Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study(575 views) Bastianello S, Romani A, Viselner G, Tibaldi EC, Giugni E, Altieri M, Cecconi P, Mendozzi L, Farina M, Mariani D, Galassi A, Quattrini C, Mancini M, Brescia VM, Lagace A, Mcdonald S, Bono G, Bergamaschi R
Bmc Neurol (ISSN: 1471-2377, 1471-2377linking), 2011 Oct 26; 11: 132-132.
Department of Public Health and Neurosciences, IRCCS C, Mondino National Institute of Neurology Foundation, University of Pavia, Italy. stefano.bastianello@yahoo.it
Interdepartmental Research Centre on Multiple Sclerosis, C. Mondino National Institute of Neurology Foundation, Pavia, Italy
Department of Neurology and Psychiatry and Department of Neurosciences, Sapienza University of Rome, Italy
Multiple Sclerosis Centre, IRCCS Don Gnocchi, Milan, Italy
CCSVI Project, Policlinico di Monza, University of Milan, Italy
Hospital of Civitanova, Marche, Italy
Barrie Vascular Imaging, Barrie ON, Canada
References: Not available.
Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study
BACKGROUND: Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association with specific MS phenotypes, and potential pathophysiological role are debated.; METHOD: We analysed the clinical data of 710 MS patients attending six centres (five Italian and one Canadian). All were submitted to venous Doppler sonography and diagnosed as having or not having CCSVI according to the criteria of Zamboni et al.; RESULTS: Overall, CCSVI was diagnosed in 86% of the patients, but the frequency varied greatly between the centres. Even greater differences were found when considering singly the five diagnostic criteria proposed by Zamboni et al. Despite these differences, significant associations with clinical data were found, the most striking being age at disease onset (about five years greater in CCSVI-positive patients) and clinical severity (mean EDSS score about one point higher in CCSVI-positive patients). Patients with progressive MS were more likely to have CCSVI than those with relapsing-remitting MS.; CONCLUSION: The methods for diagnosing CCSVI need to be refined, as the between-centre differences, particularly in single criteria, were excessively high. Despite these discrepancies, the strong associations between CCSVI and MS phenotype suggest that the presence of CCSVI may favour a later development of MS in patients with a lower susceptibility to autoimmune diseases and may increase its severity.
Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study
No results.
Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(607 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote