Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.991, 5-year impact factor: 4.756
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80255132720&partnerID=40&md5=687f3b08e33f326422b4f968325a0153
Keywords: [ 18f]fedaa1106, Dosimetry, Translocator Protein, 18 Kda Translocator Protein, Fedaa 1106, Fluorine 18, Radioligand, Radiopharmaceutical Agent, Transcription Factor, Unclassified Drug, Adult, Article, Bladder, Brain, Clinical Assessment, Controlled Study, Dose Response, Drug Distribution, Female, Heart, Human, Human Experiment, Kidney, Liver, Normal Human, Radiation Detection, Radiation Dose, Salivary Gland, Small Intestine, Spleen, Stomach, Thyroid Gland, Time Series Analysis, Whole Body Pet, Acetamides, Positron-Emission Tomography, Radiation Dosage, Radiometry, Receptors, Whole Body Imaging, [18f] Fedaa1106,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
Department of Nuclear Medicine, Karolinska Institutet, Stockholm, Sweden
CDE Dosimetry Services, Inc., Knoxville, TN, United States
Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
Bayer Schering Pharma AG, Berlin, Germany
References:
Anholt, R.R.H., Pedersen, P.L., De Souza, E.B., Snyder, S.H., The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane (1986) Journal of Biological Chemistry, 261 (2), pp. 576-58
Anholt, R.R.H., Murphy, K.M.M., Mack, G.E., Snyder, S.H., Peripheral-type benzodiazepine receptors in the central nervous system: Localization to olfactory nerves (1984) Journal of Neuroscience, 4 (2), pp. 593-603
Benavides, J., Quarteronet, D., Imbault, F., Labeling of 'peripheral-type' benzodiazepine binding sites in the rat brain by using [ 3H]PK 11195, an isoquinoline carboxamide derivative: Kinetic studies and autoradiographic localization (1983) Journal of Neurochemistry, 41 (6), pp. 1744-1750
Cymerman, U., Pazos, A., Palacios, J.M., Evidence for species differences in 'peripheral' benzodiazepine receptors: An autoradiographic study (1986) Neuroscience Letters, 66 (2), pp. 153-158. , DOI 10.1016/0304-3940(86)90182-5
Jayakumar, A.R., Panickar, K.S., Norenberg, M.D., Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells (2002) Journal of Neurochemistry, 83 (5), pp. 1226-1234. , DOI 10.1046/j.1471-4159.2002.01261.x
Schoemaker, H., Boles, R.G., Horst, W.D., Yamamura, H.I., Specific high-affinity binding sites for [ 3H]Ro 5-4864 in rat brain and kidney (1983) Journal of Pharmacology and Experimental Therapeutics, 225 (1), pp. 61-69
Papadopoulos, V., Baraldi, M., Guilarte, T.R., Knudsen, T.B., Lacapere, J.-J., Lindemann, P., Norenberg, M.D., Gavish, M., Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function (2006) Trends in Pharmacological Sciences, 27 (8), pp. 402-409. , DOI 10.1016/j.tips.2006.06.005, PII S0165614706001532
Myers, R., Manjil, L.G., Cullen, B.M., Price, G.W., Frackowiak, R.S., Cremer, J.E., Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion (1991) J Cereb Blood Flow Metab, 11, pp. 314-322. , 1997503 10.1038/jcbfm.1991.64 1:CAS:528:DyaK3MXktVKgtr8%3D
Stephenson, D.T., Schober, D.A., Smalstig, E.B., Mincy, R.E., Gehlert, D.R., Clemens, J.A., Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat (1995) J Neurosci, 15, pp. 5263-5274. , 7623150 1:CAS:528:DyaK2MXmvFCrsLc%3D
Cagnin, A., Brooks, D.J., Kennedy, A.M., Gunn, R.N., Myers, R., Turkheimer, F.E., Jones, T., Banati, R.B., In-vivo measurement of activated microglia in dementia (2001) Lancet, 358 (9280), pp. 461-467. , DOI 10.1016/S0140-6736(01)05625-2
Goerres, G.W., Revesz, T., Duncan, J., Banati, R.B., Imaging cerebral vasculitis in refractory epilepsy using [ 11C](R)-PK11195 positron emission tomography (2001) American Journal of Roentgenology, 176 (4), pp. 1016-1018
Banati, R.B., Cagnin, A., Brooks, D.J., Gunn, R.N., Myers, R., Jones, T., Birch, R., Anand, P., Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury (2001) NeuroReport, 12 (16), pp. 3439-3442
Junck, L., Olson, J.M.M., Ciliax, B.J., Koeppe, R.A., Watkins, G.L., Jewett, D.M., McKeever, P.E., Young, A.B., PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site (1989) Annals of Neurology, 26 (6), pp. 752-758. , DOI 10.1002/ana.410260611
Pappata, S., Levasseur, M., Gunn, R.N., Myers, R., Crouzel, C., Syrota, A., Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK11195 (2000) Neurology, 55, pp. 1052-1054. , 11061271 1:STN:280:DC%2BD3crgvVyjtA%3D%3D
Roivainen, A., Någren, K., Hirvonen, J., Oikonen, V., Virsu, P., Tolvanen, T., Rinne, J.O., Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2- chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans
An imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography (2009) Eur J Nucl Med Mol Imaging, 36, pp. 671-682. , 19050880 10.1007/s00259-008-1000-1 1:CAS:528:DC%2BD1MXivVKgsbk%3D
