Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.199, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036318922&partnerID=40&md5=a8a68b80a1bfdb224b40edd859c582df
Keywords: Growth Hormone, Somatomedin C, Acromegaly, Adult, Article, Atherosclerotic Plaque, Cardiomyopathy, Cardiovascular Disease, Cardiovascular Risk, Clinical Article, Common Carotid Artery, Controlled Study, Diastolic Blood Pressure, Disease Association, Doppler Echocardiography, Doppler Flowmetry, Exercise, Female, Heart Ejection Fraction, Heart Function, Heart Left Ventricle Hypertrophy, Heart Performance, Heart Rate, Human, M Mode Echocardiography, Morphology, Onset Age, Priority Journal, Scintiangiography, Systolic Blood Pressure, Cardiovascular System, Drug Administration Schedule, Human Growth Hormone, Insulin-Like Growth Factor I, Octreotide, Radionuclide Angiography, Reference Values, Time Factors,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Italy
Nuclear Medicine Center of the National Council of Research, Department of Biomorphological and Functional Sciences, Italy
Federico II University, 80131 Naples, Italy
References:
Colao, A., Marzullo, P., Di Somma, C., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol (Oxf), 54, pp. 137-15
Hejtmancik, M.R., Bradfield, J.Y., Herrmann, G.R., Acromegaly and the heart: A clinical and pathologic study (1951) Ann Intern Med, 34, pp. 1445-1456
Lie, J.T., Grossman, S.J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) Am Heart J, 100, pp. 41-52
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Villa, E., Sancho, J.M., Moya-Mur, J.L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Baldelli, R., Marzullo, P., Ferretti, E., Ferone, D., Gargiulo, P., Petretta, M., Liuzzi, A., Systemic hypertension and im-paired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Marzullo, P., Cuocolo, A., Ferone, D., Pivonello, R., Salvatore, M., Lombardi, G., Colao, A., Cardiac effect of thyrotoxicosis in acromegaly (2000) J Clin Endocrinol Metab, 85, pp. 1426-1432
Colao, A., Merola, B., Ferone, D., Lombardi, G., Acromegaly (1997) J Clin Endocrinol Metab, 82, pp. 2777-2781
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Baldelli, R., Ferretti, E., Cassone, R., Gulino, A., Tamburrano, G., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clin Endocrinol (Oxf), 49, pp. 101-106
Fazio, S., Cittadini, A., Biondi, B., Palmieri, E.A., Riccio, G., Bone, F., Oliviero, U., Sacca, L., Cardiovascular effects of short-term growth hormone hypersecretion (2000) J Clin Endocrinol Metab, 85, pp. 179-182
Colao, A., Spiezia, S., Cerbone, G., Pivonello, R., Marzullo, P., Ferone, D., Di Somma, C., Lombardi, G., Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly (2001) Clin Endocrinol (Oxf), 54, pp. 515-524
Otsuki, M., Kasayama, S., Yamamoto, H., Saito, H., Sumitani, S., Kouhara, H., Saitoh, Y., Arita, N., Characterization of premature atherosclerosis of carotid arteries in acromegalic patients (2001) Clin Endocrinol (Oxf), 54, pp. 791-796
Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Sacca, L., A preliminary study of growth hormone in the treatment of dilated cardiomyopathy (1996) N Engl J Med, 334, pp. 809-814
Volterrani, M., Desenzani, P., Lorusso, R., D'Aloia, A., Manelli, F., Giustina, A., Hemodynamic effects of intravenous growth hormone in congestive heart failure (1997) Lancet, 349, pp. 1067-1068
Isgaard, J., Bergh, C.-H., Caidhal, K., Lonsky, M., Hjalmarson, Å., Bengtsson, B.-Å., A placebo-controlled study of growth hormone in patients with congestive heart failure (1998) Eur Heart J, 19, pp. 1704-1711
Osterziel, K.J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S.D., Dietz, R., Randomised, double-blind placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy (1998) Lancet, 351, pp. 1233-1237
Prysor-Jones, R.A., Jenkins, J.S., Effects of excessive secretion of growth hormone on tissue of the rat, with particular reference to the heart and skeletal muscle (1980) J Endocrinol, 85, pp. 75-82
Timsit, J., Riou, B., Bertherat, J., Wisnewsky, C., Kato, N.S., Weisberg, A.S., Lubetzki, J., Mercadier, J.J., Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosine adenosine triphosphatase activity of rat left ventricle (1990) J Clin Invest, 86, pp. 507-515
