Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.849, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035207159&partnerID=40&md5=dedb68250eb2b3b625188504205f9717
Keywords: Aids, Nf-κb, Peptide Nucleic Acids, Pna-Dna Chimeras, Transcription Factors, Glycine Derivative, Hybrid Protein, Immunoglobulin Enhancer Binding Protein, Isoprotein, Nuclear Factor, Oligonucleotide, Protein P50, Proteinase, Article, Binding Site, Gene Expression, Gene Therapy, Human Immunodeficiency Virus 1, Long Terminal Repeat, Lymphoid Cell, Molecular Dynamics, Molecular Interaction, Molecular Model, Prediction, Priority Journal, Protein Determination, Protein Protein Interaction, Protein Stability, Protein Structure, Simulation, Animals, Circular Dichroism, Drug Stability, Hiv-1, Macromolecular Substances, Nf-Kappa B, Nucleic Acid Conformation, Protein Conformation, Recombinant Fusion Proteins, Thermodynamics,
Affiliations:
*** IBB - CNR ***
Biocrystallography Research Center, CNR, Ferrara University, Napoli, Italy
Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
Biotechnology Centre, Ferrara University, Ferrara, Italy
References:
Lim, C.S., Jabrane-Ferrat, N., Fontes, J.D., Okamoto, H., Garovoy, M.R., Peterlin, B.M., Hunt, C.A., Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys (1997) Nucleic Acids Res., 25, pp. 575-58
Kozlov, I.A., Kubareva, E.A., Ivanovskaya, M.G., Shabarova, Z.A., Design of new reagents on the base of DNA duplexes for irreversible inhibition of transcription factor NF-kappa B (1997) Antisense Nucleic Acid Drug Dev., 7, pp. 279-289
Iwase, R., Namba, M., Yamaoka, T., Murakami, A., Gene regulation by decoy approach (I): Synthesis and properties of photo-crosslinked oligonucleotides (1997) Nucleic Acids Symp. Series, 37, pp. 203-204
Yamashita, J., Yoshimasa, T., Arai, H., Hiraoka, J., Tayaya, K., Miyamoto, Y., Ogawa, Y., Nakao, K., Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy (1998) J. Biol. Chem., 273, pp. 15993-15999
Clusel, C., Meguenni, S., Elias, I., Vasseur, M., Blumenfeld, M., Inhibition of HSV-1 proliferation by decoy phosphodiester oligonucleotides containing ICP4 recognition sequences (1995) Gene Expr., 4, pp. 301-309
Morishita, R., Gibbons, G.H., Horiuchi, M., Ellison, K.E., Nakama, M., Zhang, L., Kaneda, Y., Dzau, V.J., A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 5855-5859
Cho-Chung, Y.S., Park, Y.G., Nesterova, M., Lee, Y.N., Cho, Y.S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol. Cell. Biochem., 212, pp. 29-34
Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E.J., Kaneda, Y., Nakashima, Y., Shirasuna, K., Sueishi, K., Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities (2000) Cancer Res., 60, pp. 6531-6536
Kawauchi, M., Suzuki, J., Morishita, R., Wada, Y., Izawa, A., Tomita, N., Amano, J., Isobe, M., Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates (2000) Circ. Res., 87, pp. 1063-1068
Lee, Y.N., Park, Y.G., Choi, Y.H., Cho, Y.S., Cho-Chung, Y.S., CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: Cross-talk with p53 signaling pathway (2000) Biochemistry, 39, pp. 4863-4868
Mischiati, C., Feriotto, G., Borgatti, M., Giacomini, P., Gambari, R., Characterization of a major histocompatibility complex class II X-box-binding protein enhancing tat-induced transcription directed by the human immunodeficiency virus type 1 long terminal repeat (2000) J. Virol., 74, pp. 8989-9001
Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Ogihara, T., In vivo transfection of cis element 'decoy' against nuclear factor-kappaB binding site prevents myocardial infarction (1997) Nat. Med., 3, pp. 894-899
Khaled, A.R., Butfiloski, E.J., Sobel, E.S., Schiffenbauer, J., Functional consequences of the SHP-1 defect in motheaten viable mice: Role of NF-kappa B (1998) Cell. Immunol., 185, pp. 49-58