Kropholler, M.A., Boellaard, R., Schuitemaker, A., Folkersma, H., Van Berckel, B.N.M., Lammertsma, A.A., Evaluation of reference tissue models for the analysis of [ 11C](R)-PK11195 studies (2006) Journal of Cerebral Blood Flow and Metabolism, 26 (11), pp. 1431-1441. , DOI 10.1038/sj.jcbfm.9600289, PII 9600289
Okuyama, S., Chaki, S., Yoshikawa, R., Ogawa, S.-I., Suzuki, Y., Okubo, T., Nakazato, A., Tomisawa, K., Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106 (1999) Life Sciences, 64 (16), pp. 1455-1464. , DOI 10.1016/S0024-3205(99)00079-X, PII S002432059900079X
Chaki, S., Funakoshi, T., Yoshikawa, R., Okuyama, S., Okubo, T., Nakazato, A., Nagamine, M., Tomisawa, K., Binding characteristics of [ 3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors (1999) European Journal of Pharmacology, 371 (2-3), pp. 197-204. , DOI 10.1016/S0014-2999(99)00118-1, PII S0014299999001181
Fujimura, Y., Ikoma, Y., Yasuno, F., Suhara, T., Ota, M., Matsumoto, R., Nozaki, S., Ito, H., Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain (2006) Journal of Nuclear Medicine, 47 (1), pp. 43-50
Maeda, J., Suhara, T., Zhang, M.-R., Okauchi, T., Yasuno, F., Ikoma, Y., Inaji, M., Suzuki, K., Novel Peripheral Benzodiazepine Receptor Ligand [ 11C]DAA1106 for PET: An Imaging Tool for Glial Cells in the Brain (2004) Synapse, 52 (4), pp. 283-291. , DOI 10.1002/syn.20027
Zhang, M.-R., Maeda, J., Furutsuka, K., Yoshida, Y., Ogawa, M., Suhara, T., Suzuki, K., [ 18F]FMDAA1106 and [ 18F]FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) (2003) Bioorganic and Medicinal Chemistry Letters, 13 (2), pp. 201-204. , DOI 10.1016/S0960-894X(02)00886-7, PII S0960894X02008867
Imaizumi, M., Kim, H.-J., Zoghbi, S.S., Briard, E., Hong, J., Musachio, J.L., Ruetzler, C., Fujita, M., PET imaging with [ 11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat (2007) Neuroscience Letters, 411 (3), pp. 200-205. , DOI 10.1016/j.neulet.2006.09.093, PII S0304394006009499
Imaizumi, M., Briard, E., Zoghbi, S.S., Gourley, J.P., Hong, J., Musachio, J.L., Gladding, R., Fujita, M., Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain (2007) Synapse, 61 (8), pp. 595-605. , DOI 10.1002/syn.20394
Zhang, M.-R., Tsuchiyama, A., Haradahira, T., Yoshida, Y., Furutsuka, K., Suzuki, K., Development of an automated system for synthesizing 18F- labeled compounds using [ 18F]fluoroethyl bromide as a synthetic precursor (2002) Applied Radiation and Isotopes, 57 (3), pp. 335-342. , DOI 10.1016/S0969-8043(02)00075-1, PII S0969804302000751
Siegel, J.A., Thomas, S.R., Stubbs, J.B., Stabin, M.G., Hays, M.T., Koral, K.F., Robertson, J.S., Brill, A.B., MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates (1999) Journal of Nuclear Medicine, 40 (2), pp. 37S-61S
(1981) ICRP Publication 30: Limits of Intakes of Radionuclides by Workers, p. 8. , International Commission on Radiological Protection Ann ICRP. Pergamon
ICRP publication 70: Basic anatomical and physiological data for use in radiological protection: The skeleton (1994) Ann ICRP. Pergamon, p. 25. , International Commission on Radiological Protection
Stabin, M.G., Sparks, R.B., Crowe, E., OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine (2005) Journal of Nuclear Medicine, 46 (6), pp. 1023-1027
(1975) ICRP Publication 23: Report of the Task Group on Reference Man, , International Commission on Radiological Protection Pergamon
Loevinger, R., Budinger, T.F., Watson, E.E., (1991) MIRD Primer for Absorbed Dose Calculations, , New York: Society of Nuclear Medicine
ICRP publication 60: Recommendations of the International Commission on Radiological Protection (1991) Ann ICRP. Pergamon, p. 21. , International Commission on Radiological Protection
Bribes, E., Carriere, D., Goubet, C., Galiegue, S., Casellas, P., Simony-Lafontaine, J., Immunohistochemical Assessment of the Peripheral Benzodiazepine Receptor in Human Tissues (2004) Journal of Histochemistry and Cytochemistry, 52 (1), pp. 19-28
Woods, M.J., Williams, D.C., Multiple forms and locations for the peripheral-type benzodiazepine receptor (1996) Biochemical Pharmacology, 52 (12), pp. 1805-1814. , DOI 10.1016/S0006-2952(96)00558-8, PII S0006295296005588
Hirvonen, J., Roivainen, A., Virta, J., Helin, S., Någren, K., Rinne, J.O., Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation (2010) Eur J Nucl Med Mol Imaging, 37, pp. 606-612. , 19862517 10.1007/s00259-009-1298-3 1:CAS:528:DC%2BC3cXhvFKgsbs%3D
Brown, A.K., Fujita, M., Fujimura, Y., Liow, J.-S., Stabin, M., Ryu, Y.H., Imaizumi, M., Innis, R.B., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: A PET radioligand to image inflammation (2007) Journal of Nuclear Medicine, 48 (12), pp. 2072-2079. , http://jnm.snmjournals.org/cgi/reprint/48/12/2072, DOI 10.2967/jnumed.107.044842