Mayoux, E., Ventura-Clapier, R., Timsit, J., Bèhar-Cohen Hoffmann, C., Mercadier, J.-J., Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion (1993) Circ Res, 72, pp. 57-64
Cittadini, A., Strömer, H., Katz, S.E., Clark, R., Moses, A.C., Morgan, J.P., Douglas, P.S., Differential cardiac effects of growth hormone and IGF-I in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Strömer, H., Cittadini, A., Douglas, P.S., Morgan, J.P., Exogenously administered growth hormone and IGF-I alter intracellular calcium handling and enhance cardiac performance: In vitro evaluation in the isolated isovolumic buffer perfused rat heart (1996) Circ Res, 79, pp. 227-236
Thuesen, L., Christiansen, J.S., Sørensen, K.E., Jørgensen, J.O.L., Ørskov, H., Henningsen, P., Increased myocardial contractility following growth hormone administration in normal men (1988) Dan Med Bull, 35, pp. 193-196
Colao, A., Lombardi, G., Growth hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Hypertension control. Report of a WHO expert committee (1996) WHO Tech Rep Ser, 862, pp. 1-83
Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
Expert Panel Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39
Colao, A., Ferone, D., Lastoria, S., Marzullo, P., Cerbone, G., Di Sarno, A., Longobardi, S., Lombardi, G., Prediction of efficacy of octreotide therapy in patients with acromegaly (1996) J Clin Endocrinol Metab, 81, pp. 2356-2362
Giustina, A., Barkan, A., Casanueva, F.F., Cavagnini, F., Frohman, L., Ho, K., Veldhuis, J., Melmed, S., Criteria for cure of acromegaly: A consensus statement (2000) J Clin Endocrinol Metab, 85, pp. 526-529
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R.B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (SUPPL. 2), pp. 19-26
Gamble, G., Zorn, J., Sanders, G., MacMahon, S., Sharpe, N., Estimation of arterial stiffness, compliance and distensibility from M-mode ultrasound measurements of the common carotid artery (1994) Stroke, 25, pp. 11-16
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Ikkos, D., Luft, R., Siogren, B., Water and sodium in patients with acromegaly (1954) J Clin Invest, 33, pp. 989-994
Møller, J., Jörgensen, J.O.L., Möller, N., Hansen, K.W., Pedersen, E.B., Christiansen, J.S., Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man (1991) J Clin Endocrinol Metab, 72, pp. 768-772
Lancranjan, I., Atkinson, A.B., Results of a European multicentre study with sandostatin LAR in acromegalic patients (1999) Pituitary, 1, pp. 105-114
Ferone, D., Colao, A., Van der Lely, A.-J., Lamberts, S.W.J., Pharmacotherapy or surgery as primary treatment for acromegaly? (2000) Drugs, 17, pp. 81-92
Gunal, A.I., Isik, A., Celiker, H., Eren, O., Celebi, H., Gunal, S.Y., Luleci, C., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Demirtas, E., Sag, C., Kursaklioglu, H., Uzun, M., Uzbay, T., Tore, H.F., Kose, S., Demirkan, D., Effects of octreotide in patients with hypertrophic obstructive cardiomyopathy (1998) Jpn Heart J, 39, pp. 173-181
Crick, S.J., Sheppard, M.N., Ho, S.Y., Anderson, R.H., Localisation and quantitation of autonomic innervation in the porcine heart. I. Conduction system (1999) J Anat, 195, pp. 341-357
Colao, A., Cuocolo, A., Marzullo, P., Nicolai, E., Ferone, D., Della Morte, A.M., Pivonello, R., Lombardi, G., Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (2001) J Clin Endocrinol Metab, 86, pp. 1551-1557
Hejtmancik, M. R., Bradfield, J. Y., Herrmann, G. R., Acromegaly and the heart: A clinical and pathologic study (1951) Ann Intern Med, 34, pp. 1445-1456
Lie, J. T., Grossman, S. J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) Am Heart J, 100, pp. 41-52
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Villa, E., Sancho, J. M., Moya-Mur, J. L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Osterziel, K. J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S. D., Dietz, R., Randomised, double-blind placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy (1998) Lancet, 351, pp. 1233-1237
Prysor-Jones, R. A., Jenkins, J. S., Effects of excessive secretion of growth hormone on tissue of the rat, with particular reference to the heart and skeletal muscle (1980) J Endocrinol, 85, pp. 75-82
Cittadini, A., Str mer, H., Katz, S. E., Clark, R., Moses, A. C., Morgan, J. P., Douglas, P. S., Differential cardiac effects of growth hormone and IGF-I in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Str mer, H., Cittadini, A., Douglas, P. S., Morgan, J. P., Exogenously administered growth hormone and IGF-I alter intracellular calcium handling and enhance cardiac performance: In vitro evaluation in the isolated isovolumic buffer perfused rat heart (1996) Circ Res, 79, pp. 227-236
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R. B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (SUPPL. 2), pp. 19-26
Sacc, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
M ller, J., J rgensen, J. O. L., M ller, N., Hansen, K. W., Pedersen, E. B., Christiansen, J. S., Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man (1991) J Clin Endocrinol Metab, 72, pp. 768-772
Gunal, A. I., Isik, A., Celiker, H., Eren, O., Celebi, H., Gunal, S. Y., Luleci, C., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Crick, S. J., Sheppard, M. N., Ho, S. Y., Anderson, R. H., Localisation and quantitation of autonomic innervation in the porcine heart. I. Conduction system (1999) J Anat, 195, pp. 341-357
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.199, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036318922&partnerID=40&md5=a8a68b80a1bfdb224b40edd859c582df
Keywords: Growth Hormone, Somatomedin C, Acromegaly, Adult, Article, Atherosclerotic Plaque, Cardiomyopathy, Cardiovascular Disease, Cardiovascular Risk, Clinical Article, Common Carotid Artery, Controlled Study, Diastolic Blood Pressure, Disease Association, Doppler Echocardiography, Doppler Flowmetry, Exercise, Female, Heart Ejection Fraction, Heart Function, Heart Left Ventricle Hypertrophy, Heart Performance, Heart Rate, Human, M Mode Echocardiography, Morphology, Onset Age, Priority Journal, Scintiangiography, Systolic Blood Pressure, Cardiovascular System, Drug Administration Schedule, Human Growth Hormone, Insulin-Like Growth Factor I, Octreotide, Radionuclide Angiography, Reference Values, Time Factors,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Italy
Nuclear Medicine Center of the National Council of Research, Department of Biomorphological and Functional Sciences, Italy
Federico II University, 80131 Naples, Italy
References:
Colao, A., Marzullo, P., Di Somma, C., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol (Oxf), 54, pp. 137-15
Hejtmancik, M.R., Bradfield, J.Y., Herrmann, G.R., Acromegaly and the heart: A clinical and pathologic study (1951) Ann Intern Med, 34, pp. 1445-1456
Lie, J.T., Grossman, S.J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) Am Heart J, 100, pp. 41-52
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Villa, E., Sancho, J.M., Moya-Mur, J.L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Baldelli, R., Marzullo, P., Ferretti, E., Ferone, D., Gargiulo, P., Petretta, M., Liuzzi, A., Systemic hypertension and im-paired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Marzullo, P., Cuocolo, A., Ferone, D., Pivonello, R., Salvatore, M., Lombardi, G., Colao, A., Cardiac effect of thyrotoxicosis in acromegaly (2000) J Clin Endocrinol Metab, 85, pp. 1426-1432
Colao, A., Merola, B., Ferone, D., Lombardi, G., Acromegaly (1997) J Clin Endocrinol Metab, 82, pp. 2777-2781
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Baldelli, R., Ferretti, E., Cassone, R., Gulino, A., Tamburrano, G., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clin Endocrinol (Oxf), 49, pp. 101-106
Fazio, S., Cittadini, A., Biondi, B., Palmieri, E.A., Riccio, G., Bone, F., Oliviero, U., Sacca, L., Cardiovascular effects of short-term growth hormone hypersecretion (2000) J Clin Endocrinol Metab, 85, pp. 179-182
Colao, A., Spiezia, S., Cerbone, G., Pivonello, R., Marzullo, P., Ferone, D., Di Somma, C., Lombardi, G., Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly (2001) Clin Endocrinol (Oxf), 54, pp. 515-524
Otsuki, M., Kasayama, S., Yamamoto, H., Saito, H., Sumitani, S., Kouhara, H., Saitoh, Y., Arita, N., Characterization of premature atherosclerosis of carotid arteries in acromegalic patients (2001) Clin Endocrinol (Oxf), 54, pp. 791-796
Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Sacca, L., A preliminary study of growth hormone in the treatment of dilated cardiomyopathy (1996) N Engl J Med, 334, pp. 809-814
