The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (378 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.199, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036962058&partnerID=40&md5=4dfa393b5029da45cca021eab5ddb41c
Keywords: Fibrinogen, Growth Hormone, High Density Lipoprotein Cholesterol, Low Density Lipoprotein Cholesterol, Recombinant Hormone, Somatomedin, Triacylglycerol, Adult, Article, Cardiovascular Risk, Cholesterol Blood Level, Clinical Article, Controlled Study, Diastolic Blood Pressure, Disease Course, Disease Severity, Echocardiography, Electrocardiography, Exercise, Female, Growth Hormone Deficiency, Heart Function, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Mass, Heart Rate, Heart Size, Hemodynamic Monitoring, Hormone Substitution, Human, Physical Performance, Priority Journal, Prospective Study, Scintiangiography, Statistical Significance, Systolic Blood Pressure, Treatment Outcome, Cardiovascular Diseases, Disease Progression, Human Growth Hormone, Insulin-Like Growth Factor I, Lipids, Middle Aged, Prospective Studies, Recombinant Proteins, Reference Values, Risk Factors,
Affiliations:
*** IBB - CNR ***
Dept. of Molec./Clin. Endocrinol./O., Federico II University of Naples, 80131 Naples, Italy
Dept. of Biomorphological/Funct. S., Nucl. Med. Ctr. of the N. C. of R., Federico II University of Naples, 80131 Naples, Italy
Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Sci. Inst. for Res./Care Neuromed, 86077 Pozzilli, Italy
Dept. of Molec. /Clin. Endocrinol. /O., Federico II University of Naples, 80131 Naples, Italy
References:
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-39
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Barkan, A.L., Clemmons, D.R., Molitch, M.E., Stewart, P.M., Young W.F., Jr., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P.V., Christ, E.R., Sonksen, P.H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B.A., Johannsson, G., Shalet, S.M., Simpson, H., Sonken, P.H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Colao, A., Di Somma, C., Marzullo, P., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol (Oxf), 54, pp. 137-154
Gibney, J., Wallace, J.D., Spinks, T., Schnorr, L., Ranicar, A., Cuneo, R.C., Lockhart, S., Russell-Jones, D., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Lombardi, G., The growth hormone (GH) response to arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Amato, G., Mazziotti, G., Di Somma, C., Lalli, E., De Felice, G., Conte, M., Rotondi, M., Colao, A., Recombinant growth hormone (GH) therapy in GH deficient adults: A long-term controlled study on daily vs. thrice weekly injections (2000) J Clin Endocrinol Metab, 85, pp. 3720-3725
Consensus conference: Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
Report of the National Cholesterol Education Program Expert Panel on Detection. Evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Morte, A.M., Pivonello, R., Nicolai, E., Lombardi, G., Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (2000) Clin Endocrinol (Oxf), 52, pp. 447-455
Cuocolo, A., Nicolai, E., Colao, A., Longobardi, S., Cardei, S., Fazio, S., Merola, B., Salvatore, M., Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography (1996) Eur J Nucl Med, 23, pp. 390-394
Miller, T.R., Grossman, S.G., Schechtman, K.B., Biello, D.R., Ludbrook, P.A., Ehansi, A.A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R.O., Vitale, D.F., Bacharach, S.L., Maron, B.J., Green, M.V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Cuocolo, A., Storto, G., Izzo, R., Iovino, G.L., Damiano, M., Bertocchi, F., Mann, J., Trimarco, B., Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril (1999) J Hypertens, 17, pp. 1759-1766
Feigenbaum, H., (1979) Echocardiography, 2nd Ed., , Philadelphia: Lea and Febiger
Rosen, T., Bengtsson, B.A., Premature mortality due to cardiovascular disease in hypopituitarism (1990) Lancet, 336, pp. 285-288
Bates, A.S., Van't Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bulöw, B., Hagmar, L., Mikoczy, Z., Nordström, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Beshyah, S.A., Johnston, D.G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Amato, G., Carella, C., Fazio, S., La Montagna, G., Cittadini, A., Sabatini, D., Marciano-Mone, C., Bellastella, A., Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses (1993) J Clin Endocrinol Metab, 77, pp. 1671-1676
Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Sacca, L., Lombardi, G., Cardiac structural and functional abnormalities in adult patients with GH deficiency (1993) J Clin Endocrinol Metab, 77, pp. 1658-1661