Kreisl, W.C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K.J., Kannan, P., Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker (2010) Neuroimage, 49, pp. 2924-2932. , 19948230 10.1016/j.neuroimage.2009.11.056 1:CAS:528:DC%2BC3cXktlSkt7k%3D
Owen, D.R., Howell, O.W., Tang, S.P., Wells, L.A., Bennacef, I., Bergstrom, M., Two binding sites for [3H]PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation (2010) J Cereb Blood Flow Metab, 30, pp. 1608-1618. , 20424634 10.1038/jcbfm.2010.63
Owen, D.R., Gunn, R.N., Rabiner, E.A., Bennacef, I., Fujita, M., Kreisl, W.C., Mixed-affinity binding in humans with 18-kDa translocator protein ligands (2011) J Nucl Med, 52, pp. 24-32. , 21149489 10.2967/jnumed.110.079459 1:CAS:528:DC%2BC3MXhtleis7s%3D
ICRP publication 80: Radiation dose to patients from radiopharmaceuticals (1998) Ann ICRP. Elsevier, p. 28. , International Commission on Radiological Protection
Mejia, A.A., Nakamura, T., Masatoshi, I., Hatazawa, J., Masaki, M., Watanuki, S., Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies (1991) J Nucl Med, 32, pp. 699-706. , 2013810 1:CAS:528:DyaK3MXkt1Gjurs%3D
Vesselle, H., Grierson, J., Peterson, L.M., Muzi, M., Mankoff, D.A., Krohn, K.A., 18F-fluorothymidine radiation dosimetry in human PET imaging studies (2003) Journal of Nuclear Medicine, 44 (9), pp. 1482-1488
Takano, A., Halldin, C., Varrone, A., Karlsson, P., Sjöholm, N., Stubbs, J.B., Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: A human whole-body PET study (2008) Eur J Nucl Med Mol Imaging, 35, pp. 630-636. , 18000665 10.1007/s00259-007-0622-z 1:CAS:528:DC%2BD1cXjvFOgt78%3D
ICRP publication 73: Radiological protection and safety in medicine (1996) Ann ICRP. Elsevier, p. 26. , International Commission on Radiological Protection
(1998) Guidance on Medical Exposures in Medical and Biomedical Research. Radiation Protection 99, , European Commission
Verbruggen, A., Coenen, H.H., Deverre, J.R., Guilloteau, D., Langstrom, B., Salvadori, P.A., Halldin, C., Guideline to regulations for radiopharmaceuticals in early phase clinical trials in the EU (2008) Eur J Nucl Med Mol Imaging, 35, pp. 2144-2151. , 18690437 10.1007/s00259-008-0853-7 1:CAS:528:DC%2BD1cXht1artLzJ
Anholt, R. R. H., Pedersen, P. L., De Souza, E. B., Snyder, S. H., The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane (1986) Journal of Biological Chemistry, 261 (2), pp. 576-58
Anholt, R. R. H., Murphy, K. M. M., Mack, G. E., Snyder, S. H., Peripheral-type benzodiazepine receptors in the central nervous system: Localization to olfactory nerves (1984) Journal of Neuroscience, 4 (2), pp. 593-603
Jayakumar, A. R., Panickar, K. S., Norenberg, M. D., Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells (2002) Journal of Neurochemistry, 83 (5), pp. 1226-1234. , DOI 10. 1046/j. 1471-4159. 2002. 01261. x
Stephenson, D. T., Schober, D. A., Smalstig, E. B., Mincy, R. E., Gehlert, D. R., Clemens, J. A., Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat (1995) J Neurosci, 15, pp. 5263-5274. , 7623150 1: CAS: 528: DyaK2MXmvFCrsLc%3D
Goerres, G. W., Revesz, T., Duncan, J., Banati, R. B., Imaging cerebral vasculitis in refractory epilepsy using [11C] (R) -PK11195 positron emission tomography (2001) American Journal of Roentgenology, 176 (4), pp. 1016-1018
Banati, R. B., Cagnin, A., Brooks, D. J., Gunn, R. N., Myers, R., Jones, T., Birch, R., Anand, P., Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury (2001) NeuroReport, 12 (16), pp. 3439-3442
Roivainen, A., N gren, K., Hirvonen, J., Oikonen, V., Virsu, P., Tolvanen, T., Rinne, J. O., Whole-body distribution and metabolism of [N-methyl-11C] (R) -1- (2- chlorophenyl) -N- (1-methylpropyl) -3-isoquinolinecarboxamide in humans
Kropholler, M. A., Boellaard, R., Schuitemaker, A., Folkersma, H., Van Berckel, B. N. M., Lammertsma, A. A., Evaluation of reference tissue models for the analysis of [11C] (R) -PK11195 studies (2006) Journal of Cerebral Blood Flow and Metabolism, 26 (11), pp. 1431-1441. , DOI 10. 1038/sj. jcbfm. 9600289, PII 9600289
Zhang, M. -R., Maeda, J., Furutsuka, K., Yoshida, Y., Ogawa, M., Suhara, T., Suzuki, K., [18F] FMDAA1106 and [18F] FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) (2003) Bioorganic and Medicinal Chemistry Letters, 13 (2), pp. 201-204. , DOI 10. 1016/S0960-894X (02) 00886-7, PII S0960894X02008867
Zhang, M. -R., Tsuchiyama, A., Haradahira, T., Yoshida, Y., Furutsuka, K., Suzuki, K., Development of an automated system for synthesizing 18F- labeled compounds using [18F] fluoroethyl bromide as a synthetic precursor (2002) Applied Radiation and Isotopes, 57 (3), pp. 335-342. , DOI 10. 1016/S0969-8043 (02) 00075-1, PII S0969804302000751