Volterrani, M., Desenzani, P., Lorusso, R., D'Aloia, A., Manelli, F., Giustina, A., Hemodynamic effects of intravenous growth hormone in congestive heart failure (1997) Lancet, 349, pp. 1067-1068
Isgaard, J., Bergh, C.-H., Caidhal, K., Lonsky, M., Hjalmarson, Å., Bengtsson, B.-Å., A placebo-controlled study of growth hormone in patients with congestive heart failure (1998) Eur Heart J, 19, pp. 1704-1711
Osterziel, K.J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S.D., Dietz, R., Randomised, double-blind placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy (1998) Lancet, 351, pp. 1233-1237
Prysor-Jones, R.A., Jenkins, J.S., Effects of excessive secretion of growth hormone on tissue of the rat, with particular reference to the heart and skeletal muscle (1980) J Endocrinol, 85, pp. 75-82
Timsit, J., Riou, B., Bertherat, J., Wisnewsky, C., Kato, N.S., Weisberg, A.S., Lubetzki, J., Mercadier, J.J., Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosine adenosine triphosphatase activity of rat left ventricle (1990) J Clin Invest, 86, pp. 507-515
Mayoux, E., Ventura-Clapier, R., Timsit, J., Bèhar-Cohen Hoffmann, C., Mercadier, J.-J., Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion (1993) Circ Res, 72, pp. 57-64
Cittadini, A., Strömer, H., Katz, S.E., Clark, R., Moses, A.C., Morgan, J.P., Douglas, P.S., Differential cardiac effects of growth hormone and IGF-I in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Strömer, H., Cittadini, A., Douglas, P.S., Morgan, J.P., Exogenously administered growth hormone and IGF-I alter intracellular calcium handling and enhance cardiac performance: In vitro evaluation in the isolated isovolumic buffer perfused rat heart (1996) Circ Res, 79, pp. 227-236
Thuesen, L., Christiansen, J.S., Sørensen, K.E., Jørgensen, J.O.L., Ørskov, H., Henningsen, P., Increased myocardial contractility following growth hormone administration in normal men (1988) Dan Med Bull, 35, pp. 193-196
Colao, A., Lombardi, G., Growth hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Hypertension control. Report of a WHO expert committee (1996) WHO Tech Rep Ser, 862, pp. 1-83
Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
Expert Panel Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39
Colao, A., Ferone, D., Lastoria, S., Marzullo, P., Cerbone, G., Di Sarno, A., Longobardi, S., Lombardi, G., Prediction of efficacy of octreotide therapy in patients with acromegaly (1996) J Clin Endocrinol Metab, 81, pp. 2356-2362
Giustina, A., Barkan, A., Casanueva, F.F., Cavagnini, F., Frohman, L., Ho, K., Veldhuis, J., Melmed, S., Criteria for cure of acromegaly: A consensus statement (2000) J Clin Endocrinol Metab, 85, pp. 526-529
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R.B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (SUPPL. 2), pp. 19-26
Gamble, G., Zorn, J., Sanders, G., MacMahon, S., Sharpe, N., Estimation of arterial stiffness, compliance and distensibility from M-mode ultrasound measurements of the common carotid artery (1994) Stroke, 25, pp. 11-16
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Ikkos, D., Luft, R., Siogren, B., Water and sodium in patients with acromegaly (1954) J Clin Invest, 33, pp. 989-994
Møller, J., Jörgensen, J.O.L., Möller, N., Hansen, K.W., Pedersen, E.B., Christiansen, J.S., Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man (1991) J Clin Endocrinol Metab, 72, pp. 768-772
Lancranjan, I., Atkinson, A.B., Results of a European multicentre study with sandostatin LAR in acromegalic patients (1999) Pituitary, 1, pp. 105-114
Ferone, D., Colao, A., Van der Lely, A.-J., Lamberts, S.W.J., Pharmacotherapy or surgery as primary treatment for acromegaly? (2000) Drugs, 17, pp. 81-92
Gunal, A.I., Isik, A., Celiker, H., Eren, O., Celebi, H., Gunal, S.Y., Luleci, C., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Demirtas, E., Sag, C., Kursaklioglu, H., Uzun, M., Uzbay, T., Tore, H.F., Kose, S., Demirkan, D., Effects of octreotide in patients with hypertrophic obstructive cardiomyopathy (1998) Jpn Heart J, 39, pp. 173-181
Crick, S.J., Sheppard, M.N., Ho, S.Y., Anderson, R.H., Localisation and quantitation of autonomic innervation in the porcine heart. I. Conduction system (1999) J Anat, 195, pp. 341-357
