Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study(419 views) Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
Keywords: [ 18f]fedaa1106, Dosimetry, Translocator Protein, 18 Kda Translocator Protein, Fedaa 1106, Fluorine 18, Radioligand, Radiopharmaceutical Agent, Transcription Factor, Unclassified Drug, Adult, Article, Bladder, Brain, Clinical Assessment, Controlled Study, Dose Response, Drug Distribution, Female, Heart, Human, Human Experiment, Kidney, Liver, Normal Human, Radiation Detection, Radiation Dose, Salivary Gland, Small Intestine, Spleen, Stomach, Thyroid Gland, Time Series Analysis, Whole Body Pet, Acetamides, Positron-Emission Tomography, Radiation Dosage, Radiometry, Receptors, Whole Body Imaging, [18f] Fedaa1106,
Affiliations: *** IBB - CNR ***
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
Department of Nuclear Medicine, Karolinska Institutet, Stockholm, Sweden
CDE Dosimetry Services, Inc., Knoxville, TN, United States
Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
Bayer Schering Pharma AG, Berlin, Germany
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Goerres, G. W., Revesz, T., Duncan, J., Banati, R. B., Imaging cerebral vasculitis in refractory epilepsy using [11C] (R) -PK11195 positron emission tomography (2001) American Journal of Roentgenology, 176 (4), pp. 1016-1018
Banati, R. B., Cagnin, A., Brooks, D. J., Gunn, R. N., Myers, R., Jones, T., Birch, R., Anand, P., Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury (2001) NeuroReport, 12 (16), pp. 3439-3442
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Kropholler, M. A., Boellaard, R., Schuitemaker, A., Folkersma, H., Van Berckel, B. N. M., Lammertsma, A. A., Evaluation of reference tissue models for the analysis of [11C] (R) -PK11195 studies (2006) Journal of Cerebral Blood Flow and Metabolism, 26 (11), pp. 1431-1441. , DOI 10. 1038/sj. jcbfm. 9600289, PII 9600289
Zhang, M. -R., Maeda, J., Furutsuka, K., Yoshida, Y., Ogawa, M., Suhara, T., Suzuki, K., [18F] FMDAA1106 and [18F] FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) (2003) Bioorganic and Medicinal Chemistry Letters, 13 (2), pp. 201-204. , DOI 10. 1016/S0960-894X (02) 00886-7, PII S0960894X02008867
Zhang, M. -R., Tsuchiyama, A., Haradahira, T., Yoshida, Y., Furutsuka, K., Suzuki, K., Development of an automated system for synthesizing 18F- labeled compounds using [18F] fluoroethyl bromide as a synthetic precursor (2002) Applied Radiation and Isotopes, 57 (3), pp. 335-342. , DOI 10. 1016/S0969-8043 (02) 00075-1, PII S0969804302000751
Siegel, J. A., Thomas, S. R., Stubbs, J. B., Stabin, M. G., Hays, M. T., Koral, K. F., Robertson, J. S., Brill, A. B., MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates (1999) Journal of Nuclear Medicine, 40 (2), pp. 37S-61S
(1981) ICRP Publication 30: Limits of Intakes of Radionuclides by Workers, p. 8. , International Commission on Radiological Protection Ann ICRP. Pergamon
Stabin, M. G., Sparks, R. B., Crowe, E., OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine (2005) Journal of Nuclear Medicine, 46 (6), pp. 1023-1027
(1975) ICRP Publication 23: Report of the Task Group on Reference Man, , International Commission on Radiological Protection Pergamon
Woods, M. J., Williams, D. C., Multiple forms and locations for the peripheral-type benzodiazepine receptor (1996) Biochemical Pharmacology, 52 (12), pp. 1805-1814. , DOI 10. 1016/S0006-2952 (96) 00558-8, PII S0006295296005588
Brown, A. K., Fujita, M., Fujimura, Y., Liow, J. -S., Stabin, M., Ryu, Y. H., Imaizumi, M., Innis, R. B., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: A PET radioligand to image inflammation (2007) Journal of Nuclear Medicine, 48 (12), pp. 2072-2079. , http: //jnm. snmjournals. org/cgi/reprint/48/12/2072, DOI 10. 2967/jnumed. 107. 044842
Kreisl, W. C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K. J., Kannan, P., Comparison of [(11) C] - (R) -PK 11195 and [(11) C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker (2010) Neuroimage, 49, pp. 2924-2932. , 19948230 10. 1016/j. neuroimage. 2009. 11. 056 1: CAS: 528: DC%2BC3cXktlSkt7k%3D
Owen, D. R., Howell, O. W., Tang, S. P., Wells, L. A., Bennacef, I., Bergstrom, M., Two binding sites for [3H] PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation (2010) J Cereb Blood Flow Metab, 30, pp. 1608-1618. , 20424634 10. 1038/jcbfm. 2010. 63
Owen, D. R., Gunn, R. N., Rabiner, E. A., Bennacef, I., Fujita, M., Kreisl, W. C., Mixed-affinity binding in humans with 18-kDa translocator protein ligands (2011) J Nucl Med, 52, pp. 24-32. , 21149489 10. 2967/jnumed. 110. 079459 1: CAS: 528: DC%2BC3MXhtleis7s%3D
Mejia, A. A., Nakamura, T., Masatoshi, I., Hatazawa, J., Masaki, M., Watanuki, S., Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies (1991) J Nucl Med, 32, pp. 699-706. , 2013810 1: CAS: 528: DyaK3MXkt1Gjurs%3D
(1998) Guidance on Medical Exposures in Medical and Biomedical Research. Radiation Protection 99, , European Commission
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study