Siegel, J. A., Thomas, S. R., Stubbs, J. B., Stabin, M. G., Hays, M. T., Koral, K. F., Robertson, J. S., Brill, A. B., MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates (1999) Journal of Nuclear Medicine, 40 (2), pp. 37S-61S
(1981) ICRP Publication 30: Limits of Intakes of Radionuclides by Workers, p. 8. , International Commission on Radiological Protection Ann ICRP. Pergamon
Stabin, M. G., Sparks, R. B., Crowe, E., OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine (2005) Journal of Nuclear Medicine, 46 (6), pp. 1023-1027
(1975) ICRP Publication 23: Report of the Task Group on Reference Man, , International Commission on Radiological Protection Pergamon
Woods, M. J., Williams, D. C., Multiple forms and locations for the peripheral-type benzodiazepine receptor (1996) Biochemical Pharmacology, 52 (12), pp. 1805-1814. , DOI 10. 1016/S0006-2952 (96) 00558-8, PII S0006295296005588
Brown, A. K., Fujita, M., Fujimura, Y., Liow, J. -S., Stabin, M., Ryu, Y. H., Imaizumi, M., Innis, R. B., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: A PET radioligand to image inflammation (2007) Journal of Nuclear Medicine, 48 (12), pp. 2072-2079. , http: //jnm. snmjournals. org/cgi/reprint/48/12/2072, DOI 10. 2967/jnumed. 107. 044842
Kreisl, W. C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K. J., Kannan, P., Comparison of [(11) C] - (R) -PK 11195 and [(11) C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker (2010) Neuroimage, 49, pp. 2924-2932. , 19948230 10. 1016/j. neuroimage. 2009. 11. 056 1: CAS: 528: DC%2BC3cXktlSkt7k%3D
Owen, D. R., Howell, O. W., Tang, S. P., Wells, L. A., Bennacef, I., Bergstrom, M., Two binding sites for [3H] PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation (2010) J Cereb Blood Flow Metab, 30, pp. 1608-1618. , 20424634 10. 1038/jcbfm. 2010. 63
Owen, D. R., Gunn, R. N., Rabiner, E. A., Bennacef, I., Fujita, M., Kreisl, W. C., Mixed-affinity binding in humans with 18-kDa translocator protein ligands (2011) J Nucl Med, 52, pp. 24-32. , 21149489 10. 2967/jnumed. 110. 079459 1: CAS: 528: DC%2BC3MXhtleis7s%3D
Mejia, A. A., Nakamura, T., Masatoshi, I., Hatazawa, J., Masaki, M., Watanuki, S., Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies (1991) J Nucl Med, 32, pp. 699-706. , 2013810 1: CAS: 528: DyaK3MXkt1Gjurs%3D
(1998) Guidance on Medical Exposures in Medical and Biomedical Research. Radiation Protection 99, , European Commission
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.991, 5-year impact factor: 4.756
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80255132720&partnerID=40&md5=687f3b08e33f326422b4f968325a0153
Keywords: [ 18f]fedaa1106, Dosimetry, Translocator Protein, 18 Kda Translocator Protein, Fedaa 1106, Fluorine 18, Radioligand, Radiopharmaceutical Agent, Transcription Factor, Unclassified Drug, Adult, Article, Bladder, Brain, Clinical Assessment, Controlled Study, Dose Response, Drug Distribution, Female, Heart, Human, Human Experiment, Kidney, Liver, Normal Human, Radiation Detection, Radiation Dose, Salivary Gland, Small Intestine, Spleen, Stomach, Thyroid Gland, Time Series Analysis, Whole Body Pet, Acetamides, Positron-Emission Tomography, Radiation Dosage, Radiometry, Receptors, Whole Body Imaging, [18f] Fedaa1106,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
Department of Nuclear Medicine, Karolinska Institutet, Stockholm, Sweden
CDE Dosimetry Services, Inc., Knoxville, TN, United States
Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
Bayer Schering Pharma AG, Berlin, Germany
References:
Anholt, R.R.H., Pedersen, P.L., De Souza, E.B., Snyder, S.H., The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane (1986) Journal of Biological Chemistry, 261 (2), pp. 576-58
Anholt, R.R.H., Murphy, K.M.M., Mack, G.E., Snyder, S.H., Peripheral-type benzodiazepine receptors in the central nervous system: Localization to olfactory nerves (1984) Journal of Neuroscience, 4 (2), pp. 593-603
Benavides, J., Quarteronet, D., Imbault, F., Labeling of 'peripheral-type' benzodiazepine binding sites in the rat brain by using [ 3H]PK 11195, an isoquinoline carboxamide derivative: Kinetic studies and autoradiographic localization (1983) Journal of Neurochemistry, 41 (6), pp. 1744-1750
Cymerman, U., Pazos, A., Palacios, J.M., Evidence for species differences in 'peripheral' benzodiazepine receptors: An autoradiographic study (1986) Neuroscience Letters, 66 (2), pp. 153-158. , DOI 10.1016/0304-3940(86)90182-5
Jayakumar, A.R., Panickar, K.S., Norenberg, M.D., Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells (2002) Journal of Neurochemistry, 83 (5), pp. 1226-1234. , DOI 10.1046/j.1471-4159.2002.01261.x
Schoemaker, H., Boles, R.G., Horst, W.D., Yamamura, H.I., Specific high-affinity binding sites for [ 3H]Ro 5-4864 in rat brain and kidney (1983) Journal of Pharmacology and Experimental Therapeutics, 225 (1), pp. 61-69
Papadopoulos, V., Baraldi, M., Guilarte, T.R., Knudsen, T.B., Lacapere, J.-J., Lindemann, P., Norenberg, M.D., Gavish, M., Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function (2006) Trends in Pharmacological Sciences, 27 (8), pp. 402-409. , DOI 10.1016/j.tips.2006.06.005, PII S0165614706001532
Myers, R., Manjil, L.G., Cullen, B.M., Price, G.W., Frackowiak, R.S., Cremer, J.E., Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion (1991) J Cereb Blood Flow Metab, 11, pp. 314-322. , 1997503 10.1038/jcbfm.1991.64 1:CAS:528:DyaK3MXktVKgtr8%3D
Stephenson, D.T., Schober, D.A., Smalstig, E.B., Mincy, R.E., Gehlert, D.R., Clemens, J.A., Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat (1995) J Neurosci, 15, pp. 5263-5274. , 7623150 1:CAS:528:DyaK2MXmvFCrsLc%3D
Cagnin, A., Brooks, D.J., Kennedy, A.M., Gunn, R.N., Myers, R., Turkheimer, F.E., Jones, T., Banati, R.B., In-vivo measurement of activated microglia in dementia (2001) Lancet, 358 (9280), pp. 461-467. , DOI 10.1016/S0140-6736(01)05625-2
Goerres, G.W., Revesz, T., Duncan, J., Banati, R.B., Imaging cerebral vasculitis in refractory epilepsy using [ 11C](R)-PK11195 positron emission tomography (2001) American Journal of Roentgenology, 176 (4), pp. 1016-1018
Banati, R.B., Cagnin, A., Brooks, D.J., Gunn, R.N., Myers, R., Jones, T., Birch, R., Anand, P., Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury (2001) NeuroReport, 12 (16), pp. 3439-3442
Junck, L., Olson, J.M.M., Ciliax, B.J., Koeppe, R.A., Watkins, G.L., Jewett, D.M., McKeever, P.E., Young, A.B., PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site (1989) Annals of Neurology, 26 (6), pp. 752-758. , DOI 10.1002/ana.410260611
Pappata, S., Levasseur, M., Gunn, R.N., Myers, R., Crouzel, C., Syrota, A., Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK11195 (2000) Neurology, 55, pp. 1052-1054. , 11061271 1:STN:280:DC%2BD3crgvVyjtA%3D%3D
Roivainen, A., Någren, K., Hirvonen, J., Oikonen, V., Virsu, P., Tolvanen, T., Rinne, J.O., Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2- chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans
An imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography (2009) Eur J Nucl Med Mol Imaging, 36, pp. 671-682. , 19050880 10.1007/s00259-008-1000-1 1:CAS:528:DC%2BD1MXivVKgsbk%3D
Kropholler, M.A., Boellaard, R., Schuitemaker, A., Folkersma, H., Van Berckel, B.N.M., Lammertsma, A.A., Evaluation of reference tissue models for the analysis of [ 11C](R)-PK11195 studies (2006) Journal of Cerebral Blood Flow and Metabolism, 26 (11), pp. 1431-1441. , DOI 10.1038/sj.jcbfm.9600289, PII 9600289
Okuyama, S., Chaki, S., Yoshikawa, R., Ogawa, S.-I., Suzuki, Y., Okubo, T., Nakazato, A., Tomisawa, K., Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106 (1999) Life Sciences, 64 (16), pp. 1455-1464. , DOI 10.1016/S0024-3205(99)00079-X, PII S002432059900079X
Chaki, S., Funakoshi, T., Yoshikawa, R., Okuyama, S., Okubo, T., Nakazato, A., Nagamine, M., Tomisawa, K., Binding characteristics of [ 3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors (1999) European Journal of Pharmacology, 371 (2-3), pp. 197-204. , DOI 10.1016/S0014-2999(99)00118-1, PII S0014299999001181
Fujimura, Y., Ikoma, Y., Yasuno, F., Suhara, T., Ota, M., Matsumoto, R., Nozaki, S., Ito, H., Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain (2006) Journal of Nuclear Medicine, 47 (1), pp. 43-50
Maeda, J., Suhara, T., Zhang, M.-R., Okauchi, T., Yasuno, F., Ikoma, Y., Inaji, M., Suzuki, K., Novel Peripheral Benzodiazepine Receptor Ligand [ 11C]DAA1106 for PET: An Imaging Tool for Glial Cells in the Brain (2004) Synapse, 52 (4), pp. 283-291. , DOI 10.1002/syn.20027
Zhang, M.-R., Maeda, J., Furutsuka, K., Yoshida, Y., Ogawa, M., Suhara, T., Suzuki, K., [ 18F]FMDAA1106 and [ 18F]FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) (2003) Bioorganic and Medicinal Chemistry Letters, 13 (2), pp. 201-204. , DOI 10.1016/S0960-894X(02)00886-7, PII S0960894X02008867
Imaizumi, M., Kim, H.-J., Zoghbi, S.S., Briard, E., Hong, J., Musachio, J.L., Ruetzler, C., Fujita, M., PET imaging with [ 11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat (2007) Neuroscience Letters, 411 (3), pp. 200-205. , DOI 10.1016/j.neulet.2006.09.093, PII S0304394006009499
Imaizumi, M., Briard, E., Zoghbi, S.S., Gourley, J.P., Hong, J., Musachio, J.L., Gladding, R., Fujita, M., Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain (2007) Synapse, 61 (8), pp. 595-605. , DOI 10.1002/syn.20394
Zhang, M.-R., Tsuchiyama, A., Haradahira, T., Yoshida, Y., Furutsuka, K., Suzuki, K., Development of an automated system for synthesizing 18F- labeled compounds using [ 18F]fluoroethyl bromide as a synthetic precursor (2002) Applied Radiation and Isotopes, 57 (3), pp. 335-342. , DOI 10.1016/S0969-8043(02)00075-1, PII S0969804302000751
Siegel, J.A., Thomas, S.R., Stubbs, J.B., Stabin, M.G., Hays, M.T., Koral, K.F., Robertson, J.S., Brill, A.B., MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates (1999) Journal of Nuclear Medicine, 40 (2), pp. 37S-61S
(1981) ICRP Publication 30: Limits of Intakes of Radionuclides by Workers, p. 8. , International Commission on Radiological Protection Ann ICRP. Pergamon
ICRP publication 70: Basic anatomical and physiological data for use in radiological protection: The skeleton (1994) Ann ICRP. Pergamon, p. 25. , International Commission on Radiological Protection
Stabin, M.G., Sparks, R.B., Crowe, E., OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine (2005) Journal of Nuclear Medicine, 46 (6), pp. 1023-1027
(1975) ICRP Publication 23: Report of the Task Group on Reference Man, , International Commission on Radiological Protection Pergamon
Loevinger, R., Budinger, T.F., Watson, E.E., (1991) MIRD Primer for Absorbed Dose Calculations, , New York: Society of Nuclear Medicine
ICRP publication 60: Recommendations of the International Commission on Radiological Protection (1991) Ann ICRP. Pergamon, p. 21. , International Commission on Radiological Protection
Bribes, E., Carriere, D., Goubet, C., Galiegue, S., Casellas, P., Simony-Lafontaine, J., Immunohistochemical Assessment of the Peripheral Benzodiazepine Receptor in Human Tissues (2004) Journal of Histochemistry and Cytochemistry, 52 (1), pp. 19-28
Woods, M.J., Williams, D.C., Multiple forms and locations for the peripheral-type benzodiazepine receptor (1996) Biochemical Pharmacology, 52 (12), pp. 1805-1814. , DOI 10.1016/S0006-2952(96)00558-8, PII S0006295296005588
Hirvonen, J., Roivainen, A., Virta, J., Helin, S., Någren, K., Rinne, J.O., Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation (2010) Eur J Nucl Med Mol Imaging, 37, pp. 606-612. , 19862517 10.1007/s00259-009-1298-3 1:CAS:528:DC%2BC3cXhvFKgsbs%3D
Brown, A.K., Fujita, M., Fujimura, Y., Liow, J.-S., Stabin, M., Ryu, Y.H., Imaizumi, M., Innis, R.B., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: A PET radioligand to image inflammation (2007) Journal of Nuclear Medicine, 48 (12), pp. 2072-2079. , http://jnm.snmjournals.org/cgi/reprint/48/12/2072, DOI 10.2967/jnumed.107.044842
Kreisl, W.C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K.J., Kannan, P., Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker (2010) Neuroimage, 49, pp. 2924-2932. , 19948230 10.1016/j.neuroimage.2009.11.056 1:CAS:528:DC%2BC3cXktlSkt7k%3D
Owen, D.R., Howell, O.W., Tang, S.P., Wells, L.A., Bennacef, I., Bergstrom, M., Two binding sites for [3H]PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation (2010) J Cereb Blood Flow Metab, 30, pp. 1608-1618. , 20424634 10.1038/jcbfm.2010.63
Owen, D.R., Gunn, R.N., Rabiner, E.A., Bennacef, I., Fujita, M., Kreisl, W.C., Mixed-affinity binding in humans with 18-kDa translocator protein ligands (2011) J Nucl Med, 52, pp. 24-32. , 21149489 10.2967/jnumed.110.079459 1:CAS:528:DC%2BC3MXhtleis7s%3D
ICRP publication 80: Radiation dose to patients from radiopharmaceuticals (1998) Ann ICRP. Elsevier, p. 28. , International Commission on Radiological Protection
Mejia, A.A., Nakamura, T., Masatoshi, I., Hatazawa, J., Masaki, M., Watanuki, S., Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies (1991) J Nucl Med, 32, pp. 699-706. , 2013810 1:CAS:528:DyaK3MXkt1Gjurs%3D
Vesselle, H., Grierson, J., Peterson, L.M., Muzi, M., Mankoff, D.A., Krohn, K.A., 18F-fluorothymidine radiation dosimetry in human PET imaging studies (2003) Journal of Nuclear Medicine, 44 (9), pp. 1482-1488
Takano, A., Halldin, C., Varrone, A., Karlsson, P., Sjöholm, N., Stubbs, J.B., Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: A human whole-body PET study (2008) Eur J Nucl Med Mol Imaging, 35, pp. 630-636. , 18000665 10.1007/s00259-007-0622-z 1:CAS:528:DC%2BD1cXjvFOgt78%3D
ICRP publication 73: Radiological protection and safety in medicine (1996) Ann ICRP. Elsevier, p. 26. , International Commission on Radiological Protection
(1998) Guidance on Medical Exposures in Medical and Biomedical Research. Radiation Protection 99, , European Commission
Verbruggen, A., Coenen, H.H., Deverre, J.R., Guilloteau, D., Langstrom, B., Salvadori, P.A., Halldin, C., Guideline to regulations for radiopharmaceuticals in early phase clinical trials in the EU (2008) Eur J Nucl Med Mol Imaging, 35, pp. 2144-2151. , 18690437 10.1007/s00259-008-0853-7 1:CAS:528:DC%2BD1cXht1artLzJ
Anholt, R. R. H., Pedersen, P. L., De Souza, E. B., Snyder, S. H., The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane (1986) Journal of Biological Chemistry, 261 (2), pp. 576-58