Colao, A., Cuocolo, A., Marzullo, P., Nicolai, E., Ferone, D., Della Morte, A.M., Pivonello, R., Lombardi, G., Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (2001) J Clin Endocrinol Metab, 86, pp. 1551-1557
Hejtmancik, M. R., Bradfield, J. Y., Herrmann, G. R., Acromegaly and the heart: A clinical and pathologic study (1951) Ann Intern Med, 34, pp. 1445-1456
Lie, J. T., Grossman, S. J., Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients (1980) Am Heart J, 100, pp. 41-52
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Villa, E., Sancho, J. M., Moya-Mur, J. L., Garcia-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Osterziel, K. J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S. D., Dietz, R., Randomised, double-blind placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy (1998) Lancet, 351, pp. 1233-1237
Prysor-Jones, R. A., Jenkins, J. S., Effects of excessive secretion of growth hormone on tissue of the rat, with particular reference to the heart and skeletal muscle (1980) J Endocrinol, 85, pp. 75-82
Cittadini, A., Str mer, H., Katz, S. E., Clark, R., Moses, A. C., Morgan, J. P., Douglas, P. S., Differential cardiac effects of growth hormone and IGF-I in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Str mer, H., Cittadini, A., Douglas, P. S., Morgan, J. P., Exogenously administered growth hormone and IGF-I alter intracellular calcium handling and enhance cardiac performance: In vitro evaluation in the isolated isovolumic buffer perfused rat heart (1996) Circ Res, 79, pp. 227-236
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Devereux, R. B., Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods (1987) Hypertension, 9 (SUPPL. 2), pp. 19-26
Sacc, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
M ller, J., J rgensen, J. O. L., M ller, N., Hansen, K. W., Pedersen, E. B., Christiansen, J. S., Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man (1991) J Clin Endocrinol Metab, 72, pp. 768-772
Gunal, A. I., Isik, A., Celiker, H., Eren, O., Celebi, H., Gunal, S. Y., Luleci, C., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Crick, S. J., Sheppard, M. N., Ho, S. Y., Anderson, R. H., Localisation and quantitation of autonomic innervation in the porcine heart. I. Conduction system (1999) J Anat, 195, pp. 341-357
Cardiovascular consequences of early-onset growth hormone excess
Acromegaly has relevant effects on the cardiovascular system, but few data deal with the early effects of GH and IGF-I excess. To study the early stage of acromegalic cardiomyopathy and give indirect evidence of the mechanisms underlying GH and IGF-I action on the human heart, 25 patients with uncomplicated acromegaly [15 young subjects with short-term ( ≤ 5 yr) disease and 10 with long-term ( > 5 yr) disease] and 25 sex- and age-matched controls were studied. Cardiovascular risk parameters were studied by standard methods; cardiac morphology by M-mode and Doppler echocardiography, cardiac function at rest and at peak exercise by equilibrium radionuclide angiography, and vascular disease at common carotid arteries by Doppler ultrasonography. In the patient group these measurements were repeated after 6 months of treatment with octreotide-LAR (20-40 mg, im, every 28 d). Glucose, glycosylated hemoglobin, insulin, low density lipoprotein cholesterol, triglycerides, and fibrinogen levels were higher, and high density lipoprotein cholesterol levels were lower in acromegalic patients than in controls. Resting blood pressure was similar in patients and controls, whereas heart rate at rest and systolic blood pressure at peak exercise were higher in the patients. The left ventricular mass index was higher in acromegalic patients than in controls (123.3 ± 8.9 vs. 81.5 ± 4.3 g/m 2; P < 0.001); seven patients had left ventricular hypertrophy. Diastolic function was similar in the two groups. The ejection fraction at rest, but not at peak exercise, was significantly increased in the patients compared with controls. As a consequence the exercise-induced changes in the ejection fraction were lower in patients than controls (8.7 ± 1.1% vs. 21.9 ± 3.5%; P < 0.001). At common carotid ultrasonography, young patients with acromegaly had increased diastolic peak velocity and increased intima media thickness, even if neither patient nor controls had atherosclerotic plaques. Six months after OCT-LAR treatment, GH and IGF-I levels remarkably decreased in all patients; 8 (53.3%) achieved disease control. Insulin, total cholesterol, and fibrinogen levels reduced, whereas high density lipoprotein cholesterol levels increased. Both at rest and at peak exercise, heart rate significantly decreased, whereas systolic and diastolic blood pressures did not change. The left ventricular mass index was significantly reduced, but it was still higher than the control value (101.6 ± 3.5 g/m 2; P < 0.01). The left ventricular ejection fraction at rest was significantly reduced, but its response at peak exercise was increased (16.3 ± 2.4%), becoming similar to the control value. At common carotids, the intima media thickness of right and left arteries was significantly reduced as was the diastolic peak velocity without any change in systolic peak velocity. Short-term GH excess, despite causing enhanced cardiac performance at rest, reduces cardiac performance on effort and impairs vascular morphology. These deleterious effects of early-onset acromegaly are ameliorated by suppressing GH/IGF-I levels for 6 months.
Acromegaly has relevant effects on the cardiovascular system, but few data deal with the early effects of GH and IGF-I excess. To study the early stage of acromegalic cardiomyopathy and give indirect evidence of the mechanisms underlying GH and IGF-I action on the human heart, 25 patients with uncomplicated acromegaly [15 young subjects with short-term ( ≤ 5 yr) disease and 10 with long-term ( > 5 yr) disease] and 25 sex- and age-matched controls were studied. Cardiovascular risk parameters were studied by standard methods; cardiac morphology by M-mode and Doppler echocardiography, cardiac function at rest and at peak exercise by equilibrium radionuclide angiography, and vascular disease at common carotid arteries by Doppler ultrasonography. In the patient group these measurements were repeated after 6 months of treatment with octreotide-LAR (20-40 mg, im, every 28 d). Glucose, glycosylated hemoglobin, insulin, low density lipoprotein cholesterol, triglycerides, and fibrinogen levels were higher, and high density lipoprotein cholesterol levels were lower in acromegalic patients than in controls. Resting blood pressure was similar in patients and controls, whereas heart rate at rest and systolic blood pressure at peak exercise were higher in the patients. The left ventricular mass index was higher in acromegalic patients than in controls (123.3 ± 8.9 vs. 81.5 ± 4.3 g/m 2; P < 0.001); seven patients had left ventricular hypertrophy. Diastolic function was similar in the two groups. The ejection fraction at rest, but not at peak exercise, was significantly increased in the patients compared with controls. As a consequence the exercise-induced changes in the ejection fraction were lower in patients than controls (8.7 ± 1.1% vs. 21.9 ± 3.5%; P < 0.001). At common carotid ultrasonography, young patients with acromegaly had increased diastolic peak velocity and increased intima media thickness, even if neither patient nor controls had atherosclerotic plaques. Six months after OCT-LAR treatment, GH and IGF-I levels remarkably decreased in all patients; 8 (53.3%) achieved disease control. Insulin, total cholesterol, and fibrinogen levels reduced, whereas high density lipoprotein cholesterol levels increased. Both at rest and at peak exercise, heart rate significantly decreased, whereas systolic and diastolic blood pressures did not change. The left ventricular mass index was significantly reduced, but it was still higher than the control value (101.6 ± 3.5 g/m 2; P < 0.01). The left ventricular ejection fraction at rest was significantly reduced, but its response at peak exercise was increased (16.3 ± 2.4%), becoming similar to the control value. At common carotids, the intima media thickness of right and left arteries was significantly reduced as was the diastolic peak velocity without any change in systolic peak velocity. Short-term GH excess, despite causing enhanced cardiac performance at rest, reduces cardiac performance on effort and impairs vascular morphology. These deleterious effects of early-onset acromegaly are ameliorated by suppressing GH/IGF-I levels for 6 months.
Cardiovascular consequences of early-onset growth hormone excess
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Cardiovascular consequences of early-onset growth hormone excess
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
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Impact Factor: 0.481
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Cuocolo A, Nicolai E, Fazio S, Pace L, Maurea S, Cittadini A, Sacca L, Salvatore M
Impaired left ventricular diastolic filling in patients with acromegaly: Assessment with radionuclide angiography (261 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Feb; 36(2): 196-201.
Impact Factor: 3.491
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Nappi A, Cuocolo A, Nicolai E, Imbriaco M, Pace L, Salvatore M
Ambulatory monitoring of left ventricular function with a radionuclide detector system (295 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992; 84(1-2): 132-139.
Impact Factor: 0.967
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (166 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (266 views)
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Impact Factor: 4.621
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Gargiulo S, Gramanzini M, Mancini M
* Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models (373 views) (PDF 187 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Sep 9; 17(9): N/D-N/D.
Impact Factor: 3.226
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Perrino C, Imbriaco M, Magliulo F, Ponsiglione A, Puglia M, Stabile E, Avvedimento M, Esposito G, Perrone Filardi P, Cuocolo A, Galderisi M, Trimarco B
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Impact Factor: 6.189
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
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Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Ruggiero L, Fiorillo C, Tessa A, Manganelli F, Iodice R, Dubbioso R, Vitale F, Storti E, Soscia E, Santorelli F, Santoro L
* Muscle fiber type disproportion (FTD) in a family with mutations in the LMNA gene (332 views)
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Impact Factor: 2.713
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Petretta M, Pellegrino T, Cuocolo A
* The "gray Zone" For The Heart To Mediastinum Mibg Uptake Ratio (310 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2014; 21(5): 921-924.
Impact Factor: 2.942
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (556 views)
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Impact Factor: 3.675
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Ferro A, Petretta M, Acampa W, Fiumara G, Daniele S, Petretta MP, Cantoni V, Cuocolo A
* Post-stress left ventricular ejection fraction drop in patients with diabetes: A gated myocardial perfusion imaging study (347 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2013 Nov 14; 13: 99-99.
Impact Factor: 1.5
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Pellegrino T, Petretta M, Paolillo S, Boemio A, Carotenuto R, Petretta MP, Di Nuzzo C, Perrone-filardi P, Cuocolo A
* Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure (520 views)
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Impact Factor: 5.217
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (461 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1104 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Petretta M, Cuocolo A
In search of a marker of vulnerable carotid plaque: is the key in the heart? (307 views)
Atherosclerosis (ISSN: 1879-1484, 0021-9150), 2012 Jul; 223(1): 95-97.
Impact Factor: 3.706
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (777 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (319 views)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (579 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
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Imbriaco M, Messalli G, Avitabile G, Cuocolo A, Maurea S, Soscia F, Pisani A
* Cardiac magnetic resonance imaging illustrating Anderson-Fabry disease progression (283 views)
Br J Radiol (ISSN: 0007-1285, 1748-880xelectronic, 0007-1285linking), 2010 Dec; 83(996): e249-e249.
Impact Factor: 2.062
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Storto G, Nicolai E, Petretta M, Spinelli L, Acampa W, Evangelista L, Daniele S, Trimarco B, Cuocolo A
* Cardiac performance during exercise in hypertensive patients without ventricular hypertrophy (423 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2009 Sep; 39(8): 664-670.
