Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates
Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates(515 views) Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
Keywords: Dopamine Transporter, Radiobiology Dosimetry, Radiotracer Tissue Kinetics, Reference Tissue Method, Methyl 8 (4 Fluoro But 2 En 1 Yl) 3 (4 Tolyl) 8 Azabicyclo[3 2 1]octane 2 Carboxylate F 18, Radiopharmaceutical Agent, Unclassified Drug, Animal Experiment, Article, Caudate Nucleus, Controlled Study, Corpus Striatum, Drug Accumulation, Drug Blood Level, Drug Excretion, Drug Protein Binding, Female, Mesencephalon, Nonhuman, Positron Emission Tomography, Primate, Priority Journal, Putamen, Quantitative Analysis, Radiation Dose Distribution, Radioactivity, Thalamus, Tissue Distribution, Brain, Cocaine, Dopamine Plasma Membrane Transport Proteins, Fluorine Radioisotopes, Macaca Mulatta, Positron-Emission Tomography, Radiometry, Time Factors, X-Ray Computed, Treatment Outcome, Methyl 8 (4 Fluoro But 2 En 1 Yl) 3 (4 Tolyl) 8 Azabicyclo [3 2 1] Octane 2 Carboxylate F 18,
Affiliations: *** IBB - CNR ***
Department of Clinical Neuroscience, Centre for Psychiatry Research, R5:02, Karolinska Hospital, SE-17176, Stockholm, Sweden
INSERM U930, CHRU Tours, Tours, France
Laboratoires Cyclopharma, Saint Beauzire, France
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States
Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
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Girault, J. -A., Greengard, P., The Neurobiology of Dopamine Signaling (2004) Archives of Neurology, 61 (5), pp. 641-644. , DOI 10. 1001/archneur. 61. 5. 64
Ciliax, B. J., Drash, G. W., Staley, J. K., Haber, S., Mobley, C. J., Miller, G. W., Mufson, E. J., Levey, A. I., Immunocytochemical localization of the dopamine transporter in human brain (1999) Journal of Comparative Neurology, 409 (1), pp. 38-56. , DOI 10. 1002/ (SICI) 1096-9861 (19990621) 409: 1<38:: AID-CNE4>
3. 0. CO
Doll, F., Emond, P., Mavel, S., Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C] LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET (2006) Bioorg Med Chem, 14, pp. 1115-1125
Doll, F., Hinnen, F., Emond, P., Radiosynthesis of [18F] LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET (2006) J Labelled Comp Radiopharm, 49, pp. 687-698
Doll, F., Helfenbein, J., Hinnen, F., One-step radiosynthesis of [18F] LBT-999: A selective radioligand for the visualization of the dopamine transporter with PET (2007) J Labelled Comp Radiopharm, 50, pp. 716-723
Clark, J. D., Gebhart, G. F., Gonder, J. C., Keeling, M. E., Kohn, D. F., Special report: The 1996 guide for the care and use of laboratory animals (1997) ILAR J, 38, pp. 41-48
Ryzhikov, N. N., Seneca, N., Krasikova, R. N., Preparation of highly specific radioactivity [18F] flumazenil and its evaluation in cynomolgus monkey by positron emission tomography (2005) Nucl Med Biol, 32, pp. 109-116
Saleem, K. S., Logothesis, N. K., (2007) A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, , 1st ed. Oxford, U. K.: Academic Press
Melchitzky, D. S., Lewis, D. A., Tyrosine hydroxylase- and dopamine transporter-immunoreactive axons in the primate cerebellum: Evidence for a lobular- and laminar-specific dopamine innervation (2000) Neuropsychopharmacology, 22 (5), pp. 466-472. , DOI 10. 1016/S0893-133X (99) 00139-6, PII S0893133X99001396
Carson, R. E., Parameter estimation in PET (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and the Heart, pp. 287-346. , Phelps M, Schelbert H, eds. New York, NY: Raven Press
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) Journal of Cerebral Blood Flow and Metabolism, 27 (9), pp. 1533-1539. , DOI 10. 1038/sj. jcbfm. 9600493, PII 9600493
Zoghbi, S. S., Shetty, H. U., Ichise, M., PET imaging of the dopamine transporter with 18F-FECNT: A polar radiometabolite confounds brain radioligand measurements (2006) J Nucl Med, 47, pp. 520-527
Sprague, D. R., Chin, F. T., Liow, J. S., Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F] SPA-RQ: Comparison of thin-slice, bisected, and 2-dimensional planar image analysis (2007) J Nucl Med, 48, pp. 100-107
Deloar, H. M., Fujiwara, T., Shidahara, M., Nakamura, T., Watabe, H., Narita, Y., Itoh, M., Watanuki, S., Estimation of absorbed dose for 2- [F-18] fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging (1998) European Journal of Nuclear Medicine, 25 (6), pp. 565-574. , DOI 10. 1007/s002590050257
Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates
Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates
No results.
Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates
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