Nass, R., Huber, R.M., Klauss, V., Muller, O.A., Schopol, J., Strasburger, C.J., Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood (1995) J Clin Endocrinol Metab, 80, pp. 552-557
Valcavi, R., Gaddi, O., Zini, M., Iavicoli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adults with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Johansson, G., Bengtsson, B.A., Andersson, B., Isgaard, J., Caidahl, K., Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients (1996) Clin Endocrinol (Oxf), 45, pp. 305-314
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-39
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Barkan, A. L., Clemmons, D. R., Molitch, M. E., Stewart, P. M., Young W. F., Jr., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P. V., Christ, E. R., Sonksen, P. H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B. A., Johannsson, G., Shalet, S. M., Simpson, H., Sonken, P. H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Miller, T. R., Grossman, S. G., Schechtman, K. B., Biello, D. R., Ludbrook, P. A., Ehansi, A. A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Maron, B. J., Green, M. V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Bates, A. S., Van't Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bul w, B., Hagmar, L., Mikoczy, Z., Nordstr m, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.199, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036962058&partnerID=40&md5=4dfa393b5029da45cca021eab5ddb41c
Keywords: Fibrinogen, Growth Hormone, High Density Lipoprotein Cholesterol, Low Density Lipoprotein Cholesterol, Recombinant Hormone, Somatomedin, Triacylglycerol, Adult, Article, Cardiovascular Risk, Cholesterol Blood Level, Clinical Article, Controlled Study, Diastolic Blood Pressure, Disease Course, Disease Severity, Echocardiography, Electrocardiography, Exercise, Female, Growth Hormone Deficiency, Heart Function, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Mass, Heart Rate, Heart Size, Hemodynamic Monitoring, Hormone Substitution, Human, Physical Performance, Priority Journal, Prospective Study, Scintiangiography, Statistical Significance, Systolic Blood Pressure, Treatment Outcome, Cardiovascular Diseases, Disease Progression, Human Growth Hormone, Insulin-Like Growth Factor I, Lipids, Middle Aged, Prospective Studies, Recombinant Proteins, Reference Values, Risk Factors,
Affiliations:
*** IBB - CNR ***
Dept. of Molec./Clin. Endocrinol./O., Federico II University of Naples, 80131 Naples, Italy
Dept. of Biomorphological/Funct. S., Nucl. Med. Ctr. of the N. C. of R., Federico II University of Naples, 80131 Naples, Italy
Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Sci. Inst. for Res./Care Neuromed, 86077 Pozzilli, Italy
Dept. of Molec. /Clin. Endocrinol. /O., Federico II University of Naples, 80131 Naples, Italy
References:
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-39
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Barkan, A.L., Clemmons, D.R., Molitch, M.E., Stewart, P.M., Young W.F., Jr., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P.V., Christ, E.R., Sonksen, P.H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B.A., Johannsson, G., Shalet, S.M., Simpson, H., Sonken, P.H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Colao, A., Di Somma, C., Marzullo, P., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol (Oxf), 54, pp. 137-154
Gibney, J., Wallace, J.D., Spinks, T., Schnorr, L., Ranicar, A., Cuneo, R.C., Lockhart, S., Russell-Jones, D., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Lombardi, G., The growth hormone (GH) response to arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Amato, G., Mazziotti, G., Di Somma, C., Lalli, E., De Felice, G., Conte, M., Rotondi, M., Colao, A., Recombinant growth hormone (GH) therapy in GH deficient adults: A long-term controlled study on daily vs. thrice weekly injections (2000) J Clin Endocrinol Metab, 85, pp. 3720-3725
Consensus conference: Treatment of hypertriglyceridemia (1984) JAMA, 251, pp. 1196-1200
Report of the National Cholesterol Education Program Expert Panel on Detection. Evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Morte, A.M., Pivonello, R., Nicolai, E., Lombardi, G., Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (2000) Clin Endocrinol (Oxf), 52, pp. 447-455
Cuocolo, A., Nicolai, E., Colao, A., Longobardi, S., Cardei, S., Fazio, S., Merola, B., Salvatore, M., Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography (1996) Eur J Nucl Med, 23, pp. 390-394