Ono, S., Date, I., Onoda, K., Shiota, T., Ohmoto, T., Ninomiya, Y., Asari, S., Morishita, R., Decoy administration of NF-kappa B into the subarachnoid space for cerebral angiopathy (1998) Hum. Gene Ther., 9, pp. 1003-1011
Sharma, H.W., Perez, J.R., Higgins-Sochaski, K., Hsiao, R., Narayanan, R., Transcription factor decoy approach to decipher the role of NF-kappa B in oncogenesis (1996) Anticancer Res., 16, pp. 61-69
Tomita, N., Morishita, R., Tomita, S., Yamamoto, K., Aoki, M., Matsushita, H., Hayashi, S., Ogihara, T., Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells (1998) J. Hypertens., 16, pp. 993-1000
Vos, I.H., Govers, R., Grone, H.J., Kleij, L., Schurink, M., De Weger, R.A., Goldschmeding, R., Rabelink, T.J., NF kappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts (2000) FASEB J., 14, pp. 815-822
Hosoya, T., Takeuchi, H., Kanesaka, Y., Yamakawa, H., Miyano-Kurosaki, N., Takai, K., Yamamoto, N., Takaku, H., Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides (1999) FEBS Lett., 461, pp. 136-140
Uhlman, E., Peyman, A., Antisense oligonucleotides: A new therapeutic principle (1990) Chem. Rev., 90, pp. 543-549
Egholm, M., Buchardt, O., Nielsen, P.E., Berg, R.H., Peptide nucleic acids (PNA): Oligonucleotide analogues with an achiral peptide backbone (1992) J. Am. Chem. Soc., 114, pp. 1895-1897
Betts, L., Josey, J.A., Veal, J.M., Jordan, S.R., A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex (1995) Science, 270, pp. 1838-1841
Larsen, H.J., Nielsen, P.E., Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription (1996) Nucleic Acids Res., 24, pp. 458-463
Hanvey, J.C., Peffer, N.J., Bisi, J.E., Thomson, S.A., Cadilla, R., Josey, J.A., Ricca, D.J., Babiss, L.E., Antisense and antigene properties of peptide nucleic acids (1992) Science, 258, pp. 1481-1485
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immuno-deficiency virus type 1 promoter (1999) J. Biol. Chem., 274, pp. 33114-33122
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Saviano, M., Romanelli, A., Bucci, E., Pedone, C., Mischiati, C., Bianchi, N., Feriotto, G., Gambari, R., Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-kappaB binding sites (2000) J. Biomol. Struct. Dyn., 18, pp. 353-362
Saviano, M., Bucci, E., Romanelli, A., Pedone, C., Conformational feature of Peptidic Nucleic Acids for the rational design of biologically active PNAs and hybrid PNA-oligonucleotides (1999) Minerva Biotecnologica, 11, pp. 175-185
Misra, H.S., Pandey, P.K., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid-DNA chimera lacking the phosphate backbone are novel primers for polymerase reaction catalyzed by DNA polymerases (1998) Biochemistry, 37, pp. 1917-1925
Uhlmann, E., Peyman, A., Will, D.W., Antisense: Chemical modifications (1997) Encyclopedia of Cancer, 1, pp. 64-81. , Bertino, J.R., ed. Academic Press, San Diego, CA
Vinayak, R., Van der Laan, A.C., Brill, R., Otteson, K., Andrus, A., Kuyl-Yeheskiely, E., Van Boom, J.H., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1656
Will, D.W., Breipohl, G., Langner, D., Knolle, J., Uhlmann, E., The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy (1995) Tetrahedron, 51, pp. 12069-12082
Saviano, M., Aida, M., Corongiu, G., Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: A conformational study (1991) Biopolymers, 31, pp. 1017-1024
Sen, S., Nilsson, L., Molecular dynamics of duplex systems involving PNA: Structural and dynamical consequences of the nucleic acid backbone (1998) J. Am. Chem. Soc., 120, pp. 619-631
Feriotto, G., Mischiati, C., Gambari, R., Sequence-specific recognition of the HIV-1 long terminal repeat by distamycin: A DNAase I footprinting study (1994) Biochem. J., 299, pp. 451-458
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res., 11, pp. 1475-1489
Chen, F.E., Huang, D., Chen, Y., Ghosh, G., Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA (1998) Nature, 391, pp. 410-413
Rasmussen, H., Kastrup, J.S., Nielsen, J.N., Nielsen, J.M., Nielsen, P.E., Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution (1997) Nat. Struct. Biol., 4, pp. 98-101
Bloomfield, V.A., Crothers, D.M., Tinoco I.T., Jr., Nucleic Acids: structures, properties and functions, , University Science Book, Sausalito, CA
Nelsen, B., Sen, R., Regulation of immunoglobulin gene transcription (1992) Int. Rev. Cytol., 133, pp. 121-149
Gaynor, R., Cellular transcription factors involved in the regulation of HIV-1 gene expression (1992) AIDS, 6, pp. 347-363
McShean, W.M., Rossen, R.D., Laughter, A.H., Trial, J., Kessler, D.J., Zendegui, J.G., Hogan, M.E., Orson, F.M., Inhibition of transcription of HIV-1 in infected human cells by oligodeoxy-nucleotides designed to form DNA triple helices (1992) J. Biol. Chem., 267, pp. 5712-5721
Lim, C. S., Jabrane-Ferrat, N., Fontes, J. D., Okamoto, H., Garovoy, M. R., Peterlin, B. M., Hunt, C. A., Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys (1997) Nucleic Acids Res., 25, pp. 575-58
Kozlov, I. A., Kubareva, E. A., Ivanovskaya, M. G., Shabarova, Z. A., Design of new reagents on the base of DNA duplexes for irreversible inhibition of transcription factor NF-kappa B (1997) Antisense Nucleic Acid Drug Dev., 7, pp. 279-289
Cho-Chung, Y. S., Park, Y. G., Nesterova, M., Lee, Y. N., Cho, Y. S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol. Cell. Biochem., 212, pp. 29-34
Lee, Y. N., Park, Y. G., Choi, Y. H., Cho, Y. S., Cho-Chung, Y. S., CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: Cross-talk with p53 signaling pathway (2000) Biochemistry, 39, pp. 4863-4868
Khaled, A. R., Butfiloski, E. J., Sobel, E. S., Schiffenbauer, J., Functional consequences of the SHP-1 defect in motheaten viable mice: Role of NF-kappa B (1998) Cell. Immunol., 185, pp. 49-58
Sharma, H. W., Perez, J. R., Higgins-Sochaski, K., Hsiao, R., Narayanan, R., Transcription factor decoy approach to decipher the role of NF-kappa B in oncogenesis (1996) Anticancer Res., 16, pp. 61-69
Vos, I. H., Govers, R., Grone, H. J., Kleij, L., Schurink, M., De Weger, R. A., Goldschmeding, R., Rabelink, T. J., NF kappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts (2000) FASEB J., 14, pp. 815-822
Larsen, H. J., Nielsen, P. E., Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription (1996) Nucleic Acids Res., 24, pp. 458-463
Hanvey, J. C., Peffer, N. J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Babiss, L. E., Antisense and antigene properties of peptide nucleic acids (1992) Science, 258, pp. 1481-1485
Demidov, V. V., Potaman, V. N., Frank-Kamenetsk, M. D., Egholm, M., Buchard, O., Sonnichsen, S. H., Nielsen, P. E., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Misra, H. S., Pandey, P. K., Modak, M. J., Vinayak, R., Pandey, V. N., Polyamide nucleic acid-DNA chimera lacking the phosphate backbone are novel primers for polymerase reaction catalyzed by DNA polymerases (1998) Biochemistry, 37, pp. 1917-1925
Will, D. W., Breipohl, G., Langner, D., Knolle, J., Uhlmann, E., The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy (1995) Tetrahedron, 51, pp. 12069-12082
Dignam, J. D., Lebovitz, R. M., Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res., 11, pp. 1475-1489
Chen, F. E., Huang, D., Chen, Y., Ghosh, G., Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA (1998) Nature, 391, pp. 410-413
Bloomfield, V. A., Crothers, D. M., Tinoco I. T., Jr., Nucleic Acids: structures, properties and functions, , University Science Book, Sausalito, CA
McShean, W. M., Rossen, R. D., Laughter, A. H., Trial, J., Kessler, D. J., Zendegui, J. G., Hogan, M. E., Orson, F. M., Inhibition of transcription of HIV-1 in infected human cells by oligodeoxy-nucleotides designed to form DNA triple helices (1992) J. Biol. Chem., 267, pp. 5712-5721
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.849, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035207159&partnerID=40&md5=dedb68250eb2b3b625188504205f9717
Keywords: Aids, Nf-κb, Peptide Nucleic Acids, Pna-Dna Chimeras, Transcription Factors, Glycine Derivative, Hybrid Protein, Immunoglobulin Enhancer Binding Protein, Isoprotein, Nuclear Factor, Oligonucleotide, Protein P50, Proteinase, Article, Binding Site, Gene Expression, Gene Therapy, Human Immunodeficiency Virus 1, Long Terminal Repeat, Lymphoid Cell, Molecular Dynamics, Molecular Interaction, Molecular Model, Prediction, Priority Journal, Protein Determination, Protein Protein Interaction, Protein Stability, Protein Structure, Simulation, Animals, Circular Dichroism, Drug Stability, Hiv-1, Macromolecular Substances, Nf-Kappa B, Nucleic Acid Conformation, Protein Conformation, Recombinant Fusion Proteins, Thermodynamics,
Affiliations:
*** IBB - CNR ***
Biocrystallography Research Center, CNR, Ferrara University, Napoli, Italy
Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
Biotechnology Centre, Ferrara University, Ferrara, Italy
References:
Lim, C.S., Jabrane-Ferrat, N., Fontes, J.D., Okamoto, H., Garovoy, M.R., Peterlin, B.M., Hunt, C.A., Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys (1997) Nucleic Acids Res., 25, pp. 575-58
Kozlov, I.A., Kubareva, E.A., Ivanovskaya, M.G., Shabarova, Z.A., Design of new reagents on the base of DNA duplexes for irreversible inhibition of transcription factor NF-kappa B (1997) Antisense Nucleic Acid Drug Dev., 7, pp. 279-289
Iwase, R., Namba, M., Yamaoka, T., Murakami, A., Gene regulation by decoy approach (I): Synthesis and properties of photo-crosslinked oligonucleotides (1997) Nucleic Acids Symp. Series, 37, pp. 203-204
Yamashita, J., Yoshimasa, T., Arai, H., Hiraoka, J., Tayaya, K., Miyamoto, Y., Ogawa, Y., Nakao, K., Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy (1998) J. Biol. Chem., 273, pp. 15993-15999
Clusel, C., Meguenni, S., Elias, I., Vasseur, M., Blumenfeld, M., Inhibition of HSV-1 proliferation by decoy phosphodiester oligonucleotides containing ICP4 recognition sequences (1995) Gene Expr., 4, pp. 301-309
Morishita, R., Gibbons, G.H., Horiuchi, M., Ellison, K.E., Nakama, M., Zhang, L., Kaneda, Y., Dzau, V.J., A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 5855-5859
Cho-Chung, Y.S., Park, Y.G., Nesterova, M., Lee, Y.N., Cho, Y.S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol. Cell. Biochem., 212, pp. 29-34
Ishibashi, H., Nakagawa, K., Onimaru, M., Castellanous, E.J., Kaneda, Y., Nakashima, Y., Shirasuna, K., Sueishi, K., Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities (2000) Cancer Res., 60, pp. 6531-6536
Kawauchi, M., Suzuki, J., Morishita, R., Wada, Y., Izawa, A., Tomita, N., Amano, J., Isobe, M., Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates (2000) Circ. Res., 87, pp. 1063-1068
Lee, Y.N., Park, Y.G., Choi, Y.H., Cho, Y.S., Cho-Chung, Y.S., CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: Cross-talk with p53 signaling pathway (2000) Biochemistry, 39, pp. 4863-4868
Mischiati, C., Feriotto, G., Borgatti, M., Giacomini, P., Gambari, R., Characterization of a major histocompatibility complex class II X-box-binding protein enhancing tat-induced transcription directed by the human immunodeficiency virus type 1 long terminal repeat (2000) J. Virol., 74, pp. 8989-9001
Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Ogihara, T., In vivo transfection of cis element 'decoy' against nuclear factor-kappaB binding site prevents myocardial infarction (1997) Nat. Med., 3, pp. 894-899