Impact Factor: 2.643
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (395 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
* Cardiac performance during exercise in patients with Fabry's disease (367 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2008 Dec; 38(12): 910-917.
Impact Factor: 2.784
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1586 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
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Ciampi Q, Betocchi S, Losi MA, Ferro A, Cuocolo A, Lombardi R, Villari B, Chiariello M
* Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (336 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2007 Nov; 14(6): 869-875.
Impact Factor: 2.359
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Santomauro M, Pace L, Duilio C, Ottaviano L, Borrelli A, Ferro A, Monteforte N, Cuocolo A, Salvatore M, Chiariello M
* Left ventricular pacing in patients with heart failure: Evaluation study with Fourier analysis of radionuclide ventriculography (274 views)
Ital Heart J (ISSN: 1129-471x), 2004 Dec; 5(12): 906-911.
Impact Factor: 6.023
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Ciampi Q, Betocchi S, Violante A, Lombardi R, Losi M, Storto G, Manganelli F, Tocchetti C, Aversa M, Pezzella E, Finizio F, Cuocolo A, Chiariello M
* Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects (403 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2003 Mar; 10(2): 154-160.
Impact Factor: 1.629
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (430 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (315 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Ciampi Q, Betocchi S, Lombardi R, Losi M, Manganelli F, Storto G, Aversa M, Miranda M, Cuocolo A, Tocchetti CG, Chiariello M
* The diastolic function in hypertrophic cardiomyopathy (208 views)
Cardiologia, 2002 Nov 5; 33(8): 741-746.
Impact Factor: 0
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Ciampi Q, Betocchi S, Lombardi R, Manganelli F, Storto G, Losi MA, Pezzella E, Finizio F, Cuocolo A, Chiariello M
* Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (289 views)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2002 Jul 17; 40(2): 278-284.
Impact Factor: 6.278
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Manganelli F, Betocchi S, Ciampi Q, Storto G, Losi MA, Violante A, Briguori C, Tocchetti CG, Lombardi R, Cuocolo A, Chiariello M
* Myopia and IOP (416 views)
Ann Ottalmol Clin Ocul, 2002 Jun 15; 115(10): 1053-1058.
Impact Factor: 0
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (444 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Clampi Q, Losi M, Violante A, Manganelli F, Pezzella E, Storto G, Tocchetti C, Finizio F, Lombardi R, Briguori C, Cuocolo A, Betocchi S
Effects of isometric exercise in obstructive hypertrophic cardiomyopathy (253 views)
Circulationcirculation (ISSN: 0009-7322), 1999 Nov 2; 100(18SUPPL.): N/D-N/D.
Impact Factor: 9.903
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Manganelli F, Betocchi S, Ciampi Q, Losi MA, Tocchetti GC, Cuocolo A, Storto G, Violante A, Lombardi R, Chiariello M
Haemodynamic determinants of syncope in hypertrophic cardiomyopathy (243 views)
European Heart Journal (ISSN: 0195-668x), 1999 Sep; 20(ABSTR.SUPPL.): N/D-N/D.
Impact Factor: 3.21
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Cuocolo A, Nicolai E, Fazio S, Pace L, Maurea S, Cittadini A, Sacca L, Salvatore M
Impaired left ventricular diastolic filling in patients with acromegaly: Assessment with radionuclide angiography (261 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Feb; 36(2): 196-201.
Impact Factor: 3.491
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Nappi A, Cuocolo A, Nicolai E, Imbriaco M, Pace L, Salvatore M
Ambulatory monitoring of left ventricular function with a radionuclide detector system (295 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992; 84(1-2): 132-139.
Impact Factor: 0.967
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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60 Records (51 excluding Abstracts).
Total impact factor: 270.207 (230.397 excluding Abstracts).
Total 5 year impact factor: 240.977 (201.289 excluding Abstracts).
Total impact factor: 270.207 (230.397 excluding Abstracts).
Total 5 year impact factor: 240.977 (201.289 excluding Abstracts).
420 views. Last view on Tuesday 28 March 2023, 10:36:25
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