Miller, T.R., Grossman, S.G., Schechtman, K.B., Biello, D.R., Ludbrook, P.A., Ehansi, A.A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R.O., Vitale, D.F., Bacharach, S.L., Maron, B.J., Green, M.V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Cuocolo, A., Storto, G., Izzo, R., Iovino, G.L., Damiano, M., Bertocchi, F., Mann, J., Trimarco, B., Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril (1999) J Hypertens, 17, pp. 1759-1766
Feigenbaum, H., (1979) Echocardiography, 2nd Ed., , Philadelphia: Lea and Febiger
Rosen, T., Bengtsson, B.A., Premature mortality due to cardiovascular disease in hypopituitarism (1990) Lancet, 336, pp. 285-288
Bates, A.S., Van't Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bulöw, B., Hagmar, L., Mikoczy, Z., Nordström, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Beshyah, S.A., Johnston, D.G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Amato, G., Carella, C., Fazio, S., La Montagna, G., Cittadini, A., Sabatini, D., Marciano-Mone, C., Bellastella, A., Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses (1993) J Clin Endocrinol Metab, 77, pp. 1671-1676
Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Sacca, L., Lombardi, G., Cardiac structural and functional abnormalities in adult patients with GH deficiency (1993) J Clin Endocrinol Metab, 77, pp. 1658-1661
Nass, R., Huber, R.M., Klauss, V., Muller, O.A., Schopol, J., Strasburger, C.J., Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood (1995) J Clin Endocrinol Metab, 80, pp. 552-557
Valcavi, R., Gaddi, O., Zini, M., Iavicoli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adults with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Johansson, G., Bengtsson, B.A., Andersson, B., Isgaard, J., Caidahl, K., Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients (1996) Clin Endocrinol (Oxf), 45, pp. 305-314
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-39
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Barkan, A. L., Clemmons, D. R., Molitch, M. E., Stewart, P. M., Young W. F., Jr., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P. V., Christ, E. R., Sonksen, P. H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B. A., Johannsson, G., Shalet, S. M., Simpson, H., Sonken, P. H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Miller, T. R., Grossman, S. G., Schechtman, K. B., Biello, D. R., Ludbrook, P. A., Ehansi, A. A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Maron, B. J., Green, M. V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Bates, A. S., Van't Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bul w, B., Hagmar, L., Mikoczy, Z., Nordstr m, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study
Increased cardiovascular morbidity and mortality were reported in GH deficiency (GHD), and GH replacement can ameliorate cardiac abnormalities of adult GIlD patients. To test the potential progression of untreated GIlD on the cardiovascular risk and cardiac function, cardiovascular risk factors, cardiac size, and performance were prospectively evaluated in 15 GHD patients (age, 18-56 yr) who were treated with recombinant GH at the dose of 0.15-1.0 mg/d, 15 GHD patients (age, 18-56 yr) who refused GH replacement, and 30 healthy subjects (age, 18-53 yr). Electrocardiogram, systolic and diastolic blood pressure, and heart rate measurement, serum IGF-I, total cholesterol, low- and high-density lipoprotein (LDL, HDL) cholesterol, triglycerides, and fibrinogen level assay, echocardiography, and equilibrium radionuclide angiography were performed basally and after 12 months. At study entry, low IGF-I levels, unfavorable lipid profile, and inadequate cardiac and physical performance were found in GHD patients compared with controls. After 12 months of GH treatment, IGF-I levels normalized; HDL-cholesterol levels, left ventricular (LV) mass index (LVMi), left ventricular ejection fraction (LVEF) at peak exercise, peak filling rate, exercise duration and capacity significantly increased; total-and LDL-cholesterol levels significantly decreased. After 12 months in GH-untreated GHD patients, IGF-I levels remained stable, and HDL-cholesterol levels, LVEF both at rest and at peak exercise, and exercise capacity were further reduced; total- and LDL-cholesterol levels increased slightly. LVEF at rest and its response at peak exercise normalized in 60 and 53.3%, respectively, of GH-treated patients and in none of the GH-untreated patients. In conclusion, 12 months of GH replacement normalized IGF-I and improved lipid profile and cardiac performance in adult GHD patients. A similar period of GH deprivation induced a further impairment of lipid profile and cardiac performance. This finding strongly supports the need of GH replacement in adult GHD patients.