Khaled, A.R., Butfiloski, E.J., Sobel, E.S., Schiffenbauer, J., Functional consequences of the SHP-1 defect in motheaten viable mice: Role of NF-kappa B (1998) Cell. Immunol., 185, pp. 49-58
Ono, S., Date, I., Onoda, K., Shiota, T., Ohmoto, T., Ninomiya, Y., Asari, S., Morishita, R., Decoy administration of NF-kappa B into the subarachnoid space for cerebral angiopathy (1998) Hum. Gene Ther., 9, pp. 1003-1011
Sharma, H.W., Perez, J.R., Higgins-Sochaski, K., Hsiao, R., Narayanan, R., Transcription factor decoy approach to decipher the role of NF-kappa B in oncogenesis (1996) Anticancer Res., 16, pp. 61-69
Tomita, N., Morishita, R., Tomita, S., Yamamoto, K., Aoki, M., Matsushita, H., Hayashi, S., Ogihara, T., Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells (1998) J. Hypertens., 16, pp. 993-1000
Vos, I.H., Govers, R., Grone, H.J., Kleij, L., Schurink, M., De Weger, R.A., Goldschmeding, R., Rabelink, T.J., NF kappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts (2000) FASEB J., 14, pp. 815-822
Hosoya, T., Takeuchi, H., Kanesaka, Y., Yamakawa, H., Miyano-Kurosaki, N., Takai, K., Yamamoto, N., Takaku, H., Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides (1999) FEBS Lett., 461, pp. 136-140
Uhlman, E., Peyman, A., Antisense oligonucleotides: A new therapeutic principle (1990) Chem. Rev., 90, pp. 543-549
Egholm, M., Buchardt, O., Nielsen, P.E., Berg, R.H., Peptide nucleic acids (PNA): Oligonucleotide analogues with an achiral peptide backbone (1992) J. Am. Chem. Soc., 114, pp. 1895-1897
Betts, L., Josey, J.A., Veal, J.M., Jordan, S.R., A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex (1995) Science, 270, pp. 1838-1841
Larsen, H.J., Nielsen, P.E., Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription (1996) Nucleic Acids Res., 24, pp. 458-463
Hanvey, J.C., Peffer, N.J., Bisi, J.E., Thomson, S.A., Cadilla, R., Josey, J.A., Ricca, D.J., Babiss, L.E., Antisense and antigene properties of peptide nucleic acids (1992) Science, 258, pp. 1481-1485
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immuno-deficiency virus type 1 promoter (1999) J. Biol. Chem., 274, pp. 33114-33122
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Saviano, M., Romanelli, A., Bucci, E., Pedone, C., Mischiati, C., Bianchi, N., Feriotto, G., Gambari, R., Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-kappaB binding sites (2000) J. Biomol. Struct. Dyn., 18, pp. 353-362
Saviano, M., Bucci, E., Romanelli, A., Pedone, C., Conformational feature of Peptidic Nucleic Acids for the rational design of biologically active PNAs and hybrid PNA-oligonucleotides (1999) Minerva Biotecnologica, 11, pp. 175-185
Misra, H.S., Pandey, P.K., Modak, M.J., Vinayak, R., Pandey, V.N., Polyamide nucleic acid-DNA chimera lacking the phosphate backbone are novel primers for polymerase reaction catalyzed by DNA polymerases (1998) Biochemistry, 37, pp. 1917-1925
Uhlmann, E., Peyman, A., Will, D.W., Antisense: Chemical modifications (1997) Encyclopedia of Cancer, 1, pp. 64-81. , Bertino, J.R., ed. Academic Press, San Diego, CA
Vinayak, R., Van der Laan, A.C., Brill, R., Otteson, K., Andrus, A., Kuyl-Yeheskiely, E., Van Boom, J.H., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1656
Will, D.W., Breipohl, G., Langner, D., Knolle, J., Uhlmann, E., The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy (1995) Tetrahedron, 51, pp. 12069-12082
Saviano, M., Aida, M., Corongiu, G., Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: A conformational study (1991) Biopolymers, 31, pp. 1017-1024
Sen, S., Nilsson, L., Molecular dynamics of duplex systems involving PNA: Structural and dynamical consequences of the nucleic acid backbone (1998) J. Am. Chem. Soc., 120, pp. 619-631