Anholt, R. R. H., Murphy, K. M. M., Mack, G. E., Snyder, S. H., Peripheral-type benzodiazepine receptors in the central nervous system: Localization to olfactory nerves (1984) Journal of Neuroscience, 4 (2), pp. 593-603
Jayakumar, A. R., Panickar, K. S., Norenberg, M. D., Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells (2002) Journal of Neurochemistry, 83 (5), pp. 1226-1234. , DOI 10. 1046/j. 1471-4159. 2002. 01261. x
Stephenson, D. T., Schober, D. A., Smalstig, E. B., Mincy, R. E., Gehlert, D. R., Clemens, J. A., Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat (1995) J Neurosci, 15, pp. 5263-5274. , 7623150 1: CAS: 528: DyaK2MXmvFCrsLc%3D
Goerres, G. W., Revesz, T., Duncan, J., Banati, R. B., Imaging cerebral vasculitis in refractory epilepsy using [11C] (R) -PK11195 positron emission tomography (2001) American Journal of Roentgenology, 176 (4), pp. 1016-1018
Banati, R. B., Cagnin, A., Brooks, D. J., Gunn, R. N., Myers, R., Jones, T., Birch, R., Anand, P., Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury (2001) NeuroReport, 12 (16), pp. 3439-3442
Roivainen, A., N gren, K., Hirvonen, J., Oikonen, V., Virsu, P., Tolvanen, T., Rinne, J. O., Whole-body distribution and metabolism of [N-methyl-11C] (R) -1- (2- chlorophenyl) -N- (1-methylpropyl) -3-isoquinolinecarboxamide in humans
Kropholler, M. A., Boellaard, R., Schuitemaker, A., Folkersma, H., Van Berckel, B. N. M., Lammertsma, A. A., Evaluation of reference tissue models for the analysis of [11C] (R) -PK11195 studies (2006) Journal of Cerebral Blood Flow and Metabolism, 26 (11), pp. 1431-1441. , DOI 10. 1038/sj. jcbfm. 9600289, PII 9600289
Zhang, M. -R., Maeda, J., Furutsuka, K., Yoshida, Y., Ogawa, M., Suhara, T., Suzuki, K., [18F] FMDAA1106 and [18F] FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) (2003) Bioorganic and Medicinal Chemistry Letters, 13 (2), pp. 201-204. , DOI 10. 1016/S0960-894X (02) 00886-7, PII S0960894X02008867
Zhang, M. -R., Tsuchiyama, A., Haradahira, T., Yoshida, Y., Furutsuka, K., Suzuki, K., Development of an automated system for synthesizing 18F- labeled compounds using [18F] fluoroethyl bromide as a synthetic precursor (2002) Applied Radiation and Isotopes, 57 (3), pp. 335-342. , DOI 10. 1016/S0969-8043 (02) 00075-1, PII S0969804302000751
Siegel, J. A., Thomas, S. R., Stubbs, J. B., Stabin, M. G., Hays, M. T., Koral, K. F., Robertson, J. S., Brill, A. B., MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates (1999) Journal of Nuclear Medicine, 40 (2), pp. 37S-61S
(1981) ICRP Publication 30: Limits of Intakes of Radionuclides by Workers, p. 8. , International Commission on Radiological Protection Ann ICRP. Pergamon
Stabin, M. G., Sparks, R. B., Crowe, E., OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine (2005) Journal of Nuclear Medicine, 46 (6), pp. 1023-1027
(1975) ICRP Publication 23: Report of the Task Group on Reference Man, , International Commission on Radiological Protection Pergamon
Woods, M. J., Williams, D. C., Multiple forms and locations for the peripheral-type benzodiazepine receptor (1996) Biochemical Pharmacology, 52 (12), pp. 1805-1814. , DOI 10. 1016/S0006-2952 (96) 00558-8, PII S0006295296005588
Brown, A. K., Fujita, M., Fujimura, Y., Liow, J. -S., Stabin, M., Ryu, Y. H., Imaizumi, M., Innis, R. B., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: A PET radioligand to image inflammation (2007) Journal of Nuclear Medicine, 48 (12), pp. 2072-2079. , http: //jnm. snmjournals. org/cgi/reprint/48/12/2072, DOI 10. 2967/jnumed. 107. 044842
Kreisl, W. C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K. J., Kannan, P., Comparison of [(11) C] - (R) -PK 11195 and [(11) C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker (2010) Neuroimage, 49, pp. 2924-2932. , 19948230 10. 1016/j. neuroimage. 2009. 11. 056 1: CAS: 528: DC%2BC3cXktlSkt7k%3D
Owen, D. R., Howell, O. W., Tang, S. P., Wells, L. A., Bennacef, I., Bergstrom, M., Two binding sites for [3H] PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation (2010) J Cereb Blood Flow Metab, 30, pp. 1608-1618. , 20424634 10. 1038/jcbfm. 2010. 63
Owen, D. R., Gunn, R. N., Rabiner, E. A., Bennacef, I., Fujita, M., Kreisl, W. C., Mixed-affinity binding in humans with 18-kDa translocator protein ligands (2011) J Nucl Med, 52, pp. 24-32. , 21149489 10. 2967/jnumed. 110. 079459 1: CAS: 528: DC%2BC3MXhtleis7s%3D
Mejia, A. A., Nakamura, T., Masatoshi, I., Hatazawa, J., Masaki, M., Watanuki, S., Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies (1991) J Nucl Med, 32, pp. 699-706. , 2013810 1: CAS: 528: DyaK3MXkt1Gjurs%3D
(1998) Guidance on Medical Exposures in Medical and Biomedical Research. Radiation Protection 99, , European Commission
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
