining of testicular germ cells (GC2) shows that AKAP121 concentrates on mitochondria in interphase and on mitotic spindles during M phase. Purified tubulin binds directly to S-AKAP84 but not to a deletion mutant lacking the mitochondrial targeting domain (MT) at residues 1-30. The MT is predicted to form a highly hydrophobic α-helical wheel that might also mediate interaction with tubulin. Disruption of the wheel by site-directed mutagenesis abolished tubulin binding and reduced mitochondrial attachment of an MT-GFP fusion protein. Some MT mutants retain tubulin binding but do not localize to mitochondria. Thus, the tubulin-binding motif lies within the mitochondrial attachment motif. Our findings indicate that S-AKAP84/AKAP121 use overlapping targeting motifs to localize signaling enzymes to mitochondrial and cytoskeletal compartments. © 2002 Elsevier Science Ltd. All rights reserved.
A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs
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A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (621 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (528 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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* Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related Cancers (7 views)
Pathogens (ISSN: 2076-0817linking), 2023 Mar 2; 12(3): 402-417.
Impact Factor: 4.531
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De Rosa V, Iommelli F, Terlizzi C, Leggiero E, Camerlingo R, Altobelli GG, Fonti R, Pastore L, Del Vecchio S
* Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER-Mitochondria Interface in Oncogene-Driven NSCLC (17 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 17; 13 (16 ): N/D-N/D.
Impact Factor:
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (170 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (118 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J, Group MIMIC-A, F , Frye RE, Rizzo (mimic-ag A, Fiumara R, Meli C, Gulisano M, Maugeri F, Prato A, Russo G, Tabbì G
* A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses (182 views) (PDF 101 views)
Front Psychiatry (ISSN: 1664-0640linking), 2018 Dec 7; 9: 636-636.
Impact Factor: 2.857
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De Michele G, Sorrentino P, Nesti C, Rubegni A, Ruggiero L, Peluso S, Antenora A, Quarantelli M, Filla A, De Michele G, Santorelli FM
* Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (271 views)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Impact Factor: 3.508
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (316 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
Impact Factor: 3.098
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (460 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (373 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (271 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (497 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (376 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (646 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (447 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1246 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (252 views)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (565 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (375 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (615 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (605 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4500 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (498 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (436 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (439 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (571 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (509 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (336 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (440 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (448 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (438 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (621 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (528 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
View Export to BibTeX Export to EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
View Export to BibTeX Export to EndNote
44 Records (39 excluding Abstracts).
Total impact factor: 187.645 (169.12 excluding Abstracts).
Total 5 year impact factor: 166.404 (146.286 excluding Abstracts).
Total impact factor: 187.645 (169.12 excluding Abstracts).
Total 5 year impact factor: 166.404 (146.286 excluding Abstracts).
725 views. Last view on Tuesday 30 May 2023, 19:26:45
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