Feriotto, G., Mischiati, C., Gambari, R., Sequence-specific recognition of the HIV-1 long terminal repeat by distamycin: A DNAase I footprinting study (1994) Biochem. J., 299, pp. 451-458
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res., 11, pp. 1475-1489
Chen, F.E., Huang, D., Chen, Y., Ghosh, G., Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA (1998) Nature, 391, pp. 410-413
Rasmussen, H., Kastrup, J.S., Nielsen, J.N., Nielsen, J.M., Nielsen, P.E., Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution (1997) Nat. Struct. Biol., 4, pp. 98-101
Bloomfield, V.A., Crothers, D.M., Tinoco I.T., Jr., Nucleic Acids: structures, properties and functions, , University Science Book, Sausalito, CA
Nelsen, B., Sen, R., Regulation of immunoglobulin gene transcription (1992) Int. Rev. Cytol., 133, pp. 121-149
Gaynor, R., Cellular transcription factors involved in the regulation of HIV-1 gene expression (1992) AIDS, 6, pp. 347-363
McShean, W.M., Rossen, R.D., Laughter, A.H., Trial, J., Kessler, D.J., Zendegui, J.G., Hogan, M.E., Orson, F.M., Inhibition of transcription of HIV-1 in infected human cells by oligodeoxy-nucleotides designed to form DNA triple helices (1992) J. Biol. Chem., 267, pp. 5712-5721
Lim, C. S., Jabrane-Ferrat, N., Fontes, J. D., Okamoto, H., Garovoy, M. R., Peterlin, B. M., Hunt, C. A., Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys (1997) Nucleic Acids Res., 25, pp. 575-58
Kozlov, I. A., Kubareva, E. A., Ivanovskaya, M. G., Shabarova, Z. A., Design of new reagents on the base of DNA duplexes for irreversible inhibition of transcription factor NF-kappa B (1997) Antisense Nucleic Acid Drug Dev., 7, pp. 279-289
Cho-Chung, Y. S., Park, Y. G., Nesterova, M., Lee, Y. N., Cho, Y. S., CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth (2000) Mol. Cell. Biochem., 212, pp. 29-34
Lee, Y. N., Park, Y. G., Choi, Y. H., Cho, Y. S., Cho-Chung, Y. S., CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: Cross-talk with p53 signaling pathway (2000) Biochemistry, 39, pp. 4863-4868
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Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites
The decoy approach against nuclear factor κB (NF-κB) is a useful tool to alter NF-κB dependent gene expression using synthetic oligonucleotides (ODNs) carrying NF-κB specific cis-elements. Unfortunately, ODNs are not stable and need to be extensively modified to be used in vivo or ex vivo. We have previously evaluated the possible use of peptide nucleic acids (PNAs) as decoy molecules. The backbone of PNAs is composed of N-(2-aminoethyl)glycine units, rendering these molecules resistant to both nucleases and proteases. We found that the binding of NF-κB transcription factors to PNAs was either very low (binding to PNA-PNA hybrids) or exhibited low stability (binding to PNA-DNA hybrids). The main consideration of the present paper was to determine whether PNA-DNA chimeras mimicking NF-κB binding sites are capable of stable interactions with proteins belonging to the NF-κB family. Molecular modeling was employed for the design of PNA-DNA chimeras; prediction of molecular interactions between chimeras and NF-κB nuclear proteins were investigated by molecular dynamics simulations, and interactions between PNA-DNA chimeras and NF-κB proteins were studied by gel shifts. We found significant differences between the structure of duplex NF-κB PNA-DNA chimera and duplex NF-κB DNA-DNA. However, it was found that these differences do not prevent the duplex PNA-DNA chimera from binding to NF-κB transcription factors, being able to suppress the molecular interactions between HIV-1 LTR and p50, p52 and nuclear factors from B-lymphoid cells. Therefore, these results demonstrate that the designed NF-κB DNA-PNA chimeras could be used for a decoy approach in gene therapy.
