Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (503 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
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Paper type: Journal Article,
Impact factor: 4.991, 5-year impact factor: 4.756
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80255132720&partnerID=40&md5=687f3b08e33f326422b4f968325a0153
Keywords: [ 18f]fedaa1106, Dosimetry, Translocator Protein, 18 Kda Translocator Protein, Fedaa 1106, Fluorine 18, Radioligand, Radiopharmaceutical Agent, Transcription Factor, Unclassified Drug, Adult, Article, Bladder, Brain, Clinical Assessment, Controlled Study, Dose Response, Drug Distribution, Female, Heart, Human, Human Experiment, Kidney, Liver, Normal Human, Radiation Detection, Radiation Dose, Salivary Gland, Small Intestine, Spleen, Stomach, Thyroid Gland, Time Series Analysis, Whole Body Pet, Acetamides, Positron-Emission Tomography, Radiation Dosage, Radiometry, Receptors, Whole Body Imaging, [18f] Fedaa1106,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
Department of Nuclear Medicine, Karolinska Institutet, Stockholm, Sweden
CDE Dosimetry Services, Inc., Knoxville, TN, United States
Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
Bayer Schering Pharma AG, Berlin, Germany
References:
Not available.
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.991, 5-year impact factor: 4.756
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80255132720&partnerID=40&md5=687f3b08e33f326422b4f968325a0153
Keywords: [ 18f]fedaa1106, Dosimetry, Translocator Protein, 18 Kda Translocator Protein, Fedaa 1106, Fluorine 18, Radioligand, Radiopharmaceutical Agent, Transcription Factor, Unclassified Drug, Adult, Article, Bladder, Brain, Clinical Assessment, Controlled Study, Dose Response, Drug Distribution, Female, Heart, Human, Human Experiment, Kidney, Liver, Normal Human, Radiation Detection, Radiation Dose, Salivary Gland, Small Intestine, Spleen, Stomach, Thyroid Gland, Time Series Analysis, Whole Body Pet, Acetamides, Positron-Emission Tomography, Radiation Dosage, Radiometry, Receptors, Whole Body Imaging, [18f] Fedaa1106,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm 171 76, Sweden
Department of Nuclear Medicine, Karolinska Institutet, Stockholm, Sweden
CDE Dosimetry Services, Inc., Knoxville, TN, United States
Karolinska Trial Alliance, Karolinska University Hospital, Stockholm, Sweden
Bayer Schering Pharma AG, Berlin, Germany
References:
Not available.
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
Purpose: [ 18F]FEDAA1106 is a recently developed positron emission tomography (PET) radioligand for in vivo quantification of the 18 kDa translocator protein [TSPO or, as earlier called, the peripheral benzodiazepine receptor (PBR)]. TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [ 18F]FEDAA1106 based on human whole-body PET measurements. Methods: PET scans were performed for a total of 6.6 h after the injection of 183.8 ± 9.1 MBq of [ 18F]FEDAA1106 in six healthy subjects. Regions of interest were drawn on coronal images. Estimates of the absorbed doses of radiation were calculated using the OLINDA software. Results: Peak uptake was largest in lungs, followed by liver, small intestine, kidney, spleen and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lungs (27.1%ID at 0.2 h), liver (21.1%ID at 0.6 h), small intestine (10.4%ID at 6.3 h), kidney (4.9%ID at 1.8 h) and spleen (4.6%ID at 0.6 h). The largest absorbed dose was found in the spleen (0.12 mSv/MBq), followed by kidneys (0.094 mSv/MBq). The calculated mean effective dose was 0.036 mSv/MBq. Conclusion: Based on the distribution and dose estimates, the estimated radiation burden of [ 18F]FEDAA1106 is moderately higher than that of [ 18F]fluorodeoxyglucose (FDG). In clinical studies, the administered activity of this radioligand ought to be adjusted in line with regional regulations. This result would be helpful for further clinical TSPO imaging studies. © 2011 Springer-Verlag.
Purpose: [ 18F]FEDAA1106 is a recently developed positron emission tomography (PET) radioligand for in vivo quantification of the 18 kDa translocator protein [TSPO or, as earlier called, the peripheral benzodiazepine receptor (PBR)]. TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [ 18F]FEDAA1106 based on human whole-body PET measurements. Methods: PET scans were performed for a total of 6.6 h after the injection of 183.8 ± 9.1 MBq of [ 18F]FEDAA1106 in six healthy subjects. Regions of interest were drawn on coronal images. Estimates of the absorbed doses of radiation were calculated using the OLINDA software. Results: Peak uptake was largest in lungs, followed by liver, small intestine, kidney, spleen and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lungs (27.1%ID at 0.2 h), liver (21.1%ID at 0.6 h), small intestine (10.4%ID at 6.3 h), kidney (4.9%ID at 1.8 h) and spleen (4.6%ID at 0.6 h). The largest absorbed dose was found in the spleen (0.12 mSv/MBq), followed by kidneys (0.094 mSv/MBq). The calculated mean effective dose was 0.036 mSv/MBq. Conclusion: Based on the distribution and dose estimates, the estimated radiation burden of [ 18F]FEDAA1106 is moderately higher than that of [ 18F]fluorodeoxyglucose (FDG). In clinical studies, the administered activity of this radioligand ought to be adjusted in line with regional regulations. This result would be helpful for further clinical TSPO imaging studies. © 2011 Springer-Verlag.
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
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Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study
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9 Records (8 excluding Abstracts).
Total impact factor: 36.655 (34.247 excluding Abstracts).
Total 5 year impact factor: 40.658 (38.2 excluding Abstracts).
Total impact factor: 36.655 (34.247 excluding Abstracts).
Total 5 year impact factor: 40.658 (38.2 excluding Abstracts).
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