Purpose: [ 18F]FEDAA1106 is a recently developed positron emission tomography (PET) radioligand for in vivo quantification of the 18 kDa translocator protein [TSPO or, as earlier called, the peripheral benzodiazepine receptor (PBR)]. TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [ 18F]FEDAA1106 based on human whole-body PET measurements. Methods: PET scans were performed for a total of 6.6 h after the injection of 183.8 ± 9.1 MBq of [ 18F]FEDAA1106 in six healthy subjects. Regions of interest were drawn on coronal images. Estimates of the absorbed doses of radiation were calculated using the OLINDA software. Results: Peak uptake was largest in lungs, followed by liver, small intestine, kidney, spleen and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lungs (27.1%ID at 0.2 h), liver (21.1%ID at 0.6 h), small intestine (10.4%ID at 6.3 h), kidney (4.9%ID at 1.8 h) and spleen (4.6%ID at 0.6 h). The largest absorbed dose was found in the spleen (0.12 mSv/MBq), followed by kidneys (0.094 mSv/MBq). The calculated mean effective dose was 0.036 mSv/MBq. Conclusion: Based on the distribution and dose estimates, the estimated radiation burden of [ 18F]FEDAA1106 is moderately higher than that of [ 18F]fluorodeoxyglucose (FDG). In clinical studies, the administered activity of this radioligand ought to be adjusted in line with regional regulations. This result would be helpful for further clinical TSPO imaging studies. © 2011 Springer-Verlag.
Purpose: [ 18F]FEDAA1106 is a recently developed positron emission tomography (PET) radioligand for in vivo quantification of the 18 kDa translocator protein [TSPO or, as earlier called, the peripheral benzodiazepine receptor (PBR)]. TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [ 18F]FEDAA1106 based on human whole-body PET measurements. Methods: PET scans were performed for a total of 6.6 h after the injection of 183.8 ± 9.1 MBq of [ 18F]FEDAA1106 in six healthy subjects. Regions of interest were drawn on coronal images. Estimates of the absorbed doses of radiation were calculated using the OLINDA software. Results: Peak uptake was largest in lungs, followed by liver, small intestine, kidney, spleen and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lungs (27.1%ID at 0.2 h), liver (21.1%ID at 0.6 h), small intestine (10.4%ID at 6.3 h), kidney (4.9%ID at 1.8 h) and spleen (4.6%ID at 0.6 h). The largest absorbed dose was found in the spleen (0.12 mSv/MBq), followed by kidneys (0.094 mSv/MBq). The calculated mean effective dose was 0.036 mSv/MBq. Conclusion: Based on the distribution and dose estimates, the estimated radiation burden of [ 18F]FEDAA1106 is moderately higher than that of [ 18F]fluorodeoxyglucose (FDG). In clinical studies, the administered activity of this radioligand ought to be adjusted in line with regional regulations. This result would be helpful for further clinical TSPO imaging studies. © 2011 Springer-Verlag.
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
No results. |
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
Other filter: ([btitle,keywords] "[ 18f]fedaa1106" OR ...
Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (862 views) (PDF 304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
View Export to BibTeX Export to EndNote
Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (736 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
View Export to BibTeX Export to EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (301 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (525 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (269 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (321 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
View Export to BibTeX Export to EndNote
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (862 views) (PDF 304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
View Export to BibTeX Export to EndNote
Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (736 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
View Export to BibTeX Export to EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (301 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (525 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (269 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (321 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
View Export to BibTeX Export to EndNote
9 Records (8 excluding Abstracts).
Total impact factor: 36.655 (34.247 excluding Abstracts).
Total 5 year impact factor: 40.658 (38.2 excluding Abstracts).
Total impact factor: 36.655 (34.247 excluding Abstracts).
Total 5 year impact factor: 40.658 (38.2 excluding Abstracts).
419 views. Last view on Saturday 14 January 2023, 19:55:27
ibb.cnr.it