The decoy approach against nuclear factor κB (NF-κB) is a useful tool to alter NF-κB dependent gene expression using synthetic oligonucleotides (ODNs) carrying NF-κB specific cis-elements. Unfortunately, ODNs are not stable and need to be extensively modified to be used in vivo or ex vivo. We have previously evaluated the possible use of peptide nucleic acids (PNAs) as decoy molecules. The backbone of PNAs is composed of N-(2-aminoethyl)glycine units, rendering these molecules resistant to both nucleases and proteases. We found that the binding of NF-κB transcription factors to PNAs was either very low (binding to PNA-PNA hybrids) or exhibited low stability (binding to PNA-DNA hybrids). The main consideration of the present paper was to determine whether PNA-DNA chimeras mimicking NF-κB binding sites are capable of stable interactions with proteins belonging to the NF-κB family. Molecular modeling was employed for the design of PNA-DNA chimeras; prediction of molecular interactions between chimeras and NF-κB nuclear proteins were investigated by molecular dynamics simulations, and interactions between PNA-DNA chimeras and NF-κB proteins were studied by gel shifts. We found significant differences between the structure of duplex NF-κB PNA-DNA chimera and duplex NF-κB DNA-DNA. However, it was found that these differences do not prevent the duplex PNA-DNA chimera from binding to NF-κB transcription factors, being able to suppress the molecular interactions between HIV-1 LTR and p50, p52 and nuclear factors from B-lymphoid cells. Therefore, these results demonstrate that the designed NF-κB DNA-PNA chimeras could be used for a decoy approach in gene therapy.
Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites
| ▼ Gadd45 beta and its implication in chronic inflammation |
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Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
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Zanoli L, Dagata R, Spoto G
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
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Impact Factor: 3.446
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Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
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Impact Factor: 0.723
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
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Impact Factor: 1.844
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
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Impact Factor: 4.104
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
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Impact Factor: 3.19
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
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The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (431 views)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (538 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (249 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (650 views)
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Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (686 views)
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Impact Factor: 5.359
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (436 views)
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Impact Factor: 4.779
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
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Impact Factor: 1.826
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* Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer (2 views)
Chemistry (ISSN: 0947-6539linking), 2022 Jul 1; 28 (37 ): e202200693-N/D.
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Ayoub J, Buonanno M, Di Fiore A, De Simone G, Monti SM
* Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor (10 views)
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Impact Factor: 6.208
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Scognamiglio PL, Platella C, Napolitano E, Musumeci D, Roviello GN
* From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides (28 views)
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Impact Factor: 4.411
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Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A
* Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage (11 views)
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Impact Factor: 5.611
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Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
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Impact Factor: 2.74
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Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
* Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2, 1-i]purine Derivatives (98 views)
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Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
* Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates (182 views)
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Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (308 views) (PDF 55 views)
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (849 views)
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Impact Factor: 5.476
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (279 views)
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Impact Factor: 2.559
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (465 views)
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Impact Factor: 4.5
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Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (383 views)
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Impact Factor: 9.112
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Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
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Impact Factor: 5.001
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Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (358 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
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Impact Factor: 3.914
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Sorriento D, Illario M, Finelli R, Iaccarino G
* To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator (261 views)
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Impact Factor: 2.256
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
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Impact Factor: 3.914
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (519 views)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (529 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A, Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C
* Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation (401 views)
J Neurol Sci (ISSN: 0022-510x), 2010 Nov 15; 298(1-2): 121-123.
Impact Factor: 2.167
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Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S
* Multiple catalytically active thioredoxin folds: a winning strategy for many functions (725 views)
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-682x), 2010 Nov; 67(22): 3797-3814.
Impact Factor: 7.047
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
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Impact Factor: 4.106
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (422 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (611 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (301 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (425 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (522 views)
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Impact Factor: 5.155
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
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Impact Factor: 4.351
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (302 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (345 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (399 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (260 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
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Impact Factor: 3.446
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Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (240 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (493 views)
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Impact Factor: 1.801
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (603 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (431 views)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (538 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (249 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (650 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (686 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (436 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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60 Records (57 excluding Abstracts).
Total impact factor: 228.927 (220.698 excluding Abstracts).
Total 5 year impact factor: 214.603 (203.348 excluding Abstracts).
Total impact factor: 228.927 (220.698 excluding Abstracts).
Total 5 year impact factor: 214.603 (203.348 excluding Abstracts).
431 views. Last view on Saturday 18 March 2023, 13:32:28
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