Increased cardiovascular morbidity and mortality were reported in GH deficiency (GHD), and GH replacement can ameliorate cardiac abnormalities of adult GIlD patients. To test the potential progression of untreated GIlD on the cardiovascular risk and cardiac function, cardiovascular risk factors, cardiac size, and performance were prospectively evaluated in 15 GHD patients (age, 18-56 yr) who were treated with recombinant GH at the dose of 0.15-1.0 mg/d, 15 GHD patients (age, 18-56 yr) who refused GH replacement, and 30 healthy subjects (age, 18-53 yr). Electrocardiogram, systolic and diastolic blood pressure, and heart rate measurement, serum IGF-I, total cholesterol, low- and high-density lipoprotein (LDL, HDL) cholesterol, triglycerides, and fibrinogen level assay, echocardiography, and equilibrium radionuclide angiography were performed basally and after 12 months. At study entry, low IGF-I levels, unfavorable lipid profile, and inadequate cardiac and physical performance were found in GHD patients compared with controls. After 12 months of GH treatment, IGF-I levels normalized; HDL-cholesterol levels, left ventricular (LV) mass index (LVMi), left ventricular ejection fraction (LVEF) at peak exercise, peak filling rate, exercise duration and capacity significantly increased; total-and LDL-cholesterol levels significantly decreased. After 12 months in GH-untreated GHD patients, IGF-I levels remained stable, and HDL-cholesterol levels, LVEF both at rest and at peak exercise, and exercise capacity were further reduced; total- and LDL-cholesterol levels increased slightly. LVEF at rest and its response at peak exercise normalized in 60 and 53.3%, respectively, of GH-treated patients and in none of the GH-untreated patients. In conclusion, 12 months of GH replacement normalized IGF-I and improved lipid profile and cardiac performance in adult GHD patients. A similar period of GH deprivation induced a further impairment of lipid profile and cardiac performance. This finding strongly supports the need of GH replacement in adult GHD patients.
The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study
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The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
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Impact Factor: 2.882
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
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Impact Factor: 1.156
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
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Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
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Impact Factor: 3.438
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
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Impact Factor: 2.773
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
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Impact Factor: 6.202
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
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Impact Factor: 8.172
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
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Impact Factor: 8.172
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
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Impact Factor: 2.767
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (581 views)
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Impact Factor: 2.013
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (419 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (443 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (328 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
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Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
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Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (329 views)
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Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
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Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (428 views)
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Impact Factor: 4.457
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
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Impact Factor: 2.331
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
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Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (317 views)
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Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (452 views)
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Impact Factor: 0.481
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (375 views)
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Impact Factor: 1.681
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
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Impact Factor: 1.588
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* Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin (26 views)
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Impact Factor: 5.162
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Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
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Impact Factor: 4.621
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
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Impact Factor: 3.679
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Berisio R, Ciccarelli L, Squeglia F, De Simone A, Vitagliano L
* Structural and Dynamic properties of incomplete immunoglobulin-like fold domains (477 views)
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Impact Factor: 1.994
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Perrone-Filardi P, Musella F, Savarese G, Cecere M, Marciano C, Scala O, Rengo G, Dellegrottaglie S, Cuocolo A, Leosco D
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Impact Factor: 3.669
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
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Impact Factor: 3.891
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
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Impact Factor: 3.578
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
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Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (664 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (395 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
View Export to BibTeX Export to EndNote
Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
View Export to BibTeX Export to EndNote
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
View Export to BibTeX Export to EndNote
Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (581 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (419 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (443 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (328 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (428 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (317 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (452 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (375 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
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41 Records (38 excluding Abstracts).
Total impact factor: 175.644 (159.3 excluding Abstracts).
Total 5 year impact factor: 147.712 (133.314 excluding Abstracts).
Total impact factor: 175.644 (159.3 excluding Abstracts).
Total 5 year impact factor: 147.712 (133.314 excluding Abstracts).
378 views. Last view on Wednesday 15 March 2023, 6:11:50
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